Milli-Q® Direct

Water Purification
System
Pure and ultrapure water
directly from tap water

The life science business

of Merck operates as
MilliporeSigma in the
U.S. and Canada.
Pure and ultrapure water
from a single water system
Scientists need: The Milli-Q® Direct answer:
Scientists need a system that can deliver pure and The Milli-Q® Direct is designed as a single water
ultrapure water directly from tap water: system which produces pure and ultrapure water
directly from tap water. The system:
• Meeting increasing quality standards
• Exceeds the requirements of the most
• Providing convenience
demanding norms
• Optimizing lab space
• Provides manual and volumetric water
• Allowing low running costs dispense at low and high flow rate
• Has a low footprint: wall- or
bench-integrated installation
• Allows optimized global costs

Optimum water production

Pure water
Tap water is first purified to pure (Type 3) water • Unique system adapts to feed water temperature
by reverse osmosis (RO) designed and optimized in order to avoid flow rate decrease during the
using our techniques: wintertime when tap water is colder.
• Progard® pretreatment cartridge validated • Unique safety device ensures that only low ionic
to extend the lifetime of the RO cartridge. permeate water will be sent to the tank in order to
warrant adequate pure water quality and to increase
• Reject recirculation loop recycles reject water
the lifetime of the ion-exchange cartridge used to
treated by the Progard® to minimize tap water usage
produce ultrapure water.
(recovery up to 66%)* and extend Progard® lifetime
while avoiding fouling or scaling issues that might • Complete process monitoring system systematically
shorten the RO cartridge lifetime. checks water temperature, pressure, conductivity and
RO rejection using calibrated meters at different steps.

Ultrapure water
• Water is purified using unique Jetpore® ion-exchange resin, synthetic activated carbon and a
UV lamp to reach a resistivity of 18.2 MΩ.cm at 25°C and a TOC value below
5 ppb; both values are monitored by advanced analytical techniques.
• This water is sent through a small recirculation loop to the Application Pak, where a final
purification step, critical for specific experiments, removes contaminants just before water is
dispensed from the system.
*depending on feed water quality

The pure water produced by reverse osmosis is From the storage tank, water can be sourced
stored in a tank designed to minimize risks of through a front valve, sent by a delivery pump
contamination during water storage. Our tank level to feed instruments such as a glassware washing
sensor will allow the system to automatically start machine, or further processed by the Milli-Q® Direct
or stop producing water when you want it to, and to produce ultrapure (Type 1) water.
will accurately display the tank’s water level on the
system’s screen. Safety devices prevent overflow or
the system from running dry.

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Convenience in water delivery

Easily prepare The 75 cm long tubing

solutions with the reaches the sink for
low flow function easy glassware washing
to precisely adjust at mid or high flow
the meniscus in (up to 2 L per min).
volumetric flasks.

Save time with the Deliver water

volumetric function that hands-free using the
automatically delivers footswitch option for
the water volume you added convenience.
need, and the dispensing
arm designed to fit the
height and shape of all
laboratory glassware.

Select an Application Pak to get the best-adapted water for your research:

Application Pak range

Biopak® Polisher VOC-Pak® Polisher EDS-Pak® Polisher LC-Pak® Polisher Millipak® Filter
Bacteria-free, Water for volatile Water for endocrine Water for ultratrace Bacteria-free and
pyrogen-free and organic compounds disrupters experiments organic analysis particulate-free water
nuclease-free water analysis

3
Milli-Q® Direct System at a glance

Built-in photooxidation
High recovery reverse osmosis for
UV lamp for TOC
pure water production at low cost
reduction and measure
Dispenser removable
from support
Large digital and graphic screen
with detailed procedures for full
Application Pak adapted to online support
specific contaminants removal

Progard® pretreatment
Consistent delivery of ultrapure cartridge to increase RO
quality water adapted to your module lifetime — with e-Sure
needs at low or high flow rate tag for safety and traceability

Dispenser on support adaptable QPAK® polishing cartridge

to glassware height and shape adapted to general application —
for automatic volume delivery with e-Sure tag for safety
and traceability

Quick Reference Guide with all

necessary information in left door

Milli-Q® Direct water purification pathway

1 2 4 5 6

12

7
9 10

3
11

19
13

20
16 17
14
18

15

1. Tap water feed 8. Drain 16. R

 esistivity and temperature
measure for ultrapure water
2. Inlet solenoid valve 9. Permeate conductivity cell
TOC indicator
3. Progard® pretreatment pack 10. 3-way solenoid valve
17. QPAK® polishing cartridge
4. Booster pump 11. Bactericidal UV Lamp (optional)
18. U
 ltrapure water resistivity
5.  easure of feed water
M 12. Tank for Type 3 water storage and temperature measure
conductivity and temperature
13. Recirculation and delivery pump 19. Ultrapure water dispenser
6. Reverse Osmosis cartridge(s)
14. Photooxidation UV lamp 20. A
 pplication Pak polisher
7.  everse Osmosis reject
R adapted to application
15. 3
 -way solenoid valve – part of the
recovery loop
TOC indicator

