2014 - Helminski - Effectiveness of The Canalith Repositioning Procedure in The Treatment of Benign Paroxysmal Positional Vertigo
2014 - Helminski - Effectiveness of The Canalith Repositioning Procedure in The Treatment of Benign Paroxysmal Positional Vertigo
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Janet O. Helminski
J.O. Helminski, Physical Therapy, Midwestern University, 555 31st St, Downers Grove, IL
[Helminski JO. Effectiveness of the canalith repositioning procedure in the treatment of benign
practice of physical therapy. The Cochrane Library is a respected source of reliable evidence related to
health care. Cochrane systematic reviews explore the evidence for and against the effectiveness and
for and against the use of diagnostic tests for specific conditions. Cochrane reviews are designed to
facilitate the decisions of clinicians, patients, and others in health care by providing a careful review and
interpretation of research studies published in the scientific literature.1 Each article in this PTJ series
summarizes a Cochrane review or other scientific evidence on a single topic and presents clinical
scenarios based on real patients or programs to illustrate how the results of the review can be used to
directly inform clinical decisions. This article focuses on an adult patient with benign paroxysmal
positional vertigo.
Benign Paroxysmal Positional Vertigo (BPPV) presents with brief periods of vertigo experienced
with a change in the position of the person’s head relative to gravity. BPPV is a mechanical
disorder of the inner ear caused by abnormal stimulation of one or more of the three semicircular
canals (Figure 1). The otoconia from the utricle dislodge and settle within one of the three
semicircular canals changing the fluid filled canal dynamics from detecting rotation of the canals
to detecting gravitation forces on the head. With BPPV, changing the plane of the involved
canal relative to gravity causes debris to settle to the lowest part of the canal, changing the fluid
pressure across the cupula, deflecting the hair cells, and generating the characteristic ocular
nystagmus with associated vertigo. There are three mechanisms of BPPV, the most common
being debris within the long arm of the canal called canalithiasis.1 Debris may also be found in
the short arm of the canal2 or attached to the cupula weighting the membrane called
cupulolithiasis.2 The most common canal involved is the posterior semicircular canal (PC).3
The diagnosis of BPPV is based on history and findings on positional testing.4,5 If patients
complain of vertigo with rolling in bed or getting out of bed, patients are 4.3 times more likely to
have BPPV.6 The Dix-Hallpike test7 and the Side-Lying test8 are the standard tests4,5 for
evaluating posterior canal BPPV. A comparison of the Dix-Hallpike test and Side-Lying test
found no significant difference between the two techniques.8 Frenzel lenses or video
oculography should be used to prevent suppression of ocular nystagmus. The diagnostic criteria
for posterior canal BPPV are vertigo associated with the characteristic nystagmus of torsional,
superior pole towards the lowermost ear - the involved ear, and upbeating9 with a 1-45 s latency
before the onset,10-12 duration of <60 s,13 and fatigue with repeated positioning.13 For the DHT,
the estimated sensitivity is 79% (95% confidence interval [CI]=65-94) and specificity is 75%
Once identified, posterior canal BPPV may be effectively treated with a particle repositioning
maneuver such as the canalith repositioning maneuver (CRP) described by Epley.15 The canalith
repositioning maneuver is a series of four head positions designed to use the effects of gravity to
treat canalithiasis (Fig. 2A). With each head position, the debris settles to the lowest portion of
the canal moving the debris away from the ampulla, into the common crus, and then into the
utricle. With each change in position (steps 2-4), the movement of debris through the canal away
from the ampulla may create changes in pressure across the cupula resulting in the generation of
the same typical torsional and upbeating nystagmus predicting successful outcome of the
maneuver (Fig. 3A:video 1).16 If during the third and/or fourth step of the maneuver, the
movement of debris through the canal reverses direction, the debris moves towards the ampulla,
a reversal in direction of nystagmus may be observed predicting treatment failure (Fig. 3B).16
through the canals and to prevent suppression of nystagmus. The procedure is repeated a
minimum of three times within the treatment session. Repeating the CRP more than once is
significantly more effective than performing the CRP once within a treatment session.17
Acceptable modifications to the CRP as described by Epley include performance of the CRP
without mastoid vibration (thought to prevent debris from adhering to the canal walls) and self-
administration of the CRP.4,5 Short term outcome is the same for patients with and without post-
intervention positional and activity restrictions.18,19 But, a reduced number of treatment sessions
are required to produce a negative Dix-Hallpike test if post-intervention positional and activity
