Health Report 2023
Health Report 2023
HAEMATOLOGY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Interpretation: HbA1c%
≤5.6 Normal
5.7-6.4 At Risk For Diabetes
≥6.5 Diabetes
Comments:
A 3 to 6 monthly monitoring is recommended in diabetics. People with diabetes should get the test done more often if their blood
sugar stays too high or if their healthcare provider makes any change in the treatment plan. HbA1c concentration represent the
integrated values for blood glucose over the preceding 8-12 weeks and is not affected by daily glucose fluctuation, exercise &
recent food intake.
Please note, Glycemic goal should be individualized based on duration of diabetes, age/life expectancy, comorbid conditions,
known CVD or advanced microvascular complications, hypoglycemia unawareness, and individual patient considerations.
Factors that interfere with HbA1c Measurement: Hemoglobin variants, elevated fetal hemoglobin (HbF) and chemically modified
derivatives of hemoglobin (e.g. carbamylated Hb in patients with renal failure) can affect the accuracy of HbA1c measurements.
Factors that affect interpretation of HbA1c Measurement: Any condition that shortens erythrocyte survival or decrease mean
erythrocyte age (e. g., recovery from acute blood loss, hemolytic anemia, HbSS, HbCC, and HbSC) will falsely lower HbA1c test
results regardless of the assay method used. Iron deficiency anemia is associated with higher HbA1c.
Note: Presence of Hemoglobin variants and/or conditions that affect red cell turnover must be considered, particularly when the
HbA1c result does not correlate with the patient's blood glucose levels.
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PO No :APT7X5QNJCTD
HAEMATOLOGY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
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PO No :APT7X5QNJCTD
HAEMATOLOGY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
As per the recommendation of International council for Standardization in Hematology, the differential leucocyte counts
are additionally being reported as absolute numbers of each cell in per unit volume of blood.
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PO No :APT7X5QNJCTD
HAEMATOLOGY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
ESR provides an index of progress of the disease and is widely used as an indicator of inflammation, infection, trauma, or
malignant diseases. Changes are more significant than a single abnormal test
It is specifically indicated to monitor the course or response to the treatment of diseases like rheumatoid arthritis,
tuberculosis bacterial endocarditis ,acute rheumatic fever ,Hodgkins disease,temporal arthritis , and systemic lupus
erythematosis; and to diagnose and monitor giant cell arteritis and polymyalgia rheumatica.
An elevated ESR may also be associated with many other conditions, including autoimmune disease, anemia,
infection,malignancy,pregnancy, multiple myeloma, menstruation, and hypothyroidism.
Although a normal ESR cannot be taken to exclude the presence of organic disease, its rate is dependent on various
physiologic and pathologic factors.
The most important component influencing ESR is the composition of plasma. High level of C-Reactive Protein, fibrinogen,
haptoglobin, alpha-1antitrypsin, ceruloplasmin and immunoglobulins causes the elevation of Erythrocyte Sedimentation
Rate.
Drugs that may cause increase ESR levels include: dextran, methyldopa, oral contraceptives, penicillamine, procainamide,
theophylline, and Vitamin A. Drugs that may cause decrease levels include: aspirin, cortisone, and quinine
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PO No :APT7X5QNJCTD
HAEMATOLOGY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Blood Grouping
Blood Group (ABO typing) A Tube agglutination(forward
and reverse)
Rh Factor Positive Tube agglutination
Comment:
Blood group is identified by antigens and antibodies present in the blood. Antigens are protein molecules found on the surface of
red blood cells. Antibodies are found in plasma. To determine blood group, red cells are mixed with different antibody solutions
to give A,B,O or AB. The test is performed by both forward as well as reverse grouping methods. The report is of sample
received. It is presumed that the sample belongs to the patient.
Notes
Reconfirm the Blood Group & Rh Typing along with cross matching before blood transfusion.
Recent blood transfusion, if any, interferes with interpretation of blood grouping.
The blood group and Rh antigen may change in the new born, hence please repeat the test after 6 months.
Subgroups and Bombay blood group needs to be further verified
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PO No :APT7X5QNJCTD
BIOCHEMISTRY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
SGPT/ALT :
Present in large concentrations in liver, kidney; in smaller amounts, in skeletal muscle and heart.
Released with tissue damage, particularly liver injury. ALT is the preferred enzyme for evaluation of liver injury.