4
Easy access to information

• Simplified and detailed • Clear graphics help you • Critical information, such as set
information (in local language). perform specific tasks such as points or units, is accessible only
maintenance. From the same to the designated responsible
• Alerts and alarms (which can be
screen, you can even print user and is protected by a login
enhanced by a buzzer) are visible
reports on the system’s water and a password.
on the system’s main screen, with
quality and history.
complete information on actions • Automatically stop ultrapure
required. These are accessible water dispense after a fixed time
at the touch of a finger. period set by the user, in order to
avoid water loss or lab flooding.
• Sensors regularly monitor
the operation of the system
to ensure it operates within
specifications. For instance, if
ionic contamination of feed water
exceeds specifications, causing
high conductivity, the built-in
Feed Water Conductivity Meter
will trigger an alarm to alert you.

A Quick Reference Guide located in the door of the Milli-Q® Direct water system provides
all the information required to understand the operation and maintenance of the system.
The system comes with a complete and detailed user manual in 8 languages on CD-ROM.
A printed manual contains essential information (in local language).

5
Easy and reduced maintenance

Maintenance frequency is minimal, and the procedures are simplified

Progard® pack replacement QPAK® polishing cartridge replacement Millipak® Express 40 replacement

• Progard® pretreatment pack or the QPAK® polishing • The system will alert you to replace consumables
cartridge replacement takes less than 5 minutes. or schedule service visits at least 15 days before
maintenance is actually required.
• Quick and easy traceability thanks to RFID tag,
which automatically registers the catalog and
other new consumables in the system’s memory.

Milli-Q® Services
We provide a comprehensive range of service programs performed by certified field service
engineers to thoroughly maintain and qualify your Milli-Q® system for full compliance with your
industry’s regulatory standards.
Milli-Q® Services can cover all maintenance requirements, such as installation, customized
user training, scientific and technical support, troubleshooting, preventive maintenance visits,
and all validation requirements using ad hoc calibrated equipment, procedures, workbooks and
suitability tests within a GXPs environment.

Safety Certification
The Milli-Q Direct system is tested by an
®
The Milli-Q® Direct system is delivered with
independent and accredited company for a Certificate of Conformity ensuring that it has
compliance with the CE directives related been built and tested fully assembled following
to safety and electromagnetic compatibility. our Standard Operating Procedures, and a
Certificate of Calibration for the temperature and
A certificate is delivered with the system and
resistivity meters built into the system.
the report can be consulted on request at the
manufacturing site. The Milli-Q® Direct consumables are automatically
delivered with a Certificate of Quality.
The Milli-Q® Direct system is built using components
and practices recommended by UL and has been cUL Our manufacturing site is ISO 9001 v.2000 and
marked. The registration can be verified on the UL ISO 140001 certified.
website: www.ul.com.

6
Milli-Q® Direct specifications

Feed Water Specifications Type 3 Water Production and Delivery

Parameter Value and Unit Parameter Value and Unit
Quality Potable tap water feed Production Flow Rate 8 L/hour (Milli-Q® Direct 8)
16 L/hour (Milli-Q® Direct 16)
Conductivity < 2000 μS/cm at 25°C
Delivery Flow rate From tap: up to 2.5 L/min
TOC < 2000 ppb From optional pump:
Pressure 1 – 6 bar up to 15 L/min at 1 bar

Temperature 5 – 35°C
Chlorine < 3 ppm*
Fouling index < 12**
Milli-Q® Direct System Dimensions
Water pH 4 to 10
Connection 1/2 in. Gaz M Parameter Value and Unit

*Feed water chlorine < 1ppm with Progard® T3 and < 3ppm with Progard® T3 + Prepak 1
System footprint 1606 cm² (249 in.²)
**Feed water SDI < 5 with Progard® T3 and < 12 with Progard® T3 + Prepak 1 System height
• Cabinet (base) 497 mm (19.56 in.)
• Dispenser arm (top) 713 mm (28.07 in.)
System width
• Cabinet (base) 332 mm (13.07 in.)
Type 1 Product Water Quality • Dispenser arm (top) 413 mm (16.25 in.)

