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MY
RESULTS
FROM 3
yrs of
Bluepri
nt:
Top 1%: Speed of aging
(epigenetic)
Top 1%: Muscle mass &
function
Top 1%: Fat mass
Top 1%: Inflammation
Top 1%: VO2 max
(cardiovascular)
Top 1%: Bone mass
Top 1%: Sleep
Top 1%: Combined
clinical markers
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year olds
+ Total Bone Mineral
Density top .2% of 30 year
olds
+ Nighttime erections 179
min, better than ave 18
year old
+ Perfect liver fat (1.36%,
top 10%.), iron & stiffness
(MRI)
+ top 99.5% muscle
volume
+ bottom 0.5% visceral fat,
muscle fat, and
subcutaneous fat volume
+ Top 1% sleep
performance & recovery
(whoop)
+ Possibly increased
thymocyte volume to 7 yrs
younger, pending further
testing
+ Ideal whole body muscle
& fat (MRI)
+ 50+ optimal clinical
outcome biomarkers
+ 100+ markers <
chronological age
+ Perfect liver markers:
ALT+AST+GGT = 49
+ Leg press single rep
max: 800 lbs. Top 1-2% of
18 yr olds.
+ Bench press single rep
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max: 240 lbs. Top 10% of 18
yr olds.
+ 12 year age reversal in
500 day average HRV
+ Reduced Alpha Klotho
biological age by 21 yrs in
5 months, from 42 to 21.
+ 31 year age reversal in
grey hair age (80%
reduction in grey hair)
+ Identified and corrected
(w/o surgery) ticking time
bomb: bilateral internal
jugular vein (IJV) stenosis
+ 30+ organ ages
quantified
+ Free testosterone index
(FTI) biological age
reduced 20 years
+ Improved homocysteine
(hcy) by 49% (5.9 umol/L).
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Blueprint
Philosop
hy:
Zeroism
20th century: Live Fast and Die
Young
2023: don’t die because we
don’t know how long and well
we can live
“Talent hits
a target no
Humans used storytelling to
one else
build society: where we came
can hit;
from; why we’re here; what
Genius hits
exists after death; what
a target no
creates meaning; what’s right
one else
and what’s wrong. Daily health
can see.”
related decisions have
- Arthur
historically been influenced by
Schopenha
story. For example, ideological
uer
lists of what one can and
cannot eat. Social norms
signaling what’s fashionable.
Meaning-making to inform
what is desirable and laudable.
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of intelligence: human, AI and
biology. Our opportunity is to be
this exciting future.
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Lucky us we exist; let’s play an
infinite game together.
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years late). A blazing fire had
ignited within me when, from
ages 19 to 21, I lived among
extreme poverty in Ecuador.
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shattering the limitations of
health and lifespan. Example
investments @Ginkgo
@numattech @justegg,
@VergeGenomics and others.
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importance of aligning with AI.
Does Blueprint
work? Here is my
data after 18
months of
adherence
OPTIMAL CLINICAL OUTCOME RANGE
OPTIMAL
BIOMARKER AGE
RESULT CLINICAL
EQUIVALENT
OUTCOMES
RANGE
(OCOR)
ALT OPTIMAL 18 <15
BMI OPTIMAL 22.8 <22.5
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Fasting
28 (max
plasma OPTIMAL 82 <95
reduction)
glucose
16 (max
Body Fat OPTIMAL 6.9 <10%
reduction)
Cholesterol
OPTIMAL 158
(total)
25 (max
DHEA OPTIMAL 310 < age 50
reduction)
Free
Testosterone OPTIMAL 0.4 41 < age 50
Index
GGT OPTIMAL 10 <14
Glutathione OPTIMAL 227 29 < age 30
Grip
33 (max
Strength OPTIMAL 134 < age 30
reduction)
Dominant
Grip
Strength 43 (max
OPTIMAL 124 < age 30
Non- reduction)
dominant
28 (max
HbA1C OPTIMAL 4.5 4.5-5.6
reduction)
HDL OPTIMAL 73 50 - 60
10 (max
hsCRP OPTIMAL 0.20 <0.55
reduction)
IGF-1 OPTIMAL 151 75 - 150
LDL OPTIMAL 74 < 100
16 (max
NAD OPTIMAL 52.6 < age 30
reduction)
22 (max
PSA OPTIMAL 0.68 < age 30
reduction)
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18 (max
RDW OPTIMAL 11.3 < age 30
reduction)
SHBG OPTIMAL 68
TSH OPTIMAL 1.94 1 - 2.1
Triglycerides OPTIMAL 55 27 - 89
33 (max
Testosterone OPTIMAL 769
reduction)
VO2 max 18 (max
OPTIMAL 53.6 < age 30
treadmill reduction)
WBC OPTIMAL 4.5 3.5 - 6
20th
percentile 28 (max
OPTIMAL 7 < age 30
telomeres reduction)
PBMC
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MY SPEED OF AGING IS
SLOWER THAN 99%
OF 20 YEAR OLDS
Blueprint
Principle
s
For thousands of years, the human experience has
been roughly the same. Things are about to
change, and radically. Blueprint is about riding the
torrid waves of technological and scientific
progress into the future.
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Principle 2: Empower your body to speak for itself
Principle 3: The aspirations we need are beyond our
imagination
Principle 4: Look in the darkness to avoid being
blinded by the light
Principle 1: self
destructive
behavior is
kinda insane
Isn’t it weird that we commit
the same self destructive
behaviors hundreds or even
thousands of times in a
lifetime? Even when we know
they shorten our life,
accelerate disease and aging,
cloud our judgement and make
us feel miserable.
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Step 5: celebrate happy you
for stopping self harm.
Principle #2:
Empower your
body to speak
for itself
What and when I eat is decided by asking my heart,
liver, lungs and my other 70+ organs what they
need to be optimal. This is done by doing hundreds
of organ measurements on a regular basis and
then carefully analyzing gold standard scientific
evidence.
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Principle #3: The
aspirations we
need are beyond
our imaginations
It would have been hard to predict the books that
would be written with the introduction of the
printing press; or what the internet would enable.
