METAMORPH

MODULE 5 MODULAR EXAMINATION

PHARMACEUTICS
MODULE 5 PHARMACEUTICS

MODULAR EXAMINATION & RATIONALE

1. Which of the following controlled substances is classified 11. The time period during which a drug product is expected to
under Schedule III? remain within the approved shelf-life specification, provided
container
that it is stored under the conditions defined on the
Codeine ' label.
II. Hydrocodone 1
Expiration date
IV: Morphine 2 B. Shelf life
C. Expiration dating period
A. I, III D. Both B and C
B. 11, IV
12. This is the license under the Comprehensive Dangerous Drugs
C.1, I
D. I1, Ill
Act of 2002 which permits the conduct of laboratory analysis
or technical research using controlled substances.
A. S-2
2. Type II glass is also called "treated soda lime glass". Type III B. S-4
glass is also called "soda lime glass".
C. S-5-C
A. First statement is correct D. S-6
B. Second statement is correct
C Both statements are correct
13. Considering the formula below:
D. Both statements are incorrect Liquid paraffin 50 g
Emulsifying agent of HLB 10.5 - 5 g
3. Leaching is a term used to describe the movement of
Water to 100 g
components of a container into the contents. Sorption
indicates the binding of molecules to polymer materials,
How much of Tween 80 (HLB 15) and Span 80 (HLB 4.3) are
includes both adsorption and absorption. /
needed? A
A. First statement is correct
B. Second stateme A. 3.5 g Tween 80, 1.5 g Span 80
C Both statements are correct B. 1.5 g Tween 80, 3.5 g Span 80
D. Both statements: C. 2.9 g Tween 80, 2.1 g Span 80•
D 2.1 g Tween 80, 2.9 g Span 80
4. What is the volume of 2 moles of an ideal gas at 25°C and 780
14. An emulsion is considered to be physically unstable if the
A. 47.65 1 internal phase upon standing tends to form aggregates of
B. 477 L globules. Also, if large globules or aggregates of globules
/ rise to the top fall to the bottom of the emulsion to form a
C. 4.76 ml
concentrated layer of the internal phase.
A. First statement is correct
5. An example of a monoclinic crystal form:
B. Second statemer
A. Sodium chloride - Cubic Both statements are correct
B. Urea D Both statements incorrect
C. Sucrose
D. lodoform - HEXA Practic

6. Theobroma oil or cocoa butter, which is a/an is the base

she r
of
used in rectal suppositories. Its most stable polymorphism is
the form.
Rate
A Oleaginous, beta • Sheering Stress
Sheering Stress
B Oleaginous, alpha
. Water-miscible, alpha
D. Water-soluble, beta
Pseudo
7. The crystalline form of the antibiotic novobiocin acid is K

well-absorbed and has activity. Its amorphous form is poorly

absorbed and has no activity. X wotiine
First statement is correct
Sheering S
B. Second statement i correct Sheering Stress Sheering Stress

C. Both statements are correct

D. Both statements are incorrect 15.
Miscosity indicates the resistance to flow of adjacent layers of
8. It is utilized for the decaffeination of coffee and tea fluid, In this graph, which graph represents pseudoplasticiy2
A. I, VI
CO
CO> B. I1, V
C. Supercritical CO2 C. 11, MV
D. III, VI
. Supercritical CO
16. Factors that
9. Any temperature that is maintained thermostatically between affect reaction rates, EXCEPT:

A. Cold temperature 11. Presence of additives

Cool temperature 1I. Temperature
C. Room temperature W. Presence of solvent
D. Freezer

A. 1, II
10. A drug suspension (25 mg/mL) decays by zero-order kinetics B. I1I, IV
with a reaction rate constant of 0.5 mg/mL/h. What the C. 11, M
concentration of intact drug remaining after 3 days (72 hours),
and what is its tl/2?
D. None of the above

