Cvs Phypharm All MCQ
Cvs Phypharm All MCQ
Note: Encircle the alphabet which corresponds to the single best response.
1. A graph is plotted by taking time on x axis and concentration of reactant on y
axis for a reaction following a pseudo first order. The pattern of the graph is:
A . curve B. hyperbola
C. parabola D. straight line
2. In the photochemical degradation of multisulpha preparation, the order that a
reaction does follow is:
A. first B. pseudo first
C. second Diero
3. The integral rate equation for a reaction (in common notation) is written as
log c log c (kt/2.303). When a graph is drawn log c vs. t, the slope will
= -
be:
negative B. one
C. positive D. zero
PHYSICAL PHARMACEUTICS
42
notation) k = Xat(a-x) is concerned withh
The integral equation (in
common
4.
the order B. pseudo first
A. first
D. zero
second
involved in a reaction, the 'overall rate' of a
5. When a series of steps are
12. In the degradation studies of aspirin suspension, the orders observed initially
and at the end, respectively, are:
A. first, second B. first, zero
C. second, first Le zero, first
6. 5 g/100 mL. The
13. A prescription of liquid aspirin preparation contained
order of reaction in the
solubility of aspirin at 25°C is 0. 33 g/100 mL. The
kinetic study is:
A. apparent first LB. apparent zero
C. first D. second
drug in solution is a
the complete degradation of a
14. The time required for
reaction is:
finite value. The order of that
B. pseudo first
A. first
C. second Dzero
presence of
H* and (OH)
Normally, ethyl acetate undergoes hydrolysis in
15.
reaction observed in the
acidic and alkaline solutions,
ions. The order of the
r e s p e c t i v e l y , are:
expression for
a
rate
19. The general ,2.305 og e
B. k C
A d c / d t = -kC
X
D. deldt =k
C. k= at (d-x) reaction under
forms exhibit
faster rate of
dosage
20. Which one of the following
normal conditions?
B. Ointments
A. Emulsions
D. Suspensions
where de
as (-de/di),
CSolutions of a reaction is expressed
kinetics, the rate does it refer to?
21. In chemical Whose
concentration
concentration.
refers to the B. Product
A: Catalyst D. Solvent medium
L Reactant
P PHYSICAL PHARMACEUTICs
44
of the following can be designated as the molecularity of.
a
22. Which one
reaction?
A. Half
One
D. Zero
C. One and half
23. Which one of them is refered as a general rate equation (-dc/dt) fora second
order?
A. A°B A'B
C. A'B2 D. AB2
24. Which one of the following orders have abundant applications in biological
processes?
A First B. Second
C. Third D. Zero
25. In chemical reaction, the rate constant is
a independent of the initial
concentration. Which one of them is the order?
A. First B. Second
C. Third B Zero
QUESTION BANK
Each question carries 1 mark
Note : Encircle the alphabet which corresponds to the single best rep
1. The accelerated stability studies are primarily used to
detc
A. energy of the activation of the reaction
B. k value at elevated
temperatures
C. k value at the room
temperature
shelf life of the product
2. specific rate constant (k) determined
The
buffer at 1l mg/mL concentration is 2.0 x
for aspirin hydrolysis in
10-min-l at 25 °C. The shelf
pH 1.0
A I n k =- aE, + In A B. Ink=
= a +In A
2.303 RT RT
log k
- log A D. k= Ae alRT
C.
2.303 RT
eneral. reaction rate constants in
neutral pH are comparatively:
A. equal B. higher
e lowver D. zero
5. The expiry date for a tablet
is not mentioned
on the label the
It means
means that
that tnc
time in years is:
expiry
Ch-2 DRUG STABILITY
91
f i v e years B. nil
C. three years D. two years
Penicillin G is prepared as a salt of procaine penicillin G. Now the rate of
decomposition of penicillin G will be:
A. increased
UBreduced
C. unchanged D. unpredictable
7 According to International Pharmaceutical Federation, the recommended
overages be limited to the maximum percent of:
A. five B. ten
thirty D. twenty
8. Usually, the rate of a chemical reaction may be enhanced by:
of picil.