The same principle applies to what the human race
can become when paired with the torrid wave of
technological and scientific progress. We can take
baby steps as we work on stretching our
imaginations:
Principle 4: Look
in the Darkness
to avoid being
blinded by the
light
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A person is looking for their keys under a street
light. Someone walks by and inquires, “Are you
certain you lost your keys here?”
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vibrancy.
Blueprint
Protocol
Starter
Guide
This web site is provided for educational and informational
purposes only and does not constitute providing medical
advice or professional services. The information provided
should not be used for diagnosing or treating a health
problem or disease, and those seeking personal medical
advice should consult with a licensed physician.
Contents
Blueprint by the numbers
Step 1: Meal preparation
The Green Giant
Super Veggie
Nutty Pudding
Example third meals
Extra Virgin Olive Oil
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Step 2: Supplements
Step 3: Starter Items (stuff I use, not
endorsements)
Withings scale
Measure night time erections
Grey hair reversal (7% discount
“BLUEPRINT”)
Pace of Aging Test (includes 12% discount)
NAD test (5% discount “blueprint”)
Whoop Track fitness & sleep. First month
free.
Grip Strength Trainer
Flex Beam - red light therapy
EightSleep Mattress ($100 discount
“BLUEPRINT“)
Pillow
Grounding bed sheets
(HRV) Sensate (10% discount “Blueprint”)
(HRV) Nurosym (10% discount “Blueprint”)
(HRV) Pulsetto (10% discount “Blueprint”)
Food intolerance testing (15% discount)
Pill tins
Blood glucose measurement
Bedroom blackout film
Light therapy first thing in the am
BY THE NUMBERS
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Monthly Blueprint cost = $870
Daily Calories = 2250
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t e e
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Step
Meal 1:
Prep
Three meals daily: Super Veggie and Nutty Pudding,
and a third that varies and consists of vegetables,
nuts, seeds, and berries. Each has been
methodically crafted based on gold standard
scientific evidence for optimal nutrition. They
continue to be modified at the introduction of new
evidence.
Blueprint
Recipe GUIDE →
(yes, it’s free)
A DAY’S WORTH OF
FOOD:
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Note:
disconti
nued
Green
Giant
10/23
More of a
reorganization of what
goes where.
Amino acids are
discontinued. Protein
intake is adequate.
Added spermidine (that
was in the chlorella
powder) to pills.
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Cocoa flavanols are in
Nutty Pudding
I continue to take 25 g
of collagen peptides
and 2.5 g of creatine
daily. Can add the
collagen peptides to
Nutty Pudding as is
tasteless and adds a
fun texture.
We’ve dramatically
simplified the Blueprint
stack so you don’t have
to chase around all of
details. Launch ETA is
January 2024.
Super Veggie
Super ready to serve
Veggie
(WatcH
PREP
video)
Super Veggie
Black lentils, 45 grams
hummus w/
dry, ~150 grams cooked
olive oil &
Broccoli (head+stalk),
chocolate...
250 grams (Can also
use Broccoli sprouts)
Cauliflower. 150 grams
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Shiitake or Maitake
Mushrooms, 50 grams
Garlic, 1 clove (a piece)
Ginger Root, 3 grams
Lime, 1
Cumin, 1 Tbsp
Apple Cider Vinegar, 1
Tbsp
Hemp Seeds, 1 Tbsp
After prep, drizzle 1
Tbsp of Extra Virgin
Olive Oil
(All organic)
(WatcH
PREP
video)
Weigh vegetables.
Place broccoli,
cauliflower,
mushrooms (maitake
or shiitake), ginger and
garlic in boiling water*.
Boil until tender (7-9
min). Steaming is also
acceptable.
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Lentils: bring the water
to boil in a medium
saucepan. Add lentils.
Reduce heat to low and
cook uncovered for 18-
20 or minutes until "al
dente". Place in a
colander to drain and
rinse under cold water
You can choose to
blend or keep whole
pieces.
Blend in a high-speed
blender place 1 Tbsp of
dried cumin, 1 Tbsp of
apple cider vinegar, 1
fresh Lime, cooked
black lentils, the
strained cooked
vegetables, and blend
until it becomes thick
soup. Can also serve as
the picture above.
If needed add some of
the vegetable water (or
steaming water) to thin
out the texture.
Top with hemp seeds.
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I season it with NuSalt
(potassium chloride).
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favorite: my 16 yr old eats
Super Veggie for school
😂
lunch. His friend offering
his observations
Nutty
Pudding
(Watch
Prep
VIDEO)
50-100 mL Macadamia Nut
Milk
3 Tbsp ground macadamia
nuts (20% off)
2 tsp of ground walnuts
2 Tbsp chia seeds
1 tsp of ground flaxseed
(seed that is ground into
flour)
1/4 brazil nut*
6 grams of Blueprint
cocoa
1 tsp sunflower lecithin
1/2 tsp ceylon cinnamon
1/2 cup
blueberries/raspberries/s
trawberries (your choice)
3 cherries
2 oz pomegranate juice
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*May 13th 2024: Brazil Nut
has been removed from
Nutty Pudding as the
Blueprint Stack now
includes Selenium.
(Watch
Prep
VIDEO)
Add 50-100 mL milk nut
based upon desired
consistency.
Add walnuts,
macadamia nuts,
ground flax seeds
(highest nutritional
value to buy seeds and
grind)
Add cocoa, sunflower
lecithin, cinnamon
Add 3 cherries, 1/2 cup
of berries (save half
for topping) &
pomegranate juice
Mix on high for 3 or 4
minutes
Pour into a dish.
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Add the rest of the
berries
Typically will also add
30-60 grams of pea
protein
Example Third
Meals
Aspara Asparagus Almond Beet
gus Salad Preparation
Almon Instructions
d Beet Trim and clean beets. Boil
Salad, in water till the beets can
500 be easily pierced with a
cal fork. Drain and while still
Beets warm, the skin will rub off
500 easily underwater. Set
grams aside the skinless beets
cooke in a bowl.
d
Aspara Blanch Asparagus - Set
gus aside a bowl of ice water.
