Journal of Formulation Science & Bioavailability (on A Review on Evaluation of Tablets Hart: [ASN Pharmacy Coleg, Tera Anca Pradesh, Inia nen Access Abstract Tablets are defined as sold unit dosage form of medicaments intended fr oral use. They became most popular as they were ‘easy in preparation compared to any other type of dosage forms. Bu the major drawback exists in ts manufacturing. any minor problem ocours during their manufacturing then the whole batch ofthe uni should be ciscarded. is necessary to avoid any sort of ‘errors during its manufacturing and as a result evaluation of tablets is very important before cispatching of a batch, Inthe present study, we discussed about the evaluation tests fr tablets, Keywords: Solid unit dosage; Compression method Indian pharmacopoeia; rganolepticpropeties Introduction Tablets ate a solid dosage form of medicaments with or without excipients which are prepared by compression method. According to the Indian Pharmacopoeia tablets are solid, lator biconvex unit dosage form of a medicament alone or medicament along with excipients prepared by compressing technique. They may varyinitssizeshapeand weight dependingon the medicament and ils mode of administration “Tablets ace said to be most widely used conventional dosage forms due toitsvariety ofadhantagesand 70%ofthe medicaments were dispensed in tablet forms. Mos of the medicaments canbe processed into tablets but there are some exceptions like medicaments with low density hygroscopic and the medicaments which were n0t possible ister. Post-compression studies (Evaluation parametets) plays a major roleto release any dosage form int the market [1-25 Advantages Unit dosage forms with dose precision, Least content variability, + Administration of accurate amounts of minute doses ofa drug, is possible, Economical ofall oral dosage forms as its production doesn't requires additional processing steps, © Easytransportation, Sustain release of a drug can be achieved through enteric coating, © Medicaments with bitter taste con be masked with coating technique (Sugar coating), ‘© Tablet dosage form is stable when compared to all oral dosage forms. Disadvantages Administration of drugs is no easy incase of children, Drugs with slow dissolution is not acceptable for tableting with g00d bioavailability, Medicaments with low density charactersandamorphousin nature are dificult to compress, Hygroscopic nature of drugs is not acceptable for tablet compression, Evaluation of Tablets © Appearance + Sizeand Shape, ‘+ Organoleptic properties, ‘© Uniformity of thicknoss, © Hardness, + Friability, + DrugContent Uniformity, + Weight Variation Test, + Wettingtime, + Water Absomption Ratio, © Invitro Dispersion Time, © Invitro Disintegration Test, ‘© Invitro Dissolution Studies, + ‘Twoset ofapparatus, © Apparatus-1, © Apparatus-2 Appearance Appearance is the first most required quality for the acceptance of tablet. General elegance and its identity play a major role forthe consumer acceptance, Acceptance ofthe appearance of batches of the tablethas heen done based on the measurement of the following factors like size, color, shape, presence or absence of odor, taste etc. [26-50] Size and shape Size and shape of a tablet has been determined by its thickness, “corresonding author: Hartha 8, Profesor, ASN Phatmacy Cale ‘Ava Pradesh 5220, nT; 086442 3900, E-nal Hort Received March 20,2017; Accepted Apri, 2017; Published Apt 08, 2017 Caton: Hartha 8 (2017) A Review on Evaluation of Tablets. J Formul So Bloavalay 1107, Copyright: © 2017 Hanna 8. Ths Is an opan-acess at sistbutes unsere terme of he Creatve Commens Attn License, wich pais onesiesPage 2 of 5 Size and shape of a tables plays an important role in its patient ‘compliance asthe size f the tablet increases it is not much easier for itsadministration, Micrometer isthe devise which is used todetermine the thickness of tablet. I can be acceptable ifthe batch falls within the +5%6 of standard deviation. Organoley properties ‘Color should be distributed uniformly without appearance of any signs of mottling, Colour ofthe tablet should be compared with the standard colour for comparison, Uniformity of thickness "To determine the uniformity of thickness random selection of tablets has to be done from each and every batch and need to measure its thickness independently. If the thickness of any single tablet varies then thebatch containing that batch will not be dispatched into market (Figure 1), Hardness “The abilty ofa tablet to withstand for mechanical shocks isknown as hardness, Pfizer hardness tester i the instrument which is used to determine the hardness of tablet. Iti expressed in kg/cm’. Take three tablets from each batch and hardness should be determined and the selection of tabled should be done randomly. Then the mean and standard devialtion values should be determined. Friability Roche friabilator is the equipment which is used for the determination of feiabiity isexpressed in percentage ‘Note down the initial weight of the tablets individually (W intial) “Tablets are placed ima plastic chamber which revolves at 25 rpm and they ave subjected to fall roma height of 6 inches inthe riabilator {or about 100 revolutions. Then measure the weight of the tablet (W final) and observe any weight diference before tablet and after the friabilator processing (Figure 2) Limits: loss in weight less than 05 to 1% of the initial weight of the tablet shouldbe considered as acceptable limits. Percentage of fiabiliy is calculated as: QW initial)-(W final) (W inital) 100, Drug content uniformity Initially weigh the tablet and then powder it, Now the powdered tablets transfered into a 100 mi yolumetre flask and add 0.1 N HCL upto mark. Now filter the solution and discard fist few mi of filtrate ‘Take 10 ml of filtrate should be taken into 50m volumetric flask and add 0.1 N HCL up to the mark and analysed spectrophotometiclly at 274 nm and 2345 nm. The concentration of the content of the drug Figur t: Von calipers uso dori tho caret othe tabi, Figure: Roce Nabiac: [Average woight of the tablet Percentage deviation 330 mg oa | 10 [Mor tran 130mg an ss than 328 mg is “Tablet: Percentage devin n weight variaton. (ug/ml) was calculated by using the standard calibration curve ofthe respective drug [51-73 Drug content iscalculated by using the below formula Concentration of the drug in (jig/ml) x 100 x 50/10 1000 Weight variation test Random selection of 20 tablets from each batch should be done and note dow the weight ofthe tablet individually and check for any variation inits weight. Aevording to US Pharmacopies small vations in the weight is negligible and can be accepted. Below isthe acceptable limit of percentage deviation in weight variation (Table 1). Wetting time ‘This method was performed to determine the wetting time of a tablet. piece of tse paper whichis folded twice skep in apetridish containing 6 ml of water and place the tablet on the tissue paper. ‘Observe the time taken for complete wetting ofthe tablet, Following procedure should follow thee times (three tral) for each batch and standard deviation isalso calculated from the obtained results. Water absorption ratio {A piece of tisue paper which i folded twice is kept in a petrdish (id.=6.5 cm) containing 6 ml of water and place the tablet on the tissue paper. Observe the time taken for complete wetting of the tablet ‘Thus wetted tablet was weighed. Now the water absorption ratio Ris Novi Hote Technolgy. J Mol Pnam Org Process Res 2116, 17, Osaka |, Ore 8, Akawa 4 Kimura A, Slausawa Y, eal. 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