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The Ultimate PCT Supplement (Hpta Restoration) - Looksmax - Org - Men's Self-Improvement & Aesthetics

The document discusses supplementing to restore the Hypothalamic-Pituitary-Testicular Axis (HPTA) after steroid use. It details how the HPTA works, common post-cycle therapy issues, and new compounds that block estrogen and androgen negative feedback loops. It summarizes studies showing one supplement, Novedex XT, significantly increased testosterone levels and decreased estrogen in test subjects. The author recommends Novedex XT as an effective PCT that avoids suppression, but notes they have not tried it personally.

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0% found this document useful (0 votes)
651 views25 pages

The Ultimate PCT Supplement (Hpta Restoration) - Looksmax - Org - Men's Self-Improvement & Aesthetics

The document discusses supplementing to restore the Hypothalamic-Pituitary-Testicular Axis (HPTA) after steroid use. It details how the HPTA works, common post-cycle therapy issues, and new compounds that block estrogen and androgen negative feedback loops. It summarizes studies showing one supplement, Novedex XT, significantly increased testosterone levels and decreased estrogen in test subjects. The author recommends Novedex XT as an effective PCT that avoids suppression, but notes they have not tried it personally.

Uploaded by

krakesh7848
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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 Best of the Best

 Guide THE ULTIMATE PCT SUPPLEMENT(HPTA RESTORATION) (2 Viewers)


 JustBeCurry ·  Sep 28, 2020

1 2 Next 

JustBeCurry
roped

Sep 28, 2020  #1

Let me preface this by saying please do your own research before you take
anything.
scroll down for tldr and the stack

Article on bodybuilding.com with all the information mentioned in this thread including
studies:

HPTA Supraphysiological Overcompensation: The Holy Grail Of Optimized N…


The first and most important How-to answer in the optimization of human performance
begins with HPTA Supraphysiological Overcompensation. Learn more...
www.bodybuilding.com

Technical Stuff
A brief summary of what the HPTA is, how it works, and why you do not
want to be shutting it down:

Endogenous testosterone production(testosterone made inside your body) is governed by the


HPTA(Hypothalamus-Pituitary-Testes-Axis). The hypothalamus releases a hormone called
GnRH(or LH-releasing hormone); the hypothalamus maintains homeostatic control so you do
not want to be fucking up the hypothalamus or any related part of the HPTA. The GnRH then
goes to the pituitary gland to produce two other hormones LH(Luteinizing Hormone) and
FSH(Follicle-Stimulating Hormone), which then the two hormones go the testes, and finally,
you get testosterone synthesis and sperm production. The HPTA and the GnRH, LH, and FSH
produced from it regulates the amount of testosterone, androstenediol, and DHEA in your
:
body. If your HPTA produces extra GnRH, LH, and FSH you also get all the anabolic things
like testosterone, and that is exactly why you don't want to it to crash from early steroid use
and/or shitty PCT.

Why do you get side effects from steroids and the key to fixing the HPTA:

Most people know the estrogen-related side effects of steroids and why you absolutely do not
want them. There are actually two negative feedback loops controlling the HPTA, the estrogen
negative feedback loop, and the lesser-known androgen negative feedback loop. When too
much estrogen interacts with the estrogen receptors of the hypothalamus, there's a negative
feedback loop where the gland thinks there must be too much testosterone too, causing loss
of testosterone or even shutdown. The hypothalamus also has androgen receptors, when it
senses that there is too many androgens it causes a decrease or shutdown in GnRH release.
This is probably why your balls shrink on steroids and you lose sexual function.

Common PCT and its faults:

Normal PCT would be something like Clomid, an AI(Anastrolzole is the one we're going to be
talking about), and HCG. Clomid is actually a very weak estrogen that blocks more powerful
estrogens from merging with the hypothalamic estrogen receptors, this causes the
hypothalamus to detect less estrogen and to increase GnRH release. Anastrozole is an
aromatase enzyme inhibitor that decreases conversions of androgens into estrogens, which
leads to a decrease in total circulatory estrogen and has some benefits of HPTA regeneration.
HCG or Human Chorionic Gonadotropin in males has been shown to mimic LH, so it leads to
the direct stimulation of the testes resulting in a minimal increase in sperm production and a
significant increase in testicular testosterone production.