300 Heat a large saucepan of
grams water till boiling. Add
cooke Asparagus to the boiling
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d water for 4 minutes. It
Almon may be shorter or larger
ds boiling times depending
Slivers on the size of the stalks.
21 Once asparagus is firm
grams but not crisp, remove it
Arugul from boiling water and
a 1 cup dump it into the ice bath.
Shallo Once asparagus is cool.
t1 Drain and take a paper
large towel to blot any excess
Balsa water away.
mic 3
Tables In another heated pan, add
poons the mustard seeds to a
Dijon 3 dry pan for one minute.
Tables After one minute add
poons sliced shallots and one-
Mustar fourth cup of water. Cook
d shallots and mustard
Seeds seeds down until the
1 shallots are transparent.
Tables Add more water if needed.
poons
In a small bowl add the
balsamic and the dijon
and blend well.
Once everything is
assembled and cooled to
room temperature. Chop
the beets and asparagus
into small bite-sized
pieces. Add the cooled
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shallots mixture. Add in
chopped arugula and toss
lightly. Once lightly tossed
pour dressing over and
toss lightly again. Top the
salad with slivered
almond
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Tomat
oes 14
Spring
Mix 3
cups
Arugul
a Leaf
or
Sprout
s 1 cup
Fresh
Mint ¼
cup
Fig
Balsa
mic
Vinega
r2
Tables
poon
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cooke
d On a sheet pan, roast the
Chickp grape tomatoes until they
eas 45 have popped and have a
grams bit of color.
cooke Add to a small bowl the
d avocado mash with the
Grape juice of one lime and half
Tomat of a lemon. Stir until
oes 12 creamy.
Avoca Thinly slice the radishes
do ½ and the jalapeno pepper.
Radish
es 4 Once everything is
Cilantr roasted. Build your dish.
o¼ Start with the potato,
cup slice open. Remove skin if
Jalape preferred. Pour the
no chickpea mixture over the
Pepper sweet potato, next add
1 large roasted grape tomatoes
Limes and some jalapenos. Top
2 with avocado mixture,
whole chopped fresh cilantro,
Lemon radishes, and the
1 remainder of jalapeno
whole peppers. Serve with sliced
Chile lime on the side.
Powde
r1
Teaspo
on
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Extra Virgin
Olive Oil
Highest Quality EVOO Criteria (Blueprint EVOO)
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Step
My 2:
Blueprint
Supplem
ent
Stack
(Jan
2024)
Upon waking w/Dinner at Other
I mix and 11 am (11 1 Tbsp of
drink pills) Extra
Blueprint Acarbose Virgin
Longevity 200 mg Olive Oil
Mix 1 (Rx) w/ each
scoop EPA/DHA/ meal for
Collagen DPA 800 3 Tbsp (45
Peptides mg mL) daily
12.5 g Garlic 1.2 High
GOS 1/2 g (kyolic) polyphen
tsp Metformi ol cocoa
n ER 500 6g
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Inulin 1 mg (Rx) Pea/hem
tsp NAC 1,800 p protein,
mg 29 grams
And I take Proferrin daily
these 20 10.5 mg Fermente
pills d foods
Acarbose Before bed Rapamyci
200 mg Melatonin n (Rx).
(Rx) 300 mcg Rotate 6
Blueprint and 13 mg
Essential bi-
s-3 weekly.
Blueprint 17α-E2, 8
Soft Gel - mg wk
1 transder
Blueprint mal
NAC + 112 mcg
Ginger + Levothyro
Curcumin xine, 60
-3 mg
Blueprint Armour
Red Yeast Thyroid -
Rice + daily
odor free (diagnose
garlic -1 d w/
EPA/DHA/ hypothyr
DPA 800 oidism at
mg age 21).
Garlic 1.2
g (kyolic) Change log:
Metformi 2024.3.20 -
n ER 1,500 discontinued
mg (Rx) lactoferrin
to lower my
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NR (450 Hemoglobin
mg) or levels which
NMN (500 were slightly
mg) elevated.
ProButyra
te 600 mg
Proferrin
10.5 mg
Post
workout I’ll
eat
Blueprint
Nutty
Pudding +
Blueberry
Nut Mix +
12.5 g of
collagen
peptides and
1 Tbsp of
extra virgin
Step 2:
olive oil
Supplem
ents
(pre-
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Blueprint
stack
availabili
ty)
Note: this protocol is
based upon regular
measurements.
Optimal protocol for
you may differ. How I
organize them.