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PO No :APT7X5QNJCTD
BIOCHEMISTRY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
SGOT/AST :
Present in large concentrations in liver, skeletal muscle, brain, red cells, and heart.
Released into the bloodstream when tissue is damaged, especially in liver injury.
Test is not indicatted for diagnosis of myocardial infarction.
AST/ALT ratio>1 suggests cirrhosis in patients wiyh hepatitis C.
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PO No :APT7X5QNJCTD
BIOCHEMISTRY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Elevated levels results from increased bilirubin production (eg. hemolysis and ineffective erythropoiesis), decreased
bilirubin excretion (eg. obstruction and hepatitis), and abnormal bilirubin metabolism (eg. hereditary and neonatal
jaundice).
Direct bilirubin is elevated more than indirect bilirubin in viral hepatitis, drug reactions, Alcoholic liver disease.
Direct bilirubin is also elevated more than indirect bilirubin when there is some kind of blockage of the bile ducts like in
gallstones, tumors & scarring of the bile ducts.
Elevated levels of indirect bilirubin may be a result of hemolytic or pernicious anemia and transfusion reaction.
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PO No :APT7X5QNJCTD
BIOCHEMISTRY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Increased in: Hyperparathyroidism primary and secondary, Acute and chronic renal failure, Following renal transplantation,
Osteomalacia with malabsorption, Acute osteoprosis, Malignant tumours (specially of breast, lung and kidney), Drugs: Vit. D and
A intoxication, Diuretics, estrogen, androgen, tamoxifen, lithium
Decreased in: Hypoparathyroidism, Surgical and Idiopathic, Pseudohypoparathyroidism, Chronic renal disease with uremia and
phophate retention, Malabsorption of Calcium and Vit.D, obstructive jaundice, Bone Disease ( Osteomalacia and rickets), Drugs:
Cancer chemotherapy drugs, calcitonin, loop-actives diuretics, Hypomagnesemia,Hypoalbuminemia
Page 9 of 28
PO No :APT7X5QNJCTD
BIOCHEMISTRY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Creatinine is a more specific and sensitive indicator of renal disease than Blood Urea Nitrogen.
Uses:
Increased In: Blockage in the urinary tract, Pre- and postrenal azotemia, Impaired kidney function, Loss of body fluid
(dehydration), Muscle diseases such as gigantism, acromegaly.
Decreased In: Pregnancy, certain drugs (e.g., cimetidine, trimethoprim), Myasthenia Gravis, Muscular dystrophy.
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PO No :APT7X5QNJCTD
BIOCHEMISTRY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Long-term follow-up of asymptomatic hyperuricemic patients is undertaken because many are at risk for kidney disease
that may develop as a result of hyperuricemia and hyperuricuria; few of these patients ever develop the clinical syndrome
of gout.. It is also used in the diagnosis and monitoring of pregnancy-induced hypertension (pre- eclamptic toxemia).
Concentrations in excess of 6.0 mg/dL at 32 weeks gestation have been noted to be associated with a high perinatal
mortality rate.
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PO No :APT7X5QNJCTD
BIOCHEMISTRY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Elevated Blood Urea Nitrogen can occur with kidney diseases, but it can also happen from a high protein diet, increased
protein breakdown, certain medications, dehydration or burns, GI haemorrhage, cortisol and renal failure. BUN levels often
rise with aging as well.
Abnormally low levels of Blood Urea Nitrogen can be a sign of malnutrition, lack of protein in the diet, and liver disease.
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PO No :APT7X5QNJCTD
BIOCHEMISTRY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Serum Electrolyte
Sodium 139 mmol/L 136-145 INDIRECT ISE
Potassium 4.20 mmol/L 3.5-5.1 INDIRECT ISE
Chloride 104.0 mmol/L 98-107 INDIRECT ISE
Comment:
Kidneys actively reabsorb or excrete electrolytes to maintain the electrolyte balance of the body. Owing to their small size,
almost all electrolytes are filtered at the glomerulus. After filtration, most of the electrolytes are absorbed back at the
tubular level but any problem at the tubular level will result in non- absorption and excessive loss of electrolytes in urine.
Sodium along with chloride, potassium, and water is important in the regulation of osmotic pressure and water balance
between intracellular and extracellular fluids.
