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Guides To Basic Dispensing

This document provides guidance on preparing different types of mixtures and solutions. It discusses 5 classes of mixtures: 1) simple mixtures containing soluble substances, 2) mixtures with diffusible solids, 3) mixtures with in-diffusible solids, 4) mixtures forming precipitates, and 5) miscellaneous mixtures. It also outlines general principles for preparing pharmaceutical solutions, including considering solubility, stability, and following general method steps like weighing ingredients, transferring to a container, dissolving solids, and making up the final volume. Key factors that affect solubility are particle size, stirring, viscosity, and temperature. Stability also depends on factors like temperature variation and photosensitivity.

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16 views

Guides To Basic Dispensing

This document provides guidance on preparing different types of mixtures and solutions. It discusses 5 classes of mixtures: 1) simple mixtures containing soluble substances, 2) mixtures with diffusible solids, 3) mixtures with in-diffusible solids, 4) mixtures forming precipitates, and 5) miscellaneous mixtures. It also outlines general principles for preparing pharmaceutical solutions, including considering solubility, stability, and following general method steps like weighing ingredients, transferring to a container, dissolving solids, and making up the final volume. Key factors that affect solubility are particle size, stirring, viscosity, and temperature. Stability also depends on factors like temperature variation and photosensitivity.

Uploaded by

bunmi olayemi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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GUIDES TO BASIC DISPENSING

MIXTURES
Classes:
1. Simple mixtures: Contain soluble substances only.

2. Mixtures containing diffusible solids

3. Mixtures containing in-diffusible solids

4. Mixtures containing precipitate- forming liquids

5. Miscellaneous mixtures.

General principles of solution preparation


Historically, a range of solutions have been developed in order to fulfil a wide variety of
pharmaceutical functions. It is therefore common to find solutions classified according to their
intended use (e.g. oral internal, topical, ophthalmic, nasal or parenteral), by the nature of their
formulation (e.g. simple or complex), or to be categorised by a traditional name that relates to the
solvent system used and/or their intended function (e.g. spirits, tinctures, aromatic waters, syrups
and elixirs).
Although the precise characteristics of different types of solution may vary, the essential
principles
governing their preparation remain similar. The two key characteristics that need to be
considered when compounding solutions are solubility and stability.
Solubility
The following points relating to the solubility of the drug element(s) of the formulation need to
be taken into consideration:
* Will the drug(s) dissolve in the solvent or a component of the solvent system?
* What quantity of drug will dissolve?
* How long will dissolution take?
* Will the drug(s) remain in solution and for how long?
* What is the pH of solvent required for dissolution?
Answers to many of the above questions will require the compounder to perform a solubility
calculation.
When preparing a solution, the solid(s) will need to go through a dissolution phase. During
compounding, it is worth remembering that dissolution rates generally increase with:

* smaller particle sizes


* effective stirring
* lower viscosities
* increased temperature.
Stability
In addition to the solubility of the drug element(s) of the formulation, other considerations
regarding the physical stability of the preparation will need to be taken into consideration (e.g.
temperature variation, photosensitivity, etc.), as will the chemical stability and time period, and
the microbiological stability and need for a preservative.
General method
The following general method should be used in the preparation of a solution:
1. Write out the formula either from the prescription (unofficial) or from an official text
(official).
2. Calculate the quantities required for each ingredient in the formula to produce the
required final volume. Remember, it is not usual to calculate for an overage of product in
the case of solutions as it is relatively easy to transfer the entire final contents of the
conical measure.
3. Prepare a suitable label
4. Identify the soluble solids and calculate the quantity of vehicle required to fully dissolve
the solids. If more than one solid is to be dissolved, they are dissolved one by one, in
order of solubility. In almost all cases, dissolution will take place in a glass beaker, not a
conical flask. Remember that the solubility of the soluble solids will be dependent on the
vehicle used.
5. Weigh all solids.
6. Transfer the appropriate amount of vehicle to a glass beaker.
7. If necessary, transfer the solid to a mortar and use the pestle to reduce particle size to aid
dissolution. I complete dissolution can be achieved in the solvent without size reducing,
then you do not need to use the mortar, pour the solid and solvent into the beaker directly.
8. Transfer the solid to the beaker and stir to aid dissolution. If a mortar and pestle have
been
used to reduce particle size, ensure that the mortar is rinsed with a little vehicle to ensure
complete transfer of the powders.
9. When all the solid(s) have dissolved, transfer the solution to the tarred container that
will hold the final solution.
10. Rinse out the beaker in which the solution was made with a portion of the vehicle and
transfer the rinsings to the container.
11. Add any remaining liquid ingredients, if present, to the container and shake the container.
12. Make up to final volume with remaining vehicle, label and dispense to the patient.

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