Physical Pharmaceutics 2

1 of 4 sets

Chapter: Colloidal Dispersion

1. An example for colloidal systems is:

A. clays and gels
B. ointments and pastes
C. solutions of soaps and proteins
D. suspensions and emulsions
Answer:C

2. The criterion to call a system ‘colloid’ is

o m
A. a fine state of subdivision of dispersed phase
. c
te
B. dispersed particles are in the size range of 1 nm to 1 µm
C. interface is very extensive a
q M
D. the presence of dispersed phase in a dispersion medium
Answer:B c
M
3. Solutions of proteins and starch in water are the examples of the colloidal type:
A. hydrophilic
B. hydrophobic
C. lyophilic
D. lyophobic
Answer:A

4. Electrodialysis method is employed in the colloidal chemistry for the purpose of :

A. Indentification
B. preparation
C. Purification
D. Stabilization
Answer:C
5. Silica gel is an example for the type of gel:
A. dilatants
B. elastic
C. rigid
D. thixotropic
Answer:C

6. Which of the following DO NOT form colloid spontaneously?

A. association
B. lyophilic
C. lyophobic
D. micellar
Answer:C

7. Sulphur sol is an example of colloidal type:

A. Association
B. hydrophilic
C. lyophilic
D. lyophobic
Answer:D

8. Thixotropic type of behavior is shown by the gel:

A. bentonite
B. pectin
C. silica
D. starch
Answer:A

9. In the determination of size, shape and structure of colloidal particles, which one
of the following CAN NOT be used?
A. electron microscope
B. instrument measuring light scattering
C. Langmuir film balance
D. ultramicroscope
Answer:D

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10. Surfactant solutions are termed as association colloids when their
concentrations are:
A. insufficient to saturate the bulk phase
B. insufficient to saturate the interface
C. less than critical micellar concentration (cmc)
D. more than cmc
Answer:D

11. Name the type of colloidal dispersion to which electrolytes are normally added
in small quantities to stabilize:
A. association
B. lyophilic
C. lyophobic
D. micellar
Answer:C

12. Protective colloids DO NOT:

A. aid in dispersion
B. decrease the zeta potential
C. lower the interfacial tension
D. offer a mechanical barrier
Answer:C

13. Which one of the following colloids is difficult to prepare?

A. association
B. hydrophilic
C. hydrophobic
D. lyophilic
Answer:C

14. In high concentrations, electrolytes destabilize a lyophilic sol by a process

termed as :
A. coagulation
B. dilution
C. salting out
D. solvation

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Answer:C

15. Which quality of the dispersed phase is responsible for the increased viscosity
of a hydrophilic colloidal dispersion?
A. charge
B. shape
C. size
D. surface area
Answer:D

16. Dispersion of acacia in water gives the colloid of type:

A. association
B. negative
C. neutral
D. positive
Answer:B

17. Addition of alcohol to a hydrophilic colloid leads to:

A. crystallization
B. hydration
C. precipitation
D. stabilization
Answer:C

18. The critical value of zeta potential (in milli volts) for a stable colloid (except
gold sol) is:
A. from 20 to 50
B. from 50 to 100
C. less than 20
D. mor than 100
Answer:A

19. If kinetic energy of interaction is about 25 kT (Where k is gas constant), the

system can be considered to have:
A. deflocculated state
B. long half life

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 C. short half life
D. weak attractiton forces
Answer:B

20. In foams, the dispersed phase and dispersion medium, respectively, are:
A. gas and liquid
B. gas and solid
C. liquid and gas
D. solid and gas
Answer:A

21. The characteristic of a lyophobic sol is that:

A. electrolytes in small amounts induce stabilization
B. it is reversible
C. particles have high electric charge
D. viscosity increases by the presence of particles
Answer:C

22. Hydrosol refers to a system in which the dispersed phase and dispersion
medium, respectively, are:
A. gas and water
B. liquid and water
C. solid and water
D. water and solid
Answer:C

23. Electrodialysis is used, when impurities in a sol are:

A. amphiphiles
B. colloids
C. electrolytes
D. nonelctrolytes
Answer:C

24. Under ultramicroscope, colloid particles appear as:

A. bright specks against dark background
B. concentric rings

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 C. dark specks against bright background
D. fluorescent specks
Answer:A

25. Which one of the following properties is extensively applied for determining the
molecular weight of polymer?
A. depression of freezing point
B. elevation of boiling point
C. lowering of vapour pressure
D. osmotic pressure
Answer:D