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gra 0 tran
m mg sde
Coc Hya rma
oa luro l
Flav nic B12
ano Aci met
ls d hyl
500 300 cob
mg mg ala
CoQ L- min
10 Lysi 1x/
100 ne wk
mg 1g Asp
D-3 L- irin
2,00 Tyro 81
0 IU sine mg
DHE 500 3x
A mg wk
25 Met 112
mg for mc
E 67 min g
mg ER Lev
EPA 500 oth
/DH mg yro
A/D (Rx) xine
PA N- , 60
800 Ace mg
mg tyl- Arm
Fise L- our
tin Cys Thyr
200 tein oid
mg e (dia
Garl (NA gno
ic C) sed
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2.4 1,80 wit
g 0 h
equ mg hyp
ival NR oth
ent 375 yroi
Garl mg dis
ic OR m
1.2 NM at
g N age
(ky 500 21)
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125 mer
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g (me
Glu n)
cos (wo
ami me
ne n) 1
Sul pill
pha
te
2KC
L
150
0
mg
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Iodi
ne
as
pot
assi
um
iodi
de
125
mc
g
K2-
MK
4, 5
mg
K1,
1.5
mg
K2
MK
-7
600
mc
g
Lith
ium
1
mg
Lyc
ope
ne
10
mg
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Lysi
ne 1
g
Met
for
min
ER
1,50
0
mg
(Rx)
Nic
otin
ami
de
Rib
osid
e
375
mg
N-
Ace
tyl-
L-
Cys
tein
e
(NA
C)
1,80
0
mg
Pro
ferr
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in
10
mg
Spe
rmi
din
e 10
mg
Tur
mer
ic 1
g
Taur
ine
2g
Vivi
sca
l
(ma
le)
(fe
mal
e) 1
pill
Zea
xan
thin
(20
mg
Lut
ein,
4
mg
Zea
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xan
thin
)
3x/
wk
Zin
c 15
mg
Step
Track3:
progress
Basic Vitamin A serum, DHEA-S
blood B1 serum, B2 Testosteron
panel serum, B3 e
Cystati serum, B6 Estrogen
nC serum, B7 SHBG
Compl serum, B9
ete serum, B12 Urine
blood serum, C serum, Iodine
count D serum, alpha Iodine to
with tocopherol creatinine
differe serum, PIVKA- ratio
ntial, II/a.k.a. DCP albumin to
RDW, (vitamin K
WBC, deficiency)
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MCV serum, CoQ10 creatinine
BUN serum ratio
Creati
nine Calcium serum,
HbA1c chloride serum,
IGF-1 chromium
venous serum, copper
glucos plasma,
e magnesium
lipid serum,
panel manganese
total plasma,
protei phosphate
n serum,
albumi potassium RBC,
n selenium
liver plasma/serum,
panel zinc
thyroid serum/plasma
panel
hsCRP
https://rejuvenationolympics.com/
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Bryan
Johnson’
sBlueprint
Protocol
PROFESSIONAL
REJUVENATION
ATHLETE
Objective: I am trying to maximally slow the speed
of my biological aging. My goal: one year of
chronological time passes and my biological age
stays the same. There is no magic pill for this.
+ 78 organ biological age rejuvenation
+ 200+ science backed protocols
+ 1,000 Peer-reviewed References
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Philosophical
Principles
1. My path here, Hi, I am Bryan Johnson
2. How I approach problems Zeroth Principle
Thinking & solve them My Goal Alignment
Problem
3. Building systems to solve things
systematically: My Autonomous Self and I fired
myself
4. Blueprint is born: Project Blueprint
5. Blueprint + Kernel: Sleep & Impulse Control
6. Contemplations: A Plan for Humanity
All together: Ashlee Vance: How to Be 18 Years Old
Blueprint
Again for Only $2 Million a Year
at a
glance
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BASICS....
Chronological age: 2250 daily caloric
46 intake
Pace of aging: .69 Vegan (except for
171 lbs collagen peptides)
9.1% body fat 16-18 hr daily fast
4.3% bone mass 70+ lbs of
60.2% body water veggies/mthly
21.9 BMI 19% protein, 33%
carbs, 48% fat
WHAT
BLUEPR
INT IS...
scientifically
rigorous
data/evidence vs
opinion/fads
a systematic way
of being
WHAT IS HEALTHY
CHOCOLATE?
(what i use)
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LEVEL 1: Chocolate is good for you. A snickers
bar isn’t that bad!
LEVEL 2: Any brand advertising “dark
chocolate”
LEVEL 3: Un-dutched dark chocolate
LEVEL 4: Un-dutched dark chocolate, tested for
heavy metals
LEVEL 5: Un-dutched dark chocolate, tested for
heavy metals and from specific regions of the
world with the highest polyphenol density
Decision algorithm*
What studies have been done on chocolate?
Do the chocolate studies meet our statistical
thresholds?
Should I take chocolate of a certain type and
dose based on 1 and 2?
How do I personally check that chocolate is
safe and effective for me?
*See appendix for more detailed description of
decision algorithm
Current
Results
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Science and engineering begin with counting.
Health is no different. During this past year, I’ve
had hundreds of measurements taken. Some are
standard, such as biofluids and fitness scores.
Some are advanced, such as MRI and ultrasound.
And some uncommon, such as my lungs, nerves,
hearing, and intestinal tract. Below is a sampling
of these measurements.
Results:
Optimal
Clinical
Outcome
Range OPTIMAL
BIOMARKER AGE
RESULT CLINICAL
EQUIVALENT
OUTCOMES
RANGE
(OCOR)
ALT OPTIMAL 18 <15
BMI OPTIMAL 22.8 <22.5
Fasting OPTIMAL 82 28 (max <95
plasma reduction)
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glucose
16 (max
Body Fat OPTIMAL 6.9 <10%
reduction)
Cholesterol
OPTIMAL 158
(total)
25 (max
DHEA OPTIMAL 149 < age 50
reduction)
Free
Testosterone OPTIMAL 0.39 41 < age 50
Index
GGT OPTIMAL 13 <14
Glutathione OPTIMAL 227 29 < age 30
Grip
33 (max
Strength OPTIMAL 134 < age 30
reduction)
Dominant
Grip
Strength 43 (max
OPTIMAL 124 < age 30
Non- reduction)
dominant
28 (max
HbA1C OPTIMAL 4.5 4.5-5.6
reduction)
HDL OPTIMAL 73 50 - 60
10 (max
hsCRP OPTIMAL 0.46 <0.55
reduction)
IGF-1 OPTIMAL 125 75 - 150
LDL OPTIMAL 74 < 100
16 (max
NAD OPTIMAL 52.6 < age 30
reduction)
22 (max
PSA OPTIMAL 0.68 < age 30
reduction)
18 (max
RDW OPTIMAL 11.3 < age 30
reduction)
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SHBG OPTIMAL 68
TSH OPTIMAL 1.94 1 - 2.1
