EUROPEAN PHARMACOPOEIA 11.0 4.1.1.

Reagents

04/2013:40000 Acacia solution. 1000101.

Dissolve 100 g of acacia R in 1000 mL of water R. Stir with
a mechanical stirrer for 2 h. Centrifuge at about 2000 g for
30 min to obtain a clear solution.
Storage : in polyethylene containers of about 250 mL
capacity at a temperature of 0 °C to − 20 °C.
4. REAGENTS Acebutolol hydrochloride. 1148900. [34381-68-5].
Additional information for reagents that can only be fully See Acebutolol hydrochloride (0871).
identified by a trademark or whose availability is limited may
be found in the Knowledge database on the EDQM website. Acetal. C6H14O2. (Mr 118.2). 1112300. [105-57-7].
This information is given only to make it easier to obtain Acetaldehyde diethyl acetal. 1,1-Diethoxyethane.
such reagents and this does not suggest in any way that the Clear, colourless, volatile liquid, miscible with water and with
mentioned suppliers are especially recommended or certified by ethanol (96 per cent).
the European Pharmacopoeia Commission or the Council of 20
Europe. It is therefore acceptable to use reagents from another d 20 : about 0.824.
source provided that they comply with the standards of the n D20 : about 1.382.
Pharmacopoeia.
bp : about 103 °C.
Acetaldehyde. C2H4O. (Mr 44.1). 1000200. [75-07-0].
07/2018:40100 Ethanal.
Clear, colourless flammable liquid, miscible with water and
with ethanol (96 per cent).
20
d 20 : about 0.788.

4.1. REAGENTS, STANDARD n D20 : about 1.332.

bp : about 21 °C.
SOLUTIONS, BUFFER SOLUTIONS
Acetaldehyde ammonia trimer trihydrate.
Where the name of a substance or a solution is followed by the
C6H15N3,3H2O. (Mr 183.3). 1133500. [58052-80-5].
letter R (the whole in italics), this indicates a reagent included
2,4,6-Trimethylhexahydro-1,3,5-triazine trihydrate.
in the following list. The specifications given for reagents do
not necessarily guarantee their quality for use in medicines. Content : minimum 95.0 per cent.
Within the description of each reagent there is a 7-digit Colourless or white or pale yellow crystals or powder.
reference code in italics (for example, 1002501). This number, mp : 95 °C to 97 °C.
which will remain unchanged for a given reagent during Assay. Dissolve 0.900 g in water R and dilute to 50.0 mL
subsequent revisions of the list, is used for identification with the same solvent. Titrate with 1 M hydrochloric acid,
purposes by the Secretariat, and users of the Pharmacopoeia determining the end-point potentiometrically (2.2.20).
may also find it useful, for example in the management of
reagent stocks. The description may also include a CAS 1 mL of 1 M hydrochloric acid is equivalent to 61.08 mg of
number (Chemical Abstract Service Registry Number) C6H15N3,3H2O.
recognisable by its typical format, for example 9002-93-1. Acetic acid, anhydrous. C2H4O2. (Mr 60.1). 1000300.
Some of the reagents included in the list are toxic and are to be [64-19-7].
handled in conformity with good quality control laboratory Content : minimum 99.6 per cent m/m of C2H4O2.
practice.
Colourless liquid or white or almost white, shining, fern-like
Reagents in aqueous solution are prepared using water R. crystals, miscible with or very soluble in water, in ethanol
For liquid chromatography, water for chromatography R is (96 per cent), in glycerol (85 per cent), and in most fatty and
used for the preparation of mobile phases when water, or an essential oils.
aqueous solution, is one of the components. Where a reagent 20
solution is described using an expression such as ‘hydrochloric
d 20 : 1.052 to 1.053.
acid (10 g/L HCl)’, the solution is prepared by an appropriate bp : 117 °C to 119 °C.
dilution with water R of a more concentrated reagent solution A 100 g/L solution is strongly acid (2.2.4).
specified in this chapter. Reagent solutions used in the limit A 5 g/L solution neutralised with dilute ammonia R2 gives
tests for barium, calcium and sulfates are prepared using reaction (b) of acetates (2.3.1).
distilled water R. Where the name of the solvent is not stated,
an aqueous solution is intended. Freezing point (2.2.18) : minimum 15.8 °C.
The reagents and reagent solutions are to be stored in Water (2.5.12) : maximum 0.4 per cent. If the water content
well-closed containers. The labelling should comply with the is more than 0.4 per cent it may be adjusted by adding the
relevant national legislation and international agreements. calculated amount of acetic anhydride R.
Storage : protected from light.
Acetic acid, glacial. C2H4O2. (Mr 60.1). 1000400. [64-19-7].
01/2023:40101 See Acetic acid, glacial (0590).

Acetic acid. 1000401.

Content : 290 g/L to 310 g/L of C2H4O2 (Mr 60.1).
Dilute 30 g of glacial acetic acid R to 100 mL with water R.
4.1.1. REAGENTS Acetic acid, dilute. 1000402.
Acacia. 1000100. Content : 115 g/L to 125 g/L of C2H4O2 (Mr 60.1).
See Acacia (0307). Dilute 12 g of glacial acetic acid R to 100 mL with water R.

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