Methylene Blue & Metabolic Medicine

The “Magic Bullet” & Futuristic Medicine.

Many of the suggestions in this chapter are not meant to be performed without consulting your
healthcare provider first.

Metabolic Medicine, the Future of Medicine.

Metabolic medicine is the future of medicine as the most
“upstream” aspect of health and is at the root of most all
diseases. Our current pharmaceutical-based medical
system is a broken system. Your body is a self
It has failed miserably as we healing, self
have more disease than regulating and
many countries here in the USA while we possess most of the intelligent
organism with
medicines, yet we are much sicker than most countries with far less
contains all it
“modern” pharmaceutical-based health care. Bottom line is our
needs to be
drugs are killing us. The idea that we healthy and repair
Many human can “cure” disease by giving a certain itself.
diseases involve
molecule (drug) for a certain
abnormal metabolic
states that interrupt condition has shown to be like painting over rust leaving the
normal physiology patient as the victim to only need more drugs for side effects of the
and lead to tissue first drug and so on. Your body is a self-healing, self-regulating
and cellular and intelligent organism with contains all it needs to be healthy
disruption.
and repair itself. It’s not about chasing genes either because your
genes fail due to a poor stress response which is generally caused by a poor metabolic capacity
of your cells. Any human diseases involve abnormal metabolic states that interrupt normal
physiology and lead to tissue and cellular disruption. When you get to the top of the mountain
where the stream begins you have metabolism and the ability to make adequate energy with as
little waste as possible. This is a new health paradigm for treating disease which will allow the
body with its innate wisdom to figure the complexities out with its new found spark of life. Not
only does this medicine work but it actually
addresses the cause of many conditions. In this
article we will dive into how to use the science of
metabolic medicine to gain better health and
vitality. In order to fully understand how
metabolic medicine works you need to have a base
of knowledge of the mitochondria.

Mitochondria & Cellular Wellness

The mitochondria are where you convert glucose and oxygen into energy through something
called the electron transport chain. This is where electrons are moved through a chain of
chemical reactions to produce what's called an exothermic reaction. Moving electrons creates
energy your cells utilize to do work, like keeping up with all of their functions. Just like a train
which burns coal to produce energy that drives the train down the tracks, your cells burn sugar.
And just like the train produces toxins that are released when the coal is burned in the form of
smoke, your cells also produce a toxic by product called
Melatonin is produced
oxidation. The ability of the mitochondria to stay healthy and
by every mitochondria
and is the primary way continue to efficiently make energy hinges on its ability to
that the mitochondria neutralize these harmful byproducts. Antioxidants are the
neutralizes the stress of primary method the mitochondria use to do this. Consider your
oxidation. brain is 2% of your bodyweight however it consumes 20% of
the overall energy. Your brain and your heart are the two most energy demanding systems and
require a high total energy supply. When that starts to run low, both your heart and your brain
being very “metabolically sensitive” organs will begin to show signs of stress such as being
 fatigued and developing disease. Making your
mitochondria more efficient is the name of the
game to improve all aspects of health, vitality and
lifespan. The good news is there are some great
ways to do this through something called the
cytochrome pathway. There are 4 complexes in the
cytochrome pathway and I will reveal a way to
access all 4 cytochrome pathways later. I will also be discussing strategies to greatly improve
mitochondrial function through something called autophagy and mitophagy. First it is important
to fully understand how stress and cytokines work at the cellular level to appreciate some of my
methods that I will share.

Stress, Cytokines & Melatonin.

All stressors lead to one outcome which is inflammation. Whether it's a sunburn, an infection or
even intense exercise there is a specific set of cytokines that are responsible for the inflammation
that occurs, which in essence is cellular stress. When that inflammation or the cytokines become
too overwhelming for the cell to deal with, it switches its energy production method from
moving electrons in the mitochondria to a very primitive way of making energy called aerobic
glycolysis. The problem with aerobic glycolysis is that it only produces 10% of the energy that is
otherwise created through the electron transport chain. This is what chokes off the energy
reserves with COVID-19 when a patient goes into a cytokine storm that typically leads to death
due to acute respiratory distress syndrome. Melatonin is the molecule that is the primary
antioxidant within all of your cells that neutralizes this oxidation and can return the energy
production back to its proper 100% functioning
through the electron transport chain. I wrote a
book called Melatonin: Miracle Molecule. You
can find information on this at
melatoninbook.com. In that book, we discussed
how melatonin has been shown to enhance the
health of virtually every system in your body.
There is a large body of research that supports the use of high dose melatonin for a variety of
different diseases. When you consider that the brain and the heart are the two most metabolically
sensitive organs in the body it is easy to understand that melatonin may improve the function of
the central nervous system and support many people looking to improve the health of their brain.

