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Cvs Phypharm All MCQ

1) The document is a question bank containing 22 multiple choice questions related to chemical kinetics. 2) The questions cover topics such as reaction orders (zero order, first order, pseudo-first order), rate constants, reaction rates, and molecularity. 3) The response format requires circling the letter corresponding to the single best answer for each question.

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0% found this document useful (0 votes)
443 views22 pages

Cvs Phypharm All MCQ

1) The document is a question bank containing 22 multiple choice questions related to chemical kinetics. 2) The questions cover topics such as reaction orders (zero order, first order, pseudo-first order), rate constants, reaction rates, and molecularity. 3) The response format requires circling the letter corresponding to the single best answer for each question.

Uploaded by

imrujlaskar111
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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QUESTION BANK

Each question carries 1 mark

Note: Encircle the alphabet which corresponds to the single best response.
1. A graph is plotted by taking time on x axis and concentration of reactant on y
axis for a reaction following a pseudo first order. The pattern of the graph is:
A . curve B. hyperbola
C. parabola D. straight line
2. In the photochemical degradation of multisulpha preparation, the order that a
reaction does follow is:
A. first B. pseudo first
C. second Diero
3. The integral rate equation for a reaction (in common notation) is written as
log c log c (kt/2.303). When a graph is drawn log c vs. t, the slope will
= -

be:
negative B. one
C. positive D. zero
PHYSICAL PHARMACEUTICS
42
notation) k = Xat(a-x) is concerned withh
The integral equation (in
common
4.
the order B. pseudo first
A. first
D. zero

second
involved in a reaction, the 'overall rate' of a
5. When a series of steps are

reaction depends upon the rate(s) of:


A. all steps
B. all steps which follow the slowest step
e a l l steps which precede the slowest step

D. the slowest step


6. The solid state decomposition of aspirin in presence of moisture follows the
order:
A. first B. pseudofirst
C. second Dzero
7. The reaction rate constant (k) is 2. Ox103 minl for aspirin hydrolysis in
0. 1 N hydrochloric acid solution at 1 mg/mL concentration. Under same
conditions, if the product contains aspirin 4 mg/mL of the initial concentration,
the k value in minutes will be:
A. 0.5 x 103 B 2.0 x 10-3
C. 4.0x 10 D. 8.0x 10-3
8. A second order reaction follows pseudo-first order reaction, when the
concentrations of:
A. two reactants are high
B. two reactants are low
Cone reactant is far higher than the other reactant.
D. two reactants are
equal
9. In the study of the rate of a
reaction, 100 mL of 0.1 N acd hydrochloric
solution is added to 10 mL
methyl acetate for the reaction to occur. The
reason for making such a isproportion to make
A. analysis of degradation is easy
B. reaction to follow first
order
C. reaction to proceed slowly
D. reaction to undergo a
pseudo first order
10. The conversion of
trans-stilbene to cis-stilbene follows
A. bimolecular the moleculariy"
B. termolecular
.unimolecular D. zeromolecular
11. In the
hydrolysis of sucrose in hydrochloric acid solution, the change in he
optical rotation follows the order:
Apseudofirst B. pseudo zero
C. second
D. zero
Ch-1 CHEMICAL KINETICS 43

12. In the degradation studies of aspirin suspension, the orders observed initially
and at the end, respectively, are:
A. first, second B. first, zero
C. second, first Le zero, first
6. 5 g/100 mL. The
13. A prescription of liquid aspirin preparation contained
order of reaction in the
solubility of aspirin at 25°C is 0. 33 g/100 mL. The
kinetic study is:
A. apparent first LB. apparent zero

C. first D. second
drug in solution is a
the complete degradation of a
14. The time required for
reaction is:
finite value. The order of that
B. pseudo first
A. first
C. second Dzero
presence of
H* and (OH)
Normally, ethyl acetate undergoes hydrolysis in
15.
reaction observed in the
acidic and alkaline solutions,
ions. The order of the
r e s p e c t i v e l y , are:

B. pseudo first and second


A. first and second first
D. second and pseudo
C. second and first
half life is expressed by equation:
reactions that follow first order kinetics,
16. In
B. 0.301/k,
0.693/k D. k,/0.693
C. 0.105/k, for a second order reaction are:
rate constant
17. The units for
the specific
B. liter. sec/moles
Aliter/moles. sec
D. moles. sec/liter
C. moles/liter. sec
What is its shelf
life (in
reaction is 4 years.
half life of a first order
18. The
years)? B. 0.03
A. 0.02
0.61
C. 0.17 notation) is:
first order
reaction (in common

expression for
a
rate
19. The general ,2.305 og e
B. k C
A d c / d t = -kC

X
D. deldt =k
C. k= at (d-x) reaction under
forms exhibit
faster rate of
dosage
20. Which one of the following
normal conditions?
B. Ointments
A. Emulsions
D. Suspensions
where de
as (-de/di),
CSolutions of a reaction is expressed
kinetics, the rate does it refer to?
21. In chemical Whose
concentration
concentration.
refers to the B. Product
A: Catalyst D. Solvent medium
L Reactant
P PHYSICAL PHARMACEUTICs
44
of the following can be designated as the molecularity of.
a
22. Which one

reaction?

A. Half
One
D. Zero
C. One and half

23. Which one of them is refered as a general rate equation (-dc/dt) fora second

order?

A. A°B A'B
C. A'B2 D. AB2
24. Which one of the following orders have abundant applications in biological
processes?

A First B. Second
C. Third D. Zero
25. In chemical reaction, the rate constant is
a independent of the initial
concentration. Which one of them is the order?
A. First B. Second
C. Third B Zero
QUESTION BANK
Each question carries 1 mark
Note : Encircle the alphabet which corresponds to the single best rep
1. The accelerated stability studies are primarily used to
detc
A. energy of the activation of the reaction
B. k value at elevated
temperatures
C. k value at the room
temperature
shelf life of the product
2. specific rate constant (k) determined
The
buffer at 1l mg/mL concentration is 2.0 x
for aspirin hydrolysis in
10-min-l at 25 °C. The shelf
pH 1.0

life of the product is (in minutes):


A. 2.0 LB52
C. 104 D. 346
3. Identify the equation that is NOT of Arrhenius:

A I n k =- aE, + In A B. Ink=
= a +In A
2.303 RT RT

log k
- log A D. k= Ae alRT
C.
2.303 RT
eneral. reaction rate constants in
neutral pH are comparatively:
A. equal B. higher
e lowver D. zero
5. The expiry date for a tablet
is not mentioned
on the label the
It means
means that
that tnc
time in years is:
expiry
Ch-2 DRUG STABILITY
91
f i v e years B. nil
C. three years D. two years
Penicillin G is prepared as a salt of procaine penicillin G. Now the rate of
decomposition of penicillin G will be:

A. increased
UBreduced
C. unchanged D. unpredictable
7 According to International Pharmaceutical Federation, the recommended
overages be limited to the maximum percent of:
A. five B. ten
thirty D. twenty
8. Usually, the rate of a chemical reaction may be enhanced by:

A. cooling the reaction mixture


B. increasing the rate of stirring

raising the temperature of the reaction mixture


D. using stoichiometric quantities of each reactant
for the determination of shelf
9. Which of the following expression is correct
life for a first order decomposition?
B. t90 = 0.693/k
A. 0.105/k
C. t 0.693/k D1900.105/k
the rate of reaction, solvents
10. Regarding the influence of the solvent on

having the internal pressure:


HIGHER internal pressure
A HIGHER produce products with LOWER internal
B. HIGHER favour the formation
of products having
pressure
C. LOWER yield products having HIGHER internal pressure
of products with LOWER internal pres-
D. LOWER retard the formation
sure
straw colour is observed. It is
dextrose solution, a
11. During autoclaving of called:
substance
due to the presence of a
5-hydroxymethylfurfural
A. furfural
D. 5-methylfurfural
C. 5-hydroxyfurfural
the degradation reactions in the following
12. In injections, procaine undergoes
sequence:
A. decarboxylation and hydrolysis
Bhydrolysis and decarboxylation
and oxidation
C. hydrolysis, decarboxylation
and hydrolysis
D. oxidation, decarboxylation
from light'. What type of decompo-
13. On a product, the label states 'protect
sition does the product undergo?
B. Decarboxylation
A. Carboxylation
C. Hydrolysis Oxidation
PHYSICAL PHARMACEUTIC

