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Peripheral Neuropathy

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7 views2 pages

Peripheral Neuropathy

Uploaded by

quojo041
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Peripheral Neuropathy Causes of predominant sensory neuropathy

Causes of peripheral neuropathy  Ca – lung, breast, ovary


“DAM IT BICH”  Paraproteins
 Drugs & toxins – isoniazid, vincristine, phenytoin,  B6 intoxication
nitrofurantoin, cisplatin, amiodarone, lge dose B6, heavy  Sjogrens
metals  DM
 Alcohol  Syphilis
 Metabolic – DM, uremia, hypothyroidism, porphyria  B12 deficiency
 Immune-mediated – GBS  Idiopathic
 Tumour – lung Ca
 Vit B12, B1, B5 or B6 deficiency Painful causes
 Idiopathic  DM
 CT disease or vasculaitis – SLE, PAN  EtOH
 Hereditary  B1 or B12 deficiency
DM 30%, hereditary 30%, idiopathic 30% all other 10%  Carcinoma
 Porphyria
Causes of predominant motor neuropathy  Arsenic or thallium poisoning
 GBS  Hereditary
 CIDP
 Hereditary motor & sensory neuropathy – CMT Ix
 Acute intermittent porphyria  Bloods – FBC for anaemia, fasting BGL, eLFT, vitamin
 Lead poisoning levels, serum EPP
 DM  Urine EPP & BJP
 Multifocal neuropathy  Urine & faecal porphyrins
 MND & NMJ d/o’s  NCS
 Ix for malignancy
Mononeuritis multiplex
 Separate involvement of more than one peripheral nerve
(rarely CNs)
 Common causes – ACUTE
o DM
o PAN
o CT – SLE, RA
 Common causes – CHRONIC
o Multiple compression neuropathies
o Sarcoid
o Acromegaly
o Leprosy
o Lyme disease
o Ca (rare)
o Idiopathic

Hereditary motor & sensory neuropathy


CMT
 Pes cavus
 Distal MM atrophy – usually not above elbow or above mid
thigh
 Absent reflexes
 Slight to no sensory loss in limbs
 Thickened nerves
 Optic atrophy – Argyll Robertson pupils (rare)

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