Stress & The Metabolic Ceiling.

In the image above factors that dictate metabolic capacity or the ceiling are factors that affect mitochondrial
function. Poor mitochondrial function will become limiting when there becomes more stress than you are
able to adapt or compensate for and you hit the ceiling!

Whenever we want to create strength or activate a healing response in the body it is always
through stressors acting on your genes where your body responds and you have a net gain in
health. They call the zone that you benefit most from the hormesis zone. The familiar zone is
when there is too little to activate any changes and the danger zone is when it’s too much
activation or stimulation. The metabolic ceiling is what limits the hormetic zone’s outer boarder.
Using metabolic medicine to support the mitochondrial function, you get stronger autonomics
and better fuel delivery and utilization. This way you have a positive effect on how far you can
push into the hermetic zone before hitting the danger zone.
The Cytochrome Complex. What is it & why would you
want to know about it?
The word cytochrome when you break
it down is cyto /cell and chrome/light. It
is a way your cells can use the energy in
light to convert it into energy. The
cytochrome complex consists of
cytochrome I-VI and consist of small
"hemeproteins" found associated with
all of your mitochondria. The complex
belongs to the cytochrome c family of
proteins and plays a major role in cell
apoptosis and is an essential component
of the electron transport chain, where it actually carries an electron. It primarily transfers
electrons between Complexes III (Coenzyme Q ) and IV (CCO). The cytochrome complex helps
your mitochondria shuffle electrons which allows your cells to make energy. Next, I will get into
red light therapy and how your mitochondria convert red light into ATP and later how methylene
blue can supercharge this system.

Red Light Therapy & Photo-Bio-Modulation.

Photo-bio-modulation refers to Photo/light, Bio/Your Body.
Cells then, of course, have the ability to modulate them to
support them to be stronger and more resilient. Photo-bio-
modulation therapy relies on the use of specific light
parameters to promote tissue repair. Although demonstrated
in different cell models and tissues. Studies suggested that
cellular healing and repair is enhanced by both red and near-
infrared light. Photobiomodulation involves the activation of
the mitochondrial respiratory chain using the cytochrome
complex. The healing effects of light therapy was first used in the late 1800s to treat skin
tuberculosis (TB), and NASA used it in the 1980s to grow plants in outer space.

Low-level laser/light therapy or photobiomodulation, refers to the use of red-to-near-infrared

range (620–1100 nm) to stimulate cellular functions for physiological or clinical benefits.
Photobiomodulation has been used to improve wound healing 1,2, reduce pain 3,4, and many
other healing and regenerative applications. The light can be supplied by lasers or light-emitting
diodes (LEDs). Transcranial LLLT has amazing therapeutic
uses in various neurological and psychological conditions, including ischemic stroke 5,6,
chronic traumatic brain injuries 7,8, and depression 9,10. Using endo-nasal along with
transcranial LLLT is a promising upgrade. A Study using a LLLT to the forehead, Barrett and
Gonzalez-Lima demonstrating that LLLT to the forehead benefits cognition in healthy humans,
including enhanced attention, working memory, and executive functions 11,12,13. Remember
though the red light only works on the one cytochrome oxidase (CCO) complex IV. What if we
can get all 4 complexes to activate? We will discuss ways to further enhance this to the max for
even greater benefit.
Red light as a treatment is considered bio-active in humans cells and can directly and specifically
affect and improve mitochondria function through the CCO. [14] Red light photons are absorbed
by our cells and converted to energy. This energy produced can then stimulate the production of
collagen, elastin, and adenosine triphosphate (ATP), which is great for skin however it goes
much deeper and can have diverse positive effects on all aspects of health and vitality due to its
mitochondrial enhancing properties.