26. Aerosol is the reverse of :

A. emulsion
B. liquid foam
C. smoke
D. solid foam
Answer:B

27. In the determination of the gold number of a protective colloid, the endpoint is
indicated by:
A. measuring the change in particle size
B. noting sedimentation volume of gold
C. observing the color change
D. weighing of the precipitate
Answer:C

28. The semipermeable membrane used in haemodialysis is:

A. cellophane
B. cellulose acetate
C. polyethene
D. polyvinyl acetate
Answer:A

29. The stability of acacia in water is due to:

A. formation of micelles

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 B. hydration of solids
C. lowering interfacial tension
D. presence of electrical charge
Answer:B

30. The molecular weight of dispersed solids in a colloidal system can be

determined using an instrument:
A. ultracentrifuge
B. ultrafilters
C. ultramicroscope
D. zeta meter
Answer:A

31. When the size of particle is less than 1nm then it is called
A. Molecular dispersions
B. Colloidal dispersions
C. Suspension
D. Emulsion
Answer:A

32. The movement of colloidal particles through a liquid under the influence of
electric field is called
A. Electrophoresis
B. Electro-osmosis
C. Electro chemical reaction
D. Electrodialysis
Answer:A

33. The potential difference develop when particles settle under the influence of
gravity is called
A. Streaming potential
B. Oxidation Potential
C. Reduction potential
D. Sedimentation potential
Answer:D

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34. When distance between the particle are large, the particles experience
attractive force and aggregates are formed. This is known as
A. Primary minimum
B. Potential barrier
C. secondary minimum
D. Interparticle distance
Answer:C

35. According to schulze-Hardy rule, the precipitating power increases rapidly

with the
A. Presence of valence or charge of the ions
B. Lowering the interfacial tension
C. Decreasing the freezing point
D. Elevationof boiling point
Answer:A

36. When a beam of light is pass through a colloidal solution, the path of light gets
illuminated. This phenomenon is known as
A. Brownian movement
B. Diffusion
C. Tyndall effect
D. Donnan effect
Answer:C

37. The continuous collisions between the colloidal particles and molecules of
dispersion medium produce zigzag movement of colloidal particles which is known
as
A. Brownian movement
B. Tyndall effect
C. Diffusion
D. Sedimentation
Answer:A

38. The protective ability of colloids is measured as

A. Zeta potential
B. Streaming potential

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 C. Gold number
D. None of the above
Answer:C

39. If the gold number is less then the protective action will be
A. more
B. Less
C. Half
D. Zero
Answer:A

40. In sol, the dispersed phase and dispersion medium are

A. Solid and liquis
B. Liquid and liquid
C. Solid and solid
D. Liquid and Gas
Answer:A

41. Homogenous phase (True solution) having size range of

A. 0.5 to 1.0 µm
B. <0.1 nm
C. >0.01 µm
D. <0.01 µm
Answer:D

42. Heterogeneous phase (Coarse dispersion) having size range of …

A. 0.5 to 1.0 µm
B. 10 to 100 µm
C. 10 to 1000 µm
D. 1 to 10 µm
Answer:C

43. Solubility of Drug can be improved by…

A. Targeting drug to specific organ
B. Addition of emulsifying agent

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 C. Addition of thickening agent
D. Addition of Surface active agent
Answer:D

44. Targeting of drugs to specific organs can be achieved by

A. Liposomes
B. Emulsion
C. Syrup
D. Suspension
Answer:A

45. The following statement is appropriate for Molecular Dispersion

A. Diffusion rate is slow
B. Impermeable across semipermeable membrane
C. Does not scatter light
D. Particle size less than 1.0 µm
Answer:C

46. The following statement is NOT appropriate for Molecular dispersion

A. Shows tyndall effect
B. Does not scatter light
C. Diffusion rate is rapid
D. Does not settle on ultracentrifugation
Answer:A

47. The following statement is true for Colloidal dispersion

A. Diffusion rate is slow
B. Impermeable across semipermeable membrane
C. Shows tyndall effect
D. All of above
Answer:D

48. In _____Colloids, dispersed particles have a greater affinity to the dispersion

medium.
A. Lyophilic colloids
B. Lyophobic colloids

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 C. Association colloids
D. Molecular colloids
Answer:A

49. Dispersion of rubber or polystyrene in benzene or ethyl methyl ketone is

referred to as________
A. Hydrophilic colloids
B. Lyophilic colloids
C. Lyophobic colloids
D. Hydrophobic colloids
Answer:B

50. Lyophobic colloids can be prepared by

A. Chemical method
B. Peptization method
C. Electric arc method
D. All of above
Answer:D

51. A .......... is a mixture in which one substance of microscopically dispersed

insoluble particles is suspended through another substance.
A. Suspension
B. Colloid
C. Emulsion
D. None of the above
Answer:A

52. Few colloids are translucent because of the ..

A. Tyndall effect
B. Splitting effect
C. Scattering
D. None of the above
Answer:A

53. The comparatively fast sedimentation rate of the dispersed phase produced by
means of gravity or other forces this is characteristic of..............