An increase in sodium concentration (hypernatremia) may indicate impaired sodium excretion or dehydration.
Hypernatremia is rare but occurs most often in the elderly and is often hospital-acquired. A decrease in sodium
concentration (hyponatremia) may reflect over hydration, abnormal sodium loss, or decreased sodium intake, seen in
conditions such as nephrotic syndrome, heart failure, generalized edema, and cirrhosis.
Hypokalemia and hyperkalemia are caused by changes in potassium intake, altered excretion, or transcellular shifts.
Diuretic use and gastrointestinal losses are common causes of hypokalemia, whereas kidney disease, hyperglycemia, and
medication use are common causes of hyperkalemia. When severe, potassium disorders can lead to life-threatening
cardiac conduction disturbances and neuromuscular dysfunction. Therefore, a first priority is determining the need for
urgent treatment through a combination of history, physical examination, laboratory, and electrocardiography findings.
Serum chloride concentration can be elevated above the normal range – hyperchloremia - either by the addition of excess
chloride to the ECF compartment or by the loss of water from this compartment, and vice versa. The serum chloride
concentration can be reduced below the normal range (hypochloremia) by the loss of chloride from the ECF or the addition
of water to this compartment.Hyperchloremia is common in critically ill people.Severe dehydration, Diarrhea and excessive
urination, Metabolic acidosis, Kidney disease, Chemotherapy may lead to hyperchloremia. Newborn babies often have
hyperchloremia because their chloride levels rise in the week after birth. However, this is nothing to worry about, as the
levels rise naturally and do not indicate a health problem.Hypochloremia may be seen in Low salt intake in the
diet, Metabolic alkalosis, Certain medications, such as diuretics and laxatives, as these may reduce the amount of fluid in
the body, Addison's Disease, etc.
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PO No :APT7X5QNJCTD
BIOCHEMISTRY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Glucose - Fasting
Glucose - Fasting 80 mg/dL 70-100 Hexokinase
Comment:
Impaired glucose tolerance (IGT) fasting, means a person has an increased risk of developing type 2 diabetes but does not
have it yet. A level of 126 mg/dL or above, confirmed by repeating the test on another day, means a person has diabetes.
IGT (2 hrs Post meal ), means a person has an increased risk of developing type 2 diabetes but does not have it yet. A 2-hour
glucose level of 200 mg/dL or above, confirmed by repeating the test on another day, means a person has diabetes
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PO No :APT7X5QNJCTD
BIOCHEMISTRY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Lipid Profile
Cholesterol - Total 173 mg/dL Desirable <200, Enzymatic
Borderline High 200 -
239,
High >=240
Triglycerides 80 mg/dL Normal: <150, Glycerol Phosphate
Borderline: 150 - 199, Oxidase
High:200-499,
Very High>=500
Cholesterol - HDL 40 mg/dL Undesirable/high risk Accelerator Selective
<=40mg/dL Detergent
Desirable/low
risk>=60mg/dl
Cholesterol - LDL 117 mg/dL Desirable: <100 Calculated
Above desirable: 100 -
129
Borderline high : 130 -
159
High : 160 - 189
Very high : >=190
Cholesterol- VLDL 16 mg/dL <30 Calculated
Cholesterol : HDL Cholesterol 4.3 Ratio Desirable : 3.5-4.5 Calculated
High Risk : >5
LDL : HDL Cholesterol 2.93 Ratio Desirable : 2.5-3.0 Calculated
High risk : >3.5
Non HDL Cholesterol 133 mg/dl Desirable:< 130, Calculated
Above Desirable:130 -
159,
Borderline High:160 -
189,
High:190 - 219,
Very High: >= 220
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PO No :APT7X5QNJCTD
BIOCHEMISTRY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
•Lipid profile measurements in the same patient can show physiological & analytical variations. It is recommended that 3 serial
samples 1 week apart may be tested.
•Indians are at a high risk of developing atherosclerotic cardiovascular disease (ASCVD); at a much earlier age and more severe
with high mortality. Dyslipidemia (abnormal lipid profile) is the major risk factor and found in almost 80% Indians.
•Total cholesterol is the total amount of cholesterol in blood comprising of HDL, LDL-C, and VLDL.
•LDL Cholesterol (LDL-C) or “bad”cholesterol contributes most significantly to atherosclerosis leading to heart disease or
stroke and is the primary target for reducing risk for cardiovascular disease.
