MCQs TEST 6-12-2021

CHAPTER: INFLAMATION
1- Following stimuli can cause inflammation except:
A) Hypoxia
B) Microbes
C) Tissue necrosis
D) Nutritional deficiency
E) Foreign bodies
2- Local signs of acute inflammation include:
A) Redness
B) Pain
C) Swelling
D) Heat
E) All of the above
3- Vascular change in response to inflammation includes all of the following except:
A) Increased blood flow
B) Increased permeability
C) Decreased blood flow
D) Leakage proteins
E) None of the above
4- Delayed prolonged permeability response is caused by:
A) Low grade heat
B) U.V rays
C) Mild injuries
D) Burns
E) Hypoxia
5- Characteristics of exudate include:
A) Protein Rich fluid
B) Protein poor fluid
C) Found in earliest phase of inflammation
D) Neutrophils absent
E) Specific gravity <1.012
6- Secondary granules neutrophils contain:
A) Acid hydrolase
B) Myeloperoxidase
C) Lysozyme
D) Histaminase
E) c & d.
7- Chemotactic factors for Neutrophils include:
A) Fibronectin fragments
B) C5 a
C) Histamine
D) PG _ O2
E) None of the above
8- Increased permeability in acute inflammation is induced by which of the following
mediator:
A) C3b and IgG
B) Prostaglandin
C) Bradykinin
D) Histamine & NO
E) Leukotriene
9- Functions of IL-1 and TNF include
A) Fever
B) Decreased appetite
C) Neutrophilia
D) Shock
E) All of the above
10- Activation of kinin system leads to the formation of:
A) Bradykinin
B) Histamine
C) Prostaglandin
D) NO
E) All of the above
11- Predominant cells in chronic inflammation are:
A) Neutrophils
B) RBCs
C) Macrophages
D) Basophils
E) None of above

Neutrophils are dominant in Acute inflammation!

12- In H & E stain, cells containing pink granular cytoplasm, indistinct boundaries, oval
elongated less dense nucleus indicate the presence of:
A) Fibroblasts
B) Epitheloid cells
C) Lympocyte
D) Eosinophils
E) Neutrophils
13- Sarcoidosis is example of:
A) Hard tubercle
B) Gumma
C) Soft tubercle
D) Immune granuloma
E) None of above
14- Following cells are important in development in granuloma:
A) Platelet
B) Neutrophil
C) Basophils
D) Epitheloid
E) Lymphocytes
15- Granuloma having central caseous necrosis is:
A) Sarcoidosis
B) Multiple myeloma
C) Syphilis
D) Silicosis
E) Tuberculosis
16- Transformation of macrophages to Epitheloid cells is medicated by:
A) IFNr
B) TNF
C) C3b
D) Collagenase
E) IL-1
17- Immune granuloma is caused by:
A) Sutures
B) Talc
C) Microbes
D) All of the above
E) None of above
18- Rounded or stellate granuloma containing central granular debris & recognizable
neutrophils is characteristic feature of:
A) Tuberculosis
B) Leprosy
C) Cat-scratch disease

D) Syphilis

E) Silicosis

19- Acute phase response include all of the following except:

A) Fever

B) Leukocytosis

C) Acute phase proteins

D) Thrombocytopenia

E) Increased BP

2O- Impaired liver function in acute-phase response is caused by:

A) PGD

B) IgG

C) Chemokines

D) C3B

E) TNF AND IL=1

21- Regarding Acute-phase proteins all are correct except:

A) Mostly synthesized in liver

B) Level is increased in response to inflammation

C) Causes liver function impairment

D) Include CRP, SAA and fibrinogen

E) May act as opsonins

22- Skin blister resulting from a burn is an example of:

A) Serous inflammation

B) Fibrous inflammation
C) Gangrene

D) Granulomatous inflammation

23- Suppurative inflammation is characterized by:

A) Out poring of a thin fluid.

B) Large amount of pus or purulent exudate.

C) Fluid derived from secretions of Mesothelial cells.

D) Eosinophile meshwork.

