QUIZ – Questions

Molecular Basis of Inheritance

1. A nucleoside is formed through a N-glycosidic 4) Structural
linkage by joining:
1) Phosphate group with nitrogen base 8. AUG codon is:
2) Nitrogen base with nitrogen base 1) Ochre
3) Nitrogen base with pentose sugar 2) Amber
4) Pentose sugar with phosphate group 3) Initiation codon
4) Opal
2. Process used by Meselson and Stahl for
studying semi-conservative replication of 9. A nonsense/termination codon is:
DNA was: 1) UUU
1) Chromatography 2) GCG
2) Density gradient centrifugation 3) UAG/UAA
3) Buoyant density centrifugation 4) CCC
4) Centrifugation
10. Transformation experiments in bacteria were
3. Enzyme required for joining DNA fragments first performed by:
is: 1) Macleod
1) DNA polymerase 2) Griffith
2) Adenosine deaminase 3) Pasteur
3) DNA ligase 4) Meselson and Stahl
4) Topoisomerase
11. Nitrogen bases present in a codon are:
4. Sequence of amino acids in a polypeptide is 1) 4
determined by: 2) 3
1) rRNA 3) 2
2) mRNA 4) 1
3) tRNA
4) snRNA 12. Transcription involves:
1) Synthesis of RNA over DNA
5. A = T and G = C. The relationship of DNA is 2) Joining of amino acids in polypeptide
called: 3) Synthesis of RNA over ribosome
1) Chargaff's rule 4) Synthesis of DNA
2) Le Chatelier's principle
3) Coulomb's law 13. In DNA molecule:
4) Van't Hoff rule 1) Proportion of A to T varies with the
organism
6. DNA duplication or multiplication is known 2) There are two antiparallel strands
as: running in 5’ à 3’ and 3’ à 5'
1) Replication 3) Amount of purine and pyrimidine
2) Transcription nucleotides is not always equal
3) Transduction 4) There are two parallel strands running in
4) Translation 5' à 3' direction.

7. A gene of operon which forms the repressor 14. A nitrogen base found only in RNA is:
protein is 1) Adenine
1) Operator 2) Guanine
2) Promoter 3) Cytidine
3) Regulator 4) Uracil
15. hn-RNA is: 4) One nitrogenous base with pentose sugar
1) Heterogeneous nuclear RNA
2) Homonuclear RNA 23. Lac operon is turned on when allolactose
3) Heterogeneous RNA binds to:
4) Useful RNA 1) Operator gene
2) mRNA
16. During transcription, DNA site at which RNA 3) Repressor protein
polymerase binds is called: 4) Promoter site
1) Promoter
2) Receptor 24. In lac operon, structural gene 'Z' synthesizes:
3) Regulator 1) 𝛽-galactosidase
4) Enhancer 2) Galactosidase permease
3) Galactosidase transacetylase
17. Codon AUG has dual function .It is initiation 4) None of the above
codon and also codes for:
1) Methionine 25. Purines of DNA are:
2) Valine 1) Adenine and cytosine
3) Tyrosine 2) Adenine and guanine
4) Serine 3) Thymine and guanine
4) Adenine and thymine
18. Enzyme used in transcription is:
1) DNA ligase 26. GCG stands for which amino acid:
2) DNA polymerase III 1) Alanine
3) DNA polymerase I 2) Glutamine
4) RNA polymerase 3) Proline
4) Serine
19. The experimental proof for semiconservative
replication of DNA was first shown in a: 27. Transformation was discovered by:
1) Fungus 1) Griffith
2) Bacterium 2) Watson and Crick
3) Plant 3) Meselson and Stahl
4) Virus 4) Hershey and Chase

20. Number of hydrogen bonds between A and T 28. mRNA directs building of protein through a
of DNA is: sequence of :
1) 4 1) Introns
2) 3 2) Exons
3) 2 3) Anticodons
4) 1 4) Codons

21. All the terminator codon begin with: 29. Process of translation is related to :
1) Guanine 1) Ribosome synthesis
2) Uracil 2) RNA synthesis
3) Cytosine 3) Protein synthesis
4) Adenine 4) DNA synthesis

