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Sveta Chakrabarti: Experience

Svetachakrabarti has over 15 years of experience in research using Drosophila and other model systems. She is currently a Fellow at the Indian Institute of Science, Bangalore, studying the role of blood cells in inter-organ communication after wounding using Drosophila. She has published over 10 papers investigating topics like stress response pathways, gut homeostasis, and stem cell regulation using techniques such as RNA-seq, protein expression and kinase assays. She is an award-winning researcher who has given invited talks internationally.

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Nilabja Bhattacharjee
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36 views4 pages

Sveta Chakrabarti: Experience

Svetachakrabarti has over 15 years of experience in research using Drosophila and other model systems. She is currently a Fellow at the Indian Institute of Science, Bangalore, studying the role of blood cells in inter-organ communication after wounding using Drosophila. She has published over 10 papers investigating topics like stress response pathways, gut homeostasis, and stem cell regulation using techniques such as RNA-seq, protein expression and kinase assays. She is an award-winning researcher who has given invited talks internationally.

Uploaded by

Nilabja Bhattacharjee
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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S V E TA C H A K R A B A R T I

EXPER IENCE
2 0 1 6 - ON WAR D - E AR LY CARE E R FE L LO W, I I SC, B AN GALO RE , I N D I A
I am currently working on the wounding response using Drosophila as a model system.
I am trying to understand the role of blood cells in inter-organ communication,
speci cally how blood cells sense damage signals and communicate this message to
distance tissues after a wound.

2 013 - 20 1 4 - P O ST DO CTOR AL F EL LO W, EPF L , L AU SAN NE , SW I TZE RL A ND


I have extended on my thesis work and discovered the role speci cally of a stress
activated pathway called the p38 pathway in controlling not only the immune response
but also the lipid homeostasis in the intestine.

2 0 09 - 20 1 3 - G R A D UAT E ST U DI E S, E PFL , L AU SAN N E, SW I TZER L AN D


My thesis revealed the cross-talks between stress and immune pathways during
microbial infection in the gut. I showed that stress pathways usually contribute to
enduring damage caused by infection, but an excessive activation of these pathways
contribute to pathogenesis.

2 00 8 - R E S E AR C H AS S I STAN T, GRE GO R M E N DE L I N STI TU TE , V I E N N A, AU STRI A


I uncovered the role of a plant kinase in response to abiotic stress using chie y
biochemical approaches.

2 00 7 - 2 0 0 8 - G R AD UATE R OTATI O N S, I N D I AN A UN I V E RSI TY, B LO O M I N GTO N ,


U SA
I nished the mutagenesis of the eye speci c gene in Drosophila to create a chimeric
protein, and then tested its functional effect on eye development. I optimized the
expression of a recombinant Arabidopsis protein, and further tested interactions
between its domains. I produced a recombinant bacterial stress chaperone protein for
its biochemical characterization.

EDUCATI ON
• P HD IN L I FE S C IE N C ES 2 0 1 3 - SW I SS F E DE RAL I N STI TU TE O F TE CH N O LO GY
LAUS AN N E, S W I TZ E R L AN D.
• M . S P L A N T M O L . B I O L O G Y A N D B I O T E C H 2 0 0 7 - D E P T. O F P L A N T
MO L E C U L AR BI O LO GY, U N I V E RSI TY O F DE L H I , I N DI A.

CONTACT: Indian Institute of Science, Bangalore. Tell number: +918826221948


Languages: English, Hindi, French
[email protected]; [email protected]
Twitter: @svetakotak
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PUBLICATI ONS
1. S. Chakrabarti*, and S. S. Visweswariah. Intramacrophage ROS Primes the Innate
Immune System via JAK/STAT and Toll Activation. Cell Reports 2020. https://
doi.org/10.1016/j.celrep.2020.108368 (*: single corresponding author)
PMID: 33176146

2. P . Sharma, A. Vijaykumar, J. Vijaya Raghavan, S.


R. Rananaware, A. Alakesh, J. Bodele, J.Ur Rehman, S. Shukla, V.
Wagde, S. Nadig, S. Chakrabarti, S. S. Visweswariah, D. Nandi, B. Gopal, S.
Jhunjhunwala. Particle uptake driven phagocytosis in macrophages and neutrophils
enhances bacterial clearance, Journal of Controlled Release 2022

3. S. Chakrabarti. An Open Access E-book on Drosophila Protocols for College


Students. 2021. Resonance 26, 1311–1313. https://doi.org/10.1007/
s12045-021-1232-y

4. K. Gupta, V. Janardan, S. Banerjee, S. Chakrabarti, S. Srinivas, D. Mahishi, P. Raghu, S.


S. Visweswariah. An evolutionarily conserved metallophosphodiesterase is a
determinant of lifespan in Drosophila. bioRxiv 2020; doi: https://doi.org/
10.1101/2020.05.08.084137.