Triglycerides OPTIMAL 55 27 - 89
33 (max
Testosterone OPTIMAL 769
reduction)
VO2 max 18 (max
OPTIMAL 53.6 < age 30
treadmill reduction)
WBC OPTIMAL 4.5 3.5 - 6
20th
percentile 28 (max
OPTIMAL 7 < age 30
telomeres reduction)
PBMC
Results:
Younger
than
Chronolo
gical Age
REJUV REJUV REJUV IDEAL
ENATIO ENATIO ENATIO MARKE
N N N RS
POINT POINT POINT FOR
S S S Vit
QT A
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hsC RC VISI Alp
RP CA A ha
Dun PSE Tru car
edi M L ote
nPo LCC VISI ne
Am A A Bet
NA PSE Tru a
D M R Car
Frai RC ZM- ote
lty CA Faci ne
ind CIM al Lyc
ex T age ope
Tota LCC ZM ne
l A Nec Vit
glut CIM k C
athi T age B1
one RIC ZM B2
VO2 A Dec B3
max CIM olle B5
12 T te B6
min LIC age B7
run A ZM B12
dist CIM Glu Vit
anc T teal E
e TPA age (Alp
Wh Sys ZM ha
ole toli Low +
brai c er Ga
n blo lim mm
vol od b a)
um pre age Vit
e ssu Faci D
Whi re al Vit
te left K
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mat Bra spo CoQ
ter chi ts 10
vol al Faci Bic
um blo al arb
e od righ ona
Cer pre t te
ebr ssu spo Cal
al re ts ciu
vol Non Faci m
um - al Chl
e ma left orid
Tota p text e
l C2 ure Chr
sle CSB Faci omi
ep P al um
tim Non righ Cop
e - t per
Wa ma text Iodi
ke p ure ne
afte C2 Faci Ma
r CD al gne
sle BP left siu
ep PPA bro m
ons rati wn Pho
et o Faci sph
Sle AI al ate
ep AP righ Pot
effi FEV t assi
cie 1 bro um
ncy FVC wn Sel
Digi PEF Faci eni
t T al um
co DLC left Sod
mp Oc wri ium
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aris A nkl Zin
on line es c
sco qua Faci ALT
re nt al AST
Digi MIP righ ALP
t ME t GGT
sym P wri TG
bol RD nkl LDL
sco W es HDL
re EpiT Faci IGF
ETS OC2 al -1
sco .tns cen
re c tral
RAV PC spo
ENS telo ts
sco len Faci
re gth al
Lett met cen
er hyl tral
nu atio text
mb n ure
er pre Faci
seq d al
uen QFI cen
cin SH tral
g me bro
sco dia wns
re n Mo
Ven PB difi
tric MC ed
ular telo HN
vol QFI hair
um SH DHE
es 20t A-S
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Sub h Thyr
cor cen oid
tica t vol
l PB um
gre MC etri
y telo cs
mat RRI Pus
ter left h
Pitu RRI up
itar righ con
y t tinu
brig Cys ity
htn tati Ben
ess nC ch
Cer eGF pre
ebe R ss 1
llar CK rep
vol D max
um EPI Leg
e EHF pre
Sta Hz ss 1
nd Rig rep
on 1 ht max
leg 14- Grip
5 16k stre
min Hz ngt
dee Left hL
p Cal Grip
sle cul stre
ep us ngt
RM ind hR
SSD ex WC
Max Rec BF
HR essi %
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BN on DEX
P gin A
LVE giva L1-
DV l 4
LV E Ind DEX
LV A ex A
LV gin Fe
E/A giva mur
LV l DEX
E’m HbA A
LV 1c Hip
IVR FPG Ost
T CG eoc
LV M alci
PW Alb n
T umi Spi
LA n nal
A’ flex
lat ibili
LA ty
SRE Pro
LA stat
SRA ic
LA vol
SRE um
/SR e
A PSA
cfP tota
WV l
Tota
l
test
ost
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ero
ne
Fre
e
test
ost
ero
ne
ind
ex
Rou
tine
Me
asu
rem
ent Weight, body fat,
muscle mass,
body water, BMI
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Sleep: HR, HRV,
Deep, REM,
Respiration Rate,
Body Temp
Waking body temp
(ear)
SpO2 while
sleeping
Blood Glucose
MRI - whole body
Ultrasound -
whole body
Biofluids (blood,
stool, urine,
saliva)
Physical fitness -
whoop + Polar
VO2Max
Hearing
Eyes
Air quality
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performed to identify
potential venous wall
or valve pathology
related to serial
blood draws of the
ACF veins, with no
pathology identified,
suggesting further
draws at this site are
safe.
Sensory nervous
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system
measurements
- Right plantar 2
point discrimination
of 1.5 cm coming in at
age 30 equivalent
Kidneys
Zero cysts, zero
parenchymal
thickness
abnormalities (i.e.
irregular or
thinning) present
in the kidneys
Renal interlobar
arteries resistive
index (RRI) coming
in at 0.46 (right
kidney) and 0.49
(left kidney),
equal to age 25 of
a newly diagnosed
essential
hypertensive, but
otherwise
average, western
population (ref)
(non-hypertensive
population data
currently not
available)
Thyroid
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Thyroid volume
(increases with
age) coming in at
age 23 equivalent
at 20.9 milliliters
(ref)
Prostate
Prostate volume
(increases with
age) coming in at
age 30 equivalent
for a Westerner at
19.14 milliliters
(ref)
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could we find any
research showing
maxHR increase was
possible. Measured
w/ Polar H10
Waist circumference
measurement 82.8
cm, average for a 25
year old (maximum
age reduction)
My Pulse Wave
Velocity of 5.7, ranks
in 10% <30, top 5% of
45+.
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Gen
eThe
rap
y
Data from my first
longevity gene
therapy: 160%
increase in follistatin
levels. Achieving our
target objective.
Goals:
. epigenetic age
reduction
. monitoring dozen+
organs for possible
improvements
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. improved muscle
volume and strength
. reduced speed of
aging
Developed by
https://minicircle.io
Hea
rtHe
alth
MEASUREMENT
PROTOCOL
MRI
Ultrasound
RHR, HRV, VO2Max
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VO2Max 58.7
mL/(kg·min), age
18
LV septal A’ mitral:
age 70+
Aortic root
diameter age 70+
LA E’ latbasal: age
70+
RVSP: age 70
LV sepal E/E’: age
55
RV E/A: age 52
MaxHR: age 37
LV E/A: age 28
[Heart] Carotid
arteries
Pressure strain
elastic modulus
(PSEM) of the
right and left
common carotid
arteries (RCCA
and LCCA)
elasticity scoring
at 4.51 Pascal
units age 26
equivalent and
2.82 Pascal units
age 18 equivalent
respectively (ref)
Common carotid
average intima
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media
thicknesses age
32 equivalent, at
0.47 mm
thickness,
although there is
little change
between age 18
and age 32 (only
0.03 mm) (ref)
No plaque or
atherosclerosis.
