1.

Insulin has all of the following effects except:

a. Favors glycogen synthesis
b. Induces glucokinase
c. Promotes glycolysis
d. Inhibits gluconeogenesis
e. Stimulates lipolysis

2. The following statements are TRUE regarding parathormone except:

a. Increases calcium mobilization from the bone
b. Decreases calcium mobilization from the bone
c. Increases renal reabsorption of calcium
d. Increases the level of calcitriol
e. Increases the absorption of calcium from the small intestine

3. The intracellular effects of glucagon are mediated through:

a. Calcium
b. cGMP
c. Tyrosine kinase
d. cAMP
e. Phosphatidyl inositol

4. All of the following hormones act through tyrosine kinase except

a. Epidermal Growth factor
b. Platelet derived growth factor
c. Insulin like Growth factor 1 (IGF-1)
d. Insulin
e. Prolactin

5. All of the following hormones act through PIP3 except:

a. GnRH
b. GHRH
c. Oxytocin
d. TRH
e. TSH
6. All of the following are steps of thyroid hormone synthesis except
a. Iodine trapping
b. Iodination of tyrosin
c. Oxidation of iodide
d. Coupling of iodotyrosine
e. Reduction of iodide
7. NADPH is required in the following step of cholesterol synthesis

a. Formation of acetoacetyl CoA from acetyl CoA

b. Formation of isopentenyl-PP from Mevalonate-3-P-5-Di P
c. Formation of HMG CoA from Acetoacetyl CoA
d. Formation of Mevalonate from HMG CoA
e. Formation of Mevalonate-5-P from Mevalonate

8. The immediate precursor of acetoacetate in liver is:

a. Aceto-acetyl CoA
b. Acetone
c. -hydroxy-butyrate
d. 3-hydroxy-3-methyl glutaryl CoA
e. Two molecules of acetyl CoA

9. Refsum’s disease results from a defect in the following

a. -oxidation of fatty acids

b. - oxidation of fatty acids
c. Both  & -oxidation of fatty acids
d. -oxidation of fatty acids
e. Peroxisomal oxidation of fatty acids

10. Acyl carrier protein (ACP) of fatty acid synthase complex contains the vitamin

a. Biotin
b. Folic acid
c. Lipoic acid
d. Pantothenic acid
e. Pyridoxine

11. Deficiency of carnitine impairs:

a. Oxidation of long chain fatty acids in peroxisomes
b. Oxidation of long chain fatty acids in mitochondria
c. Uptake of long chain fatty acids by cells
d. Uptake of very long chain fatty acids by peroxisomes
e. All of the above

12. Adipocytes lack in enzyme

a. Acyl transferase
b. DAG-acyltransferase
c. Glycerol kinase
d. Glycerol-3-P dehydrogenase
e. Phosphatidate phospho-hydrolase
13. During synthesis of lecithin, the choline is activated at the expense of
a. One ATP only
b. One ATP and One CTP
c. One ATP and Two CTPs
d. Two ATPs
e. Two ATPs and One CTP

14. Lyso-phospholipase catalyzes the hydrolysis of fatty acid at

a. Carbon 2 of lysophosphatidic acid
b. Carbon 1 of lysophosphatidic acid
c. Carbon 1 of phosphatidic acid
d. Choline residue of lysophosphatidic acid
e. Carbon 2 of phosphatidic acid

15. During the synthesis of sphingolipids, the following step requires NADPH as
coenzyme
a. Condensation of palmitoyl – CoA and serine
b. Formation of 3-ketosphinganine
c. Formation of sphinganine
d. Formation of sphingosine
e. Formation of dihydro-ceramide

16. Lung surfactant activity is largely attributed to

a. Di-palmitoyl – phosphatidyl - Glycerol
b. Di-palmitoyl – phosphatidyl – choline
c. Di-palmitoyl –phosphatidyl – ethanolamine
d. Mono – palmitoyl – phosphatidyl – ethanolamine
e. Mono – palmitoyl – phosphatidyl – choline

17. Ceramide is present in all of the following EXCEPT

a. Cerebrosides
b. Gangliosides
c. Plasmalogens
d. Sphingomyelins
e. Sulfatides

18. Transamination of oxaloacetate forms:

a. Lysine
b. Aspartate
c. Tyrosine
d. Serine
e. Glutamate
19. Glycine is involved in the synthesis of all of the following except:
a. Synthesis of heam
b. Synthesis of glutathione
c. Synthesis of purine nucleus
d. Synthesis of creatine
e. Synthesis of epinephrine

20. Transamination transfers alpha amino nitrogen to alpha-ketoglutarate,forming:

a. Glutamate
b. Aspartate
c. Oxalate
d. Fumarate
e. Urates

21. Amino acid oxidases remove nitrogen as:

a. Urea
b. Urates
c. Ammonia
d. Amine
e. None of the above

22. Urea cycle disorders are characterized by:

a. Hyperammonemia,encephalopathy and respiratory alkalosis
b. Hyperammonemia,encephalopathy and respiratory acidosis
c. Hyperammonemia,migraine and respiratory alkalosis
d. Hypoammonemia,encephalopathy and respiratory acidosis
e. Hypoammonemia,encephalopathy and respiratory alkalosis

23. Cleavage of Arginine releases urea and re-forms:

a. Citrulline
b. Lysine
c. Arginine
d. Ornithine
e. Leucine

24. All of the following are features of Marasmus except

a. Anemia
b. Diarrhea
c. Vomiting
d. Monkey face
e. Fatty Liver
25. Human milk contains all of the following except
a. Lactose
b. Vitamin A
c. Casein
d. Calcium
e. Iron