anmnie
92 observed in the
degradation
reactions is
following
4. Which of the
lin? Hydrolysis
D. Recimization
A. Decarboxylation
It
It can
c a n be
be prevented by:
C. Oxidation formulation.
in a
decomposition antioxidant
an
5 . Aspirin undergoes B. adding
a chelating agent its solubility
A. adding LE. suppressing
it from light chemical decomposition2
C. protecting NOT a
is primarily
the following
16. Which o n e of B. Hydrolysis
A. Isomerisation
DVolatilization
C. Oxidation
studies of
solution dosage form, the
of accelerated stability of kcal/mol):
17. For the validity in the range of (in units
of activation should be
energy B 1 1 to 30
A. O to 10
D. 51 to 70
C. 31 to 50
effective in preventing the rate
of these methods is the MOST
18. Which one
of hydrolysis?
B. Complexation
A. Buffer
D. Suppression of solubility
Removal of water
is observed in a suspension due to:
19. Duringstorage, crystal growth
A. absorption of water
Bfluctuations in the ambient temperatures
16. The true density of talc is 2.7 g/em', the bulk density (g/cm') of talc will
be:
A. equal to 2.7 B. greater than 2.7
Cless than 2.7 D. unrelated
17. The angle of repose values are utilized to:
LAmeasure the movement of granules from hopper to the table of tabletting/
capsule machine
B. select proper containers for capsules of a given mass of powders.
C. study the absorption of drugs.
D. understand dissolution of medicament
18. The term 'light' as applied to pharmaceutical powders means:
A. low bulk density B. low granule density
C. low true density D. slightly coloured
19. The type of particle diameter that is obtained by microscope method of
evaluation is:
A projected B. Stokes'
C. volume D. volume-surface
20. Porosity of a porous powder is defined as:
A. bulk volume/void volume B . void volume/bulk volume
C. void volume/true volume D. true volume/bulk volume
QUESTION BANK
Each question carries one mark
Note Encircle the alphabet which corresponds to the single best response.
1. Flocculated suspensions exhibit the flow of a type:
A. dilatant B. Newtonian
Leplastic D. pseudoplastic
2. A limitation that is NOT related to the falling sphere viscometer:
A.
applicable to only less viscous liquids
B. large volume of
sample is required
C. needs the
sample to be transparent
Dplug flow
3. In general,
Newtonian fluids are expressed in terms of
viscosity. A
corresponding expression in non-Newtonian fluids (in terms of viscosity)
is:
LA. apparent B. dynamic
C. intrinsic D. kinematic
4. One of the following is NOT a one
point viscometer, but
the same purpose. Pick the viscometer can be used for
of this type.
Cup and bob B. Falling sphere
C. Ostwald
D. Rolling ball
5. Fluidity is a term associated with
Newtonian fluids. An
plastic flow fluids is: equivalent term in
A. apparent viscosity
B. flexibility
e mobility
D. plastic viscosity
6. Dilatant flow is characterized as a
reverse
A. Newtonian flow phenomenon of
B. plastic flow
epseudoplastic flow D. rheopexy
7. Deflocculated suspension with high concentration
exhibits the flow of type: of the dispersed solids
X. dilatant
B. Newtonian
C. plastic
D. pseudoplastic
8. In antithixotropy, the down-curve is
frequently positioned
to up-curve): to: (with respect
Ch-7 RHEOLOGY 315
A. left B. origin
right D. superimposible
9. At equilibrium, the thixotropic behaviour of a pseudoplastic system exhibit
the state of:
A. gel B. paste
sol D. wax
10. Which one of the following physical property is NOT a rheological prop-
erty?
A. Body and slip B. Spreadability
Surface tension D. Viscosity
11. The pseudoplastic flow behaviour can be explained by:
Aapparent viscosity B. area of hysteresis loop
C. hysteresis loopP D. yield value
Which is relevant?