Details: total
plaque area
across 6 carotid
artery branches of
0 cm^2, showing
no significant
atherosclerosis;
with plaque being
defined as any
thickening of the
intima media
beyond 1 mm.
Internal carotid
artery maximum
intima media
thicknesses age
25 equivalent, as
low as is possible
to score, at 0.51
and 0.45 mm (ref)
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Intraventricular
relaxation time
(IVRT) of 50.6 ms
scored at age 19
average (ref)
E/A pulsed wave
doppler in the
mitral valve of 1.67
score
(dimensionless)
coming in at age
28, with the E
component at 0.96
m/s of age 15
average for
healthy caucasian
men (This is a
measure of how
well blood is
flowing through
the mitral valve)
(ref)
Tissue doppler
showed septal LV
E’ (e prime) mitral
annulus speed of
11.12 cm/s at age
24 average (ref)
(This is a measure
of how well the
left ventricle
septum is
contracting back
and forth)
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Mitral valve pulsed
wave doppler still
taken during
echocardiogram.
Clearly shows the
four chambers of the
heart and the blood
flow toward and
away from the
transducer, red and
blue colors
respectively.
Bra
inHe
alth
MEASUREMENT
PROTOCOL
Complex small
voxel non-
contrast 3D T1, T2,
T2 FLAIR, mag,
phase, minIP, SWI,
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2/3D MRA, 2/3D
MRV, 3D DTI, triple
2D DWI, ASL, CSF,
SPACE,
ultrasound,
cognitive testing,
EEG, peripheral
blood markers
etc.
MARKERS
White Matter
Hyperintensities:
age 48
Pineal
calcification: >40
TBC
Ventricular
volume: age 48
Cortical grey vol:
age 45
AI T1 brain age:
age 44
RAVENS PM: age
41
Total Cerebral
WMV: age 37
WASO: age 37
NOTES
Bi-lateral,
congenital IJV
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Lun
gHe
alth
MEASUREMENT
PROTOCOL
Ultrasound
Functional
markers
MARKERS
FEV1 age 22
FVC age 26
PEFR age 33
A lines age 33
DLCOc, 32.8
ml/min/mmHg,
age 38.5
equivalent, a
measure of the
ability of the
lungs air sacs,
alveoli, to pass
oxygen into the
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red blood cells in
the lung
capillaries
KCOc, 4.32 1/min,
age 54
MIP & MEP are
diaphragm
measurements -
maximum
inspiratory (MIP)
and expiratory
(MEP) pressure
scored at 155 and
117 cmH2O
respectively, = to
age 20 (maximum
possible
reduction) for
both markers.
These measure
the strength of
the double-domed
diaphragm muscle
below the lungs,
with my
Diaphragm
showing no signs
of weakening with
chronological age.
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Gas
troi
nte
stin
alHe
alth
MEASUREMENT
PROTOCOL
Small bowel
capsule camera
(large bowel
capsule camera
TBC)
Acquired 33,537
images
Looking for
lymphoma,
Crohn’s
ulcerations, small
bowel cancer,
diverticula, and
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polyps. Nothing
found.
Microbiome, GI
Effects, other.
Stool
MARKERS
SCFAs & elastase:
age 70+ (8/21,
since have started
intervention)
Polyps negative
Bleeds negative
Serial FIT FOBT,
Cologuard Gen 1
negative
Intestinal Tract - I
swallowed this pill,
the size of a baby
carrot, after fasting
for 24 hours. Then
took laxatives for 6
hours. It reemerged
10 hours and 38
minutes later, having
taken 33,537 images
of my intestinal
tract. Main things we
were looking for:
lymphoma, Crohn’s
ulcerations, small
bowel cancer,
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diverticula, and
polyps. Nothing
found. Most common
small bowel changes
with age are motility,
peristalsis reduction,
dysphagia and
enteric neuropathy.
Advantages of small
bowel pillcams
include screening
and baseline results
for n=1 study. Here
are some of the
pictures.
Joi
nts
We are exploring if
we can restore my
joints to that of an 18
year old.
Problem
Our joints (i.e. knees,
hips, etc.) break
down with age.
Resulting in pain,
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stiffness and
movement
restriction. While I do
not have any major
joint problems, I do
have small aches and
pains. We are testing
if we can repair
normal age related
damage, restore
vitality, and
preventatively lessen
future deterioration.
Therapy
Last week, I had 300
million bone
marrow-derived
mesenchymal stem
cells (MSCs) injected
into six joints over
two days: both knees,
shoulders, and hips
as part of a clinical
trial in the Bahamas.
We may repeat this
therapy as needed to
achieve the outcome
objectives.
MSC’s were
manufactured by
Cellcolabs. Injections
were performed by
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Dr. Steven Sampson
of Physical Longevity.
Measurement
Prior to the therapy,
we completed
comprehensive
baseline analysis of
each joint with MRI
and musculoskeletal
ultrasound. Here
were the findings:
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knee mild to
moderate
effusion/bursitis.
(fluid in knee).
+ Bilateral hip
gluteus medius
tendinosis (chronic
degeneration).
Bilateral Hip Cam
impingement
syndrome. (Can
predispose to
osteoarthritis)
Treatment plan
+ Intra Articular
injection of bilateral
shoulders, hips, and
knees.
+ Bilateral
supraspinatus
rotator cuff and
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bursa injections.
+ Right shoulder
anterior labrum
injection.
Bilateral hip gluteus
medius tendon
injections.