In the study “Interplay between up-regulation of CCO and hemoglobin oxygenation induced by
laser”, the author describes how this process using red-to-near-infrared light can stimulate
cellular functions for physiological or clinical benefits. The mechanism of LLLT is assumed to
rely on photon absorption by cytochrome c oxidase (CCO). [15]
A case study at UCSF found light therapy had positive effects for a pro hockey player with
persistent post-concussive symptoms, [16] and several VA Boston case studies showed good
outcomes of light therapy for former pro football players with symptoms due to repetitive head
impacts. In addition, researchers are studying light therapy for PTSD, Parkinson’s Disease (see
also Dr. John Mitrofanis’ book Running in the Light),
Alzheimer's Disease, and dementia. The effects include
increased cerebral blood flow, increased (ATP) energy
production, increased neuroprotection and brain repair, and
reduced inflammation. A 2019 study found that using light
therapy applied to the head (transcranial) and intra-nasally has a
positive effect on brain wave patterns in just one treatment; read
more about the study here. [17] I wish I could place lasers on my balloons when I treat patients!
Using red light therapy may enhance any endo-nasal release program. We use it intravenously as
well with Lumestem. The use of this type of therapy into the ears holds promise. Read more
about this in chapter 11. Red light therapy is best done for NO more than 10 minutes per day. I
personally stand between eight panels every morning. Next, we dive into how you can enhance
all 4 cytochrome subunits to really drive healing and regeneration.

Introduction to Methylene Blue. A Key to Cellular Wellness

A brilliant blue salt, methylene blue or MB was first used as a dye. It is now known that MB
improves mitochondria respiration and might be a magic bullet within metabolic medicine. In
1870, MB was discovered and used as an industrial dye. Soon after MB was found to be a great
way to stain human tissues and microbes for microscope examination. They found that MB
would even inactivate certain microbes. An anti-microbial that leaves cells and tissues virtually
unharmed. That’s right, a powerful antimicrobial! It gets even more impressive so stay with me.
MB was one of the first chemotherapeutic medications ever tested in humans. It was used to treat
malaria, in 1891. Of course, it was replaced by antibiotics when they first came on the scene
even though MB is superior to them. With heavy marketing by big pharma to doctors a shift was
made to these new “superior” anti-microbials. Are they really superior? We have now found that
antibiotics can have negative effects to our health through killing our microbiome and that many
bugs can become resistant to the antibiotics. The treatment of malaria with antibiotics has
proven that this is not the best way as many of the antibiotics have created resistant strains thus
making them useless. With MB there has been NO detection that the micro-organism have
resistance to MB unlike antibiotics. Your micro biome is an incredibly important diverse group
of bacteria that coexist in your body, mostly your gut. The malarial parasites, Plasmodium
falciparum, is now showing an increased resistance to common antimalarial drugs. As a result,
methylene blue is being considered a better option.

Methylene Blue & Nitric Oxide

MB is a powerful inhibitor of nitric oxide or N0. There is a lot of hype
NOS is a
around the benefits of NOS and its ability for open up blood vessels to signaling
improve circulation. Viagra works on NOS and has been hugely successful molecule
to improve the male and female erection. But is it really as safe as is and assists
generally thought? There are 3 types of NOS named according to their
us in stress
responses.
activity or the tissue type in which they were first described. They
are neuronal NOS (or nNOS), endothelial NOS (or eNOS) and inducible NOS (or iNOS). NOS is
released in short and brief moments of stress exposure and it is a vital and important molecule to
support us. NOS is also a free radical and is a powerful oxidant that the body needs to neutralize.
Too much NOS is associated with tissue damage and is an aging accelerate. It is also part of the
toxic air pollutant. In 1990, droves of scientific research were released claiming NOS to be safe
as well as a powerful molecule to treat many diseases such as erectile dysfunction, heart function
and as a stroke preventative. In 1992, NOS was pro-claimed molecule of the year. NOS went
overnight from toxic free radical to miracle drug.

NOS is Part of the Bodies Stress Response!

NOS is a signaling molecule and is best used in short and measured dosage. We use Ozone in
our clinic with great success and it is also a powerful free radical. Why is ozone helpful? Ozone
like NOS is a signaling molecule and signals stress in the body that can enroll a hermetic
response as long as its dosage is within the hermetic zone and not into the danger zone.
Chronically elevated NOS or ozone would NOT be beneficial to the body for the same reasons.