of picil.
anmnie
92 observed in the
degradation

reactions is
following
4. Which of the
lin? Hydrolysis
D. Recimization
A. Decarboxylation
It
It can
c a n be
be prevented by:
C. Oxidation formulation.
in a
decomposition antioxidant
an
5 . Aspirin undergoes B. adding
a chelating agent its solubility
A. adding LE. suppressing
it from light chemical decomposition2
C. protecting NOT a
is primarily
the following
16. Which o n e of B. Hydrolysis
A. Isomerisation
DVolatilization
C. Oxidation
studies of
solution dosage form, the
of accelerated stability of kcal/mol):
17. For the validity in the range of (in units
of activation should be
energy B 1 1 to 30
A. O to 10
D. 51 to 70
C. 31 to 50
effective in preventing the rate
of these methods is the MOST
18. Which one

of hydrolysis?
B. Complexation
A. Buffer
D. Suppression of solubility
Removal of water
is observed in a suspension due to:
19. Duringstorage, crystal growth
A. absorption of water
Bfluctuations in the ambient temperatures

C. presence of suspending agent


D. volatilization of solids
20. The storage directions on a parenteral solution specify store in a cool

place. This may be stored in:


A. an air-conditioned area at 10 °C
LB a refrigerator at 15 °C
C. a place whose temperature is set at 5 °C
D. room temperature, at 25 °C
QUESTION BANK
Each question carries one mark
Note Encircle the alphabet which corresponds to the single best response

1. One micrometer is equal to:


A. 10 centimeter B. 103 centimeter
1 0 meter D. 10 meter
2. Which of the following properties of a particle significantly affects the
physical, chemical and biological properties of the drug?
A. Density B. Sedimentation
C. Size DSurface area
3. It is difficult to express the size of particles in a meaningful diameter. The
reason is that the particles in a powder are:
Airregular in shape B. irregular surface
C. spherical shape D. uniform in size
4. The type of a particle diameter obtained largely depends on:
Amethod by which it is determined
B. nature of the powder
C. procedure by which it is calculated
D. way it is defined and described
5. When cumulative percent frequency on a
probability scale is plotted against
logarithm of the particle size, 50% on the probability scale gives the
powder particle diameter of:
A. arithmetic mean B. arithmetic mode
geometric mean D. harmonic mean
6. Which one of these distributions is more important in the design of dosage
forms?
A. Gaussian B. Normal
C. Number . Weight
7. In the formulation development of emulsions and suspensions, what type o
diameter is important?
A. Length number
B. Projected
C. Sieve . Stokes'
Ch-6 MICROMERITICS
271
8. Sieving method is used for size distribution analysis of powders. The
disadvantage of this method is:
A.
agglomerates can be identified
8 attrition of powder is possible
C. large
number of sieves are required
D. tedious and time consuming
9. While using sedimentation method for size analysis, addition of a
deflocculating agent to a suspension is necessary in order to:
A. accelerate the process of sedimentation
B.make the particles spherical
prevent the aggregation
D. satisfy Reynolds number
10. Stokes' law cannot be used, if Reynolds number is more than:
A. 0.2 B. 1.8
C. 9. D. 18.0
11. Andreasen apparatus consists of:
A. balance B. electrode
C. hydrometer
pipette
12. When Coulter-counter apparatus is employed for powder analysis, the
following criterion is important:
A. dispersion medium should be coloured
LB dispersion medium should be conducting
C. suspended particles should be charged
D. suspended particles should be spherical
13. In Coulter-counter, as the particles travel through the orifice, the event that
OCcurs is:
A. conductance between the electrodes increases
B. electronic scanners produce photographs for volume measurement
Le. resistance between the electrodes increases
D. sedimentation increases
14. Fisher subsieve sizer is used to determine the surface area of the powder.
The surface area is measured based on the change in:
A. light transmission of gas that reaches the detector
B. pressure across the compacted powder
C. thermal conductivity of gas across the powdered pack
weight of powder when air is passed through the powdered pack
. High repose angle of the granules indicates:

A. bulk density of the granules


B porosity of the granules
roughness of the granule surface
D.Smoothness of the granule surface
272 PHYSICAL PHARMACEUTICS