A. 130 h
B. 125 h
C. 120 h
D. 115 h

COPYRIGHT NO 12023
MODULE 5 METAMORPH
PHARMACEUTICS MODULAR EXAMINATION

17. Purified Water, USP is water obtained by distillation, ion / 25. In the class I methods, sodium chloride or some other
exchange or by reverse osmosis. It is used as a solvent for the substance is added to the solution of the drug to lower the
preparation of parenteral solutions.;
freezing with
point of the solution to -this
0.52C and thus make
A. First statement is correct
isotonic body fluids. Under included
class are the
B Second statement is correct
cryoscopic method and the sodium chloride equivalent
method.
Both statements are correct D17 menod
D. Both statements are incorrect First statement is correct
B. Second statement is correct
18. Syrup, NF has a concentration of and specific gravity of Both statements are correct
D. Both statements are incorrect
85% w/v ; 1.313
B. 65% w/v ; 1.000
26. How much sodium chloride is required to render 100 mL1 fa
80% w/v: 1.616 1% solution of apomorphine hydrochloride isotonic with blood
serum?
D 90% w/v ; 1.800
A. 0.76%
19. Elixirs are
B. 7.6%
A. Alcoholic or hydroalcoholic solutions prepared from C. 76%
vegetable materials or from chemical substances and D. 0.076%
contains alcohol in amounts ranging from approximately
15% to 80%.
27. RA 9994:
B Clear, aqueous solutions saturated with volatile oils or other A. Dangerous Drugs Act of 1972
aromatic or volatile substances. B. Special Law on Counterfeit Drugs
C. Alcoholic or hydroalcoholic solutions of volatile substances C. Expanded Senior Citizens Act of 2010
which alcoholic concentration is usually over 60%. .Traditional and Alternative Medicine Act
D Clear, sweetened hydroalcoholic solutions intended for oral
28. It is the process in which water-insoluble or partly
use and are usually flavored to enhance their palatability.
soluble substances are brought into aqueous solution by
20. Below are examples of ointment bases. Choose the letter that incorporation into micelles.
corresponds to their types. . Detergency
. Aquaphor ab comption bast B. Critical micelle concentration/
C. Solubilization
111 Yellow Ointment oleaginou D. Surface tension
IV. PEG Ointment - 1g0 col
29. These were originally used by physicians in extemporaneous
A. 1-Water soluble base, II-Water removable base, Ill- preparation of parenteral solutions.
Oleaginous base, IV-Absorption base A. Hypodermic tablets •
B. I-Water soluble base, II-Absorption base, I1I-Oleaginous base, B. Dispensing tablets
IV-Water removable base C. Molded tablets
C. I-Water removable base, IIl-Water soluble base, 111- D. Effervescent tablets
Oleaginous base, IV-Absorption base
D. I-Absorption base, II-Water removable base, III-Oleaginous 30. These produce flexibility and elasticity of the coating and thus
base, IV-Water soluble base provide durability.
A. Opaquants
21. Part of a transdermal drug delivery system that prevents
insensible water loss from the skin beneath the patch.
B. Alloying substances
C. Surfactants
A. Adhesive layer D. Plasticizers v
B. Matrix system
C. Occlusive backing film 31. Arrange the following steps in coating tablet:
D. Release liner I. Finishing and coloringt
22. Eutectic mixtures of powders can cause problems because
I1I. Polishing©
they may liquefy. One remedy is to add an inert powder, such
IV. Waterproofing
real su sm lgrusing) cuco palith
as magnesium oxide, to separate the eutectic materials.
v. Smoothing and final rounding )
A. First statement is correct
B. Second statement is correct
C. Both statements are correct
D. Both statements are incorrect