NOS is taken commonly by body builders and men with ED on a daily basis. l-arginine and
citrulline are both precursors to NOS that are in many body building and endurance supplements.
NOS can give you a pump through an enhanced inflammatory response within the muscles but
may not be the healthiest strategies long term.

Also, anyone looking at maximizing fitness might consider this study in 2015 where a scientist
found that NOS powerfully inhibits testosterone. Using a NOS inhibitor like MB might negate
these effects as in the above study. “Warning to men: Erection drugs might kill you!” In this
article by Michael Castlemen. [18] Since its approval in 1998, Viagra has been implicated in
1,828 deaths and Cialis 236 and Levetra 221. Between the 3, that accounts for 2500 deaths and
25,000 other side effects such as mini stroke, vision loss and hearing loss.

The dirty secret with these studies is that the studies look at only
a few thousand and if a drug kills say 1 in say 100,000 that side
effect may not show up in the study. The problem is that
millions of men are now taking Viagra and the results are that
thousands have died due to this fact. The most common problem
that leads to dearth is when there is a co-administration of nitroglycerine so the person would get
a double dose of NOS in that case.

Chronic elevated NOS levels can cause cardiovascular disease, MS, Alzheimer’s, Dementia and
other degenerative neurological diseases. Recent study showed a dramatic increase in skin cancer
after Viagra use with an 84% increase in melanoma. [19]

Just because NOS dilates blood vessels doesn’t mean it’s good for you long term. It will help the
tissues receive more blood flow however due to the cytokine elevation it will inhibit the oxygen
utilization through the electron transport chain through inhibition of CCO. NOS in high amounts
cause the opposite and you will have vasoconstriction. NOS is also involved in the inflammatory
response. [20]

In the paper called “The NOS Hypothesis of Aging” the author presents the causes of aging,
suggesting one of the prominent theories of aging is the free radical theory. According to this
theory, free radicals generated through mitochondrial metabolism can act to cause abnormal
function and cell death. Various toxins in the environment can injure mitochondrial enzymes,
leading to increased generation of free radicals that, over the life span, eventually play a major
part in aging. [21] Aging of the anterior pituitary and pineal will result in decreased secretion of
pituitary hormones and the pineal hormone melatonin. The induction of iNOS in the
temperature- regulating centers by infections may cause the decreased febrile response in the
elderly by loss of thermosensitive neurons. NOS may play a role in the progression of
Alzheimer’s disease and Parkinsonism.[22] Activation of cytokine and iNOS production in the
cardiovascular system leads to coronary heart disease. [23] Antioxidants, such as MB,
melatonin, vitamin C, and vitamin E play important roles in reducing or eliminating the oxidant
damage produced by NOS. [24]

NOS and angiogenesis. In the short term, like following an injury, elevated levels of NOS to
increase angiogenesis might be helpful, however, chronic activation of angiogenesis might put
you as a higher risk of cancer.

It’s not the virus that kills, it’s the cytokine storm. NOS is the primary molecule that causes the
cytokine storm. The cytokines then signal a shift in the cellular energy away from the electron
transport chain to aerobic glycolysis. This cuts down available energy by 90% causing the
immune system to literally starve and become taken over by the infection. This is, in essence, the
cytokine storm with COVID-19 and any other viral infection. We will dive deeper into how MB
supports recovery from infection later. Its inhibition of NOS is one way besides its anti-viral
properties.

Looking close up one see’s NOS as an enhancement of circulation however step back and look at
things more wholistically it’s clear that it’s not the right approach and its likely to cause more
harm than good. MB as a powerful inhibitor of NOS and this is one of the ways MB supports the
body.
Methylene Blue: Magic Bullet.
The term magic bullet is a scientific
concept developed by a German Nobel
laureate Paul Ehrlich in 1900.[25]
Ehrlich formed an idea that it could be
possible to kill specific microbes (such
as bacteria), which cause diseases in the
body, without harming the body itself. He named this agent as Zauberkugel, the "magic bullet."
This magic bullet was methylene blue! Methylene blue does seem to have very little negative
effects and is extremely safe to consume. Since it works on an upstream aspect of health which is
the energy production or metabolism, it supports the body in a wide range of conditions. If you
give the energy reserves the body needs to work, it will correct disease much better than any
man-made chemical such as with virtually all pharmaceutical approaches to health and disease.