16. The true density of talc is 2.7 g/em', the bulk density (g/cm') of talc will
be:
A. equal to 2.7 B. greater than 2.7
Cless than 2.7 D. unrelated
17. The angle of repose values are utilized to:
LAmeasure the movement of granules from hopper to the table of tabletting/
capsule machine
B. select proper containers for capsules of a given mass of powders.
C. study the absorption of drugs.
D. understand dissolution of medicament
18. The term 'light' as applied to pharmaceutical powders means:
A. low bulk density B. low granule density
C. low true density D. slightly coloured
19. The type of particle diameter that is obtained by microscope method of
evaluation is:
A projected B. Stokes'
C. volume D. volume-surface
20. Porosity of a porous powder is defined as:
A. bulk volume/void volume B . void volume/bulk volume
C. void volume/true volume D. true volume/bulk volume
QUESTION BANK
Each question carries one mark
Note Encircle the alphabet which corresponds to the single best response.
1. Flocculated suspensions exhibit the flow of a type:
A. dilatant B. Newtonian
Leplastic D. pseudoplastic
2. A limitation that is NOT related to the falling sphere viscometer:
A.
applicable to only less viscous liquids
B. large volume of
sample is required
C. needs the
sample to be transparent
Dplug flow
3. In general,
Newtonian fluids are expressed in terms of
viscosity. A
corresponding expression in non-Newtonian fluids (in terms of viscosity)
is:
LA. apparent B. dynamic
C. intrinsic D. kinematic
4. One of the following is NOT a one
point viscometer, but
the same purpose. Pick the viscometer can be used for
of this type.
Cup and bob B. Falling sphere
C. Ostwald
D. Rolling ball
5. Fluidity is a term associated with
Newtonian fluids. An
plastic flow fluids is: equivalent term in
A. apparent viscosity
B. flexibility
e mobility
D. plastic viscosity
6. Dilatant flow is characterized as a
reverse
A. Newtonian flow phenomenon of
B. plastic flow
epseudoplastic flow D. rheopexy
7. Deflocculated suspension with high concentration
exhibits the flow of type: of the dispersed solids
X. dilatant
B. Newtonian
C. plastic
D. pseudoplastic
8. In antithixotropy, the down-curve is
frequently positioned
to up-curve): to: (with respect
Ch-7 RHEOLOGY 315

A. left B. origin
right D. superimposible
9. At equilibrium, the thixotropic behaviour of a pseudoplastic system exhibit
the state of:

A. gel B. paste
sol D. wax
10. Which one of the following physical property is NOT a rheological prop-
erty?
A. Body and slip B. Spreadability
Surface tension D. Viscosity
11. The pseudoplastic flow behaviour can be explained by:
Aapparent viscosity B. area of hysteresis loop
C. hysteresis loopP D. yield value

12. Brook-field viscometer is an example of type:


A. cone and plate B. extrusion
C. rotating sphere W. rotating spindle
13. High viscosity indicates one of the following relationships in a system.

Which is relevant?
A. Free from intermolecular interactions

B Intermolecular attractions are stronger

C. Intermolecular attractions are weaker


D. Shape of the molecuies is spherical
14. An emulsion of o/w type has the viscosity:
A . greater than that of the internal phase

B greater than that of the vehicle


C. less than that of the internal phase
D. less than that of the vehicle
analyse the viscoelastic property of:
15. Creep testing is applied to

A. emulsions B. lotions

e ointments D. suspensions
transformation is known as:
16. The system that undergoes gel-to-sol
B. pernmanent deformation
A. elastic
C. shear thickening D. shear thinnin
T7. The type of viscosity specified in 1.P. (Ostwald viscometer) is:

A. absolute viscosity B. dynamic viscosity


D. viscosity coetticient
Lekinematic viscosily
18. After giving the i.m. injection of procaine penicillin G, the process of

Torming a depot in the muscle is due to:


A. high yield value B. low consisteney
C. low yield value rapid thixotropic recovery
316 PHYSICAL PHARMACEUTICS
19. Pick the reason for the calibration of an instrument.
A. Most of the instruments are not reliable
B. To calculate the constant for the instrument
C. To calculate the relative property
T o correct the errors in the working of an instrument
20. Plug flow is NOT observed in cone and plate viscometer. The reason is:
A. cleaning and filling of sample is easy
B. rate of shear is independent of the radius
eshear can be maintained uniformly
D. temperature can be maintained uniformly
PHYSICAL PHARMACEUTI
406
QUESTION BANK