What happened
The injections were
completed in the
Bahamas in
collaboration with
Cellcolabs Clinical
Ltd. and Dr. Steven
Sampson of Physical
Longevity. Treatment
was under a clinical
trial approved by the
national stem cell
ethics committee in
the Bahamas. Cellco
Labs provided best-
in-class, gold-
standard cell
manufacturing of
allogeneic bone
marrow-cultured
mesenchymal stem
cells (MSCs). 50
million MSCs were
injected into each of
six joints, shoulders,
knees, and hips, over
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two days. Cells were
prepared and shipped
from Sweden and
were cryopreserved
with liquid nitrogen.
Cells were checked
for viability at the
point of care in the
Bahamas and
injected under
ultrasound guidance
by Dr Sampson for
proper deployment
under strict protocol.
Hai
rHe
alth
Based upon my
genetics, I should be
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bald by now. I started
greying and losing
my hair in my late
20s. Been a lot of
work to try and keep
it.
PROTOCOL
Custom hair
formulation.
Recipe:
Caffeine USP 1%
Finasteride USP
0.25%
Minoxidil USP 5%
Azelaic Acid 1.5%
Diclofenac 0.5%
Tea Tree Oil 5%
Rosemary Oil 0.37%
Ginko Biloba 0.05%
Biotin 0.01%
Melatonin USP
0.0033%
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it appears to be
working for me.
If you want to
double up on
treatment (use
gloves, stains
hands)
MARKERS
Grey+white:
measuring age 41
Quant Hamilton-
Norwood:
measuring age 26
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Ski
nHe
alth
MEASUREMENT
PROTOCOL
Multi Spectral
Imaging
Autofluorescence
Merz
MARKERS
Spots: Age 10
Wrinkles: Age 10
Texture: Age 14
Pores: Age 50
UV Spots: Age 62
Brown spots: Age
11
Red areas: Age 70
Autofluorescence:
age 32
Multispectral
imaging face age:
41
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DAILY PROTOCOL
Face wash
Moisturizer
Tretinoin .1%
UVA+B mineral
sunscreen
UV environmental
filters
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Hz Up to 200
mw/cm^2
irradiance at 6
inches 60 J/cm^2
dose at 6 inch
distance.
Be careful not to
burn yourself by
standing too
close. Protocol
(mine, is device
dependent): 12
min, 3x weekly.
Objectives:
. accelerated
healing
. skin health
. possible helper
w/ anxiety +
depression (only if
applied to
forehead)
. sleep
bought mine from
http://reddotled.c
om
Eye
He
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alth
MEASUREMENT
PROTOCOL
Drusen volume 0
Enhanced depth
imaging optical
coherence
tomography
subfoveal
choroidal
thickness high n=1
accuracy read left
age 51, right age
70, prior to axial
length/refractive
error regression
adjustment
IOP 13 mmHg, age
38
Accommodative
distance high n=1
accuracy read TBC
Eyelash length
age 70+
(genetically short)
EYE MEASUREMENTS
Sub-foveal
choroidal
thickness on
enhanced depth
imaging spectral
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domain optical
coherence
tomography (sfCT
EDI-SD-OCT) was
acquired showing
332 microns and
400 microns
respectively;
however, future 3D
choroidal
quantification
methods we will
perform will have
lower standard
deviation and
higher biological
age resolution
Ear
He
alth
MEASUREMENT
PROTOCOL
Research grade
digital
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audiometric setup
with high n=1
accuracy reads
RESULTS: Left
(me), Right (my 17
yr old)
MARKERS
Right ear normal
freq: age 61
Left ear normal
freq: age 51
Right ear EHF: age
60
Left ear EHF: age
32
Typmpanometric,
OAE, cochlear
magnetic
resonance
markers, waxome
TBC
Pinna age 30
Ora
l
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He
alth
MEASUREMENT
PROTOCOL
Plaque index,
recession,
attachment loss
MARKERS
Most recent
plaque index was
24.4% which is
ideal
Reduced
attachment loss
by 41% via
specially designed
procedures
DAILY PROTOCOL
Brush 2 min
(am/pm)
Water pik (am/pm)
Floss (am/pm)
Tongue scraper
Tea tree oil rinse
CoQ10 gel
RESULTS
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My dentist reports
“you have the
gums of a healthy
teenager”
Improved plaque
index to 63.6%
(tracked plaque in
mouth post
brushing to
assess how to
improving
brushing
technique)
Filled the one
remaining 4 mm
pocket on #11.
Sle
ep
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He
alth
Sleep
Is A
Lighth
ouse
Perhaps the most
important
health/wellness
practice, I’ve been
working on achieving
consistent, high
quality sleep for
years (Sleep is the
new coffee). These
are the things that
work for me.
PROTOCOL
Blacked out room
Same bedtime
daily
Sleep alone
Blue light
blocking glasses
1 hr downtime
before bed
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Temp controlled
mattress
8/2023 - completed 6
months of achieving
100% sleep score
performance via
Whoop. Also, my one
month recovery
score is in the top
1.4% of all male
whoop users.
Other
Measure
ments
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RED BONE ORGANS TO SEXUAL
MARROW COMPLETE HEALTH
PBMC MEASUREM Urine
LIfeleng ENT FOR Chlamyd
th QFISH Thymus ia
median Liver & Urine
telomer GB Gonorrh
e length: Pancrea ea
42 s Hepatiti
Bone sB
PANCREAS marrow [blood]
Pancrea Retina HepB
tic Stomach core
elastase , antib
: 70+ esophag ody,
us, large surfa
MSK Bowel/s ce
Tendons mall antib
enthuse bowel ody,
s US: 51 Mesente and
[other] ry surfa
Trachea ce
PROSTATE Larynx antig
Volume Pharynx en
(Bolivia Lips Hepatiti
tribe): 59 Bronchi/ sC
Volume oles [blood]
(western Glympha Herpes
er): 30 tics Simplex
Lymphat Virus I
ARTERIES ics (Typicall
Spleen
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Abdo Ureters, y Oral
aorta bladder, Herpes)
IMT: age urethra Herpes
46 Middle Simplex
CCA IMT: ear Virus II
age 32 Nose, (Typicall
tongue y Genital
Peno- Herpes)
scrotal Oral
Cartilag Human
e, Papillom
ligament a Virus
s (HPV)
Motor & PCR
sensory HPV
nerves, 20
spinal subty
cord pes
HIV 1
[blood]
HIV 2
[blood]
RPR
Syphilis
[blood]
Also
have the
Gardasil
9 HPV
vaccine
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Diet and
Supplem
ents
Diet recipes & Supplements lists are located in
the Blueprint Starter Guide.