A. Free from intermolecular interactions
A. emulsions B. lotions
e ointments D. suspensions
transformation is known as:
16. The system that undergoes gel-to-sol
B. pernmanent deformation
A. elastic
C. shear thickening D. shear thinnin
T7. The type of viscosity specified in 1.P. (Ostwald viscometer) is:
type:
A hydrophilic B. hydrophobic
C. lyophilic D. lyophobic
4. Electrodialysis method is employed in the colloidal chemistry for the pur
pose of:
A. identification B. preparation
purification D. stabilization
5. Silica gel is an example for the type of gel:
A. dilatant B. elastic
erigid D. thixotropic
6. Which of the following DO NOT form colloid spontaneously'?
A. Association B. Lyophilic
eLyophobic D. Micellar
7. Sulphur sol is an example of colloidal type:
A. association B. hydrophilic
C. lyophilic lyophobic
8. Thixotropic type of behaviour is shown by the gel:
Abentonite B. pectin
C. silica D. starch
9. In the determination of size, shape and structure of colloidal partcic
which one of the following CANNOT be used?
A. Electron microscope
B. Instrument measuring light scattering
C. Langmuir film balance
Ulramicroscope
10. Surfactant solutions are termed as association colloids when their co
trations are:
A. insufficient to saturate the bulk phase
B. insufficient to saturate the interface
Ch-9 COLLOIDAL DISPERSIONS
407
A. coagulation B. dilution
Csalting out D. solvation
15. Which characteristic of the dispersed phase is responsible for the increased
viscosity of a hydrophilic colloidal dispersion?
A. Charge B. Shape
C. Size Surface area
16. Dispersion of acacia in water gives the colloid of type:
A. Association BNegative
C. Neutral D. Positive
17. Addition of alcohol to a hydrophilic colloid leads to:
A. crystallization B. hydration
Cprecipitation D. stabilization
18. The critical value of zeta potential (in milli volts) for a stable colloid
(except gold sol) is:
Afrom 20 to 50 B. from 50 to 100
C. less than 20 D. more than 100
19, If kinetic energy of interaction is about 25 KT, the system can be considered
to have:
A. deflocculated state l o n g half life
C. short half life D. weak attraction forces
20. In foams, the dispersed phase and dispersion medium, respectively, are:
Electrodialysis
is used, B. colloids
23.
A. amphiphiles D. nonelectrolytes
eelectrolytes appear
as:
colloid particles
24. Under ultramicroscope,
dark background
Abright specks against
B. concentric rings
bright background
C. dark specks against
D. fluorescent specks for determin-
properties is extensively applied
the following
25. Which one of
of polymers?
ing the molecular weight B. Elevation of boiling point
A. Depression of freezing point
DOsmotic pressure
C. Lowering of vapour pressure
of:
26. Aerosol is the reverse
B liquid foam
A. emulsion
D. solid foam
C. smoke
determination of the gold number, the endpoint is
indicated by:
27. In the
size
A. measuring the change in particle
B. noting sedimentation volume of gold
e . observing the color change
D. weighing of the precipitate
28. The semipermeable membrane used in haemodialysis is:
Acellophane B. cellulose acetate
C. polyethene D. polyvinyl acetate
Aultracentrifuge B. ultrafilters
C. ultramicroscope D. zeta meter
QUESTICON BANK
Each question carries 1 mark
Note: Encircle the alphabet which corresponds to the single best response.
1. A wetting agent is included in the formulation of a suspension, particularly
when the
suspended particles:
Aare hydrophobic B. are more denser than the vehicle
C. are water soluble D. have lesser interfacial tension
2. For a flocculated suspension, one of the following criterion is satisfied or
established.
A. High inter-particle repulsions B. Strong inter-particle attractions
e Weak inter-particle attractioons D. Weak inter-particle repulsions
3. In Stokes' relationship, a parameter that greatly changes the velocity of
settling is:
A. density of the liquid B. density of particle
e radius of the particle D. viscosity of the medium
4. The protamine-zinc insulin suspension is prepared by a method viz.,:
Aaltered pH precipitation B. dispersion method
C. double decomposition D. organic solvent precipitation
5. Methyl cellulose is a polymer, which is of a type:
A. anionic B. amphilytic
C. cationic Dnon-ionic
6. For a flocculated suspension, the degree of flocculation is observed to be
one. The sedimentation volume is also 1 (one). These values, respectively,
indicate the limits:
A. lower and lower VB. lower and upper
C. upper and lower D. upper and uPper
440
PHYSICAL PHARMACEUTIC
volume should be:
7. For an ideal suspension, the sedimentation
B. less than one
equal to one
C. more than one D. zero
below are true EXCEPT that:
8. In case suspensions, all statements
of
A. j contains a suspending agent
B.it does not include a preservative
C. it is an injectable preparation
D. it is an oral preparation
9. In practice, an acceptable suspension should have particles:
A. of nearly 0.1 micrometer
which can be readily re-dispersible after they settle
C. which should form a cake after settling
D. should not settle
10. For oral administration of a suspension to a patient, which one of the
factors is the most important?