Addressing the androgen negative feedback loop:

Until pretty recently hypothalamus-specific androgen inhibition wasn't possible, there are
some 'new' compounds that have been introduced.
3-OHAT: 6,17-dioxo-etiocholene-3-ol or 3-OHAT is a metabolite of a popular anti-aromatase
supplement 4-androstene-36,17-trione(AT). 3-OHAT has a longer half-life than AT, and it is
also a non-androgenic aromatase inhibitor(very important for the androgen negative feedback
loop). 3-OHAT is a fast-acting long-term destroyer of the estrogen negative feedback loop,
and consequently increases testosterone
ATD:3,17-dioxo-etiochol-1,4,6-triene or ATD is 2.8 times more powerful than AT and more
powerful than 3-OHAT in a different way. In vitro studies have shown ATD to be a powerful
androgen receptor blocker of the hypothalamus, but not of peripheral androgen receptors.
Basically, this means it blocks the androgen negative feedback loop caused by the
hypothalamus, so in turn GnRH release increases resulting in decreased estrogen production
while increasing natural testosterone production. If the dosages of 3-OHAT and ATD are
:
combined correctly there is an average increase in bioavailable testosterone of up to 400%
and a direct decrease in estrogens of an average 50%, and this is proven by studies.

Real-world testing:

Eight human test subjects were used in a study on ATD and 3-OHAT, four were placebo base-
line and the other four received a blend consisting of 3-OHAT and ATD.

Placebo Group:
No significant changes in total or free testosterone and estradiol(obvious)

Subject 1 (24yr old male:


Pre-testing-
Total T: 350ng/dl
Free T: 83.00pg/ml
Estradiol: 39pg/ml
14 Days-
Total T: 1803ng/dl
Free T: 522.90pg/ml
Estradiol:27pg/ml
42 Days-
Total T: 2895ng/dl
Free T: 839.20pg/ml
Estradiol: <20

Subject 2 (33yr old male):


Pre-testing-
Total T: 538ng/dl
Free T: 129.0pg/ml
Estradiol: 30pg/ml
14 Days-
Total T: 998ng/dl
Free T: 233.0pg/ml
Estradiol: 22pg/ml
42 Days-
Total T: 1416ng/dl
:
Free T: 421.3pg/ml
Estradiol: 22pg/ml

Subject 3 (25yr old male):


Pre-testing-
Total T: 555ng/dl
Free T: 104.00pg/ml
Estradiol: <20
14 Days-
Total T: 1624ng/dl
Free T: 405.7pg/ml
Estradiol: <20
42 Days-
Total T: 1837ng/dl
Free T: 405.7pg/ml
Estradiol: <20

Subject 4 (51yr old male):


Pre-testing-
Total T: 584ng/dl
Free T: 13.40ng/dl
Estradiol: 47pg/ml
14 Days-
Total T: 851ng/dl
Free T: 26.10ng/dl
Estradiol <20
42 Days-
Total T: 875ng/dl
Free T: 30.30ng/dl
:
Estradiol: <20

What does this mean for looksmax.me and roidcels:

So basically we need to take something with 3-OHAT and ATD to successfully prevent
androgen and estrogen negative feedback loops. There used to exist products with actual 3-
OHAT and ATD, but most of them have been recalled, as well as ATD being banned as a
supplement. Unless if you have some contacts then getting real 3-OHAT and ATD is a no-go
for most of us.