26. All of the following conditions increase BMR except

a. Leukemia
b. Hyperthyroidism
c. Addison’s Disease
d. Cushing’s Disease
e. Hypertension

27. Arginosuccinate is cleaved to yeild:

a. Arginine and succinate
b. Arginine and fumarate
c. Arginine and oxalate
d. Arginine and malate
e. Arginine and pyruvate

28. Citrulline condenses with ------------- to form arginosuccinate.

a. Succinate
b. Fumarate
c. Aspartate
d. Arginine
e. Ornithine

29. All of the following statements are true regarding BMR Except :
a. With advacing age , BMR gradually falls
b. BMR is directly propotional to the body surface
c. Pregnancy itself exerts no specific effect upon BMR
d. Women normally have lower BMR than men.
e. BMR increases with the increase of temperature

30. All of the following is true about Marasmus Except :

a. Diet may be adequate in proteins but insufficient in calories
b. It is usually seen in infants less than one year
c. Skin of the child is thin,wrinkled and flaccid
d. Child is less lively and refuses to eat
e. Child has typical “monkey face”
31. Edema is a feature of all of the following Except:
a. Renal failure
b. Heart Failure
c. Liver failure
d. Kwashiokor
e. Marasmus

32. Cytochromes consist of Porphyrin nucleus with--------atom in its center.

a. Copper
b. Sulphur
c. Cobalt
d. Iron
e. Carbon

33. Electrons from succinate enter ETC at:

a. Complex I
b. Complex II
c. Complex III
d. Complex Iv
e. None of the above

34. In the final stage of ETC, the transported electrons, the free protons and the
molecular oxygen combine to produce-------------
a. ATP
b. H2O
c. H2 O2
d. NADH
e. FMN

35. Which of the following is not a component of ETC.?

a. Nicotinamide.
b. Ubiquinone.
c. Thiamine
d. Riboflavin.
e. NAD+ /NADH

36. Cyanide is the inhibitor of

a. Complex I
b. Complex II
c. Complex III
d. Complex IV
e. All of the above
37. Rotenone is an inhibitor of ETC at:
a. Complex I
b. Complex II
c. Complex III
d. Complex IV
e. Complex V

38. Which of the following complexes of electron transport chain act as proton pumps?
a. Complex I and II
b. Complex II and III
c. Complex II , III and IV
d. Complex I , III and IV
e. Complex I ,II, III and IV

39. Which of the following statement is not true about citric acid cycle?

a. It starts with condensation reaction

b. Oxygen is required at substrate level in this cycle
c. Reactions of this cycle are catalyzed by 08 enzymes
d. This cycle comprises of 10 reactions
e. This cycle occurs in mitochondrion

40. Inorganic phosphate is required as a reactant in reaction catalyzed by

a. Citrate synthase
b. Malate dehydrogenase
c. Isocitrate dehydrogenase
d. Succinyl CoA synthetase
e. Fumarase

41. Synthesis of DNA strand occurs in the following direction

a. Any direction along with both strand
b. 3  5 along with leading strand & 3  5 along with lagging strand
c. 3  5 along with leading strand & 5  3 along with lagging strand
d. 5  3 along with leading strand & 3  5 along with lagging strand
e. 5  3 along with leading strand & 5  3 along with lagging strand

42.Formation of RNA primer

a. Follows replication
b. Follows transcription
c. Precedes protein synthesis
d. Precedes replication
e. Precedes transcription
43. Hypo-uricemia can occur in:

a. Deficiency of ribonucleotide reductase

b. G-6-Phosphate deficiency
c. HGPRT deficiency
d. Leukaemia
e. Xanthine oxidase deficiency

44. A superactive PRPP synthetase can cause:

a. Gout
b. Immunodeficiency
c. Lesch-Nyhan syndrome
d. Orotic acidurias
e. Von Gierke’s disease

45. Which of the following is catabolic in nature?

a. Conversion of glucose to glycogen

b. Conversion of glucose to pyruvate
c. Conversion of pyruvate to lactate
d. Conversion of pyruvate to glucose
e. Conversion of lactate to glucose

46. Which of the following pathway is not included purely in carbohydrate metabolism?

a. Kreb’s cycle
b. Hexose monophosphate shunt
c. Glycolysis
d. Embden-Meyerhof Pathway
e. Breakdown of glycogen

47. Glycolytic pathway occurs in

a. Nucleus
b. Mitochondrion
c. Microsome
d. Cytosol
e. Plasma membrane
48. Which of the following is not a regulatory enzyme in glycolysis

a. Glucokinase
b. Phosphoglycerate kinase
c. Hexokinase
d. Phosphofructokinase
e. Pyruvate kinase

49. Following statements are correct about glycolysis except

a. Regulatory enzymes are activated in starvation

b. Regulatory enzymes are in-activated in diabetes mellitus
c. Insulin increases the synthesis of regulatory enzymes
d. Epinephrine inhibits glycolysis by phosphorylating enzymes
e. Glycolysis increases in hypoxic conditions

50. Glycolysis in erythrocytes is anaerobic because

a. NADH is used to reduce glutathione in erythrocytes

b. Erythrocytes lack mitochondria
c. Oxygen is bound to hemoglobin in erythrocytes
d. 2,3-Biphosphoglycerate is bound to hemoglobin in mitochondria
e. 1,3-Biphosphoglycerate is converted into 3-phospho glycerate