BY THE NUMBERS
2,250 calories
daily
~10% Caloric
Restriction
Vegan
(preference, not
necessity)
70+lbs of veggies
monthly
100+ pills daily
MEASUREMENTS
biofluids, devices,
imaging, fitness
tests
ROUTINE
Green Giant + 54
pills
One hour workout
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Super Veggie
Skin/oral/hair/eye
care
Travel to work
Nutty Pudding
Third dish + 34
pills
Fitn
ess
Daily routine
Having fun workout
(Oct 21)
PROTOCOL (here’s
a video showing it)
1 hr day
~25 exercises
7 hrs wkly
88-105 bpm ~1 hr
106-159 bpm -4hr
30 min
159+ bpm 90
minutes
ROUTINE
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Backwards Sled, 2
min
Posture exercises
(video)
Tricep extensions
1x25
Face pulls 1x15
Butterfly, 1x15
Band pull apart
(back muscles),
1x15
Back extensions
(on a
hyperextension),
1x25
Obliques (each
side, on a
hyperextension),
1x25
Stretches
Kneeling shin
Hip flexor
Couch
Leg raises (for
abdomen), 1x50
Seated calf raises,
1x25
Poliquin step ups,
3x10, each leg
Slant board
squats, 3x15
ATG Split squats,
3x10
Nordics, 1x10
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Reverse Nordics,
1x10
Tibialis raises, 1x25
IsoTib ankle
rotations (each),
1x15
Pull ups, 1x15
Chin ups, 1x15
10 min HIIT (M,W,F)
Hiking on
weekends,
basketball, tennis
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Grip strength
(dominant hand)
60 kg, above the
age related peak
that occurs in
men at age 32.5
(Jamar
Dynamometer
Corporation
reference data
Notable
Challeng
es
CON LUN HEA
GEN GB RT
ITAL LIN REJ
BILA ES UVE
9 when I
TER should
have 2
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Possible
AL patholog
NATI
IJV ical
confirm
ON
STE ation via
hyperpol Several
NOS arized heart
markers
MRI
IS Possible includin
g LV
CASE eliminati
on via septal A’
NOTES
multi- mitral,
DECEMBER
compon Aortic
2021
ent root
44yo
nebulise diamete
male
d r, LA E’
RIJV: 70-
protocol latbasal
80%
and
stenosis
RVSP are
LIJV:
100%
GRA all
coming
stenosis Y in
Below
decades
referenc HAI older
e range
flow in R than my
chrono
all Excessiv age. No
position e stress, sympto
s on chronic ms.
duplex depressi Need to
bilateral on from formulat
IJV age 20- e a plan
doppler 40
Missing whitene
left
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transver d my
se sinus hair
MAX
on MRV;
cerebral
Struggli
ng to
HR
venous reverse In
thrombo it (8/23 twelve
sis? update months,
Severe 8/23 - improve
headach we’ve d from
e made 169 bpm
sympto some to 183
ms meaning bpm
causing ful Struggli
to wake progress ng to
in the with this make
night, on formulat further
acetazol ion gains
amide “Bluepri
250 mg nt for
since 7% off”)
25th Jan
2022
Likely
cause:
bilateral
styloid +
atlatl
transver
se
process
compres
sion of
the IJVs
both
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sides;
multiple
signs of
raised
ICP on
serial
MRIs
Possible
TOS
(thoraci
c outlet
syndrom
e seen
on
subclavi
an MRA)
20 years
history
of
nocturn
al
bruxism
untreate
d until
2021
No
previous
stroke,
TIA,
aphasia,
blurred
vision or
other
medical
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conditio
ns.
Deciding
next
steps RE
tests
and
surgical
interven
tion.
Medical disclaimer
This website, including any experimental results
presented, is for informational purposes only and does
not constitute medical advice or professional services.
The information provided should not be used for
diagnosing or treating a health problem or disease.
Individuals seeking medical advice should consult with a
licensed physician.
Context
The protocol presented on this website is based on
scientific research, ranging from mouse studies to
meta-analyses of randomized controlled trials and
international clinical practice guidelines. These have
been carefully reviewed for their unique relevance to my
personal situation. The protocol encompasses a mix of
on-label, off-label, and unlicensed therapies, as well as
research-use-only tests. Some of these tests and
therapies are still under scientific investigation and
have not yet received on-label licensing for specific
health conditions. All tests and therapies, regardless of
their licensing status, carry risks. These risks have been
assessed for my personal use by a specialized team of
clinicians and scientists. This protocol represents an
experimental clinical research project. Results will be
periodically published in peer-reviewed journals,
adhering to international quality standards relevant to
various types of clinical studies, including case reports,
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randomised controlled trials, and systematic reviews.
Case reports, case series, and systematic reviews are
important components of evidence-based medicine,
helping inform the design of gold-standard randomised
controlled trials and guiding clinical practice.
Rx
The use of Prescription only Medicines (PoMs) such as
HGH, acarbose, rapamycin, metformin, thyroxine,
testosterone, statins, phenylbutyric acid, tadalafil and
others discussed in this protocol should not be
considered an endorsement or promotion of these
products. PoMs should only be prescribed by a licensed
doctor who has assessed that the benefits and risks are
acceptable for the individual and acquired through
licensed pharmacies in a jurisdictionally legal manner.
The prescribing doctor should be made aware of all
other PoMs being taken and other relevant interventions
such as foods, supplements and medical history to
enable accurate assessment for safe prescribing and
monitoring of combination interventions.
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