Methylene Blue & Mitochondria

Methylene blue is anti-inflammatory and neuroprotective showing promise in treatment of
diseases such as stroke, Alzheimer's disease and Parkinson’s disease. [26]

Remember your mitochondria works through the electron transport chain where it shuffles
electrons, which releases chemical energy that the body uses to make ATP, which is the energy
currency in our cells. Methylene blue is an electron carrier and even recycles electrons, which
allows it to improve mitochondrial function. It basically turns your mitochondria into super
mitochondria! It is highly beneficial in toxic situations in the brain as it encourages cellular
oxygen consumption and decreases anaerobic glycolysis. This fits into the melatonin
conversation where stress induces cytokines (inflammation) and causes the cell to switch to the
inefficient, anaerobic glycolysis. We will dive into melatonin in another section. Where
methylene blue really shines is that it improves the electron transport chain in the mitochondria
such that it recycles electrons. This shifts your cells into a very efficient energy producing
quality.
Methylene Blue & The Brain
Studies show a memory-enhancing and neuroprotective
metabolic mechanisms of action of methylene blue for the
brain. The memory-enhancing effects have been associated
with improvement of memory consolidation. In addition,
low doses of methylene blue have also been used for
neuroprotection against mitochondrial dysfunction in human
disease. There are neurometabolic mechanisms for memory
enhancement and neuroprotection from methylene blue. [27]
Another study showed that MB administered could enhance
memory through an increase in brain cytochrome oxidase activity. Another study using brain
MRI’s showed impressive brain support. Multimodal Randomized Functional MR Imaging of
the Effects of Methylene Blue in the Human Brain. [28]
Extinction Memory Improvement by the Metabolic Enhancer Methylene Blue. Ref MB may also
function as a cholinesterase inhibitor, [29] increasing the amount of acetylcholine available, a
neurotransmitter in the brain responsible for arousal, attention, memory and motivation. [30]

The relationship between methylene blue (MB) and Alzheimer's disease (AD) has recently
attracted increasing scientific attention since it has been suggested that MB may slow down the
progression of this disease. MB has been shown to reverse the formations of amyloid plaques
and neurofibrillary tangles responsible for AD, and to partially repair impairments in
mitochondrial function and cellular metabolism. [31] This pharmaceutical drug derived from MB

has also shown benefit in both Alzheimer’s disease and frontal temporal dementia (Lewy Body
Disease) and is currently in late phase trials. [32] I’m sure these types of trials may place MB at
risk of becoming too expensive for many of us. MB has also been shown to assist healing in
traumatic brain injuries by promoting a self-cleaning mechanism called Autophagy and calming
down the inflammation that occurs after a head trauma that is associated with microglial cells
becoming over activated. “Methylene blue exerts a neuroprotective effect against traumatic brain
injury by promoting autophagy and inhibiting microglial activation.” [33]
Methylene Blue is Anti-Viral.
Besides improving mitochondrial function, methylene blue
also has antiviral properties. It displays broad-spectrum
virucidal activity in the presence of UV light and has been
shown to be effective in inactivating various viruses in blood
products prior to transfusions. [34] Methylene blue displays
virucidal preventive and therapeutic activity against influenza virus H1N1 and SARS-CoV-2.
[35]
A recent French publication on a cohort of 2500 end stage cancer patients treated with MB
during the first wave of CoviD-19 mentions a possible protective role of MB against respiratory
viruses, as this study group showed no reported cases of influenza or SARS-CoV-2 infections.
[36] It makes sense that immune cells with stronger energy reserves work better to keep you safe
from infections. The “inner mask” is more powerful than an outer mask. Experts that have
looked into the efficacy of wearing a mask find them to be ineffective anyway. [37]

The body will not become sick or warn out prematurely for no reason. Having treated many dis-
eases over the years, I've come to the conclusion that it's either toxins or infections that are at the
root of the disease. New science is demonstrating that many of the proteins such as beta amyloid
and alpha synuclein are the immune system's response to these toxins and or infections and most
often there are both involved. I have found virtually all of the patients that have come to me test
positive for at least one but typically two different viruses. I often test for Epstein Barr,
cytomegalovirus, and HHV6 as well as an immune marker called CD57. A lab called Cyrex runs
an array 12 that tests about 25 different microbes. Things like ozone & methylene blue have
qualities to both improve mitochondrial status as well as having an antiviral/anti-microbial effect
making them great therapeutic substances for any brain-based conditions.

