lla s s PATHOLOGY. 2023 : __ ~_ Internal Assessment Examination Time = 1 hr. Full Marks-100 0 ~ Answer All Question 1. Long Question: : Define inflammation. Describe the major events of acute inflammation. - Differentiate between acute & chronic inflammation. ee OR Define shock. Classify types of shock. Describe briefly the various stages : of shock and pathogenesis of septic shock. (4+6+10) | (4+10+6) | 2. Explain with reasons: 5 (5 x2 = 10) a) Unlike apoptosis, necrosis is associated with inflammation. b) Neutrophil extra cellular traps (NETs) are also called as beneficial suicide by neutrophils. 3, Write Short notes on the following: (Any Five) (6x5 = 30) ES: a) Differentiate extravascular and intravascular hemolysis. iating features of CSF findings in bacterial and tubercular "- @} Staining-pattern of amyloidwi f) Acute phase reactants: 4, Write the most appropriate answer of the following: (2x10 = 20) I.Which of the following is not an APC (Antigen presenting cell) : a) Dendritic cell c) B-Lymphocyte b) Natural (NK) cell d) Macrophage II, Which is not a reactive ox gen species: : a) 202) OFV. Red infarct is seen in a) lung ©) Kidney 7b) ‘Heart — d) Spleen VI. False regarding airembolismis a) seen in puerperium —_¢) also called Caisson disease b) seen in deep sea diver d) associated with bends and chokes VIL. Which of the following is not usually associated with M2 Macrophages a) 1L13_c) TGF Beta : b)1L10_ d) IFN Gamma VII. Naked granuloma is usually seen with a) Cats-cratch disease c) Sarcoidosis b) Q fever d) Syphilis IX." Odd one out regarding their respective patterns of inheritance a) Duchenne muscular dystrophy c) Osteogenesis imperfecta b) Hemophilia d) Alport’s syndrome X. Auto splenectomy is associated with : a) Thalassemia ¢) Vit B12 deficiency 4b) Sideroblastic anemia d) Homozygosity in HbS 5." Filfin the blanks: ¢ a) Positive acute pilase reactant causing anemia ia chronic d b) Cannibalism by a cell of its own contents is known as... ©) Myositis ossificans exemplifies which type of metaplasia... d) Name a disease having autosomal dominant inheritance... e) Anti-inflammatory cytokine also aiding tissue repair is.... f) Hallmark of malignancy is.... g) Anticoagulant used in Westergren pipette for performing ESR is... h) Megaloblastic anemia associated with peripheral neuropathy is Suspected in deficiency of... 1) Diagnostic test for glucose in urine is.... J) Zimportant preformed cellular mediators of inflammation are... &PATHOLOGY Internal Assessment Examination Time -1 hr. Full Marks - 100 Answer All Question 1, Long Question: Gey ~~ A. _ Define neoplasia.Mention molecular hallmarks of neoplasia. Describe role of P53 gene in Cancer causation. (3+6+6) OR B. A415 Yr female with fever, fatigue and bleeding gum since one month. No lymphadinopathy/ hepatosplenomegsaly. CBC shows TWBC > 1L, Hb 5g%, TPC 40,000. Give your diagnosis. Write the peripheral smear features and bone marrow findings. write the major subtypes given by WHO (2444445) 2. Explain with reasons: (2x3=6) a) Tumor antigen could evade natural immune surveillance. b) Low risk HPV is unable to cause carcinoma of cervix. 3. Write Short notes onthe following: (Any Four) (6x 4=24) a) Barrett's oesophagus. b) Burkitt's lymphoma. c) Difference between Type -1 and Type - 2 endometrial carcinoma. d) Papillary carcinoma thyroid diagnostic clues in histology. e) Roll of £6 & E_7 HPV protein in carcinoma cervix. 4, Write the most appropriate answer of the following: (2 x 10 = 20) L.Risk factors for oesophagial carcinoma are all except: a) Plummer Vinson Syndrome __c) Barrett's esophagus b) HPV infection d) Eosinophilic Oesophagitis IIA person succumbed to HIV infection.Lung autopsy showing intranuclear basophil inclusions. CD4 count was less than 100/ microL. Possible cause of death due to: a) CMVinfection c) Herpes infection b) ARDS d) Pneumocystis Carini infection. Il. Cancer cachexia is caused by all except: a) TNF c) IL_2 b) IL-1 d) IL_6 IV. Which of the following is a tumor marker + a) Serotonin ¢) Epinephrine b) Calcitonin. ) Prazocin TURNOVER = —> SuFDTESTETSSORUNEROGIEII 1 [JA EERERSMMNNRORIED OE ememennT 11611131) 2913747 7177 emmaV. DIC is common in which variant of AML : a) MonocyticMS — c) Erythrocytes Mé b) Promyelocytic M3 d) Megakaryocytic M7 VI. Cyclin_D1is expressed in : a) Follicular Lymphoma _ c) Mantle cell lymphoma b) CLL d) Marginal lymphoma Vil. Which is not TRUE for Endometrial carcinoma type _2: a) Thin built c) High Estrogen b) Atrophic Uterus d) >60yrs Vill. Modifiable risk factors for Atherosclerosis are all except: a) Diabetes c) Obesity b) HTN d) Increasing age IX. Which is a reversible condition in carcinoma of cervix: a) HSIL c) Carcinoma in situ b) CIN_1 d) Invasive carcinoma X. Most accepted postulation for Endometriosis is: a) Regurgitation theory c) The metaplastic theory b) Benign metastasis theory d) The extra uterine Stem cell theory 5. Fill in the blanks: (2x 10 = 20) a) Chromosomal translocation in CMLis__ b) Increase level of ___a.a. is a risk factor for atherosclerosis ¢) ___is a carcinogenic bacteria. d) In pregnancy uterine licomyoma has a possible chance of__type degeneration e) Acidic PH of vagina is maintained by__. f) Hall mark cell found in__ Lymphoma. g)___is an important screening test for Ca.cx. | h) Write the missing stage of team building...forming.. Storming..norming and___ \) High risk HPVis___ J) Orphane Annie eye nuclear feature found in__. im ioPATHOLOGY, 2023 i Internal Assessment Examination Time - 1 hr. Full Marks - 100 Answer All Question 1. Write Short notes on the following: (Any Six) (10 x 6 = 60) A)NASH. B) Seminoma of testis. C) Difference between Nephrotic syndrome and Nephritic syndrome. D) Name different classes of Lupus nephropathy and mention which is very common. E) Difference between Ulcerative collitis and Crohn’s disease. F) Define the ischemic heart disease. Enumerate the clinical syndrome associated with ischemic heart diasease. G) Teratoma of ovary. 2. Fill in the blanks: (2 x 10 = 20) A. Incirrhosis of liver collagen is laid down by cells and they are located in. part of hepatic lobules. B. “Loss of function” mutation in gene give rise to familial gastric tumor and most of diffuse gastric tumor which encodes protein. c Plays an important role in the formation of crescent in RPGN and Creasent contains type of epithelial cells, D. Type of necrosis seen in myocardial infarction is, and earliest light microscopy change observed is, E. Schawmann bodies are seen in where as ferruginous bodies are seen in F. There is increased risk of and in Hydatidiform mole. G. STIC lesion of fallopian tube prone to give rise type. epithelial carcinoma of H. Diffuse effacement of epithelial foot process is seen in, and. |, The classic adenoma-carcinoma sequence in most of the s Poradic colon tumors typically includes and genes. J, Hallmark histology of Paget's disease of bone is of lamellar bone seen in phase. TURNOVER ——>3. Write the most a propriate answer of the following: (2x 10 = 20) 1. Sub-epithelial humps are characteristic of a) MCD b) MPGN c) PSGN d) Membranous GN 2. “Ground Glass” hepatocytes are seen in a) HAV b) HBV c) HCV d) HeV 3) Gleason's grading system is used for. a) Ca Testis b) Ca colon c) Ca thyroid d) Ca prostate 4) Nodular sclerosis with fibrin caps and Capsular drops are seen in which nephropathy a) SLE b) Amyloidosis c) Diabeties Mellitus d) Hypertension 5) Most common complication of peptic ulcer a) Bleeding b)Acid reflux c) Vomiting d) Burning sensation 8) In primary atypical pneumonia inflammatory cells accumulate in a) Alveolar lumen b) Bronchioles c) Alveolar wall d) Pleural space 7) Active viral replication in HBV infection in signified by which serum marker 2) HBeAg b) HBV-DNA c) DNA polymerase d) all the above 8) Ca prostate arises from zone. a) Lateral b) Central c) Peripheral d) Medial 9) Eosinophil, Curschmann spirals with Charcot Leyden crystal in sputum characteristically found in 2) Emphysema b) Bronchiectasis ¢) Asthma d) Chronic bronchitis 40) Non neoplastic polyps in Gi tract are all except a) Hamartomatous polyp. b) Inflammatory polyp c) Juvenile polyp d) Adenomatous polyp