restrictions are maintained.20 To determine the results of the CRP, the Dix-Hallpike test should
A Cochrane systematic review by Hilton and Pinder22 examined the evidence to determine the
effectiveness of the CRP compared to other treatments available or no treatment for individuals
with posterior canal BPPV. This review is an update of a Cochrane Review first published in the
Cochrane Library in Issue 1, 2002 and then updated in 2004 and 2007. Randomized controlled
trials were included if participants were adults (> 16 years of age) with the clinical diagnosis of
posterior canal BPPV based on positive findings during the Dix-Hallpike test (observation of the
characteristic nystagmus and symptoms of associated vertigo). Trials compared the effectiveness
of the modified CRP (without the use of vibration) with a sham maneuver or an untreated
control. There was no evidence comparing the effectiveness of the CRP with other physical,
medical or surgical therapy for posterior canal BPPV. Follow-up ranged from <24 hours,21,23 to
resolution of symptoms and conversion from a positive to a negative Dix-Hallpike test, the only
objective physiological change resulting from treatment. The search date of the review was May
Take-Home Message
The review reported the results of five randomized controlled trials involving 292 adults with a
clinical diagnosis of posterior canal BPPV based on history and positive findings on the Dix-
Hallpike test. The outcome of the CRP was compared to an untreated control26 in one study or a
sham treatment in the remaining 4 studies.21,23-25 The sham treatment consisted of lying on
CRP performed as if opposite ear affected.21,23 Two trials instructed subjects in post-intervention
restrictions24,25 and three trials had no post-intervention restrictions.21,23,26 The overall risk for
bias was graded low for four trials21,23-25 and unable to determine for 1 trial.26
Pooled data showed a statistically significant difference in symptom resolution and in conversion
from a positive to a negative Dix-Hallpike test in favor of the CRP.22 At short term follow-up
(less than one month), subjective symptom resolution for patients treated with the CRP were
32% to 80%,21,23-26 those obtained with the sham treatment were 10% to 34%,21,23-25 and that
obtained with the control was 35%.26 The pooled odds in favor of complete subjective symptom
resolution were 4.42 times higher (95% CI=2.62-7.44) with the CRP than with the sham
treatment/control.21,23-26 At short term follow-up, the success rates for patients treated with the
CRP who converted to a negative Dix-Hallpike test were 34% to 89%,21,23-26 those obtained with
the sham treatment were 10% to 38%,21,23-25 and that obtained with the control was 65%.26 The
magnitude of the effect of the CRP compared with that of the sham treatment/control was
significant in all five studies. The pooled odds in favor of conversion of positive to negative
Dix-Hallpike test were 6.40 times higher (95% CI=3.63-11.28) with the CRP than with the sham
from 3.03 (95% CI=1.01-9.07) to 37.33 (95% CI=8.75-159.22). There were no reported adverse
tolerate positions due to cervical spine dysfunction,24 emesis during treatment,21,24 nausea,21 and
fainting.26
“Dr. X” is a 40 year old female with a seven year history of episodic positional vertigo, the most
recent episode beginning seven days ago when she rolled over in bed and woke with severe
vertigo and nausea. She was evaluated by a neuro-otologist, diagnosed with BPPV, and referred
to outpatient physical therapy for vestibular rehabilitation. To differentiate between BPPV and
other causes of dizziness, the physical therapy evaluation consisted of completion of self-
reported participation questionnaires, a history, a neurologic screen, and positional testing. The
handicap due to dizziness, and the Activities Balance Confidence (ABC) scale,28 designed to
(Table 2). The patient reported constant nausea; vertigo when rolling in bed towards the right,
getting in and out of bed, bending forward, looking up, and moving her head rapidly; and
vomiting during the physician’s examination. She slept in bed propped upright on five pillows
to avoid provoking positions, experienced difficulty concentrating at work, and felt anxious. The
patient’s history and findings on the Dizziness Handicapped Inventory suggested severe BPPV
while the total score of the Dizziness Handicapped Inventory suggested severe 0suppression of
ocular nystagmus, the patient medicated with ondansetron(Zofran®) prior to the evaluation per
The neurologic screen was negative. She had no contraindications for further positional testing or
Dynamic Gait Index,29 designed to evaluate postural stability during various walking tasks, and
Timed “Up & Go” Test30, a measurement of walking speed (Table 2). The Dix-Hallpike test was
performed with the use of video-oculography to avoid visual fixation that suppresses ocular
position was negative. The right head hanging position was positive, a typical nystagmus,
counterclockwise torsional (superior pole of eye directed towards the lowermost ear) and
upbeating, was observed with a two second latency before onset of nystagmus, 21 s duration of
nystagmus, and 8/10 peak velocity of nystagmus (0 no nystagmus and 10 extreme nystagmus).
