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32 views

Gly Copy Roll Ate

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vk89.nahar
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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King Edward Memorial Hospital &

Perth Children’s Hospital


Neonatology

NEONATAL Medication Monograph

GLYCOPYRROLATE (Glycopyrronium)
This document should be read in conjunction with this DISCLAIMER

Highly Restricted: Requires Neonatologist or Respiratory Physician approval before commencing

Presentation Vial: 200 microgram/mL (suitable for ORAL use)


Oral solution: 200microgram /mL

Description Antimuscarinic agent with atropine-like actions

Indications Used to reduce excessive respiratory tract secretions.

Precautions Medical conditions that preclude the use of anticholinergics

Dosage There is limited information regarding the use of glycopyrollate in


neonates – consult neonatologist prior to initiating

IV/IM: 4– 9microgram/ kg/ dose every 6 to 8 hours


Maximum: 200mcirograms
Oral: 40-100microgram/ kg/ dose 3 to 4 times daily

Dose adjusted according to response

Dosage May be required in renal impairment due to reduced administration


Adjustment

Adverse Common: Drowsiness, insomnia, tachycardia, urinary retention,


Reactions constipation, inhibition of sweating.

Serious: Arrhythmia, malignant hyperthermia

Compatible Sodium Chloride 0.9%, Glucose 5%, Glucose 10%


Fluids

Preparation Can be diluted to aid administration of small doses


Withdraw 1mL of 200microgram/mL solution and add to 4mL of a
compatible fluid.
Concentration = 200microgram/5mL
Final concentration = 40microgram/mL

Glycopyrrolate (Glycopyrronium) - Neonatal Page 1 of 2


Glycopyrrolate (Glycopyrronium) - Neonatal

Administration Oral: May be given at any time with regard to feeds.


IV: Inject over 3-4 minutes
IM: as per NCCU protocol

Monitoring Monitor heart rate, bowel sounds and movements

Storage Store at room temperature, below 25°C

Notes Antidote: Neostigmine

References British National Formulary. BNF for Children. 2018-19 ed. London,
UK: BMJ Group and Pharmaceutical Press; 2018. p. 811.
Taketomo, Carol K., J. H. Hodding, and D. M. Kraus. Pediatric and
neonatal dosage handbook. Hudson (OH): Lexi Comp, 2010.
Ainsworth SB. Neonatal formulary 7: drug use in pregnancy and the
first year of life. Seventh ed. Chichester (West Sussex): John Wiley &
Sons Inc.; 2015. p247.
Society of Hospital Pharmacists of Australia. Glycopyrronium
Bromide. In: Australian Injectable Drugs Handbook [Internet]. [St
Leonards, New South Wales]: Health Communication Network; 2019
[cited 2020 Feb 23]. Available from: http://aidh.hcn.com.au
Truven Health Analytics. Glycopyrrolate. In: NeoFax [Internet].
Greenwood Village (CO): Truven Health Analytics; 2019 [cited 2020
Feb 23 Available from: https://neofax.micromedexsolutions.com/

Keywords: Glycopyrollate, glycopyrronium, respiratory secretions


Publishing: Intranet Internet
Document owner: Head of Department - Neonatology
Author / Reviewer: KEMH & PCH Pharmacy / Neonatology Directorate
Date first issued: January 2001 Version: 3.0
Last reviewed: February 2020 Next review date: February 2023
Endorsed by: Neonatal Directorate Management Group Date: February 2020
Standards Applicable: NSQHS Standards: 1 Governance, 4 Medication Safety
Printed or personally saved electronic copies of this document are considered uncontrolled.
Access the current version from the WNHS website.
For any enquiries relating to this guideline, please email [email protected]

© Department of Health Western Australia 2019

Glycopyrrolate (Glycopyrronium) - Neonatal Page 2 of 2

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