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Internacionalization Activity Calculus

Derivatives

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8 views

Internacionalization Activity Calculus

Derivatives

Uploaded by

mariangaleano10b
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Internationalization Activity of Calculus:

Essay

Marian Andrea Echeverri, Marian Valeria Galeano – [email protected]

[email protected]

Ingeniería Biomédica, Fundación Universitaria Visión De Las Américas

Cálculo Diferencial

Ángela Liceth Pérez

06 de mayo de 2024
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Modeling the Dynamics of Life: Applications of the Calculus in Biomedical Engineering

Mathematics plays a crucial role in most fields of study, including the exploration of the universe and its

compounds. Biological systems and medical research are no exception. Among the array of mathematical

tools available, differential calculus stands out for its ability to analyze and predict the dynamic processes

within living organisms. Despite occasional assertions that biology and mathematics should remain separate

realms, the synergy between the two disciplines often leads to significant discoveries and a deeper

understanding of various phenomena.

According to [1], the formulation of a mathematical model, incorporating variations of time (commonly

denoted as Δt or Delta Time) from state A to B of a molecule, proves invaluable in determining the probability

of transitions between states at the molecular level, encompassing limits and irreversibility of approximations

using derivative methods to yield essential results. These transitions and methodologies find extensive

application in biochemistry and are particularly relevant to biomedical engineering, where they underpin the

study of reactions and the pivotal role of enzymes as catalyzers.

Biomedical engineers encounter several distinctive challenges when employing computational modeling and

simulation (CM&S) as their primary tool:

Validation in Realistic Environments: The complexity of biological processes and the inherent variability

across populations pose significant hurdles in validating models of biological systems within realistic

environments. Ensuring the fidelity of these models to real-world scenarios remains a formidable task.

Population and Biochemical Patterns Variability: Biological and biochemical systems exhibit wide-ranging

variability across different populations, complicating efforts to develop universally applicable models.

Biomedical engineers must navigate this diversity when constructing computational models and must work

first in the studies of optimizations of non-dynamic pathways as seen in [2].


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Temporal Dynamics: Biological systems undergo significant changes over time “integrating processes at

various s time and spatial scales into a single and coherent formal description to allow analysis and computer

simulation” [3], influenced by factors such as disease progression, aging, or treatment interventions.

Incorporating these temporal dynamics into computational models presents a challenge for biomedical

engineers, these dynamics are widely studied to apply in the field of microbial communities [4].

The biomedical engineering field has lots of sub-studies that not only repairing and create medical equipment

but also investigation, analysis, simulation, and discovery. The area of simulation and creation includes

modeling and testing before taking anything to reality, pursuant to [5] Computational Fluid Dynamics (CFD)

whose work with differential equations “has become a powerful tool in biomedical engineering thanks to its

potential to simulate coupled and correlated systems” as a modeling tool of human hemodynamic flows which

proves that calculus is behind each test and path to the result of behaviors or anything else.

In conclusion, calculus plays a fundamental role in biomedical engineering, being crucial to understand,

model and solve a wide range of problems in this multidisciplinary field. From the design of medical devices

to the simulation of biological processes. Calculus is an essential component of biomedical engineering,

allowing professionals in this field to address complex challenges and develop innovative solutions to

improve human health and well-being, calculus offers powerful tools for data analysis and processing,

allowing biomedical engineers to extract useful information from complex data sets, such as medical images

or physiological signals.

In summary, as students of biomedical engineering, we must recognize the importance of calculus both in its

traditional form and in its more advanced applications, such as probabilistic calculations. By mastering these

tools, we will be better equipped to meet the challenges of the field and contribute to the advancement of

science and technology in the field of health.


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References

[1] L. E.-K. Lee A. Segel, A Primer in Mathematical Models in Biology, 2013.

[2] P. M. a. J. R. B. Carmen G. Moles, "Parameter Estimation in Biochemical Pathways:," Genome Research, pp. 2467 - 2474,
2003.

[3] O. M. J.-L. G. Antoine Spicher, "Undestanding the Dynamics of Biological Systems: Lessons Learned from Integrative
Systems in Biology," ResearchGate, pp. 1 - 40, 2011.

[4] H. H. W. Carlotta Ronda, "Engineering temporal dynamics in microbial communities," ScienceDirect, vol. 65, pp. 47 - 55,
2022.

[5] V. B. N. M. I. S. G. Ninos, "Uncertainty quantification implementations in human hemodynamic flows," ScienceDirect,


2021.

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