Each question carries 1 mark


the single best response
which corresponds to on
Note Encircle the alphabet
is:
I. An example for colloidal systems
B. ointments and pastes
A. clays and gels
D. suspensions and emulsions
solutions
Csoaps and proteins
'colloid' is:
2. The criterion to call a system
subdivision of dispersed phase
A. a fine state of
of I nm to I um
Bdispersed particles are in the size range
C. interface is very extensive
D. presence of dispersed phase
3. Solutions of proteins and starch in water are the examples of the colloidal

type:
A hydrophilic B. hydrophobic
C. lyophilic D. lyophobic
4. Electrodialysis method is employed in the colloidal chemistry for the pur
pose of:
A. identification B. preparation
purification D. stabilization
5. Silica gel is an example for the type of gel:
A. dilatant B. elastic
erigid D. thixotropic
6. Which of the following DO NOT form colloid spontaneously'?
A. Association B. Lyophilic
eLyophobic D. Micellar
7. Sulphur sol is an example of colloidal type:
A. association B. hydrophilic
C. lyophilic lyophobic
8. Thixotropic type of behaviour is shown by the gel:
Abentonite B. pectin
C. silica D. starch
9. In the determination of size, shape and structure of colloidal partcic
which one of the following CANNOT be used?
A. Electron microscope
B. Instrument measuring light scattering
C. Langmuir film balance
Ulramicroscope
10. Surfactant solutions are termed as association colloids when their co
trations are:
A. insufficient to saturate the bulk phase
B. insufficient to saturate the interface
Ch-9 COLLOIDAL DISPERSIONS
407

less than critical micellar concentration (cmc)


more than cmc
e
the type of colloidal dispersion to which electrolytes are normally
11. Name
added in small quantities to stabilize:
A. association B. lyophilic
elyophobic D. micellar

12. Protective colloids DO NOT:


a i d in dispersion B. decrease the zeta potential
e lower the interfacial tension D. offer a mechanical barrier
13. Which one of the following colloids is difficult to prepare?
A. Association B. Hydrophilic
Hydrophobic D. Lyophilic
14. In high concentrations, electrolytes destabilise a lyophilic sol by a process
termed as:

A. coagulation B. dilution
Csalting out D. solvation
15. Which characteristic of the dispersed phase is responsible for the increased
viscosity of a hydrophilic colloidal dispersion?
A. Charge B. Shape
C. Size Surface area
16. Dispersion of acacia in water gives the colloid of type:
A. Association BNegative
C. Neutral D. Positive
17. Addition of alcohol to a hydrophilic colloid leads to:
A. crystallization B. hydration
Cprecipitation D. stabilization
18. The critical value of zeta potential (in milli volts) for a stable colloid
(except gold sol) is:
Afrom 20 to 50 B. from 50 to 100
C. less than 20 D. more than 100
19, If kinetic energy of interaction is about 25 KT, the system can be considered
to have:
A. deflocculated state l o n g half life
C. short half life D. weak attraction forces
20. In foams, the dispersed phase and dispersion medium, respectively, are:

Agas and liquid B. gas and solid


C. liquid and D. solid and gas
gas
21. The characteristic of a lyophobic sol is that:
A. electrolytes in small amounts induce stabilisation
B. it is
reversible
particles have high electric charge
DViscosity increases by the presence of particles
PHYSICAL PHARMACEUTIC

408 and disne.


in which the
dispersed phase
persion
refers to a system
Hydrosol
22. m edium, respectively, are:
water
B. liquid and
A. gas and
water
water and solid
D.
water
Le solid and when impurities
in a sol are:

Electrodialysis
is used, B. colloids
23.
A. amphiphiles D. nonelectrolytes

eelectrolytes appear
as:
colloid particles
24. Under ultramicroscope,
dark background
Abright specks against
B. concentric rings
bright background
C. dark specks against
D. fluorescent specks for determin-
properties is extensively applied
the following
25. Which one of
of polymers?
ing the molecular weight B. Elevation of boiling point
A. Depression of freezing point
DOsmotic pressure
C. Lowering of vapour pressure
of:
26. Aerosol is the reverse
B liquid foam
A. emulsion
D. solid foam
C. smoke
determination of the gold number, the endpoint is
indicated by:
27. In the
size
A. measuring the change in particle
B. noting sedimentation volume of gold
e . observing the color change
D. weighing of the precipitate
28. The semipermeable membrane used in haemodialysis is:
Acellophane B. cellulose acetate
C. polyethene D. polyvinyl acetate