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 A. Colloidal dispersion
B. Coarse dispersion
C. Both of the above
D. None of the above
Answer:B

54. The molecule in the molecular dispersion phase have size.............

A. Less than 10 nm
B. More than 1 nm
C. Less than 1 nm
D. More than 10 nm
Answer:C

55. The .......... colloids have strong attraction towards solvents.

A. Lyophilic
B. Lyophobic
C. Associated
D. None of the above
Answer:A

56. .......... is the method accountable for the development of stable dispersion of
colloidal particles in dispersion medium.
A. Coacervation
B. Peptization
C. Flocculation
D. Coagulation
Answer:B

57. The phenomenon which involves separation of macromolecular solutions into

two liquid layers is called as.........
A. Liquid separation
B. Coagulation
C. Flocculation
D. Coacervation
Answer:D

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58. …..is directly proportional to the molecular weight of lyophilic colloid.
A. Solubility
B. Turbidity
C. Density
D. None of the above
Answer:B

Chapter: Rheology

59. Flocculated suspensions exhibit the flow of a type:

A. Dilatant
B. Newtonian
C. Plastic
D. Pseudoplastic
Answer:C

60. A limitation that is NOT related to the falling sphere viscometer:

A. Applicable to only less viscous liquids
B. Large volume of sample is required
C. Needs the sample to be transparent
D. Plug flow
Answer:D

61. In general, Newtonian fluids are expressed in terms of viscosity. A

corresponding expression in nonNewtonian fluids (in terms of viscosity) is:
A. apparent
B. dynamic
C. intrinsic
D. kinematic
Answer:A

62. One of the following is NOT a one point viscometer, but can be used for the
same purpose. Pick the viscometer of this type.
A. cup and bob
B. falling sphere
C. Ostwald

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 D. rolling ball
Answer:A

63. Fluidity is a term associated with newtoniam fluids. An equivalent term in

plastic flow fluids is:
A. apparent viscosity
B. flexibility
C. mobility
D. plastic viscosity
Answer:C

64. Dilatant flow is characterized as a reverse phenomenon of:

A. newtoniam flow
B. plastic flow
C. pseudoplastic flow
D. rheopexy
Answer:C

65. Deflocculated suspension with high concentration of the dispersed solids

exhibits the flow of type:
A. dilatant
B. newtoniam
C. plastic
D. pseudoplastic
Answer:A

66. In antithixotropy, the down-curve is frequently positioned to: (with respect to

up-curve):
A. left.
B. origin
C. right
D. superimposible
Answer:C

67. At equilibrium, the thixotropic behavior of a pseudoplastic system exhibit the

state of:

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 A. gel
B. paste
C. sol
D. wax
Answer:C

68. Which one of the following physical Property is NOT a rheological property?
A. body and slip
B. spreadability
C. surface tension
D. viscosity
Answer:C

69. The pseudoplastic flow behavior can be explained by:

A. apparent viscosity
B. area of hysteresis loop
C. hysteresis loop
D. yield value
Answer:A

70. Brookfield viscometer is an example of type:

A. cone and plate
B. extrusion
C. rotation sphere
D. rotating spindle
Answer:D

71. High viscosity indicates one of the following relationships in a system. Which is
relevant?
A. free from intermolecular interactions
B. intermolecular attractions are stronger
C. intermolecular attractions are weaker
D. shape of the molecules is spherical
Answer:B

72. An emulsion of o/w type has the viscosity:

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 A. greater than that of the internal phase
B. greater than that of the vehicle
C. less than that of the internal phase
D. less than that of the vehicle
Answer:A

73. Creep testing is applied to analyse the viscoelastic property of:

A. emulsions
B. lotions
C. ointments
D. suspensions
Answer:C

74. The system that undergoes gel-to-sol transformation is known as:

A. elastic
B. permanent deformation
C. shear thickening
D. shear thinning
Answer:D

75. The type of viscosity specified in I.P. (Ostwald viscometer) is:

A. absolute viscosity
B. dynamic viscosity
C. kinematic viscosity
D. viscosity coefficient
Answer:C

76. After giving the i.m. injection of procaine penicillin G, the process of forming a
depot in the muscle is due to:
A. high yield value
B. low consistency
C. low yield value
D. rapid thixotropic recovery
Answer:D