Actual important bit


The ultimate PCT:

Novedex XT, this is all you need. A previous version of this Novedex XT included real 3-OHAT
and ATD, but since it's banning the formula has been updated. The new versions formula
includes 3b-hydroxy-androsta-1,4,6-triene-17-one, 3b-hydroxy-androsta-4,6-diene-17-one,
and androsta-3,5-diene-7,17-dione.
Novedex XT does not have any androgenic metabolites that could cause HPTA suppression.
3b-hydroxy-androsta-4,6-diene-17-one is the so called 'ATD imposter' due to its structure
and mechanism of action and it is a steroidal aromatase inhibitor, permanently binding to the
aromatase enzyme. 3,5-dien-7,17-dione is another potent aromatase inhibitor.

TLDR; Nolvadex XT is a PCT that will help restore


HPTA function and does not have any suppression
to it.

Thanks for reading if you read all this. TAG YOUR


FRIENDS BRO
REMINDER: I'M NOT ADVOCATING YOU TRY THIS
:
OR SHILLING FOR THIS PRODUCT, IT SEEMS
PROMISING BUT I MYSELF HAVE NOT TRIED IT,
BUT WILL IN THE FUTURE
@Lev Peshkov
@xefo69
@ItisOver
only people I know who to tag lmao
diabolusx666, GigaAscender, WadlowMaxxing and 19 others

TheEndHasNoEnd
T No avi halo

Sep 28, 2020  #2

Dnrd

Pct bro

gribsufer1, AsGoodAsItGets, Deleted member 25938 and 28 others

Warlow
Young man lost in space and time
:
Sep 28, 2020  #3

TheEndHasNoEnd said: 

Dnrd
View attachment 699537
Pct bro

.me niggas be like "aesthetic af bro"

AsGoodAsItGets, Deleted member 25938, BrahminBoss and 12 others

SteveRogers
I have to return some videotapes.

Sep 28, 2020  #4

Great thread, any reliable sources that ship to AUS?

Lev Peshkov and JustBeCurry

JustBeCurry
roped

Sep 28, 2020  #5

SteveRogers said: 

Great thread, any reliable sources that ship to AUS?

idk bro just search it

SteveRogers

BigBoletus
Platinum
:
Sep 29, 2020  #6

Everyone is a biochemist on this site I feel so mogged

wayme, IIIlIIlllIllIIIll, fjor2096 and 8 others

bruh3610
[-={Raper of barbells《♡》Slayer Crew/Roidcel}=-]

Sep 29, 2020  #7

Novedex XT? Or do u mean nolvadex bruh wtf u talking abt

MulattoTrenMaxxer

karbo
300 iq mastermind sociopath manipulator demi-god

Sep 29, 2020  #8

bruh3610 said: 

Novedex XT? Or do u mean nolvadex bruh wtf u talking abt

nah apparently 'novedex xt' is an existing product

JustBeCurry

Lev Peshkov
High T
:
Sep 29, 2020  #9

Yuyevon said: 

Are u doing pct eventually or have u decided to cruise for life

before military pct

after cruise for life

SadnessWYJ
Beauties Can Die

Sep 29, 2020  #10

What the fuck does this even mean

socaldude12

JustBeCurry
roped

Sep 29, 2020  #11

SadnessWYJ said: 

What the fuck does this even mean

are you taking or planning to take steroids yes or no otherwise this thread isnt for you

SadnessWYJ
Beauties Can Die
:
Sep 29, 2020  #12

JustBeCurry said: 

are you taking or planning to take steroids yes or no otherwise this thread isnt for you

Planning to hop in PEDs after 3-4 years, saved btw

JustBeCurry

IvanArgentina
Iron

Sep 29, 2020  #13

What about HCG to restore endogenous hormone levels?