29. The stability of acacia in water is due to:


A. formation of micelleS hydration of solids
C. lowering interfacial tension D. presence of electrical charge
be
30. The molecular weight of dispersed solidsin a colloidal system
determined using an instrument:

Aultracentrifuge B. ultrafilters
C. ultramicroscope D. zeta meter
QUESTICON BANK
Each question carries 1 mark
Note: Encircle the alphabet which corresponds to the single best response.
1. A wetting agent is included in the formulation of a suspension, particularly
when the
suspended particles:
Aare hydrophobic B. are more denser than the vehicle
C. are water soluble D. have lesser interfacial tension
2. For a flocculated suspension, one of the following criterion is satisfied or
established.
A. High inter-particle repulsions B. Strong inter-particle attractions
e Weak inter-particle attractioons D. Weak inter-particle repulsions
3. In Stokes' relationship, a parameter that greatly changes the velocity of
settling is:
A. density of the liquid B. density of particle
e radius of the particle D. viscosity of the medium
4. The protamine-zinc insulin suspension is prepared by a method viz.,:
Aaltered pH precipitation B. dispersion method
C. double decomposition D. organic solvent precipitation
5. Methyl cellulose is a polymer, which is of a type:
A. anionic B. amphilytic
C. cationic Dnon-ionic
6. For a flocculated suspension, the degree of flocculation is observed to be
one. The sedimentation volume is also 1 (one). These values, respectively,
indicate the limits:
A. lower and lower VB. lower and upper
C. upper and lower D. upper and uPper
440
PHYSICAL PHARMACEUTIC
volume should be:
7. For an ideal suspension, the sedimentation
B. less than one
equal to one
C. more than one D. zero
below are true EXCEPT that:
8. In case suspensions, all statements
of
A. j contains a suspending agent
B.it does not include a preservative
C. it is an injectable preparation
D. it is an oral preparation
9. In practice, an acceptable suspension should have particles:
A. of nearly 0.1 micrometer
which can be readily re-dispersible after they settle
C. which should form a cake after settling
D. should not settle
10. For oral administration of a suspension to a patient, which one of the
factors is the most important?
Acceptable color and odour B. Polymorphism
C. Specific surface area D. Viscosity
11. Which one of the following properties is applicable to suspensions?
A. Brownian movement B. Laminar flow
Rapid rate of sedimentation D. Stokes' law
12. Suspended particles become flocculated in a suspension, because:
attractive forces between particles are appreciable
B. particles are packed closely
C. repulsive forces between particles are appreciable
D. vehicle rejects the particles
13. Structured vehicle is included in the formulation of a suspension, in order
to:

A. decrease the interfacial tension


B. prevent the caking of the sediment
prevent the sedimentation of particles
D. reduce the size by chemical means
14. In the preparation of a structured
vehicle, which one of the followng
substances is used?
A. Bismuth subnitrate
B. Ethyl alcohol
C. Glycerin
0Methyl cellulose
15. Which type of
structured vehicle?
colloidal material is used commonly in the preparationo
A. Association
C. Hydrophobic B.Hydrophilie
. Inorganic
Ch-10 SUSPENSIONS
441
16 When charcoal powder is dusted on the surface of
(in degrees) that the charcoal exhibits is: water, the contact angle
A. zero
B. onee
90 B 1800
17 A maximum sedimentation volume will be obtained
when zeta potential is:
A. negative B. neutral
positive
UB. zero
18, A substance is dissolved in water. The
suspension has exhibited a negative
apparent zeta potential. Identify the related substance.
A. Aluminum chloride B. Bismuth subnitrate
Gelatin DSulfaguanidine
19. Calcium hydrogen phosphate is dissolved in water. The apparent zeta
potential initially is:
negative B. neutral
positive D. zero
20. Which one of these preparations is NOT qualified as a suspension.
A. Barium meal for radiodiagnostic use
B. Calamine lotion for antiseptic use
C. Procaine penicillin G for intramuscular injection
Vitamin B complex tonic as nutritional supplement
QUESTION BANK
Each question carries one mark
Note: Encircle the alphabet which
corresponds to the single best response.
I. In an emulsion, the
velocity of sedimentation is found to be negative. It
means that the creaming is:
A. absent B. in both the directions
C. in downward direction D.in upward direction
2. The density of the dispersed phase is more than that of the dispersion
medium. According to the Stokes' equation, the creaming is:
A. at the center of the emulsion B. in both the directions
e in downward direction D. in upward
direction
3. When oil and water are triturated together, the interfacial free energy was
observed to be increased. What does it indicate?
A. Decrease in the interfacial tension
Decrease in the stability
472 PHYSICAL PHARMACEUTIC