Acceptable color and odour B. Polymorphism
C. Specific surface area D. Viscosity
11. Which one of the following properties is applicable to suspensions?
A. Brownian movement B. Laminar flow
Rapid rate of sedimentation D. Stokes' law
12. Suspended particles become flocculated in a suspension, because:
attractive forces between particles are appreciable
B. particles are packed closely
C. repulsive forces between particles are appreciable
D. vehicle rejects the particles
13. Structured vehicle is included in the formulation of a suspension, in order
to:
C. Increase in stability
D. Stable film formation
4. For a stable emulsion, the phase volume rajio is generally in-oil:
A. 26/74 52/48
C. 74/26 D. 74/100
5. The HLB range of an emulsifier employed in the preparation of water-in-oil
emulsion is:
3 to 6 B. 7 to 12
C. 13 to 15 D. more than 15
6. In case of emulsions, the viscosity immediately after preparation and durino
storage, respectively, will be:
A. higher and gradually decrease
B. higher and gradually increase
elower and gradually decrease
D. lower and gradually increase
7. The distribution of globules is not uniform in an emulsion. This stage is
termed as:
A. breaking B. caking
C. coalescence
Dcreaming
8. An ow microemulsion is
prepared using a hydrophilic surfactant. The
appearance of the mnicroemulsion is:
A. intense white B. milky white
C. translucent D. transparent
9. Emulsions are defined as
thermodynamically unstable
that follow sequentially towards systems. The events
instability
are:
A. coalescence, breaking,
creaming and flocculation
B. coalescence, flocculation,
creaming and flocculation
C. flocculation,
creaming, breaking and coalescence
D. flocculation, creaming, coalescence and
10. In an emulsion, which
breaking
instability step prevented by emulsifiers?
is
A. Breaking
LB. Coalescence
C. Creaming
D. Flocculation
11. An 'emulsion within emulsion' is
A. olw/w
designated as:
C. wlolow
B wlolo
12. The main
D.wlolw
function of an emulsifier in the
develop a condensed membrane layer film preparation of an emulsion is t0
B. increase the
repulsions between globules coming
C. increase the surface free together
energy
D. reduce the interfacial
tension
13. An emulsifier can be
regarded as superior, if its mechanism of action
based on the principle of:
ch-11 EMULSIONS
A. centrifugation
B. dialysis
C. freezing B. homogenization
Microemulsion NOT considered to be
1s
a true emulsion, because
A. appearance is transparent B emulsifier is not used
immiscible phase is absent D. internal phase is not spherical
7 Among the factors intluenceing he
creaming in
open to formulation phannacist is
to regulate:
an emulsion. 'the factor
A. density of dispersion medium B. density of
globule size
dispersed phase
D. volume of
1R Normally preservatives are added to
dispersion medium
an emulsion. One of the
statements is true. following
A. Amount of the preservative added is below minimum
concentration inhibitory
B.Emulsifier should enhance the preservative action
CPreservatives remain in the aqueous phase
D. Preservatives stay in the oil
phase
19. For the formulation of w/o
emulsion, the coalescence rate of:
A. wlo has no
relationship to the type of emulsion formed
B. olw is
equal to wlo coalescence rate
eow is greater than wlo
coalescence rate
D. wlo is
greater than the olw coalescence rate
AUXiliary emulsifying agents are used to stabilize the emulsion. They act
on the principle:
A.
adjusting the HLB value
Dstrengthening the nonpolar tails of the emulsifier
Srengthening the polar heads of the emulsifier
thickening the continuous phase
Each
question carries 2 marks
e i n e an emulsion, Mention two advantages of emulsions with suitable
2. examples.
Describe two methods for identifying the type of emulsions.