JustBeCurry
roped

Sep 29, 2020  #14

IvanArgentina said: 

What about HCG to restore endogenous hormone levels?

it mimics LH so it will not restore hormones levels, the root cause of why you have low LH is
due to low GnRH release due to an androgen negative feedback loop

WadlowMaxxing, Good_Little_Goy, SteveRogers and 1 other person

rydofx
Mistral
:
Sep 30, 2020  #15

u need to be like 170 iq to even comprehend 190 to understand this. i have no idea what ur
saying. u need some pictures fam cuz this is japanese in statistics class for me lol

Deleted member 25245 and AsGoodAsItGets

rax1337
Iron

Sep 30, 2020  #16

just take nolva / clomid or any other hypothalmic antagonist. Its so easy to get pharma shit
which is way more trustworthy than this and will work way better. Antagonism mogs
aromatase inhibition, not only in terms of hpta function restoration ,also you'll have less side
effects.
Last edited: Sep 30, 2020

Chintuck22, Deleted member 4614 and JustBeCurry

Deleted member 3020


wage slaving for surgery

Sep 30, 2020  #17

just ask for @LondonVillie ’s fat and inject it in your brow ridge and orbitals

fjor2096 and eduardkoopman

JustBeCurry
roped
:
Sep 30, 2020  #18

rax1337 said: 

just take nolva / clomid or any other hypothalmic antagonist. Its so easy to get pharma shit which is
way more trustworthy than this and will work way better. Antagonism mogs aromatase inhibition, not
only in terms of hypothalmic antagonism also you'll have less side effects.

is antagonism good for developing hptas? whole reason i went through the trouble of reading
the article was to find something that will give me a better chance of not fucking up my hpta

rax1337
Iron

Sep 30, 2020  #19

JustBeCurry said: 

is antagonism good for developing hptas? whole reason i went through the trouble of reading the article
was to find something that will give me a better chance of not fucking up my hpta

ofcourse antagonism is good for the hpta lmfao. all you need is less estrogen agonism of
hypothalmic receptors. Whether that be via antagonism or lowering the amount of an agonist
it doesnt matter at all.

JustBeCurry

JustBeCurry
roped
:
Sep 30, 2020  #20

rax1337 said: 

ofcourse antagonism is good for the hpta lmfao. all you need is less estrogen agonism of hypothalmic
receptors. Whether that be via antagonism or lowering the amount of an agonist it doesnt matter at all.

i realize that but you can only have so much estrogen antagonism, you still need some
estrogen, and you can get hpta inhibition and suppression from increased androgen levels
which i dont see a way to control or regulate until they just go down on their own, but clomid
might help after androgen levels have decreased post cycle

SteveRogers

JustBeCurry
roped

Sep 30, 2020  #21

JustBeCurry said: 

i realize that but you can only have so much estrogen antagonism, you still need some estrogen, and
you can get hpta inhibition and suppression from increased androgen levels which i dont see a way to
control or regulate until they just go down on their own, but clomid might help after androgen levels
have decreased post cycle

https://forums.t-nation.com/t/steroid-myths-and-teenagers/106459 nvm ive just been too


high inhib tbh, as long as you have researched and know how to take steroids properly hpta
suppression & shutdown shouldnt be too bad if you're a teenager, still interesting thread on
something new

TITUS
Kraken
:
Oct 1, 2020  #22

"Total Testosterone: 2895ng/dl


Free Testosterone: 839.20pg/ml
Estradiol: <20"
2895ng/dl What do you want steroids for? Just get this suplements and be on natural gear all
year around? Im researching steroids and never heard about this, sounds like big bad bullshit,
at least the novedex thing, even mimicking novaldex lol.

Someone read the real studies and find out.


Last edited: Oct 1, 2020

Chintuck22, Chadius and MentalistKebab

rax1337
Iron

Oct 1, 2020  #23

JustBeCurry said: 

i realize that but you can only have so much estrogen antagonism, you still need some estrogen, and
you can get hpta inhibition and suppression from increased androgen levels which i dont see a way to
control or regulate until they just go down on their own, but clomid might help after androgen levels
have decreased post cycle

the first sentence makes no sense, antagonism doesnt lower the amount of estrogen lmfao.. it
actually increases it. please learn more about basic endocrinology terms and concepts. trust
me clomid / nolva mogs..
Last edited: Oct 1, 2020

JustBeCurry
roped
:
Oct 1, 2020  #24

rax1337 said: 

the first sentence makes no sense, antagonism doesnt lower the amount of estrogen lmfao.. it actually
increases it. please learn more about basic endocrinology terms and concepts. trust me clomid / nolva
mogs..