23. In preparation of ointments:

32. These are solid oral dosage forms that are designed to dissolve
1. Mixing can be done in a mortar or on an ointment slab or
tile or using an ointment mill or disintegrate slowly in the mouth.
I1. Liquids are incorporated by gradually adding them to an A. Lozenges
absorption-type base and mixing B. Lollipops
III. Insoluble powders are reduced to a fine powder and then Pellets
added to the base, using geometric dilution D. Pills
IV. Water-soluble substances are dissolved with water and then
incorporated into the base. 33.
Transderm Scop prevents nausea and vorniting of motion
V. Should be smooth (impalpable) and free of any abrasive sickness. This patch is placed behind the ear.
particles. First statement is correct
B. Second statement is correct
A. 1, 11, 11 C. Both statements are correct
B. I, III, IV D Both statements are incorrect
C. I1, 11I, IV
D. All of the above 34. To avoid heat-induced inversion of sucrose, a syrup may be
24. Calculate the prepared without heat by agitation. This process is more
approximate E value for a new amphetamine time consuming than the use heat, but the product has
hydrochloride derivative (molecular weight: 187; L_jso: 3.4). naximum stability.
A. 0.30
A. First statement is correct
B. 0.31
Secon statement is correct
C. 0.32
D. 033 Both statements are correct
D Both statements are incorrect

OVEMBER 2023
MODULE!
PHARMACEUTICS METAMORPH
MODULAR EXAMINATION

45. Hydrophilic ointment, USP has the following formula for 1000
g:

. Liniments Methylparaben 0.25 g

B. Collodions Propylparaben 0.15 g
C. Plasters Sodium lauryl sulfate 10 g
D. Pastes Propylene glycol 120 g
Stearyl alcohol 250 g
36.
It a flexible collodion, the castor oll renders the product
flexible,
White petrolatum 250

permitting its comfortableuse over skin areas that are Purified water 370 q

normally moved, such as joints, fingers, and toes. The camphor

makes the product waterproof. What is the purpose of methylparaben and propylparaben in this
A. First statement is correct formula?
Second statement is correct
C. Both statements are correct Emulsifying agents
D. Both statements are incorrect Colorants
37.
Advantages of systemic drug administration by rectal C. Preservatives J
suppositories include: D. None of the above

A. Avoidance of first-pass effect 46. How to make 30 mL of a 1% solution of procaine HCI isotonic
solution with body fluid? (E value: 0.21)
Suitability when the oral route is not feasible
C. Predictable drug release and absorption x A. 5 mL
Both A and B B. 6 mL
38. Agar is a/an C. 7 mL
type of emulsifying agent. D. 8 mL
A. Anionic
Cationic X 47. 35 g of phenol can be dissolved in 525 g of water. The relative
C. Protein X term to describe its solubilityi
D Carbohydrate
A. Freely soluble
Soluble
39. This is the part of the tableting machine that controls the
C. Sparingly soluble
amount of powder led into the die.
D. Slightly soluble
A. Hopper
B. Hopper shoe 1etd shof 48. How much sodium chloride is needed to adjust the following
C. Lower punch prescription to isotonicity? (E value [sodium chloride
D. Upper punch equivalents] for zinc sulfate is 0.15)?
Zinc sulfate 2%
40. Aspirin (pKa 3.49) will be most soluble at:
NaCl q.s.
A pH 6 Purified water q.s. 60 mL
B. pH 5 Make isotonic solution
C. pH 4
D. pH 3 A. 0.36 c
B. 3.6 g
41. Which equation is used to predict the stability of a drug C. 36
product at room temperature from experiments at D. 0.036 q
accelerated temperatures?
A. Stokes equation 49. RA 10918 provides for and shall govern the:
B. Arrhenius equation 1. Standardization and regulation of pharmacy education
Michaelis-Menten equation -tnagm kin/fla II. Administration of licensure examination, registration, and
D. Noyes-Whitney equation - diecotulen licensing of pharmacists
III. Supervision,
control, and regulation of the practice of
pharmacy in the Philippines
Solid Liquid V. Development and enhancement of professional
competence of pharmacists through continuing
professional development, research, and other related
activities
V. Integration of the pharmacy profession
0.0098" 1, 11, 111, IV
B. 1, 11, III, IV, V
C. 1, 111, IV, V
D. 11, III, IV

42. This is the curve which shows that the freezing point of water
decreases with increasing external pressure. 50. Electrolysis produces chemical reaction from a direct electric
current flowing through an electrolytic cell. Electrons enter
B. CA the cell from the battery at the and cations are
Anions
carry electrons and discharge them at the and
are
D. OB
A. anode, oxidized, cathode, reduced
43. A BCS class IV drug
B. cathode, oxidized, anode, reduced Red cal
A. Furosemide C. anode, reduced, cathode, oxidized
B. Propanolol D cathode, reduced, anode, oxidized