•High-density lipoprotein (HDL) or “good” cholesterol can lower risk of heart disease and stroke.
•Triglyceride (TG) level also plays a major role in CVD. Indians are more prone to Atherogenic dyslipidemia, a condition
associated with high TG, low HDL-C and high LDL-C; this is associated with diabetes, metabolic syndrome and insulin resistance.
Hence high triglyceride levels also need to be treated.
•Non-HDL-Cholesterol (Non-HDLC) measures all plaque forming lipoproteins (e.g. remnants, LDL-C, VLDL, Lp(a), Apo-B).
Monitoring of Non-HDLC is important in patients with high TG (e.g. diabetics, obese persons) and those already on statin
therapy.
•Lipid Association of India (LAI-2020) recommends:-
Screening of all Indians above the age of 20 years for CVD risk factors, esp. lipid profile.
Identification of Risk factors: Age (male ≥45 years, female ≥55 years); Family h/o heart disease at younger age (<55 yrs
in males, <65 yrs in female), Smoking/tobacco use, High blood pressure, Low HDL (males <40 mg/dl and females
<50mg/dl).
Fasting lipid profile is not mandatory for screening. Both fasting and non-fasting lipid profiles are equally important for
managing Indian patients.
Non-HDLC should be calculated in every subject. LAI recommends LDL-C as the primary target and Non-HDLC as the co-
primary target for initiating drug therapy.
Lifestyle modifications are of first and foremost importance for management and prevention of dyslipidemia. Among low
risk groups, treatment is started only after 3 months of lifestyle changes.
Testing for Apolipoprotein B, hsCRP, Lp(a ) should be considered for patients in moderate risk group.
Newer treatment goals based on Risk Groups and values of LDL-C and Non-HDLC
•As per NCEP Expert Panel (2011) guidelines, universal screening for dyslipidemia is recommended for children between 9
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BIOCHEMISTRY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
- 11 yrs (repeat at 17-21 yrs). Screening is not recommended before the age of 2yrs. Above the age of 2 yrs, selective screening
is done in children with family history of premature CVD or risk factors like obesity, diabetes, and hypertension.
Note: Reference Interval as per National Cholesterol Education Program (NCEP) Report.
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PO No :APT7X5QNJCTD
Immunology
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
TSH levels are subject to circadian variation, reaching peak levels between 2 - 4.a.m. and at a minimum between 6-10 pm
.
The variation is of the order of 50%, hence time of the day has influence on the measured serum TSH concentrations.
TSH is secreted in a dual fashion: Intermittent pulses constitute 60-70% of total amount, background continuous secretion
is 30-40%.These pulses occur regularly every 1-3 hrs.
TSH is a very sensitive and specific parameter for assessing thyroid function and is particularly suitable for early detection
or exclusion of disorders in the central regulating circuit between the hypothalamus, pituitary and thyroid.
Changes in thyroid status are typically associated with concordant changes in T3, T4 and TSH levels.
For the diagnosis of hypothyroidism and hyperthyroidism, sole dependence on TSH should not be done and assay needs
to be interpreted with the clinical condition & other investigations.
Serum TSH level changes significantly in response to even minor changes in thyroid hormones.
Transient increase in TSH level or an abnormal TSH levels can be seen in various nonthyroidal diseases.
Unexpectedly abnormal or discordant thyroid test values may be seen with some rare, but clinically significant conditions
such as central hypothyroidism, TSH-secreting pituitary tumors, thyroid hormone resistance, or the presence of
heterophilic antibodies (HAMA) or thyroid hormone autoantibodies.
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PO No :APT7X5QNJCTD
Immunology
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
TSH T3 T4 Interpretation
High Normal Normal Subclinical Hypothyroidism
Low Normal Normal Subclinical Hyperthyroidism
High High High Secondary Hyperthyroidism
Low High/Normal High/Normal Hyperthyroidism
Non thyroidal illness / Secondary
Low Low Low
Hypothyroidism
Page 19 of 28
PO No :APT7X5QNJCTD
Immunology
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Thyroxine - Total
T4, Total 8.2 µg/dL 4.87-11.72 CMIA
Comment:
Below mentioned are the guidelines for pregnancy related reference ranges for total T4.