5. S. Chakrabarti*, JP. Dudzic, X. Li, EJ. Collas, JP Boquete, M. Poidevin, and B.


Lemaitre*. Remote control of intestinal stem cell activity by haemocytes in
Drosophila. PLoS Genetics 2016. doi.org/10.1371/journal.pgen.1006089. (*: shared
corresponding author) PMID: 27231872

6. R.K. Vijendravarma, S. Narasimha, S. Chakrabarti, A. Babin, S. Kolly, B. Lemaitre, and


T. J. Kawecki. Gut physiology mediates a trade off between adaptation to
malnutrition and susceptibility to food borne pathogens. Ecology Letters 2015. 18
(10), 1078-1086. PMID: 26249109

7. S. Chakrabarti*, M. Poidevin, and B. Lemaitre*. The Drosophila MAPK p38c


Regulates Oxidative Stress and Lipid Homeostasis in the Intestine. PLoS Genetics
2014. doi/10.1371/ journal.pgen.1004647. (*: shared corresponding author)
PMID: 25254641

8. S. Chakrabarti, P. Liehl, N. Buchon and B. Lemaitre. Infection induced host


translational blockage inhibits immune responses and epithelial renewal in the
Drosophila gut. Cell Host Microbe 2012. 12(1): 60-70.PMID: 22817988
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9. D. Osman, N. Buchon, S. Chakrabarti, Y.T. Huang, W.C. Su, M. Poidevin, Y.C. Tsai, B.
Lemaitre. Autocrine and paracrine unpaired signalling regulate intestinal stem cell
maintenance and division. J Cell Sci. 2012. 125:5944-9. PMID: 23038775

10.N. Buchon, N.A.Broderick, S. Chakrabarti and B. Lemaitre. Invasive and indigenous


microbiota impact intestinal stem cell activity through multiple pathways in
Drosophila. Genes & Development 2009. 23(19): 2333-44. PMID: 19797770

11.D. Mittal, S. Chakrabarti, A. Sarkar, A. Singh, A. Grover Heat shock factor gene family
in rice: genomic organization and transcript expression pro ling in response to
high temperature, low temperature and oxidative stresses. Plant Physiology and
Biochemistry. 2009. 47 (9), 785-795 PMID: 19539489

AWARDS
• Wellcome trust-DBT India Alliance Early Career fellowship for 5 years 2016

• India Alliance Exceptional Fellows Fund 2020 for collaboration with Dr S.


Jhunhunwala at IISc

• IMEG grant for collaboration with Prof Akira Nakamura in 2019 and 2020 from
Kumamoto University

• eLIFE Ambassador 2018 and 2019.

• H.J. Muller fellowship to support Graduate studies at Indiana University 2007

• University of Delhi Endowment Scholarship for M.S tuition 2006

• Monsanto Scholarship for M.S tuition 2005

INVITE D TALK S ( AS A FELLOW)


• “Flying through the gut” webinar series. 16th May, 2022. Host: Dr Edan Foley.

• NCBS Bangalore, faculty job talk. 3rd November, 2021. Dr Raghu Pandijat.

• Shef eld Bateson Centre Research Webinar. 21st April, 2021. Host: Dr Iwan Evans.

• 62nd Annual Drosophila Research Conference. 23rd March-1st April, 2021

• TIFR, Hyderabad Research Webinar. 8th January, 2021. Host: Dr Manish Jaiswal.
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• 5th International Asia-Paci c Drosophila Research Conference in Pune. 9th January,
2020.

• Bangalore Developmental Biology Club. May 3rd, 2019.

• International Congress of Cell Biology Satellite Meeting ”Stem Cell Biology & Disease
Models” February 2-3rd, 2018.

• Indian Drosophila Research Conference 3rd Biennial Meeting, IISER Bhopal. 9th and
10th December, 2017.

• Annual Postdoctoral Symposium at NCBS. 17th and 18th November, 2016.

SK ILLS
• Good mentoring capabilities • Excellent level in Genetics and Cellular Biology •
Good project management, scienti c writing and summarization capabilities •
Cleared an Indiana University teaching English pro ciency exam for non native
speakers. • Organize and review the work of lab technicians and students • Bacterial
and Drosophila cell culture and manipulation • DNA and RNA isolation. •
Transcriptional pro ling by quantitative reverse transcription PCR (qRT-PCR) •
Statistical analysis of transcriptional data and transformation frequencies • Proteins
expression, puri cation, analysis and Kinase Assays • RNA-seq • Transgenic animals

REFER ENCE S
Prof. Sandhya Visweswariah IISc - Dept MRDG, Bangalore, India ([email protected], +
91 80 2292 2542)

Prof. Bruno Lemaitre EPFL- Global Health Institute, Lausanne, Switzerland.


(bruno.lemaitre@ep .ch, +41 21 693 18 31)

Prof Irene-Miguel Aliaga Imperial College London, UK. ([email protected],


+44 208 383 3907)
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