E) None of above

24- Excavation of surface of an organ or tissue produced by sloughing of inflammatory necrotic tissue
represents:

A) Acute inflammation

B) Serous inflammation

C) Fibrinous inflammation

D) Ulcer

E) Atrophy

25- NO causes:

A) Vasoconstriction

B) Chemotaxis

C) Pain

D) Fever

E) Vasodilation

26- Giant cells are present in:

A) Acute inflammation

B) Chronic inflammation

C) Granulomatous inflammation

D) Abscess formation

E) Fibrinous inflammation

27- Regarding chemokines:

A) Synthesized in liver
B) Derived from arginine

C) Play an important role in vasodilation

D) Act as chemo-attractants

E) Induce endothelial activation

28- Generation of following substance reduces the number of free radicals in cells:

A) Glutathione peroxidase

B) Catalase

C) H2O2

D) NADPH

E) Collagenase

29- Chemotaxis, leukocyte recruitment & activation is mediated by:

A) C5a
B) IL-1, TNF
C) Bradykinin
D) NO
E) both a & b.
30- A common feature of inflammation reaction is:
A) Leukocytosis
B) Pancytopenia
C) Thrombocytopenia
D) Anemia
E) None of above
31- The basic goal behind vascular changes associated with inflammation is:
A) Provide more nutrition
B) Provide more oxygen
C) Recruitment of leukocytes
D) Removal of dead cells
E) Removal of offending agent
32- A 45-year-old woman after silicone breast implant noted firmness with slight deformity
of breast on the left. The implants are removed & there is evidence of leakage of the implant
centers on the left. Which of the following cell type is most likely to be characteristic of the
inflammatory response in this situation?
A) Eosinophil
B) Giant cell
C) Plasma cell
D) Lymphocytes
E) Mast cell

33- A 25-year old patient having pharyngeal infection for 3 days experienced fever & chills.
On examination the pharyngeal purulent exudate was found. Which of the following type of
inflammation is present?
A) Acute inflammation
B) Chronic inflammation
C) Granulomatous inflammation
D) Abscess inflammation
E) Fibrinous inflammation

34- Chest Radiograph of 50-year old man reveals multiple Nodules, lobes sputum microscopy
reveals Acid fast bacilli. Which of the following type of inflammation is present?
A) Acute inflammation
B) Chronic inflammation
C) Granulomatous
D) Abscess formation
E) Fibrinous inflammation
35- Chest Radiograph of a 30-year old woman reveals multiple nodules of 1-4 cm in size
some of which demonstrate cavitation in the upper lobes. Sputum sample reveals presence of
acid bacilli. The nodules are formed by:
A) Macrophage
B) Neutrophil
C) Mast cell
D) Fibroblast
E) Platelet

36- Cell or tissue growth that replaces the lost structure is known as:
A) Healing
B) Scarring
C) Regeneration
D) Atrophy
E) Hypertrophy

37- Repair involving a combination of regeneration and fibrosis is known as:

A) Healing
B) Regeneration
C) Hypertrophy
D) Atrophy
E) None of above

38- A scar is composed of:

A) Fibroblast
B) Collagen
C) Macrophages
D) Both a & b.
E) None of above

39- Genetic defect in leukocyte function causing defective chemotaxis is related to:
A) Thermal injury
B) Myeloperoxidase deficiency
C) Heterophil granules
D) Leukocyte adhesion deficiency
E) Lukemia
40- Exuberant proliferation of fibroblasts & connective tissue following incisional scars are
called:
A) Scar
B) Keloid
C) Proud flesh
D) Granuloma
E) Desmoids
41- Growth factors involved in repair & healing include:
A) EGF
B) TGF
C) VEGF
D) FGF
F) All of the above
42- During angiogenesis stabilization of newly formed vessels is done by:
A) Angiopoietin 1
B) PDGF
C) TGF-B
D) Angiopoietin 2
E) VEGF
43- Deficiency of which of the following delay repair
A) Protein
B) Vit. C
C) Zinc
D) Diabetes mellitus
E) All of the above
44- Function of matrix metallo-proteinase (MMP) is tissue remodeling is:
A) Deposit collagen
B) Degradation of ECM
C) Recruitment of smooth muscle cells.
D) Mitogenic for fibroblast
E) Degradation of epithelium
45- Characteristics of primary wound healing include:
A) Less inflammatory reaction
B) Wound contraction
C) Slow healing
D, tissue renewal and repair
E, regeneration ,healing and repair
46- Which collagen type imparts greatest tensile strength to healing wounds:
A) I
B) II
C) III
D) IV
E) V
47- Replacement of dead ells cannot occur by regeneration in tissue of:
A) Labile cells
B) Stable cells
C) Permanent cells
D) Stem cells
E) Embryonic cells
48- Healing wound reaches its maximum tensile strength in :
A) 2 weeks
B) 6 weeks
C) 3 months
D) 1 year
E) variable time
49- Most important delaying factor in wound healing is:
A) Foreign body
B) Infection
C) Deep tissues
D) Calcification
E) Joint wound
50- The hall mark of healing and repair is;
A) Inflammation
B) Neutrophilic infiltration
C) Fibroblast proliferation
D) Granulation tissue
E) Wound contracture

The End