Parameter Value and Unit System depth

• Cabinet (base) 484 mm (19.05 in.)
Resistivity 1
18.2 MΩ.cm at 25°C • Dispenser arm (top) 581 mm (22.87 in.)
TOC2 ≤ 5 ppb (μg/L) System weight (packaged) 8/16 24/25 kg (52.91/55.11 lb.)
Bacteria3,4 < 0.01 CFU/mL System weight (empty) 8/16 20/21 kg (44.09/46.29 lb.)
Pyrogens (endotoxins)4 < 0.001 EU/mL (pyrogen-free) System weight (with water) 8/16 27/28 kg (59.52/61.73 lb.)
RNases4 < 1 pg/mL (RNase-free) Dispenser delivery loop length 750 mm (29.52 in.)
DNases4 < 5 pg/mL (DNase-free) Electrical power supply 290 cm (114.1 in.)
cable length
1
Resistivity can be displayed temperature-compensated at 25°C or non-temperature-compensated
as required by USP Electrical power supply voltage 100 – 230 V ± 10%
2
TOC spec – Test conditions: Milli-Q® Direct System equipped with Progard® T3 pretreatment pack,
QPAK® TEX polishing cartridge and with feed (tap) water quality within specifications. Product water Electrical power supply frequency 50 – 60 Hz ± 10%
quality may vary due to local feed water conditions.
Results with Millipak® final filter
3 Feed water connection 1/2 in. Gaz F
Results with BioPak® final polisher in place
4
Data connection Ethernet (RJ45)

Type 1 Water Delivery Q-POD® Accessory Dimensions

Parameter Value and Unit
Parameter Value and Unit
Manual dispense flow rate Adjustable between 50 and
2000 mL/min Q-POD® height 579 mm (23.50 in.)

Automatic dispense volume 100 mL, then 250 mL to 5 L Q-POD® diameter 230 mm (9.05 in.)
by 250 mL increments; 5 L to Dispenser delivery loop length 800 mm (31.49 in.)
60 L by 1 L increments
Q-POD® weight (packaged) 7.2 kg (15.87 lb.)
Volumetric dispense accuracy 3% for volumes between
250 mL and 60 L Q-POD weight (empty)
®
5 kg (11.02 lb.)

Volumetric dispense dispersion CV < 3% for volumes between Q-POD® weight (with water) 5.5 kg (12.12 lb.)
250 mL and 60 L Loop and cable to system length 290 cm (114.1 in.)
Data connection Parallel Port (25-pinD-Sub)
for printout

Type 3 Water Delivery

Parameter Value and Unit
Ions rejection 97 to 98% with new RO cartridge
Organics rejection > 99% for MW > 200 Dalton
Particulates and bacteria rejection > 99%

7
Accessories

Customize your Milli-Q® Direct system to meet your specific needs

Reservoirs
• Select from a range of tank sizes, from 30 L to 200 L,
designed for optimum pure water storage.

Wall Mounting Bracket

• Save space by installing the Milli-Q® Direct
on the wall or under the bench.

Q-POD® Dispenser: Ultrapure water delivery

at your fingertips
• Save your bench space by removing the arm
and dispenser from the Milli-Q® Direct system Protectors
and mounting it on the Q-POD® support.
• Water Sensor – placed on the floor, this sensor
stops water feed to the system if there is water
Q-POD® dispenser key features on the floor.
• Variable water flow (slow flow to 2 L/min)
• Tank Level Sensor – transfers tank level information
controlled by plunger.
to the system to start and stop pure water production
• Volumetric water delivery controlled from the at levels selected by the user.
Q-POD® base.
• Safety Level – prevents air from entering the
• Designed to accommodate all sizes of glassware — ultrapure water part when the tank is empty.
250 mL cylinder, 5 L flask or even a 30 L carboy.
• Silicone Cover – to protect your Q-POD® from harsh
• Graphic display shows the water quality specifications chemicals, such as strong acid and bases, aggressive
at a glance, and all critical information you need solvents or etchants.
(resistivity, TOC level, alerts, alarms, etc.).
• Bactericidal UV Lamp – installed upstream from
• Printer connection to instantly record water the inlet to the tank, allows reduction of the level of
quality history. bacteria in the permeate water by a factor of 1000.

Footswitch
• Connect the footswitch to the base of the Q-POD® For more information, please visit our website:
dispenser or directly to the Milli-Q® system for EMDMillipore.com/labwater
hands-free water delivery: press once to start
and once to stop.

To place an order or receive technical assistance in Europe, please call Customer Service:
France: 0825 045 645 Spain: 901 516 645 Option 1
Germany: 069 86798021 Switzerland: 0848 645 645
Italy: 848 845 645 United Kingdom: 0870 900 4645

For other countries across Europe, please call: +44 (0) 115 943 0840
Or visit: MerckMillipore.com/offices
For Technical Service visit:MerckMillipore.com/techservice

© 2020 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved. Merck, the vibrant M, Milli-Q, BioPak,
EDS-Pak, Jetpore, LC-Pak, Millipak, Progard, Q-POD, QPAK and VOC-Pak are trademarks of Merck KGaA, Darmstadt, Merck KGaA
Germany or its affiliates. All other trademarks are the property of their respective owners. Detailed information on
trademarks is available via publicly accessible resources.
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