i meant estrogen receptor antagonism which i think nolvadex does, but please correct me if i
say something wrong im just trying to learn and figure out whats the best

Asetric
Silver

Oct 1, 2020  #25

positive canthal tilt?

body is cope

poloralf
Diamond

Oct 3, 2020  #26

Harigato

MewingJBP
Master

Oct 4, 2020  #27

2895ng/dl total t looks too good to be true, what about side effects

Chadius
:
MentalistKebab
M Kraken

Oct 4, 2020  #28

TITUS said: 

"Total Testosterone: 2895ng/dl


Free Testosterone: 839.20pg/ml
Estradiol: <20"
2895ng/dl What do you want steroids for? Just get this suplements and be on natural gear all year
around? Im researching steroids and never heard about this, sounds like big bad bullshit, at least the
novedex thing, even mimicking novaldex lol.

Someone read the real studies and find out.Click to expand...

This ngl.

Just take this Novedex XT with growth hormone booster like mk677 and you should grow like
a weed in no time.

Seems too good to be true

WadlowMaxxing, Chadius and TITUS

TITUS
Kraken

Oct 4, 2020  #29

It's obviously bullshit, for lowIQcels.

Deleted member 4469


D Silver
:
Oct 5, 2020  #30

So basically I can run Novaldex XT and boost my testo like crazy ?

SteveRogers

Soalian
Kraken

Oct 6, 2020  #31

IME the ultimate PCT to jumpstart things again is Triptorelin, a Gnrh agonist peptide (ironically,
also used as a castration agent).

It's dubbed as "the single-dose PCT".

When used only ONCE, at a100 mcg dose, it will cause a sudden surge in LH (doses used for
castration are way higher, about 4mg every month to maintain castration)

HolePunch
H Iron

Oct 6, 2020  #32

What happens if you do pct without having been in a cycle?

sloopnoob
Equinox

Oct 6, 2020  #33

Im gonna run it as stand alone as many have done on roiding forums and submit blood works.
Meanwhile I came across this stuff called Letro XT the contents of it are. @JustBeCurry can u
tell me about this coz I know jack shit and u've researched alot. I am indeed mirin ur hard
work. Thanks

Lev Peshkov and JustBeCurry


:
JustBeCurry
roped

Oct 6, 2020  #34

sloopnoob said: 

Im gonna run it as stand alone as many have done on roiding forums and submit blood works.
Meanwhile I came across this stuff called Letro XT the contents of it are. @JustBeCurry can u tell me
about this coz I know jack shit and u've researched alot. I am indeed mirin ur hard work. Thanks
View attachment 715997

has the same stuff as novedex xt except androsta-3,5-diene-7,17-dione which is just an


aromatase inhibitor so it should have the same effects as novedex xt besides the extra
aromatase inhibition which might even be good in some cases, put please if you do take it
post your bloods here before and after bro

sloopnoob
Equinox

Oct 6, 2020  #35

JustBeCurry said: 

has the same stuff as novedex xt except androsta-3,5-diene-7,17-dione which is just an aromatase
inhibitor so it should have the same effects as novedex xt besides the extra aromatase inhibition which
might even be good in some cases, put please if you do take it post your bloods here before and after
bro

I will indeed post bloods since it goat shit on its own from what I think, but shipping is gonna
take time I ordered something from US before and never received it in 3 months. But Predator
Nutrition has so I can order from UK. Can you post the study which you used to show
baseline and after hormonal levels?

