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(B) Explain How The Biochemnical Characterization (Nature) of Transforming Principle 'Was

This document contains 12 assignments on the topic of molecular basis of inheritance from a Class 12 Biology textbook. The assignments cover various concepts related to DNA structure and replication, central dogma, transcription and translation. Some key questions ask students to describe experiments demonstrating semi-conservative DNA replication, transformation principle, role of operons in gene regulation, and applications of DNA fingerprinting.

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Bhavna Beniwal
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38 views

(B) Explain How The Biochemnical Characterization (Nature) of Transforming Principle 'Was

This document contains 12 assignments on the topic of molecular basis of inheritance from a Class 12 Biology textbook. The assignments cover various concepts related to DNA structure and replication, central dogma, transcription and translation. Some key questions ask students to describe experiments demonstrating semi-conservative DNA replication, transformation principle, role of operons in gene regulation, and applications of DNA fingerprinting.

Uploaded by

Bhavna Beniwal
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Class :XIl BSubject : BIOLOGY Chap : 6 Molecular Basis of Inheritance

ASSIGNMENT 1

Q.1. Howmany base pairs would a DNA segment of length 1.36 mm have? (1)
Q.2. (a) A DNA segment has a total of 1000 nucleotides, out of which 240 of them are adenine
containing nucleotide, How many pyrimidine and puríne bases this DNA segment possesses ?
(b) Draw a diagrammatic sketch of aportion of DNA segment to support your answer. (3)
Q.3. (a) State the 'Central dogma 'as proposed by Francis Críck. Are there any exception to it ?
Support your answer with a reason and an exarmple.
(b)Explain howthebiochemnical characterization (nature) of Transforming Principle 'was
determined which was not defined from Griffith's experiments. (5)
ASSIGNMENT -2

Q.1. Write the role of histone protein in packaging of DNA in eukaryotes. (1)
Q2. Name the negatively charged and positively charged cormponents of a nucleosome. (1)
Q.3Although a prokaryotic cellhas no defined nucleus , yet DNA is not scattered throughout the cll
Explain. (2) Q4. Descriíbe the structure of a nucleosome (2)
Q.5. (a) How are the following formed and involved in DNApackaging in a molecule in a nucleus of
acell?
) Histone octamer (1) Nucleosorne (ii) Chrormatíin
(b) Differentiate between Euchrormatin and Heterochromatin. (4)

ASSIGNMENT -3

Q.1.Describe the experiments that established the identity of'transforming principles' of Griffith.
(3)
0.2.Describe the experiment that helped dermonstrate the semi-conservative mode of DNA
replication. (3)
0.3.(a) Why did Hershey and Chase use radioactive sulfer and radioactive phosphorus in their
experiment ? (b) Write the conclusion they arrived at and how. (3)

ASSIGNMENT 4

Q.1. Why is RNA more reactive in comparison to DNA ? (1)


Q2. Why is DNA molecule considered as a better hereditary material than RNA molecule? (3)
Q3. Answer the following questions based on Hershey and Chase's experiment :
(a) Narne the kínd of vírus they worked with and why ?
(b) Why did they use two types of culture media to grow viruses in ? Explain.
(c) What was the need for using a blender and later a centrifuge during their experiments ?
(d) State the condusion drawn by thern after the experiments. (5)

ASSIGNMENT -5
a.1. Write the dual purpose served by Deoxyribonucleoside triphosphate in polymerization (2)
0.2.Discuss the role the enzyme DNA ligase plays during DNA replication. (2)
Q.3.(a) Draw a labeled schematic diagram of a replication fork showing continuous and
discontinuous replication of DNA strands. (3)
(b)State a reason why is the replication continuous and discontinuous in the diagram drawn.
Q.4. (a) Differentiate between a template strand and coding strand of DNA.
(b) Name the source of energy for the replication of DNA. (3)
Q.5. (0) Why does DNAreplication occur in smallreplication forks and not in its entire length?
(i) Why is DNA replication continuous and discontinuous in areplication fork?
(ii) State the importance of origin of replication in a replication fork. (5)