The patient complained of severe vertigo associated with nystagmus and became nauseous.
Upon return to the upright position, a strong downbeating nystagmus associated with vertigo and
disorientation to vertical was noted. History and findings on the Dix-Hallpike test suggested
BPPV involving the right posterior canal. The patient was identified as a good candidate for the
CRP for right posterior canal BPPV. The mechanism of BPPV and treatment options was
discussed with the patient. The patient was informed of potential treatment complications such
as a canal conversion (movement of debris into another canal), canal jam (movement of debris
from a wide to narrow portion of the canal resulting in plugging of the canal), further nausea,
emesis, and further imbalance. The patient understood that the treatment risks were minimal and
consented to treatment of right posterior canal BPPV with the right CRP.
Physical therapy intervention consisted of performance of the right CRP without the use of
mastoid vibration. Each position was maintained for the duration of the nystagmus in the second
step plus 20 seconds (Fig. 2A). Video-oculography was used to visualize nystagmus in each
position to monitor the treatment progress. To optimize effectiveness of the maneuver, three
cycles of the CRP were performed within one treatment session. During the first cycle, a
counterclockwise torsional and upbeating nystagmus was observed in the second, third, and
fourth steps suggesting movement of debris away from the right posterior canal ampulla and
successful treatment.16 The nystagmus was associated with vertigo. The patient felt nauseous
observed and the patient did not complain of vertigo or nausea. Following the procedure, the
patient sat in the clinic for 20 minutes to allow debris to settle and to be supported if she
experienced sudden imbalance or vertigo. The patient was instructed in postural and activity
restrictions to minimize the number of treatment sessions. Dr. X was instructed to sleep on the
uninvolved side with the head elevated on a wedge made of three pillows and to avoid up and
down movements of the head for one week. She was given a handout describing the
mechanisms of BPPV, treatment options, post-treatment postural and activity restrictions, and
recurrence of BPPV. She was instructed to have someone drive her home.
The treatment results were evaluated at one week follow-up. Success was defined as no
subjective complaints of vertigo and conversion from a positive to negative Dix-Hallpike test.
Patient reported maintaining postural and activity restrictions and experiencing no episodes of
positional vertigo or symptoms of nausea during her daily routine. The total score on the
Dizziness Handicapped Inventory suggested no self-perceived handicap due to dizziness and the
total score on the Activities Balance Confidence (ABC) scale and Dynamic Gait Index suggested
no residual balance deficits (Table 2). Her speed of gait on the Timed “Up & Go” Test was
within normal limits for her age (Table 2). The Dix-Hallpike test was performed using video-
oculography. No nystagmus was observed and the patient did not complain of vertigo. Findings
suggested successful resolution of BPPV following treatment with the CRP. The patient was
educated in the probability of recurrence of BPPV and factors associated with recurrence.
How did the results of the Cochrane review apply to “Dr. X”?
CRP to treat right posterior canal BPPV. Using the PICO (Patient, Intervention, Comparison,
Outcome) format, the clinician asked the question: Will a 40 year old woman diagnosed with
right PC-BPPV benefit from the CRP to resolve symptoms of vertigo and to convert from a
positive to a negative Dix-Hallpike test? Based on history and findings on the Dix-Hallpike test,
“Dr. X” had a diagnosis of right posterior canal BPPV. The results of the Cochrane review may
be applied directly to “Dr. X.” The participant population was a similar age and gender and had
Our procedure matched the published protocols of articles described in the Cochrane review.
