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Biochemistry II

This document provides information on the Biochemistry II course. The 5 ECTS course is designed for B.Sc. graduate anesthesia students and covers biochemical aspects of human life including carbohydrates, lipids, proteins and nucleic acids. The course objectives are for students to explain biochemical processes, describe biomolecule chemistry and metabolism, explain central metabolism, and correlate biochemistry with health and disease. Assessment includes class attendance, quizzes, assignments, and a final exam.

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Minilik Derseh
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247 views

Biochemistry II

This document provides information on the Biochemistry II course. The 5 ECTS course is designed for B.Sc. graduate anesthesia students and covers biochemical aspects of human life including carbohydrates, lipids, proteins and nucleic acids. The course objectives are for students to explain biochemical processes, describe biomolecule chemistry and metabolism, explain central metabolism, and correlate biochemistry with health and disease. Assessment includes class attendance, quizzes, assignments, and a final exam.

Uploaded by

Minilik Derseh
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Course title: Biochemistry II

Course code: Bioc 2052


Module name: Biomedical II module
Module code: Biom-M2053
Course ECTS: 5 (135 hrs)
Lecture: 48 hours
Tutorial: 9 hours
Home study: 60 hours
Assignment and presentation: 18 hours
Contact hours/ week: 135-87= 48 hours/ 16 weeks= 3 hours
Pre-requisite if any: Organic Chemistry
Course description:
This Biochemistry course is designed to prepare B.Sc. graduate anesthesia students who are
competent providers of anesthesia services. Students will be able to explain the
biochemical aspects of human life & describe the biochemistry of carbohydrates, proteins,
lipids and nucleic acids. It contains only the theoretical part that the trainee should pass
through to acquire the basic competence in accomplishing organizational activities relating
to its coverage.
Course Objectives:
After completing this course, the student will be able to explain the biochemical aspects of
human life; describe the chemistry and metabolism of biomolecules (carbohydrates, lipids,
proteins and nucleic acids); explain central metabolism; outline the transmission
&expression of genetic information and correlate the biochemical processes with health &
disease.
Specific Objectives:
1. Describe the structure and classification of amino acids& proteins.
2. Describe the mechanism of oxygen binding to myoglobin and hemoglobin.
3. Describe the mechanisms used by humans for removal of the nitrogen from amino acids
prior to the metabolism of their carbon skeletons.
4. Discuss the structure and composition of enzymes, including cofactors, and conditions
that affect enzymatic reactions.
5. Compare and contrast the structure and biosynthesis of purines and pyrimidines,
highlighting the differences between de novo and salvage pathways.

110
6. Describe the compositions and structures of DNA and RNA.
7. Explain how replication of DNA is achieved with high fidelity in a bidirectional manner
and in a semi-conservative fashion.
8. Describe the major steps in transcription of an RNA molecule.
9. Describe how the different RNAs involved in protein synthesis interact to produce a
polypeptide.
Delivery mode/methodology: Block
Course learning and teaching methods
Active learning methods (brain storming, discussion, etc), Lecture, group and individual
presentation, assignment
Assessment mechanisms:
Continuous assessment & summative assessment
- Class attendance (%)
- Quiz (%)
- Assignments (%)
- Final Exam (50%)
Teachers and Students Role
References:

Textbook:
Pamela C.C, and Richard A.H., Lippincott's Illustrated Reviews: Biochemistry,
3rd edition, J.B.Lippincott Company Philadelphia, 2004.
Recommended Reading:
1. Stryer L.et al.Biochemistry,5th edition, W.H. Freeman and Company &Sumanas, Inc.,
2004.
2. Murray R.K et al. Harper's Illustrated Biochemistry 27th edition,The McGraw-Hill
Companies, Inc., 2006.
3. Lehninger A.L. Principles of Biochemistry, CBS publishers and distributors, 2006.
4. Lieberman M. et al.Marks' Essential Medical Biochemistry, 2nd Edition,Lippincott
Williams & Wilkins, 2007.
5. Zubay P. et al.Principles of Biochemistry, WM.C. Brown Publishers USA, 1995.
6. Smith E.L et. al., Principles of Biochemistry, McGraw-Hill-International, 1993 or
recent edition.

111
Course Schedule: By contact time, contents/topics & reading/reference materials for each topic

1. AMINO ACIDS AND PROTEINS


Pamela C.C.
Digestion & absorption of proteins
(Page No.
1-7 Metabolism of proteins & amino acids:
229-267)
20 o Biosynthesis of nonessential amino
Harper’s
acids
Biochemistry
o Catabolism of Proteins & of
(Page No.
Amino Acid Nitrogen- Urea cycle
249-264)
o Catabolism of the carbon skeletons
of amino acids
Harper’s
o Conversion of amino acids to
Biochemistry
specialized products
(Page No-
o Metabolism of Haem:
270-286)
o Porphyrins & Bile Pigments

8. VITAMINS Harper’s
7-9 Classification of vitamins Biochemistry
Structure and function of: (Page No.
6 Water & Fat soluble vitamins 49-72)
Pamela C.C.
(Page No.
47-58)
9. MOLECULAR BIOLOGY
9-16
Nucleotide structure
Biosynthesis & Degradation of
nucleotides Pamela C.C.

DNA structure and Replication (Page No.

RNA structures and Transcription 319-330)


18 Protein Synthesis: Harper’s
The Genetic Code Biochemistry
Translation (Page No.
Mutation 481-497)
112
Re of gene expression in
gulation
Prokaryotes
Eukaryotes

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