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Phytosan PP - Specification - 2017-04 - e

Phytosan PP is an extract from soybeans that contains proteins, glycoproteins and polysaccharides. It counteracts signs of skin aging caused by biological factors and UV exposure by stimulating extracellular matrix production and providing photoprotection. Phytosan PP improves skin elasticity and microrelief by interfering with cell communication pathways and increasing protein and collagen synthesis. It also increases DNA repair and reduces UV-induced cell damage. Phytosan PP can be used at 2-5% in emulsified and gel skin care products to regenerate and protect stressed skin from premature aging.

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joanamarie cuyung
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110 views3 pages

Phytosan PP - Specification - 2017-04 - e

Phytosan PP is an extract from soybeans that contains proteins, glycoproteins and polysaccharides. It counteracts signs of skin aging caused by biological factors and UV exposure by stimulating extracellular matrix production and providing photoprotection. Phytosan PP improves skin elasticity and microrelief by interfering with cell communication pathways and increasing protein and collagen synthesis. It also increases DNA repair and reduces UV-induced cell damage. Phytosan PP can be used at 2-5% in emulsified and gel skin care products to regenerate and protect stressed skin from premature aging.

Uploaded by

joanamarie cuyung
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 3

Phytosan PP

Product Specification

Characteristics
Phytosan PP contains proteins, glycoproteins and polysaccharides isolated from soybeans.
By stimulating synthesis of extracellular matrix constituents and providing comprehensive
photoprotection, Phytosan PP counteracts the signs of biological and UV-induced premature
skin aging (such as formation of wrinkles).

INCI Name CAS No. EINECS No.


Water (EU name: Aqua) 7732-18-5 231-791-2
Glycerin 56-81-5 200-289-5
Glycine Soja (Soybean) Phytoplacenta Extract 84776-91-0 ./.

Analytical Data
20
Refractive index nD 1.365 - 1.375
Density 20 °C 1.060 - 1.090 g/ml
pH value 4-5
Dry residue (2 h, 102 °C) 18.0 - 25.0 %
Total protein (Sigma TP0200) 0.4 - 1.0 %
Phenoxyethanol 0.8 - 1.0 %
Potassium sorbate 0.2 - 0.3 %
Colony forming units
Total aerobic microbial count (TAMC) < 100/ml
Total combined yeasts/moulds count (TYMC) < 10/ml
in absence of non conforming organisms

Physiological Safety
Acute oral toxicity
Phytosan PP is made from food grade, non-genetically modified soybeans. Since the
manufacturing procedure does not chemically alter the raw material and no toxic substances
are used to produce Phytosan PP, oral toxicity testing in the rat was not conducted with this
product. Phytosan PP is considered to be non-toxic.

Eye irritation potential


The eye irritancy potential of Phytosan PP was tested in the chorioallantoic membrane at a
100 % concentration using an alternative preservation (parabens) under the product name
"Phytosan". Phytosan, undiluted, was classified as non-irritant.

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Phytosan PP
Product Specification

Human Repeated Insult Patch Test (HRIPT according to Shelanski):


An O/W cream containing 10 % Phytosan (preserved with parabens) was applied repeatedly to
50 volunteers with dry, sensitive skin (among them, 9 persons suffering from eczemas) for a
duration of 4 weeks. The cream containing Phytosan did not produce any skin irritating effects
nor signs of skin sensitization.

Mode of action
Cell-cell communication is essential for all functions of the human body. Via cell receptors and
appropriate signaling molecules metabolic and catabolic reactions can be controlled in the cell.
Environmental influences such as UV light interfere with metabolic processes in human skin by
modulating signaling pathways between the cells. Cell receptors not only recognize
endogenous signaling molecules; defined classes of substances derived from plants are also
able to influence cell responses by interacting with cell receptors.

By both in vitro experiments conducted with human skin cells and in vivo tests on humans it
could be demonstrated that the ingredients of Phytosan PP can influence cell responses. The
biological activity of Phytosan PP shows in a significant increase in total protein synthesis as a
result of signal transduction as well as in an induction of collagen biosynthesis.

Apart from a resultant improvement of the microrelief of the skin, Phytosan PP was found to
have extraordinary anti-stress activity after UV irradiation. Phytosan PP clearly prevents decrease
in ATP levels in keratinocytes after UV exposure, thus enabling cell mechanisms for prevention
of DNA damage to produce a more efficient protective effect.

Phytosan PP significantly increases the DNA repair rate after UV exposure, with resultant
decrease in the number of reparable DNA single strand breaks and less irreparable DNA
damage. Furthermore, formation of sunburn cells is reduced by modulation of UV-induced
apoptosis.

By interfering with protective mechanisms of skin cells, Phytosan PP possesses a high


photoprotective potential. As a "biological sun protection factor" Phytosan PP thus counteracts
UV-induced premature skin aging. Since it simultaneously stimulates skin regenerative cell
functions, it improves skin elasticity and the microrelief of the skin.

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Phytosan PP
Product Specification

Application
Phytosan PP is suitable for the regenerative skin care and for the care of stressed skin. It
especially counteracts UV-induced premature skin aging.
It can be u sed in emulsified and gel-type skin care products. Use of emulsifiers and/or gel
builders which are non-sensitive to electrolytes is recommended.

Dosage
2-5%

Appearance/Odor
Yellowish, transparent liquid. Characteristic odor.

Solubility
Miscible with deionized water, but yields no clear solution. A clear solution is obtainable by
dissolving, for example, 5% Phytosan PP in deionized water with added 0.5% EDTA (1/10 of
the use level of Phytosan PP).

Processing
When formulating Phytosan PP it must be noted that electrolyte sensitive raw materials of
formulations might be influenced. Small amounts of EDTA can stabilize the emulsion. Ionic
emulsifiers should not be used. Electrolyte sensitive rheology modifiers and hydrocolloids might
lose some efficacy when Phytosan PP is added. This impact can be overcome when EDTA is
added (1/10 of the used Phytosan PP quantity). The development of W/O formulations is
possible without any difficulties. The temperature should not exceed 40 °C during the
production process, precipitations could be observed in the case of higher temperatures. The
pH range of formulations with Phytosan PP is wide and allows formulations between 3.0 – 7.5.

Storage
If kept at 10 - 20 °C, protected from frost and light, in well-closed containers, Phytosan PP is
stable for at least 2 years.
Once opened, product packs should be fully used.

Packing
Available pack sizes: 1 kg, 5 kg, 25 kg
Sample size: 50 g

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