The CRP consisted of a series of four positions without the use of mastoid vibration.21,23-25 The
duration of each position was the duration of the nystagmus plus 20 seconds.24,25 Three cycles of
the CRP was performed and no nystagmus was observed during the second and third cycle. The
optimize success.21,24,25 Following the maneuver, the patient was instructed in postural and
activity restrictions with the exception of wearing a soft cervical collar24,25 to reduce the number
How well do the outcomes of the intervention provided to Dr. X match those suggested by
Within one treatment session, Dr. X achieved her goal of resolution of all symptoms of vertigo
with her daily routine. The therapist achieved her goal of conversion from a positive to negative
canal BPPV with one treatment session of the CRP is consistent with the reported Cochrane
for complete resolution of symptoms ranged from 34% to 89%,21,23-26 with an average percent
of 57+18% and for conversion from a positive to negative Dix-Hallpike test ranged from 34% to
Dr. X’s perceived level of handicap due to dizziness and perceived level of balance confidence in
performing household and community activities returned to normal. Balance control during gait
activities and speed of gait all returned to an age appropriate level. Participation and functional
level goals were not included in the trials and therefore were not included in the Cochrane
review. Dr. X’s positive outcome exceeded those that were significant in the Cochrane review.
Can you apply the results of the systematic review to your own patients?
All 292 participants in the trials included in this Cochrane review were diagnosed with posterior
canal BPPV based on history and findings on the Dix-Hallpike Test. Following one treatment
session, the short-term success rate of the CRP for complete symptom resolution on average was
57+18% and for conversion from a positive to a negative Dix-Hallpike test was on average
72+23%.22 There were few reported adverse effects of treatment and no serious complications.
The only reported limitations were emesis and cervical dysfunction preventing positioning of the
head. The results of the Cochrane Review22 may be applied to patients diagnosed with posterior
canal BPPV. However, long-term following up was lacking in all of the trials. Therefore, there
is no good evidence that the CRP provides a long-term resolution of symptoms. At the time of
the search date, there was no good evidence comparing the CRP with other particle repositioning
posterior canal BPPV31 (Figure 2B). At short term follow-up, subjective symptom resolution for
patients treated with the liberatory maneuver were 85%32 and 87%33 and those obtained with the
sham treatment were 0%33 and 14%.32 The presence of nystagmus in the same direction in the
second and third steps suggests successful treatment.34 Side effects included transient nausea,
vomiting, pallor, sweating, and loss of balance. 32,33 No trials have directly compared the
Subsequent to the Cochrane review search date, two trials have compared the CRP to Brandt-
Daroff exercises, the Liberatory maneuver, and untreated control. At one week, the short term
success rate was 81%35 and 87%36 for the CRP, 25%35 and 35%36 for the Brand-Daroff
exercises, 53% for the liberatory maneuver, 36 and 15% for the untreated control.36 Brand-Daroff
The available data is sufficient to determine that the CRP is a safe and effective short-term
treatment for posterior canal BPPV. Following one treatment session, the CRP successfully
resolves symptoms of vertigo and converts a positive to negative Dix-Hallpike test. In short-
term follow-up, individual trials and pooled data showed a statistically significant effect in favor
of the CRP over controls. The CRP is safe, with no serious complications. There is no good
evidence that the CRP provides a long-term resolution of symptoms. At the time of the search,
for posterior canal BPPV. Future updates of the review need to take into account subsequent
evidence comparing the CRP with other physical therapy treatments for posterior canal BPPV,
examining the effect size stratified by symptom duration, and comparing long-term follow-up of
symptom resolution between the CRP and other physical therapy treatments.
Special thanks to Janet Callahan, PT, DPT, MS, NCS, Sarah Hourihan, PT, DPT, Rene Crumley,
PT, DPT, NCS, CEEAA, and Tammie Ostrowski, PT, for assisting with acquisition of digital
recordings of nystagmus. Special thanks to Eric Sanderson, PT, DPT, for illustrating Figure 3
(prediction of canalith repositioning procedure success and failure).
DOI: 10.2522/ptj.20130239
Study Characteristics
• 5 small RCTs were included (Search date May 19, 2010).