Methylene Blue is an Anti-depressant

In higher doses, methylene blue seems to be a powerful anti-depressant. Keep in mind that in
higher doses, MB acts as an MAO inhibitor. This is why it can be dangerous to take
antidepressants along with higher doses
of MB. In this study, methylene blue at
15 mg/day, was compared with placebo
in treatment of severe depressive illness.
The 3-week trial showed that the
improvement in patients receiving
methylene blue was significantly greater than in those receiving placebo. Methylene blue at a
dose of 15 mg/day appears to be a potent antidepressant, and further clinical evaluation is
essential. [38]

Methylene blue increases autophagy which is cellular cleaning and recycling. This study showed
MB induced neuroprotection by enhancing autophagy. [39] Due to this, methylene blue might be
considered something helpful during fasting. We will get into fasting a little later. In order fully
understand fasting and how it works to enhance your mitochondria, we need to review some
concepts on how the body clears out old cells and mitochondria recycling them into brand new
cells and mitochondria.

MB, Fasting, Autophagy & Mitochondria

Mitochondrial dysfunction is a hallmark of metabolic decline (vitality) during aging. [40].
You’re constantly replacing your old, weak, dysfunctional mitochondria with new healthy fresh
mitochondria or “mito”. The population of all the mito of a given cell constitutes your
Chondriome. Like your microbiome, we have a healthy pool of bacteria or an unhealthy pool.
This will dictate how functional they are. The average cell in your body has between 1,000-
2,000 mito. Again, they turn over as they get old. They are recycled, and it’s a process medicated
through a gene expression ruled by mTOR.
The mTOR pathway is a central regulator of metabolism (vitality) and physiology (function).
Without getting too deep into mTOR, for now, let’s just leave it at the fact that when mTOR is
inhibited, we shift into a cleaning and recycling phase where we see Autophagy and Mitophagy.
Autophagy is a Latin word that translates into “self-eating.” Autophagy is the body’s way of
cleaning out damaged cells in order to regenerate newer, healthier cells. [41]
Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to
defective mitochondria following damage or stress. [42] Remember all the types of stress? These
ALL have an impact on the demand for Mitophagy to be activated through mTOR![43] So what
activates mTOR and Autophagy? Fasting is the primary activator of this process and MB also
activates it! We will revisit this soon, but first, we need to talk about senescent cells. What are
senescent cells, and how do they have a detrimental effect on health and life span? As they
accumulate, due to poor Autophagy (which normally removes and recycles them), they turn into
fresh, healthy cells and fresh, healthy mito.

Cellular Senescence, Zombie Cells & How to Recycle to New Cells.

Cellular senescence is an irreversible
cell-cycle arrest mechanism that acts
to protect against cancer. [44]
Basically, cellular senescence is a
permanent state of sleep a cell goes
into. This state is associated with a
release of inflammatory products, and higher energy consumption, pulling it away from your
healthy cells. They are zombies in the literal sense! Production of pro-inflammatory cytokines, is
a common feature of senescent cells.
These “zombies” will float around your body spewing inflammation and sucking the life out of
your body, by deferring vital energy that would normally be going to healthy cells.
We discussed ozone as a signaling molecule when we discussed NOS. Ozone works through
hermetic activation in the body which results in a very powerful autophagy and mitophagy
response. NOS, on the other hand, inhibits autophagy. [45] I will often have my patients do
ozone and MB during their fasting phase. There are home units you can purchase and do rectal
instillations that are very powerful. There are also saunas that can be purchased that deliver
ozone quite efficiently. As stated, methylene blue such as in Lumotol Blue activates autophagy
and can be taken during fasting. [46]
Silver & Gold Enhance MB.
Using nano silver and gold mixed with MB can
greatly enhance its photobiomodulation abilities.
The precious metals work by enhancing the
cytochrome complex when combined with MB
which allows more electrons to flow through the
chain within the mitochondria.