C. Increase in stability
D. Stable film formation
4. For a stable emulsion, the phase volume rajio is generally in-oil:
A. 26/74 52/48
C. 74/26 D. 74/100
5. The HLB range of an emulsifier employed in the preparation of water-in-oil
emulsion is:
3 to 6 B. 7 to 12
C. 13 to 15 D. more than 15
6. In case of emulsions, the viscosity immediately after preparation and durino
storage, respectively, will be:
A. higher and gradually decrease
B. higher and gradually increase
elower and gradually decrease
D. lower and gradually increase
7. The distribution of globules is not uniform in an emulsion. This stage is
termed as:
A. breaking B. caking
C. coalescence
Dcreaming
8. An ow microemulsion is
prepared using a hydrophilic surfactant. The
appearance of the mnicroemulsion is:
A. intense white B. milky white
C. translucent D. transparent
9. Emulsions are defined as
thermodynamically unstable
that follow sequentially towards systems. The events
instability
are:
A. coalescence, breaking,
creaming and flocculation
B. coalescence, flocculation,
creaming and flocculation
C. flocculation,
creaming, breaking and coalescence
D. flocculation, creaming, coalescence and
10. In an emulsion, which
breaking
instability step prevented by emulsifiers?
is
A. Breaking
LB. Coalescence
C. Creaming
D. Flocculation
11. An 'emulsion within emulsion' is
A. olw/w
designated as:

C. wlolow
B wlolo
12. The main
D.wlolw
function of an emulsifier in the
develop a condensed membrane layer film preparation of an emulsion is t0

B. increase the
repulsions between globules coming
C. increase the surface free together
energy
D. reduce the interfacial
tension
13. An emulsifier can be
regarded as superior, if its mechanism of action
based on the principle of:
ch-11 EMULSIONS

developing solid adsorption film 473


A
forming monomolecular adsorption film
oenerating multimolecular adsorption film
C.
increasing
interfa energy
D.
ulsifier is considered
be ideal, if it is
to
soluble in:
oil and gas phases B
A.
aqueous,
aqueous phase only
both aqueous and oil phases D. oil
jal scale, emulsions are
phase only
prepared by
15. On commercial

A. centrifugation
B. dialysis
C. freezing B. homogenization
Microemulsion NOT considered to be
1s
a true emulsion, because
A. appearance is transparent B emulsifier is not used
immiscible phase is absent D. internal phase is not spherical
7 Among the factors intluenceing he
creaming in
open to formulation phannacist is
to regulate:
an emulsion. 'the factor
A. density of dispersion medium B. density of
globule size
dispersed phase
D. volume of
1R Normally preservatives are added to
dispersion medium
an emulsion. One of the
statements is true. following
A. Amount of the preservative added is below minimum
concentration inhibitory
B.Emulsifier should enhance the preservative action
CPreservatives remain in the aqueous phase
D. Preservatives stay in the oil
phase
19. For the formulation of w/o
emulsion, the coalescence rate of:
A. wlo has no
relationship to the type of emulsion formed
B. olw is
equal to wlo coalescence rate
eow is greater than wlo
coalescence rate
D. wlo is
greater than the olw coalescence rate
AUXiliary emulsifying agents are used to stabilize the emulsion. They act
on the principle:
A.
adjusting the HLB value
Dstrengthening the nonpolar tails of the emulsifier
Srengthening the polar heads of the emulsifier
thickening the continuous phase
Each
question carries 2 marks
e i n e an emulsion, Mention two advantages of emulsions with suitable
2. examples.
Describe two methods for identifying the type of emulsions.

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