• Participants were 292 adults (>16 years old) with a clinical diagnosis of posterior canal BPPV
based on history and a positive Dix-Hallpike test. All studies included subjects with unilateral
posterior canal BPPV. One study also included subjects with bilateral posterior canal BPPV
and atypical BPPV. The duration of subjects’ symptoms varied.
• Intervention was modified CRP (no mastoid vibration). Comparator was sham maneuver in 4
trials or control in 1 trial.
• Follow-up ranged from immediately to 1 month post-treatment
Interventions
• Type of particle repositioning maneuver: CRP, sham maneuver (lying on affected side for 5
minutes, lying in the 1st lateral position of the liberatory maneuver for 5 minutes, and CRP
performed as if opposite ear affected), and control (untreated).
• Number of cycles per treatment session: Ranged from 1-5.
• Post-intervention postural and activity restrictions: Two trials instructed subjects in post-
intervention restrictions. Three trials had no post-intervention restrictions.
Outcomes
• Proportion of subjects who had complete resolution of their symptoms and who converted from
a positive to a negative Dix-Hallpike test.
• Two studies asked participants to complete a diary of symptoms.
Froehling et Lynn et al, Munoz et al, von Brevern Yimtae et al,
al, 200024 199525 200723 et al, 200621 200326
Measure CRP Sham CRP Sham CRP Sham CRP Sham CRP Contro
l
No. of 24 26 18 15 38 41 35 31 29 27
participants/
group
No. of 12(50 5(19) 11(61 3(20) 12(32 10(24 28(80 4(13) 12(41 1(4)
participants/ ) ) ) ) ) )
group with
complete
resolution of
symptoms (%)
No. of 16(67 10(38 16(89 4(27) 13(34 6(15) 28(80 3(10) 22(76 13(48)
participants/ ) ) ) ) ) )
group with
negative Dix-
Hallpike test
result (%)
filled semicircular canals contains sensory epithelium consisting of hair cells embedded within
the cupula, a fine, diaphragmatic membrane. Rotation of the head deflects the hair cells. The
utricular macula consists of a weighted sensory membrane, hair cells implanted within an
otolithic membrane weighted with calcite particles, otoconia. Gravitational forces on the head
for treatment of the right PC. The clinician moves the patient through a series of 4 positions,
starting with the placement of the involved canal in the head-hanging position of the Dix-
Hallpike Test. To begin, the patient is positioned in long sitting (sitting on the treatment table
with the legs extended). The patient's head is rotated 45 degrees towards the right. The patient
is then lowered into supine with the neck extended 30 degrees over the edge of the treatment
table. This is the head-hanging position. The head is rotated through 90° of motion ending in 45°
of neck rotation towards the uninvolved side, followed by rolling onto the uninvolved side while
maintaining the head on trunk position, and finally sitting up from lying on the uninvolved side.
Each position is maintained for a minimum of 45 seconds or as long as the nystagmus lasts plus
an additional 20 s. The procedure is repeated three times. (B) The liberatory (Semont)
maneuver illustrated for treatment of the right PC. The patient sits on the edge of the treatment
table. The clinician rapidly moves the patient to lying on the involved side with the head rotated
45° towards the uninvolved side. While maintaining the head on trunk position, the clinician
swings the patient from lying on the involved side to lying onto the uninvolved side. The head is
Figure 3. Movement of debris within the right PC during the canalith repositioning procedure
illustrated for treatment of the right PC. Arrow indicates direction of angular velocity and flow
successful outcome. With each position of the head, debris settles away from the cupula, creating
an ampullofugal flow of endolymph away from the cupula, exciting the hair cells within the
cristae ampullaris, and generating the same direction of nystagmus. (B) Prediction of failed
outcome. During the 2nd and/or 3rd position, the debris settles towards the cupula, reversing the
direction of flow of the endolymph towards the ampulla (ampullopetal), inhibiting the hair cells
within the cristae ampullaris, and reversing the direction of the nystagmus.
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HORIZONTAL
SEMICIRCULAR CANAL
VESTIBULE
UTRICLE
SACCULE AMPULLA
CUPULA
COCHLEA
CRISTA AMPULLARIS
DISPLACED OTOCONIA
OTOCONIA
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