D. Ranitidine 111
51.
Electrolysis produces a chemical reaction from a direct electric
current flowing through an electrolytic cell. Electrons enter
44.
What is the amount of glycerin in glycerogelatin? the cell from the battery at the and cations are
Anions carry electrons and discharge them at the and
are
B. 40%
A.
anode, oxidized, cathode, reduced
D. 10% • 2n0 B. cathode, oxidized, anode, reduced
anode, reduced, cathode, oxidized
D. cathode, reduced, anode, oxidized

COPYRIGHT NOVEMBER 21
MODULE 5 METAMORPH
PHARMACEUTICS MODULAR EXAMINATION

52. In orderto be registered and licensed as pharmacist, : 60. A satisfactory suppository base must meet all of the following
candidate must obtain a general weighted average of seventy- criteria except:
five percent (75%), with no rating lowerthan tiry percent
150%)in any ofthe subjects. An applicantwho falled inthe 1. It should be inert
licensure
allowed
examination for the third (3rd)time shall not be II. It should have narrow

III. It should melt <30°C

melting range
to take the
next succeeding examinations without should dissolve or disintegrate rapidly in the body cavity
having undertaken a refresher programin a duly accredited
institution.
JV.It

A.1, II
A. First statement is correct B. I1. Ill
Second statement is correct C. IlI only
C. Both statements are correct D. 1I. IV
D
Both statements are incorrect
61. Which of the following pairs is correct considering the graph
53.
Which of the following is/are examples of hydrogels? above?

I. Controlled release tablets - D

I1. Sustained release tablets - B
I1I. Bentonite magma - norganic III. Delayed release tablets - A
IV. Carbowax bases organoges IV. Immediate release tablets - C

A. I only
B. II only B.
C.I, IV
D. I1, IlI D. IV

54. Choose the letter of the correct answer: 62. Which condition usually increases the rate of drug dissolution
from a tablet?
Enantiotropic - polymorphism is reversible
I. Monotropic - exhibit similar properties in all directions X 1V A. Increase in the particle size of the drug
Isotropic - polymorphism is irreversible / B Decrease in the surface area of the drug
IV. Anisotropic - showing different characteristics in various C. Use of the free acid or free base form of the drug
directions D. Use of the unionized, or salt, form of the drug

A. Only 3 statements
63. Thixotropy occurs when the apparent viscosity of the system
B. Only 2 statements are correct. continues to increase with continued application of shear up
C. Only 1 statement is correct. to some equilibrium value at a given shear rate. These systems
D. All statements are incorrect. display a sol-gel transformation. X gel-60)
A First correct
55. Which of the following is/are an example of solid-gas colloidal
B. Second statement is correct
dispersion?
C. Both statements are correct
Pumice D. Both statements are incorrect
Smoke
Clouds 64. Gels (sometimes called jellies) are semisolid systems
D. None of the above
particles or large organic molecules interpenetrated by
56. In a lyophilic property of colloidal solutions, the dispersed liquid. Pastes are characterized by their high content of solids
phase consists generally of large organic molecules. In a (about 25%).v
lyophobic property, it consists of inorganic particles such as
A. First statement is correct
gold or silver.
econd statement is correct
A. First statement is correct C. Both statements are correct v
B. Second statement is correct Both statements are incorrect
C. Both statements are correct
D. Both statements are incorrect 65. Amorphous solids have the following attributes:
A. Anisotropicity - crystalling
57. This describes the random movement of colloidal particles.
B. Fixed molecular orderx
A Brownian motion C. No melting points
Diffusion D Both A and B
C. Faraday-Tyndall effect
D. None of the above 66. Itis the pressure at which equilibrium is established between
the molecules of A in the liquid state and the molecules of A in
58. It is an ISO Class 8 or cleaner room with fixed walls and
the gaseous (vapor) state in a closed, evacuated container.
doors where personnel hand hygiene, garbing procedures,
Vapor pressure
and other activities that generate high particulate levels
B. Boiling point
may be performed and is the transition room between the
unclassified area of the facility and the buffer room. Freezing point
D. Osmotic pressure
Clean rooms
Airlock 67. This occurs in
emulsion systems when the liquid particles of
C. Buffer room the
dispersed phase merge to form larger particles.
D. Ante-room - 1$0 CIAS
A. Phase inversion
59 It is the taking up of a certain amount of liquid without a B. Cracking
measurable increase in volume Creaming
D. Coalescence
A. Syneresis
B Swelling
C. Imbibition

