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HAEMATOLOGY
HbA1c (Glycated Haemoglobin) 8.2 0.0-6.0 %
HPLC-GOLD STD ON D-10 BIORAD
REMARKS
In vitro quantitative determination of HbA1c in whole blood is utilized in long term monitoring of glycemia.The HbA1c level correlates with the mean glucose
concentration prevailing in the course of the patient's recent history (approx - 6-8 weeks) and therefore provides much more reliable information for glycemia
monitoring than do determinations of blood glucose or urinary glucose. It is recommended that the determination of HbA1c be performed at intervals of 4-6
weeks during Diabetes Mellitus therapy. Results of HbA1c should be assessed in conjunction with the patient's medical history, clinical examinations and
other findings.
Mean Plasma Glucose 188.64 mg/dl
Mean Plasma Glucose is based on estimated Average Glucose (eAG) value calculated according to National Glycohemoglobin Standardization Program
(NGSP) criteria.
BIOCHEMISTRY
Blood Sugar Fasting 191.1 70.0-110.0 mg/dL
G-POD.AU480, Beckman Coulter
Interpretation (In accordance with the American diabetes association guidelines):
· A fasting plasma glucose level below 100 mg/dL is considered normal.
· A fasting plasma glucose level between 100-126 mg/dL is considered as glucose intolerant or pre diabetic. A fasting and post-prandial blood sugar test
(after consumption of 75 gm of glucose) is recommended for all such patients.
· A fasting plasma glucose level of above 126 mg/dL is highly suggestive of a diabetic state. A repeat fasting test is strongly recommended for all such
patients. A fasting plasma glucose level in excess of 126 mg/dL on both the occasions is confirmatory of a diabetic state.
IMMUNOASSAY
Thyroid Stimulating Hormone (TSH) 1.285 0.34 - 5.60 µIU/ml
Chemiluminescence Micropartical Immunoassay
INTERPRETATION
Thyroid-stimulating hormone is a glycoprotein with two non-covalently bound subunits. TSH is synthesized and secreted by the anterior pituitary in
response to a negative feedback mechanism involving concentrations of FT3 (free T3 ) and FT4 (free T4 ). Additionally, the hypothalamic tripeptide,
thyrotropin-releasing hormone (TRH), directly stimulates TSH production.
TSH interacts with specific cell receptors on the thyroid cell surface and exerts two main actions. The first action is to stimulate cell reproduction and
hypertrophy. Secondly, TSH stimulates the thyroid gland to synthesize and secrete T 3 and T4 . The ability to quantitate circulating levels of TSH is
important in evaluating thyroid function. It is especially useful in the differential diagnosis of primary (thyroid) from secondary (pituitary) and tertiary
(hypothalamus) hypothyroidism. In primary hypothyroidism, TSH levels are significantly elevated, while in secondary and tertiary hypothyroidism, TSH
levels are low.
TRH stimulation differentiates secondary and tertiary hypothyroidism by observing the change in patient TSH levels. Typically, the TSH response to TRH
stimulation is absent in cases of secondary hypothyroidism, and normal to exaggerated in tertiary hypothyroidism.
Historically, TRH stimulation has been used to confirm primary hyperthyroidism, indicated by elevated T3 and T4 levels and low or undetectable TSH levels.
TSH assays with increased sensitivity and specificity provide a primary diagnostic tool to differentiate hyperthyroid from euthyroid patients