Total T3 and T4 circulate in plasma almost entirely bound to transport proteins, mainly thyroxine-binding globulin (TBG). It
is the unbound or free hormones which diffuse into tissues and exert diverse metabolic actions.
T4 concentrations are altered by physiological or pathological changes in thyroxine binding globulin (TBG) capacity . For
example, factors such as estrogen, glucocorticoid or androgen therapy, pregnancy, oral contraceptives, nephrotic
syndrome, and genetic influences can cause substantial changes in TBG levels.
Increased Levels: Hyperthyroidism, Increased TBG, Familial dysalbuminemic hyperthyroxinemia, Increased Transthyretin,
Estrogen therapy, Pregnancy
Decreased Levels:Primary hypothyroidism, Pituitary TSH deficiency, Hypothalamic TRH deficiency, Non thyroidal illness.
Serum T4 levels in neonates and infants are higher than values in the normal adult, due to the increased concentration of
TBG in neonate serum.
Consequently, while T4 concentrations give good indications of thyroid status in many cases, compensatory changes in T4
levels can also occur and T4 levels alone may give a false impression of thyroid function.
For diagnostic purposes, results should be used in conjunction with other data; e.g., symptoms, results of other thyroid
tests, clinical impressions, etc
Various drugs can lead to interference in test results.
TSH T3 T4 Interpretation
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PO No :APT7X5QNJCTD
Immunology
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
High Normal Normal Subclinical Hypothyroidism
Low Normal Normal Subclinical Hyperthyroidism
High High High Secondary Hyperthyroidism
Low High/Normal High/Normal Hyperthyroidism
Non thyroidal illness / Secondary
Low Low Low Hypothyroidism
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PO No :APT7X5QNJCTD
Immunology
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
TriIodothyronine Total
T3, Total 0.90 ng/mL 0.64-1.52 CMIA
Comment:
Total T3 and T4 circulate in plasma almost entirely bound to transport proteins, mainly thyroxine-binding globulin (TBG). It
is the unbound or free hormones which diffuse into tissues and exert diverse metabolic actions.
T3 concentrations are altered by physiological or pathological changes in thyroxine binding protein capacity. For example,
factors such as estrogen, glucocorticoid or androgen therapy, pregnancy, oral contraceptives, nephrotic syndrome, and
genetic influences can cause substantial changes in TBG levels.
Clinically, T3 blood levels better define hyperthyroidism and are especially valuable in following the course of therapy for
this disorder.
The T3 level is also a good indicator of the ability of the thyroid to respond to both stimulatory and suppressive tests.
Total T3 Increased Levels: Pregnancy, Graves disease, T3 thyrotoxicosis, TSH dependent Hyperthyroidism
Total T3 Decreased Levels: Non-thyroidal illness, Hypothyroidism,Nutritional deficiency, Systemic illness
For diagnostic purposes, results should be used in conjunction with other data; e.g., symptoms, results of other thyroid
tests, clinical impressions, etc.
TSH T3 T4 Interpretation
High Normal Normal Subclinical Hypothyroidism
Low Normal Normal Subclinical Hyperthyroidism
High High High Secondary Hyperthyroidism
Low High/Normal High/Normal Hyperthyroidism
Non thyroidal illness / Secondary
Low Low Low Hypothyroidism
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PO No :APT7X5QNJCTD
Immunology
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Page 23 of 28
PO No :APT7X5QNJCTD
Immunology
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Vitamin D is a fat-soluble steroid prohormone involved in the intestinal absorption of calcium and the regulation of calcium
homeostasis.
Two forms of vitamin D are biologically relevant - vitamin D3 (Cholecalciferol) and vitamin D2 (Ergocalciferol).
Both vitamins D3 and D2 can be absorbed from food but only an estimated 10-20perc. of vitamin D is supplied through
nutritional intake.
Vitamin D is converted to the active hormone 1,25-(OH)2-vitamin D (Calcitriol) through two hydroxylation reactions. The
first hydroxylation converts vitamin D into 25-OH vitamin D and occurs in the liver. The second hydroxylation converts 25-
OH vitamin D into the biologically active 1,25-(OH)2-vitamin D and occurs in the kidneys as well as in many other cells of
the body.
Most cells express the vitamin D receptor and about 3perc. of the human genome is directly or indirectly regulated by the
vitamin D endocrine system.
