IVIg 2022
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Intragam P® vs Privigen®
Comparison
Existing Preparation New Preparation
Generic name Normal Immunoglobulin Infusion
Item code NORM15 NORM35
Brand name Intragam P® Privigen®
Manufacturer CSL Behring, Australia CSL Behring, Switzerland
Donor Local donors Non-local donors
Presentation 6% (3g in 50ml) 10% (2.5g in 25ml)
Storage • Store at 2°C to 8°C • Do not store above 25°C. Do not
condition (Refrigerate. Do not freeze.) freeze. (No need refrigerate)
• Protect from light. • Keep the vial in the outer
carton in order to protect from
light.
Comparison
Brand
Intragam P® Privigen®
name
Infusion • The infusion should be commenced at • The product should initially be infused at a
the rate of 1ml per minute rate of 0.3ml/kg body weight/hour, for
Rate
approximately 30 mins
• After 15 minutes, the rate may be
gradually increased to a maximum of • If well tolerated, the infusion rate can be
3 to 4ml per minute over a further 15 gradually increased to 4.8ml/kg body
minutes weight/hour
• Consideration should be given to • In patients with immunodeficiency
reducing the rate of infusion in elderly syndrome who tolerated substitution
patients and in patients with pre- treatment with Privigen well, the infusion
existing renal disease rate may be gradually increased to a
maximal value of 7.2ml/kg body
weight/hour
Adverse Effects of Privigen®
(Infusion rate dependent)
• Hypersensitivity/Infusion reactions
• Aseptic meningitis syndrome (AMS)
• Haemolytic anaemia
• Thromboembolism
• Acute renal failure
Recommended Regimen - 5days
NORMAL IMMUNOGLOBULIN INFUSION 0.1G/ML 25ML (PRIVIGEN®)
Brand: Privigen®
5days regimen: 0.4g/kg/day for 5 days; round to nearest 2.5g vial
BW ≥ 30 kg
Day 1 First bottle (2.5g) 2.5g infuse over 180mins
(max. 0.3mL/kg/hr)
Day 1 remaining dose (0.4g/kg/dose – 2.5g) infuse over 60mins
(max. 4.8mL/kg/hr)
Day 2 to 5 0.4g/kg/dose infuse over 60mins
(max. 4.8mL/kg/hr)
Example of IPMOE Orders–
0.4g/kg/day for 5 days
Day 1, initial dose
Day 1, remaining
dose
Day 2 to 5
Recommended Regimen - 2days
NORMAL IMMUNOGLOBULIN INFUSION 0.1G/ML 25ML (PRIVIGEN®)
Brand: Privigen®
2days regimen: 1g/kg/day for 2 days; round to nearest 2.5g vial
BW ≥ 30 kg
Day 1 First bottle (2.5g) 2.5g infuse over 180mins
(max. 0.3mL/kg/hr)
Day 1 remaining dose (1g/kg/dose – 2.5g) infuse over 150mins
(max. 4.8mL/kg/hr)
Day 2 1g/kg/dose infuse over 150mins
(max. 4.8mL/kg/hr)
Example of IPMOE Orders–
1g/kg/day for 2 days
Day 1, initial dose
Day 1, remaining
dose
Day 2
