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2 August Biochemistry Annotated Notes

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32 views

2 August Biochemistry Annotated Notes

Bio detailed

Uploaded by

Sreehari T
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Concepts in Biochemistry

02-08-2023

Dr. Smily Pruthi Pahwa


Do
Revise REVISE
Topics REVISE
in
my REVISE
Sequence
• Fed state -

• Fasting state -

• Starvation state -
The 4 Formulas
(Smile Formulas)
Smile formula 1

7
Smile formula 2

11
13
Smile formula 3

17
Smile formula 4

18
• TCA
• ETC

• Urea cycle
• Nucleotide, DNA , RNA synthesis
• AA & Protein synthesis
CYTOPLASM MITOCHONDRIA
HMP Beta oxidation of fatty acids
Glycogenesis Link reaction
FA synthesis Ketone body synthesis & Ketone
body utilization
Cholesterol synthesis Vital pathways -TCA & ETC
Exceptions – Glycolysis, Replication, Transcription,
Glycogenolysis Translation (for mitochondrial
DNA)
Apoptosis
The Two Lipases
The Two Lipases
How to use my Smile
formulas for Q solving ?
Q1. Which of the following is active in dephosphorylated state? (PGI)
a) Glycogen synthase
b) Pyruvate carboxylase
c) Glycogen phosphorylase
d) Acetyl CoA carboxylase
e) Pyruvate Dehydrogenase
Q2. Which of the following does not occur in mitochondria? (AIIMS
NOV 2016)
a) Beta-oxidation
b) Fatty acid synthesis
c) DNA synthesis
d) Protein synthesis
Q3. Insulin promotes lipogenesis by all except
a. Decreasing cAMP
b. Increase glucose uptake
c. Inhibiting pyruvate dehydrogenase
d. Increasing acetyl CoA
Q4. Mitochondria are involved in all of the following except:
a) ATP production
b) Apoptosis
c) Tri-carboxylic acid cycle
d) Cholesterol synthesis
Q5. Hormone sensitive lipase is not activated by-
a. Insulin b. Glucagon
c. Catecholamines d. Thyroid
Q6. Which of the following is not seen in low insulin-glucagon ratio?
A. Gluconeogenesis
B. Glycogen breakdown
C. Ketogenesis
D. Glycogen storage
Q7. Which of the following is active in dephosphorylated state?
a) Glycogen synthase
b) Pyruvate carboxylase
c) Glycogen phosphorylase
d) PEPCK
Q8. All occur in mitochondria except- (PGMEE 2015)
a. Glycolysis b. TCA cycle
c. ETC d. Ketogenesis
Q9. The biosynthesis of the enzyme pyruvate carboxylase is repressed
by- (PGMEE 2012-13)
a. Insulin b. Cortisol
c. Glucagon d. Epinephrine
Q10. Which of the following is active in phosphorylated state?
a) Glycogen synthase
b) Glycogen phosphorylase
c) Acetyl CoA Carboxylase
d) G-6-PD enzyme
Q11. A professional cyclist has been preparing for a long race competition. To
guarantee that muscle glycogen is stored after the workout, his coach strongly
advises that he consume carbs. Which of the following will most likely cause an
increase in the activity of rate limiting enzyme of muscle glycogenesis under such
resting state?

A. Glucagon
B. Epinephrine
C. Phosphorylation
D. Dephosphorylation
Cyclic AMP & Cyclic GMP
Sources of Blood glucose
Q. A person frequently eating roadside food presents with intractable
vomiting to a physician office due to food poisoning. He was unable to
eat or drink properly for the past 3 days. Blood examination still showed
normal glucose levels. Which of the following is most important for the
maintenance of the blood glucose in this patient?

A.Liver glycogenolysis
B. Liver gluconeogenesis
C. Muscle glycogenesis
D.Muscle glycogenolysis
Fuel in Fed, Fasting and
Starvation
Fed Fasting Starvation
Brain
Heart
Liver
Muscle
Adipose tissue
RBC

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