The major storage form of vitamin D is 25-OH vitamin D and is present in the blood at up to 1,000 fold higher
concentration compared to the active 1,25-(OH)2-vitamin D. 25-OH vitamin D has a half-life of 2-3 weeks vs. 4 hours for
1,25-(OH)2-vitamin D. Therefore, 25-OH vitamin D is the analyte of choice for determination of the vitamin D status.
Risk factors for vitamin D deficiency include low sun exposure, inadequate intake, decreased absorption, abnormal
metabolism, vitamin D resistance and and liver or kidney diseases.
Vitamin D deficiency is a cause of secondary hyperparathyroidism and diseases resulting in impaired bone metabolism (like
rickets, osteomalacia).
Recently, many chronic diseases such as cancer, high blood pressure, osteoporosis and several autoimmune diseases
have been linked to vitamin D deficiency.
The assay measures both D2 (Ergocalciferol) and D3 (Cholecalciferol) metabolites of vitamin D
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PO No :APT7X5QNJCTD
Immunology
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Results Interpretation:
Prostate-specific antigen (PSA), a glycoprotein is produced by the prostate gland, the lining of the urethra, and the
bulbourethral gland.
Normally, very little PSA is secreted in the blood.
PSA exists in serum in multiple forms: complexed to alpha-1-anti-chymotrypsin (PSA-ACT complex), unbound (free PSA),
and enveloped by alpha-2-macroglobulin (not detected by immunoassays).
Total PSA comprises of Free PSA and PSA-ACT complex.
Both Free and Total PSA concentration determined on serum can be used to calculate Percent Free PSA and then are used
for patient management.
Higher total PSA levels and lower percentages of free PSA are associated with higher risks of prostate cancer.
Probability of Prostate Carcinoma based on Percent Free PSA.
Clinical Use:
The total PSA range of 4.0 to 10.0 ng/ml has been described as a diagnostic "gray zone," in which the free:total PSA ratio
helps to determine the relative risk of prostate cancer.
When total PSA concentration is 10.0 ng/mL, the probability of cancer is high and prostate biopsy is generally
recommended.
1. Increases in glandular size and tissue damage caused by benign prostatic hypertrophy,
2. Prostatitis
3. Prostate carcinoma
4. Prostate ischemia
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PO No :APT7X5QNJCTD
Immunology
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Note:
1. False negative / positive results are observed in patients receiving mouse monoclonal antibodies for diagnosis or therapy.
2. PSA total and free levels may appear consistently elevated / depressed due to the interference by heterophilic antibodies
and nonspecific protein binding.
3. Results obtained with different assay kits cannot be used interchangeably.
4. All results should be correlated with clinical findings and results of other investigations.
Page 26 of 28
PO No :APT7X5QNJCTD
Immunology
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Vitamin B12 along with folate is essential for DNA synthesis and myelin formation.
Decreased levels a r e s e e n i n a n a e m i a , t e r m p r e g n a n c y , v e g e t a r i a n d i e t , i n t r i n s i c f a c t o r d e f i c i e n c y , p a r t i a l
gastrectomy/ileal damage, celiac disease, oral contraceptive use, parasitic infestation, pancreatic deficiency, treated
epilepsy, smoking, hemodialysis and advanced age.
Increased levels are seen in renal failure, hepatocelluar disorders, myeloproliferative disorders and at times with excess
supplementation of vitamins pills.
Page 27 of 28
PO No :APT7X5QNJCTD
CLINICAL PATHOLOGY
EKINCARE DIAGNOSTIC PACKAGE-EK-SRT -M HC
Test Name Result Unit Bio. Ref. Interval Method
Comment:
•Note: Pre-test condition to be observed while submitting the sample-first void, mid stream urine, collected in a clean, dry, sterile
container is recommended for routine urine analysis, avoid contamination with any discharge from vaginal, urethra, perineum,
Avoid prolonged transit time & undue exposure to sunlight.
•During interpretation, points to be considered are Negative nitrite test does not exclude the urinary tract infections. Trace
proteinuria can be seen with many physiological conditions like prolonged recumbency, exercise, high protein diet. False positive
reactions for bile pigments, proteins, glucose and nitrites can be caused by peroxidase like activity by disinfectants, therapeutic
dyes, ascorbic acid and certain drugs.• Urine microscopy is done in centrifuged urine specimens
Page 28 of 28
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