COPYRIGHT NOVEMBER 20:

 MODULE 5
PHARMACEUTICS METAMORPH
MODULAR EXAMINATION
68, How many of the statements
Tweens? below are true about Spans and
77. A ceramic mortar may be preferable to glass mortar when

Span 80 or sorbitan monooleate is used in I. A volatile oil is added to a powder mixture

emulsions. making W/O I1. Colored substances are mixed Into a powder

O Span Bois producedby the esterification of oneor more of I1I. Comminution is desired in addition to mixing /

111. the hydroxyI groups of sorbitan with a atoy acid.

Execen e0 or polyonyethylene monooleate s used in making
O/W emulsions
A. I only
B. II only
JV.
Tween B0 are more hydrophilic derivatives of Span 80.
C. 11, IlI
D. Ill only
A. 1
B.:
78. The shells of soft gelatin capsules may be made elastic or
plastic-like by the addition of:

D. A. Sorbitol
B. Povidone

are compressed
69.
These tablets that are coated with a thin laver C. PEG
of awater-insoluble Nater-soluble polymer.
or D. Lactose

A. Enteric coated tablets 79. Aside from addition of antioxidants and/or metal chelators,
B.
Chewable tablets oxidation can be prevented by purging this type of gas to
C.
Effervescent tablets create a headspace in the container.
D. Film-coated tablets
A. Oxygen /

70. It is the separation of a tablet into two or more distinct layers. B. Hydrogen
C. Nitrogen
Capping op/botor
D. Helium
B. Lamination
Picking - 80. Rectal suppositories are usually cylindrical and tapered to a
Mottling - telor unequal dirinb point, forming a bullet-like shape. Rectal suppositories for
7. The
adults weigh approximately 2 g.
following are the most commonly used fixed oils in
injections, except: A. First statement is
B. Second statement is correct
A Coconut oil
C. Both statements are correct
B. Corn oil D. Both statements are incorrect
Peanut oil
D. Sesame oil 81.
These are suppository bases that derived from coconut oil.
A. Wecobee
72. Problems are caused by excessive moisture or the inclusion of
B. Witepsol - sqt FA (C12-CI8)
substances with low melting temperatures in the formulation.
C. Cocoa butter - olec + paimitic. stearica
1. Sticking D. None of the above
11. Picking
III. Capping - Pro Carg Cr' 82. Which of the following is/are an example of diluent?
IV. Lamination Mannitol .
V. Mottling - mait than {ociot 11. Lactose anhydrous
II. Sodium starch glycolate - alcinicgiant
. 1, 11;/
IV. Magnesium stearate Gildan/thon
B. III, IV
C. V only . I and II
D. All of the above
B. 111, IV
73. This theory emulsification assumes mono-molecular layers
D. All of the above
of emulsifying agent curved around a droplet of the internal
phase of the emulsion.
83. It permits easy opening and closing of the valve.
Sur face tension theory
A. Actuator
B Oriented-wedge theory B. Dip tube
Interfacial film theory C. Mounting cup
D None of the above
D. Stem