Silver Nanoparticles Decorated with Methylene

Blue Potentiated the Photodynamic Inactivation of Pseudomonas aeruginosa and Staphylococcus
aureus. [47] Synergistic reaction of silver nitrate, silver nanoparticles, and methylene blue
against bacteria. [48]

The antimicrobial properties of light-activated polymers containing methylene blue and gold
nanoparticles. [49] Gold nanoparticles has been studied in combination with MB for cancer with
great promise as it supports photodynamic therapy (PDT). [50]

I have developed a special medical protocol called LumeBlue, combining nano gold, nano silver
and MB together in an infusion. Once the IV is dripping into the patient, a Laser IV is started
using 660nm wavelength to photoactivate the mixture. The IV lasts about 45 minutes to 1 hour.
Oxygen therapy following the IV has great benefit. In my clinic, we use both hyperbaric oxygen
therapy or the CVAC chamber. Oxygen therapy enhances the LumeBlue protocol due to drive
more oxygen into the cells to further support the electron transport chain within the
mitochondria.

Guidelines to Methylene Blue Use.

According to experts, the proper dosage for methylene blue is between 20 and 60 mg per day.
Lower doses may be taken if nano silver and gold are combined with the MB for greater effects.
Much higher doses can be used in special circumstances, however, there can be a diminishment
in effect with doses higher for mitochondrial support. It’s important that higher doses be
monitored through a healthcare practitioner. One of the
concerns with methylene blue consumption is serotonin
storm when methylene blue is taken with SSRIs,
SNRIs or drugs that increase serotonin levels such as
anti-depressants and other MAOI inhibitors. Do not
take MB if you are pregnant or breastfeeding as it is
contraindicated. At high doses (>10mg/kg), methylene
blue may cause a litany of potential side effects
including hypertension, methemoglobinemia, dizziness,
GI distress, alters pulse oximeter readings, can induce
hemolytic anemia in people with a genetic condition called G6PD.

It is important that your source of methylene blue is pharmaceutical grade as any other level of
quality may carry significant heavy metals and other toxins. MitoZen.com carries a few different
products that contain clean MB. You can find sublingual methylene blue in drops or troche’s
however this will turn your mouth completely blue which may look strange. MB is safest and
best absorbed when it is slowly released into your body. MitoZen.com has created a suppository
called Lumetol Blue which may provide better absorption due to the sustained release. This
product can also be taken orally and will not leave any blue stain in your mouth if you break up
the 300 mg suppository into quarters and place the ¼ suppository toward the back of your throat
and swallow it down with a drink.

The use of methylene blue intravenously in my clinic along with red light & oxygen therapy has
shown to be of benefit in most all cases that I have
used it. Because supporting mitochondria and overall
cellular energy is such an “upstream” therapeutic it has
benefited many of my patients with a variety of
conditions. I’ve used this protocol on neurological
cases such as Parkinsons & brain injuries, Lyme &
mold cases, viral infections, autoimmune conditions
LumeStem with Red light at 660nm. Part of the
and general wellness/longevity programs. Methylene LumoBlue protocol at Advanced Rejuvenation.
 blue is considered photo dynamic, meaning that it has a
response to light. Red light in particular in the 660 nm is the
sweet spot for methylene blue. We use a system called
Lumestem which is an intravenous laser along with the
methylene blue. We also use red light panels where are you
stand in front of them and receive the light therapy through
the skin after a MB infusion.

CVAC Pod at Advanced Rejuvenation. Cyclic

We will then use either hyperbaric oxygen therapy or the
Variations in Adaptive Conditioning is what
CVAC pod. Flooding the body with oxygen after MB further
CVAC stands for.
drives ATP production after receiving MB. We call this
protocol LumeBlue. This protocol can also be combined with fasting to allow for proper
autophagy and mitophagy to create new strong mitochondria. I have been working with a
protocol that can be done at home using methylene blue and redlight panels. Using a suppository
called Lumetol Blue along with red light panels set to 660 nm called MitoLights. It’s also great
to go out and get some sun after receiving MB to gain even more photobiomodulation activity.

“At home” example of a MB program.

