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42 views2 pages

BTG3

Uploaded by

mehakmaqbool99
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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BACHELOR WITH BIOTECHNOLOGY AS MAJOR

5TH SEMESTER
BTG 522J3: Biostatistics and Bioinformatics
CREDITS: THEORY – 4, INTERNSHIP – 2

 Course Learning Objective: Through this course, students will learn about the
applications of statistics in life sciences and about essentials of bioinformatics.
 Expected Learning Outcomes: At the end of the course students should be able to;
⮚ collect, represent and compute different parameters of data.
⮚ establish the relationship between different data variables.
⮚ use basic bioinformatics tools.
⮚ predict protein structure and make phylogenetic trees.

Unit – 1 (15 HOURS)


Sample, Population, sampling techniques (random and non-random). Data collection and its
representation (Histogram, Bar Chart, Pie chart, Frequency curve). Mean, Median, Mode and
their comparison. Dispersion (mean deviation, standard deviation and variance, coefficient of
variance).
Unit – 2 (15 HOURS)
Sampling distribution. Confidence intervals. Test of significance: standard error of mean, p-
value & statistical significance, students’ ‘t’ test, paired and unpaired t test. Chi square test.
F-test and analysis of variance (null hypothesis, analysis of variance ‘ANOVA’).

Unit – 3 (15 HOURS)


Introduction to bioinformatics and its applications. Introduction to biological databases
(types: sequence, structure, pathway & disease database). Nucleic acid databases (NCBI,
GenBank, EMBL). Protein databases (PIR, Swiss-Prot, PDB). Sequence similarity, identity
and homology. Alignment: local and global alignment, pairwise and multiple sequence
alignments, BLAST, FASTA and CLUSTALW. Introduction of PubMed.

Unit - 4 (15 hours)


Reading frames and identification of reading frames. Basics of genome annotation and gene
identification tools (NCBI genome). Basic idea of phylogenetic trees. Protein structure
analysis: importance of protein structure determination/prediction. primary structure analysis
(protparam), secondary structure prediction (JPred, PROSECSC). Introduction to protein

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motifs and domains (prosite). Tertiary structure prediction methods: homology, threading and
ab initio. Steps of homology modeling (swiss-model and BHAGEERATH).
http://www.scfbio-iitd.res.in/bioinformatics/bioinformaticssoftware.htm

INTERNSHIP (2 CREDITS)

BOOKS RECOMMENDED
1. W.W Daniel, Biostatistics: A foundation for analysis in the Health Sciences,
JohnWiley and Sons.
2. VB Rastogi, Biostatistics, Medtech
3. Kulkarni, A.P., Basics of Biostatistics, CBS Publishers & Distributors
4. Rastogi, Bioinformatics: Methods and Applications: Genomics, Proteomics and Drug
Discovery, Prentice Hall India Learning Private Limited.
5. Jin Xiong, Essential Bioinformatics, Cambridge University Press.
6. Ghosh, Z. and Mallick, B, Bioinformatics – Principles and Applications, Oxford
University Press.

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