74. This method of emulsion preparation involves mixing first 1 84. It is d when potent substances must be
part of gum and parts oil, then adding parts of water all at mixed with a large
amount of diluent.
once.
A. Sifting X
Continental method B. Tumbling
B. English method C. Geometric dilution*
C Forbes bottle method D. Trituration>
D. Wet gum method Engllh m
85. It is
75. These are types of colloids that are self-dispersing upon
opaque paper that has no moisture-resistant
properties.
addition to the dispersing medium.
Vegetable parchment
A. Natural colloids
B. White bond paper
. Artificial colloids
C. Glassine
C. All of the above
D. Waxed paper
None the above
86. The oH of : buffer
76. The sedimentation of particles in a suspension can be system can be calculated with the:
minimized by. Noyes-Whitney equation- disco ratt
B. Henderson-Hasselbach equation
I. Adding sodium benzoate
11. Increasing C. Michaelis-Menten equation - enzyme kinetics
the viscosity of the suspension
D. Stokes equation -Gedimentation
I1. Reducing the particle size of the active ingredient v
87. Which capsule size has the smallest capacity?
A. 5
B. 11, I11
B.
C. 1, 111
C. 00
D. 1, 11, III
D. 000

COPYRIGHT NOVEMBER 2023

MODULE 5
PHARMACEUTICS METAMORPH
MODULAR EXAMINATION
88. The colligative properties of a solution are related
to the:
A. pH of the 97. Identify the statements which are not compliant with good
solution
manufacturing practices.
number of ions in the solution
C total number of solute particlesin the solution I. Using a correction tape in errors made in the document to
D. number of unionized moleculesin the solution assure cleanliness of the document
Disregarding the recording of how the samples were
Which technique is typically used to millcamphor2
89.
obtained since it is minute and negligible process
A. Trituration - mix pon.der III. Manufacturing amoxicillin in the same facility with
B. Levigation paracetamol to save costs and promote efficiency
C. Pulverization by intervention J IV. Coving of junctions of walls, floors, and ceiling in critical
areas
Geometric dilution - Inturation
30. These
the
are substances that willabsorb moisture from the airto A. I, III, IV

extent that they will partially or wholly liquefy B. I1, IV

C. 11, III
A
Hygroscopic
D. I, 11, III
B. Deliquescent
Efflorescent 98. Artificial sweetener that is 300x sweeter than table sugar.
D. None of the above
A. Acesulfame potassium
91.
All
40%
particles pass through a No. 20 sieve, and not more than B. Aspartame
C. Saccharin ~
pass through a No. 60 sieve.
D. Sucralose
Very coarse
B Coarse

Moderately coarse
D. Fine
99.
Which of the following is/are
I. Glycerin/
boy humectants2
II. Sorbitol /
92. Propeller mixers are able to mix fluids Ill. Mineral oil occlucivi
in axial and radial
direction. However, a vortex may form which can cause IV. Propylene glycol
frothing and oxidation. How can we prevent vortex formation
. 11,
when using propeller mixers?
B. III only
A Off-center mounting
C. IV only
B. Installing horizontal baffles
C. Both A and B
D. None of the above 100.
This is a type of prescription error wherein only the brand
93. Convert 68°F into °C name is written. It should not be filled, should be kept, and
should be reported to the DOH.
A. Violative prescription
C. 30°C
B. Erroneous prescription
D. 35°C C. Impossible prescription
D. All of the above
94.
This is the type of container that protects the contents from
contamination by extraneous liquids, solids, or vapors; from
loss of the article; and from efflorescence, deliquescence, or
evaporation under the ordinary or customary conditions of
handling, shipment, storage, and distribution.
A. Sterile hermetic container
B. Hermetic container
C. Well-closed container
D. Tight container
95.
Which of the following is/are efflorescent powder?
. Sodium carbonate
II. Calcium chloride
III. Sodium nitrate
/I.Atropine sulfate
. Citric acid

A.I, I1, IV
B. II, III
/ only
D. I, IV, V.

96. How many grams of boric

acid should be used in
compounding the following prescription?

Phenacaine hydrochloride
Chlorobutanol
1%
0.5%
Boric acid
q.S.
Purified water, a.d.
Make isotonic solution
A. 0.7 g of boric acid
B. O.8 g of boric acid
C. 1 g of boric acid
D. 0.6 g of boric acid

OP/RIGHT NOVEMBER 2023