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Final Year Project Write Up Guide

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31 views

Final Year Project Write Up Guide

Uploaded by

idriscognitoleads
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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KWARA STATE UNIVERSITY, MALETE

The Green University for Community Development and Entrepreneurship

Faculty of Pure and Applied Sciences

ALDOSE REDUCTASE INHIBITORY ACTIVITIES OF


METHANOL EXTRACT OF Citrullus colocynthis POD AND ITS
COMPONENT PHYTOCHEMICALS

BY

ABDULRAHMAN OLAMILEKAN RAJI


(20/57BC/01352)

SEPTEMBER 2024
ALDOSE REDUCTASE INHIBITORY ACTIVITIES OF
METHANOL EXTRACT OF Citrullus colocynthis POD AND ITS
COMPONENT PHYTOCHEMICALS

BY

ABDULRAHMAN OLAMILEKAN RAJI


(20/57BC/01352)

A Research Project Submitted to the Department of Biochemistry,


Faculty of Pure and Applied Sciences, Kwara State University,
Malete, in Partial Fulfilment of the Requirements for the Award of
Bachelor of Science (B.Sc.) Degree in Biochemistry

SEPTEMBER 2024

ii
DECLARATION

I hereby declare that this research project titled “Aldose Reductase Inhibitory Activities
of Methanol Extract of Citrullus Colocynthis Pod and its Component
Phytochemicals” is my own work and has not been submitted by any other person for
any other degree or qualification at any other higher institution. I also declare that the
information provided therein are mine and those that are not mine are properly
acknowledged.

Abdulrahman Olamilekan Raji ___________________________

Name of Student Signature and Date

iii
CERTIFICATION

This is to certify that the research project titled “Aldose Reductase Inhibitory Activities

of Methanol Extract of Citrullus Colocynthis Pod and its Component

Phytochemicals” was carried out by Abdulrahman Olamilekan Raji. The project has

been read and approved as meeting part of the requirements for the award of Bachelor of

Sciences (B.Sc.) Degree in Biochemistry in the Department of Biochemistry, Faculty of

Pure and Applied Sciences, Kwara State University, Malete.

Dr. R.B. Ibrahim Date


Supervisor

Dr. E.A. Irondi Date


Ag. Head of Department

External Examiner Date

iv
DEDICATION
Times New Roman, 12pt, double line spacing.

v
ACKNOWLEDGEMENTS

Times New Roman, 12pt, double line spacing.

vi
TABLE OF CONTENTS
FRONT PAGE …………………………………………………………………………..i

TITLE PAGE …………………………………………….…………………………….. ii

DECLARATION ……………………………………………………………………… iii

CERTIFICATION …………….…………..………………………………………… ...iv

DEDICATION ………………………….….…………………………………………. v

ACKNOWLEDGEMENTS ………………………………………………………… vi

TABLE OF CONTENTS …………………………………………………………… vii

LIST OF FIGURES………..………………………………………………………… ix

LIST OF TABLES…………………………………………………………………….x

ABSTRACT ……………………….………………………………………………… xi

CHAPTER 1: INTRODUCTION

1.1 Background
1.2 Justification for the study
1.3 Objectives of the study
1.3.1 Overall Objective of the study
1.3.2 Specific Objectives of the study

CHAPTER 2: LITERATURE REVIEW

2.1 Overview of Diabetic Mellitus


2.1.1 Complication of Diabetes Mellitus
2.1.2 Diabetic Nephropathy
2.2 Role of Aldose reductase enzyme in diabetic complications

2.3 General Overview of Citrullus colocynthis Pod

2.3.1 Ethnobotanical uses of Citrullus colocynthis Pod


2.3.2 Pharmacological uses of Citrullus colocynthis Pod

vii
2.4 Overview of In silico studies: Molecular docking and ADMET determination

CHAPTER 3: MATERIALS AND METHODS

3.1 Materials
3.1.1 Plant Materials and Authentication
3.1.2 Chemicals and Reagents
3.1.3 Equipment
3.2 Methods
3.2.1 Ethnobotanical Survey
3.2.2 Collection and Identification of Plant Materials
3.2.3 Preparation of Extracts
3.2.4 Extraction of Crude Aldose Reductase Enzyme
3.2.5 Aldose Reductase Enzyme Inhibitory Assay
3.2.6 In silico Studies

3.2.6.1 Molecular Docking

3.2.6.2 ADMET Screening


CHAPTER 4: RESULTS AND DISCUSSIONS
4.1 Results
4.1.1 Aldose Reductase Enzyme Inhibitory Assay Result
4.1.2 In silico Studies Result
4.2 Discussions

CONCLUSION

RECOMMENDATION

REFERENCES

APPENDIX

viii
LIST OF FIGURES
Figure 1 ………………………………………………………………………………

Figure 2 ………………………………………………………………………………

Figure 3 ………………………………………………………………………………

Figure 4 ………………………………………………………………………………

Figure 5 ……….…..…………………………………………………………………

Figure 6 ………………………………………………………………………………

ix
LIST OF TABLES

x
ABSTRACT
Your abstract should be single-spaced of between 200 –300 words. It must not
exceed one page. If the language of your research is in non-English, provide the
English translation ona separate page.

xi
CHAPTER ONE

INTRODUCTION
1.1 Background

xii

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