ASSIGNMENT -6

Q.1. A region of acoding DNA strand has the following nucleotide sequence : -ATGC-. What shall
it
be the nucleotide sequence in (i) sister DNA segment it replicates, and (ii) m-RNA polynucleotide
transcribes ? (1)
Q.2. Name the enzyme that transcribes hnRNA in eukaryotes. (1)
Q.3. Name the three RNA polymerases found in eukaryotic cells and mention their functions? (3)
Q.4. Explain the post transcriptional modifications the hn-RNA undergoes in eukaryotic cell? (3)
Q.5. Describe Meselson and Stahl's experiment that was carried in 1958 on E. coli. Write the
conclusion they arrived at after the experiment. (5)

ASSIGNMENT -7

Q.1. Mention one difference to distinguish an exon from an intron. (1)


Q2. What is aminoacylation ? State its significance. (2)
Q.3.List the criteria a molecule that can act as genetic material must fulfil. Which one of the criteria
are best futfled by DNA or by RNA thus makingone of them a better genetic material than the other
? Explain. (5)
Q.4. (a) Draw diagram of transcription unit , describe its parts .
(b) State the function of Sigma factor and Rho factor in the transcription process in a bacterium.
(c)Write the function of RNApolymerase Iand RNA polymerase Illin eukaryotes (5)

ASSIGNMENT -8

Q.1. Name one amino acid which is coded by only one codon. (1)
Q.2. Give an example of a codon having dual function. (1)
Q.3. Mention two causes of frame-shift mutation. (1)
Q.4. Indiscriminate diagnostic practices using Xrays etc, should be avoided. Give one reason.
(1)
Q.5. Differentiate between the genetic codes given below : (2)
(a) Unarnbiguous and Universal
(b) Degenerate and Initiator, stop codon
ASSIGNMENT -9

Q.1.What is a mutagen ? Name a physical factor that can be a mutagen


(1)
Why is it referred to as an adapter
Q.2. (a) Describe the structure and function of a t-RNA molecule.
molecule?
(5)
(b) Explain the process of splicing of hn-RNA in a eukaryoticcell?
Comment on the significance of the results
Q.3. (a) Describe the series of experiments of F.Griffith.
obtained.
(5)
(b) State the contribution of Macleod, McCarthy and Avery.
replication occurs
Q.4. (a) Name the stages in the cellcycle where DNA
Highlight the role of enzyrne in the process
(b) Explain the mechanism of DNA replication .
semiconservative ? (5)
(c)Why is DNA replication said to be

ASSIGNMENT 10

during a train accident. Name


Q.1. Anumber of passengers were severely burnt beyond recognition
dead to their relatives. (3)
technique that can help hand over the
and describe a modern
DNA fingerprinting. (3)
Q.2. (a) Expand VNTRand describe its role in
fingerprinting technique.
(b) List any two applications of DNA
in an
lac-operon in E.coli . Explain its expression while
Q.3. Write the different components of a
'open' state. (5)
in E.coli.
medium affects the expression of a lac-operon
Q.4. (a) Absence of lactose in the culture
Why and how ? Explain.
expression is regulated in eukaryotes. (5)
(b) Write any two ways in which the gene

ASSIGNMENT -11

involved in human genome project. Mention how they


Q.1. (a)List the two methodologies which were
were used.

(b) Expand 'YAC and mention what was it used for. (3)

Q.2. (a)What is an operon?


promoter and a
(b)Explain how a polycistronic structural gene is regulated by a common
combination of regulatory genes in a lac-operon. (5)

ASSIGNMENT -12
Q.1. (a) Absence of lactose in the culture medium affects the expression of a lac-operon in E.coli
Why and how/Explain.
(b) Write any two ways in which the gene expression is regulated in eukaryotes. (3)
Q.2. Where is an 'operator located in a prokaryotic DNA ? How does an operator regulate gene
expression at transcriptional level in a prokaryotic? Explain. (3)
Q.3. Explain the role of lactose as an inducer in a lacoperon. (3)
Q4. Describe the interaction of t-RNA, m-RNA and ribosomes during the events of translation?
(5)

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