If you are unable to get to a clinic that provides MB IV, then I have designed a program for those
that would like to effectively use MB at home. Since there are only a handful of clinics that are
properly trained in the use of MB this might be your best option. You can find MB as an oral
tincture, nasal spray and suppository through MitoZen.com. This is the Lumotol Blue line of
products. The Lumetol Blue suppository comes in a 60 and 300 mg dose. The 60 mg is
recommended for rectal delivery and is well tolerated. The 300mg is not well tolerated rectally
and it is better for orally delivery and will not leave any blue stain in your mouth if you consume
it correctly. First break up the 300 mg suppository into quarters and place the ¼ suppository
toward the back of your throat and swallow it down with a drink. Its best to give yourself 15
minutes between each ¼ as to not cause nausea. I find that having my patients pulse the MB 2-4
times a week seems to work best. On days you choose to take MB, you might consider your dose
per day you would like to be at. Of course, it’s best to find a health care provider that can advise
you. However, if you need support, then you could reach out to my team about my coaching
programs. See our email after the conclusion. Let’s say you wanted to dose 200 mg per day for 3
days. You could take one suppository and ½ of the 300 mg Lumetol Blue (two ¼ pieces or
150mg) of such that you take the 60 mg suppository in the am after your morning bowel
movement and at the same time the two ¼ pieces. After 30 minutes to an hour, if you can, get in
front of a red-light panel that is set to 660 nm. MitoLights are panels set to work with MB and
are also available through MitoZen.com. Generally, it is suggested to do only 10 minutes a day
with red light therapy, however on MB days, I often suggest that my patients do 2 or even 3
sessions spread out though out the day. I also suggest as much direct sunlight as you can on MB
days. I will also suggest my patients consume 1 tablespoon of Argentyn 23 or Sovereign
colloidal silver 3 times throughout that day as well. If you have a hyperbaric soft chamber at
home or a clinic that has one you might consider doing that on your MB days within 1-2 hours of
consuming the MB.

Keep in mind MB is also a good supplement to take along with fasting as it promotes autophagy.
Timing is best if you take it in the morning if you’re doing intermittent fasting and skipping
breakfast. This protocol can be done for a month to boost cellular energy or for multiple months
as MB is safe to take long term such as with the case of degenerative neurologic disease. Lower
dosing such as 10-20 mg per day of MB may be considered in many cases and the Lumetol Blue
tincture or nasal spray might be a consideration. These lower doses should also be used with red
light, silver, and an oxygen therapy if available. Also be prepared to see blue to green urine for
up to 2 days following an MB Day.

Conclusion
There are few things more important than a strong metabolic
Metabolic medicine
status. Keeping your cells energized allows the full expression
addressing the
of life force through your body, particularly important to your
mitochondria and
brain and heart. MB will work much better when you are the energy reserves
getting proper sleep. I suggest that you track your sleep and in the body is the
make sure you're getting enough R.E.M. and Deep Sleep. most powerful
Sleep will support your stress adaptation response and
medicine available,
restoring health at
metabolic status. When considering MB, consider all of the
its core.
stressors that we have in today's world which makes it more
important for us to take some extra precautionary steps. It’s as easy as integrating some rituals
into your daily routine. 10 minutes of red-light therapy in the morning with a device like the
MitoLight should be considered along with methylene blue such as Lumetol Blue. I have
designed a fasting protocol called Fast Track Fast. Red light therapy along with fasting with Fast
Track Fast are great
options to enhance
your health through
metabolic pathways…
what I call “upstream
therapies”. These are therapies which address metabolic conditions through enhancement of the
mitochondria. Many types of treatments and modalities are what I called downstream where it
addresses genes or enzymes or various chemical reactions in the
body. In my clinical practice I prefer to go as upstream to the core
of what’s disturbing the health and vitality of the cell. Remember
the body is an amazing machine with self-regulating, self-healing
through the innate intelligence within the body. When your cells
are given the right energy, that wisdom can do a much better job
than throwing chemistry at a specific system. When you address
the function of the mitochondria through metabolic medicine you
have what I consider to be the ultimate situation to recover from a
condition or simply be at your functional best. I always recommend
people work with a healthcare provider whenever they start any type
of program using MB. For more information on melatonin go to the website
melatoninbook.com to find my book Melatonin: Miracle Molecule.

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