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9 views

Presentation (8th Sem)

Uploaded by

businesstechnot
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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A REVIEW ON

TRANSDERMAL DRUG DELIVERY SYSTEM

Supervisor: Presented by:


Mrs. Nisha Nakul Singh
Assistant Professor, Reg. No. 20-VIR-33
Pharmaceutics, University Roll No.
VIPER, Rohtak

Vaish Institute of Pharmaceutical Education and


Research, Rohtak
List of Contents

Sr. No. Contents

1. Introduction

2. Types Of Transdermal Patches

3. Formulation Design

4. Methods For Preparation

5. Evaluation

6. Advantages and Disadvantages

7. Transdermal Patches Available In The Market


Transdermal Drug Delivery System

Transdermal drug delivery systems (TDDS), also known as


“patches,” are dosage forms designed to deliver a therapeutically
effective amount of drug across a patient‟s skin. Recently, the use
of transdermal patches for pharmaceuticals has been limited
because only a few drugs have proven to be effectively delivered
through the skin, typically cardiac drugs such as nitro- glycerine
and hormones such as estrogen

A transdermal patch or skin patch is a medicated adhesive


patch that is placed on the skin to deliver a specific dose of
medication through the skin and into the bloodstream.

For effective Transdermal drug delivery system, the drugs


are easily able to penetrate the skin and easily reach the
target site. TDDS increase the patient compliance and
reduces the load as compared to oral route
Types Of Transdermal Patches

1. Single-layer Drug-in-Adhesive

It is distinguished by the medicine being included


right inside the skin-contacting glue.

In this transdermal system design, the adhesive


doubles as the basis for the formulation, holding
the medicine and all excipients in one backing
film while simultaneously serving as a means of
attaching the system to the skin.

This type of system's medication release rate is influenced by how quickly the drug diffuses through
the skin
2. Multi-layer Drug-in-Adhesive

It is similar to the Single-layer Drug-in-Adhesive in that the


drug is incorporated directly into the adhesive.

It refers to the addition of either a membrane or numerous


drug-in-adhesive layers

3. Drug Reservoir-in-Adhesive

It is characterized by the inclusion of a liquid compartment


containing a drug solution or suspension separated from the
release liner by a semipermeable membrane and adhesive.

Adhesive component of the product that is responsible for


skin attachment.
Formulation Design

Polymer matrix

Drug

Penetration enhancers

Adhesives

Backing membrane

Release linear
Methods For Preparation

1. Asymmetric TPX membrane method

A prototype patch can be fabricated for this a heat sealable polyester film (type 1009, 3m) with a
concave of 1cm diameter will be used as the backing membrane

The drug sample is dispensed into the concave membrane, covered by a TPX poly (4-methyl-1-
pentene) asymmetric membrane, and sealed by an adhesive.

2. Mercury substrate method

In this method, the drug is dissolved in a polymer solution along with a plasticizer.

The above solution is to be stirred for 10-15 minutes to produce a homogenous dispersion
EVALUATIONS OF TRANSDERMAL PATCHES

1. Physicochemical evaluation

Peel adhesion test: The type and amount of polymer


molecular weight and the composition of polymers
determine the adhesive properties

Rolling ball tack test: - This test involves the


measurement of the distance travelled by stainless steel
along the upward face of the adhesive
2. In-vitro Evaluation

Diffusion Cell: The design and development of the


transdermal drug delivery system is greatly aided by In-vitro
studies. The diffusion studies were done to get an idea of the
permeation of drugs through the barrier from the transdermal
system

3. In vivo Evaluation

In vivo, evaluations are the true depiction of the drug performance. The variables which cannot be
considered during in vitro studies can be fully explored during in vivo studies.

a) Animal models

b) Human models
Advantages

Self-administration medicament
Increase bioavailability.
Reduce dosing frequency
It is of great advantage in patients who are nauseated or unconscious
Maintains stable or constant and controlled blood levels for longer periods

Disadvantages
Should not use ionic drugs
May cause allergic reactions
Higher cost.
A molecular weight of less than 500 Da is essential.
Transdermal therapy is feasible for certain potent drugs only.
Transdermal Patches Available In The Market

1. Estradiol 2. NicoDerm

3. Androderm 4. Deponit
REFERENCES
Mali AD. An updated review on transdermal drug delivery systems. skin. 2015

Sudam KR, Suresh BR. A Comprehensive Review on Transdermal drug delivery systems. Int. J.
Biomed. Adv. Res. 2016

Jeong WY, Kwon M, Choi HE, Kim KS. Recent advances in transdermal drug delivery
systems: A review. Biomaterials research. 2021

Rohit Tiwari, Manish Jaimini, Shailender Mohan, Sanjay Sharma. Transdermal Drug Delivery
System: A Review. International Journal of Therapeutic Applications. 2013

Sharma N, Agarwal G, Rana Ac, Bhat Za, Kumar D. A Review: Transdermal Drug Delivery
System: A Tool for Novel Drug Delivery System. Int. J. Drug Dev. Res. 2011

Shingade Gm, Quazi A, Sabale Pm, Grampurohit Nd, Gadhave Mv, Jadhav Sl, Gaikwad Dd.
Review On: Recent Trend on Transdermal Drug Delivery System. J. Drug Deliv. Ther. 2012
THANK YOU!

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