Scribd
Upload
27 views

Metricef

The document provides information about Metricef, an intramammary suspension containing cephapirin benzathine for treatment of endometritis and repeat breeding in cows. Metricef is administered via intrauterine injection using the included disposable catheter. A single treatment is usually sufficient but a second treatment may be needed after 7-14 days if signs persist.

Uploaded by

PrakashNallappan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
27 views

Metricef

The document provides information about Metricef, an intramammary suspension containing cephapirin benzathine for treatment of endometritis and repeat breeding in cows. Metricef is administered via intrauterine injection using the included disposable catheter. A single treatment is usually sufficient but a second treatment may be needed after 7-14 days if signs persist.

Uploaded by

PrakashNallappan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 2

FOR THE USE OF A VETERINARIAN OR 358645 R1

A HOSPITAL OR A LABORATORY OR A FARM

Rx
CEPHAPIRIN BENZATHINE INTRAUTERINE
SUSPENSION IN
PRE FILLED SYRINGE
METRICEF ™

NOT FOR HUMAN USE - FOR ANIMAL TREATMENT ONLY

SCHEDULE H PRESCRIPTION DRUG – CAUTION Not to be sold by retail


without the prescription of a Registered Veterinary Practitioner only.
COMPOSITION
Each single dose syringe of 19g contains
500 mg cephapirin (as benzathine)
INDICATION(S)
Metricef is indicated for the treatment of subacute and chronic endometritis in cows (at
least 14 days after parturition) caused by bacteria sensitive to cephapirin.
Metricef can be used to treat repeat breeder cases (more than three unsuccessful
inseminations), if bacterial infections are suspected to be the cause of the fertility
problem.
CONTRAINDICATIONS
Not to be administered to animals which are known to be hypersensitive to
cephalosporin antibiotics and other β-lactam antibiotics.
TARGET SPECIES
Cows
DOSAGE AND ADMINISTRATION
The contents of one Metricef syringe should be introduced into the lumen of the uterus
using the disposable catheter provided as follows:
1. Shake the syringe before use.
2. Fix the syringe to the catheter.
3. Hold the cervix of the uterus with one gloved hand introduced into the rectum.
4. Introduce the catheter through the cervix into the lumen of the uterus by gentle
oscillating movements of the cervix.
5. Inject Metricef.
Depending on the response, a second treatment 7-14 days later may be required in
some cases if clinical signs persist.
In animals that have been inseminated, Metricef may be used at one day after
insemination. In case of pyometra, pretreatment with prostaglandin is recommended in
order to induce luteolysis and remove debris from the uterine cavity.
ADVICE ON CORRECT ADMINISTRATION
Shake the syringe before use.
WITHDRAWAL PERIOD
Meat and offal : 24 hours
Milk : 0 hours
SHELF LIFE: 36 months
SPECIAL STORAGE PRECAUTIONS
Store below 25°C.
Do not use after the expiry date stated on the label.
Keep out of the reach and sight of children.
ADVERSE REACTIONS
Allergic reactions have been observed in very rare cases.
SPECIAL WARNING(S)
Special precautions for use in animals
Use of the product should be based on susceptibility testing of the bacteria isolated from
the animal. If this is not possible, therapy should be based on local (regional, farm level)
epidemiological information about susceptibility of the target bacteria.
Special precautions to be taken by the person administering the
veterinary medicinal product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross
sensitivity to cephalosporin and vice versa. Allergic reactions to these substances may
occasionally be serious.

PSC020505 02 R1
90 x 220 mm
Moved to repository by COPPUS 23:Nov:2020 12:59
Black
Do not handle this product if you know you are sensitised, or if you have been advised
not to work with such preparations.
Handle this product with great care to avoid exposure, taking all recommended
precautions.
In case of accidental contact with eyes, rinse immediately with copious amounts of water
and obtain medical attention.
Accidental spillage on the skin should be washed off immediately with soap and water.
If you develop symptoms following exposure, such as skin rash, you should seek medical
advice and show the physician this warning. Swelling of the face, lips and eyes or
difficulty in breathing are more serious symptoms and require urgent medical attention.
Use during pregnancy and lactation
Metricef is not intended to be used in pregnant animals.
Metricef can be used during lactation.
Interaction with other medicinal products and other forms of interaction
Not to be administered concurrently with other intra-uterine antibiotic preparations.
Overdose (symptoms, emergency procedures, antidotes), if necessary
During a safety study in post-partum cows, Metricef administered up to 5 times the
recommended dosage during 3 consecutive days was well tolerated.
Incompatibilities
None known.
OTHER INFORMATION
Cephapirin, a first generation cephalosporin, is a broad spectrum antibiotic with
bactericidal action against gram-positive and gram-negative bacteria. Cephapirin is
resistant to the action of penicillinase.
After intra-uterine treatment systemic absorption is low, which is reflected by the low
plasma levels of cephapirin observed shortly after treatment. Twelve hours after
treatment, cephapirin levels in plasma are below detectable levels.
After intra-uterine administration of Metricef, high cephapirin concentrations are
observed in endometrium. Endometrium concentrations can be observed up to 24 hours.
PRESENTATION
Box of 10 syringes, 10 catheters and 10 gloves.

Manufactured by: Intervet International, BV


Wim de Körverstraat 35,
5831 AN
Boxmeer, The Netherlands

Imported & Marketed by: Intervet India Pvt. Ltd.


Sagar complex, Bldg.B-1
Gala No. 12 to 16
Ovali Village, Bhiwandi
Thane 421302

PSC020505 02 R1
90 x 220 mm
Moved to repository by COPPUS 23:Nov:2020 12:59
Black

You might also like