JustBeCurry
roped
:
Oct 6, 2020  #36

sloopnoob said: 

I will indeed post bloods since it goat shit on its own from what I think, but shipping is gonna take time I
ordered something from US before and never received it in 3 months. But Predator Nutrition has so I
can order from UK. Can you post the study which you used to show baseline and after hormonal
levels?

https://pubmed.ncbi.nlm.nih.gov/17460335/ this study was done on the original novedex xt


with ATD and 3-OHAT, which the new novedex does have two compounds related to ATD and
claims to function similarly if not better, but still take the results in this study with a grain of
salt

sloopnoob

Deleted member 2621


Kortajarena lurking

Oct 7, 2020  #37

JustBeCurry said: 

https://pubmed.ncbi.nlm.nih.gov/17460335/ this study was done on the original novedex xt with ATD
and 3-OHAT, which the new novedex does have two compounds related to ATD and claims to function
similarly if not better, but still take the results in this study with a grain of salt

Saw this study and its crazy. Did u see the possible side effects according to FDA? probably
unfounded speculation, still sounds bad

Deleted member 2621


Kortajarena lurking

Oct 7, 2020  #38

Also if I could give some own ideas: there are some ATD prohormones which are still legal,
maybe check that
:
gaymidget
Platinum

Oct 8, 2020  #39

Is the normal available novaldex already the novaldex XT or do I have to specifically buy that
one?

Vista
Bronze

Oct 9, 2020  #40

gaymidget said: 

Is the normal available novaldex already the novaldex XT or do I have to specifically buy that one?

It depends, check the ingredients of it

Vista
Bronze

Oct 9, 2020  #41

what dosage was used in the studies?

Deleted member 3990


D Kraken

Oct 11, 2020  #42

BigBoletus said: 

Everyone is a biochemist on this site I feel so mogged

Its copypasta
:
Deleted member 10172
CEO of Cope

Oct 12, 2020  #43

rydofx said: 

u need to be like 170 iq to even comprehend 190 to understand this. i have no idea what ur saying. u
need some pictures fam cuz this is japanese in statistics class for me lol

Right like what the fuck is he talking about

rydofx

Deleted member 2621


Kortajarena lurking

Oct 13, 2020  #44

rax1337 said: 

the first sentence makes no sense, antagonism doesnt lower the amount of estrogen lmfao.. it actually
increases it. please learn more about basic endocrinology terms and concepts. trust me clomid / nolva
mogs..

Im not a big fan of most antagonists but i like the idea of a t booster OCT, u think i could just
use this by itself? Sounds not bad ngl

TITUS
Kraken

Oct 14, 2020  #45

PCT is HCG, novaldex and clomid. Forget about jewish scams like this one, why the fuck is
this even stickied.

Good_Little_Goy and MentalistKebab


:
Lev Peshkov
High T

Oct 19, 2020  #46

yo man bumoing have some questons ded srs

Deleted member 10494


Bronze

Oct 27, 2020  #47

JustBeCurry said: 

Let me preface this by saying please do your own research before you take
anything.
scroll down for tldr and the stack

Article on bodybuilding.com with all the information mentioned in this thread including studies:

HPTA Supraphysiological Overcompensation: The Holy Grail Of Optimize…


Click to expand...
The first and most important How-to answer in the optimization of human performance

highest iq thread

Deleted member 3635


Mistral
:
Oct 29, 2020  #48

JustBeCurry said: 

Let me preface this by saying please do your own research before you take
anything.
scroll down for tldr and the stack

Article on bodybuilding.com with all the information mentioned in this thread including studies:

HPTA Supraphysiological Overcompensation: The Holy Grail Of Optimize…


Click to expand...
The first and most important How-to answer in the optimization of human performance

link ? i found one source but its from a supplement store so i doubt its the real deal

Lev Peshkov
High T

Nov 6, 2020  #49

Lol dumb question but will this restore fully, is this what the study says?

Will this work after every PED too?

TITUS
Kraken
:
Nov 16, 2020  #50

"I don't know if it can give a false positive for boldenone but it certainly does for testosterone.

That is why the (worthless) test results given in the ads show incredible gains in testosterone.
The test is picking up the ATD ingredient incorrectly as being testosterone.

I think it's very unlikely that even if a given test mistakenly would pick up "Novedex" as being
boldenone that there would be any evidence you could point to to back it up.

I don't have a figure on how long ATD stays in the system. "

Mystery solved, it gives false positive for testosterone. Don't waste your time and money in
bullshit.

Good_Little_Goy

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