77. Pick the reason for the calibration of an instrument.

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 A. most of the instruments are not reliable
B. to calculate the constant for the instrument
C. to calculate the relative property
D. to correct the errors in the working of an instrument
Answer:D

78. Plug flow in NOT observed in cone and plate viscometer. The reason is:
A. cleaning and filling of sample is easy
B. rate of shear is independent of the radius
C. shear can be maintained uniformly
D. temperature can be maintained uniformly
Answer:C

79. The term rheology was invented by

A. Bingham and Crawford
B. Newton
C. Michaelis and Menten
D. Watson and Crick
Answer:A

80. According to the Newton's law of viscosity, "The shear stress in flowing fluid
is__________ to the rate of shear."
A. Inversely proportional
B. directly proportional
C. Square root
D. Perpendicular
Answer:B

81. The unit of viscosity is

A. Newton sec m-2
B. Newton sec2 m2
C. Newton sec-1 m-1
D. Newton
Answer:A

82. Fluidity is

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 A. reciprocal of density
B. reciprocal of surface tension
C. reciprocal of volume
D. reciprocal of viscosity
Answer:D

83. Kinematic viscosity is the ratio of dynamic viscosity to the____________

A. density of the fluid
B. plastic viscosity
C. volume of liquid to flow
D. specific gravity of fluid
Answer:A

84. The effect of temperature on the viscosity (?) of a liquid is expressed by

A. Stoke's Law
B. Newton's law
C. Arrhenius equation
D. Michaelis Menten equation
Answer:C

85. The reciprocal of mobility is known as

A. Apparent viscosity
B. plastic viscosity
C. Dynamic viscosity
D. Kinematic viscosity
Answer:B

86. Pseudoplastic flow are also known as

A. shear thinning system
B. shear thickening system
C. Elastic deformation
D. Plastic deformation
Answer:A

87. Dilatant flow is also known as

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 A. shear thinning system
B. shear thickening system
C. Elastic deformation
D. Plastic deformation
Answer:B

88. Negative Thixotropy is a phenomenon in which there is

A. increase in viscosity on down curve
B. increase in viscosity on up curve
C. decrease in viscosity on down curve
D. decrease in viscosity on up curve
Answer:A

89. Which of the following is not a viscometers

A. Capillary
B. Falling Sphere
C. Rotational
D. Drop weight
Answer:D

90. Which of the following viscometer is also called suspended-level viscometer

A. Ubbelohde viscometer
B. Capillary viscometer
C. Ostwald viscometer
D. Cone and plate viscometer
Answer:A

91. Pseudoplastic flow is generally exhibited by

A. Jellies
B. Suspension
C. Lotion
D. Colloids
Answer:A

92. Concentrated solid suspension generally exhibit

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 A. Dilatant flow
B. Pseudoplastic flow
C. Plastic flow
D. All of the above
Answer:C

93. Rheology is the

A. Science or study of the flow of a material.
B. Study of particle size
C. Study of formation of colloids
D. Study of formation of complex
Answer:A

94. The change in velocity between two planes of liquid which is separated by
distance is called
A. Rate of shear
B. Shearing stress
C. Strain
D. Yield value
Answer:A

95. Which of the following viscometer is based on the principle of Stokes' Law.
A. Cup and Bob viscometer
B. Falling Sphere Viscometer
C. Cone and plate viscometer
D. Rotational viscometer
Answer:B

96. The resistance of a liquid to flow is termed as

A. Viscosity
B. Density
C. In ter facial tension
D. Surface tension
Answer:A

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97. A shear stress-shear rate relationship is generally explained in the form of
curve i.e. or………
A. Rheogram
B. Consistency curve
C. Both of the above
D. None of the above
Answer:C

98. The cgs physical unit for kinematic viscosity is ...............

A. Stokes (St)
B. Pascale (PS)
C. Newton
D. None of the above
Answer:A

99. As the temperature increases, the viscosity of liquid...............

A. Decreases
B. Increases
C. Sustainly increases
D. Remains constant
Answer:A

100. The curve for a pseudo plastic material rheogram................

A. starts at the origin
B. starts at the top
C. both of the above
D. none of the above
Answer:A

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