22. 3'- 5' phosphodiester linkage occurs 30. Diagram represents “central dogma” of
between: molecular biology. Choose correct
1) One DNA and other DNA strands combination of labelling:
2) One nucleoside with another nucleoside
3) One nucleotide with another nucleotide
 3) Transacetylase
4) Lactose permease and transacetylase

35. Methyl guanosine triphosphate is added at 5'

end hnRNA in a process of:
1) Tailing
1) A-Protein, B-RNA, C-DNA, D-Translation, 2) Splicing
E- Transcription 3) Capping
2) A-DNA, B- RNA, C-Protein, D- 4) None of the above
Transcription, E- Translation
3) A-RNA, B- DNA, C-Protein, D- 36. Which codon is not an indicator of
Transcription, E- Translation completion of protein synthesis?
4) A-Transcription, B- Translation, C-Protein, 1) UAG
D-DNA, E- RNA 2) AUG
3) UAA
31. Match codons with amino acids 4) UGA

I) UUU a) Serine 37. In DNA nitrogen bases are joined to each

other by:
GGG b) Methionine 1) H-bonds
II)
UCU c) Phenylalanine 2) Peptide bonds
III) 3) Glycosidic bonds
CCC d) Glycine 4) Phosphodiester bonds
IV)
AUG e) Proline 38. DNA-dependent RNA polymerase catalyzes
V)
transcription on one strand of the DNA which
1) I – c, II – d, III – a, IV – e, V – b is called the:
2) I – c, II – a, III – d, IV – e, V – b 1) Alpha strand
3) I – c, II – d, III – e, IV – a, V – b 2) Anti-strand
4) I – c, II – d, III – a, IV – c, V – e 3) Template strand
4) Coding strand
32. Which is the site of translation of mRNA?
1) Nucleus 39. Okazaki is known for his contribution to the
2) Nucleolus understanding of:
3) Golgi body 1) Transcription
4) Ribosomes 2) Translation
3) Mutation
33. AGGTATCGCAT is a sequence from the coding 4) DNA replication
strand of a gene. What will be the
corresponding sequence of the transcribed 40. Which of the following rRNAs acts as
mRNA? structural RNA as well as ribozyme in
1) AGGUAUCGCAU bacteria?
2) UGGTUTCGCAT 1) 5 srRNA
3) ACCUAUGCGAU 2) 18 srRNA
4) UCCAUAGCCUA 3) 23 srRNA
4) 5.8 srRNA
34. Which enzyme/s will be produced in a cell in
which there is a nonsense mutation in the lac 41. The result of the following reaction/
Y gene? experiment carried out by Avery et. al. on
1) 𝛽-galactosidase Streptococcus pneumoniae has proved
2) Lactose permease conclusively that DNA is the genetic material:
 1) Live 'R' strain + DNA from 'S' strain +
DNAase 48. Part of nucleotide having nitrogen is:
2) Heat killed 'R' strain + DNA from 'S' strain 1) Uracil
+ DNAase 2) Phosphoric acid
3) Live 'R' strain + DNA from 'S' strain + 3) Ribose
RNAase 4) Deoxyribose
4) Live 'R' strain + Denaturated DNA of 'S'
strain + protease 49. Taylor conducted the experiment to prove
semi-conservative mode of chromosome
42. All of the following are part of an operon replication on:
except: 1) Drosophila melanogaster
1) An operator 2) E.coli
2) Structural genes 3) Vinca rosea
3) An enhancer 4) Vicia faba
4) A promoter
50. Synthesis of RNA molecule is terminated by:
43. Addition or deletion of a single nucleotide 1) Alpha factor
produces mutation: 2) Gamma factor
1) Frameshift 3) Delta factor
2) Inversion 4) Rho factor
3) Deficiency

Answerkey
4) Duplication

44. Which of the following RNAs should be most

abundant in animal cell?
1) r-RNA Q. No. Answerkey Q. No. Answerkey
2) t-RNA 1 3 26 1
3) m-RNA 2 2 27 1
4) mi-RNA 3 3 28 4
4 2 29 3
45. In eukaryotes, RNA polymerase II transcribe: 5 1 30 2
1) hnRNA 6 1 31 1
2) 18S rRNA 7 3 32 4
3) 28S rRNA 8 3 33 1
4) snRNA 9 3 34 1
10 2 35 3
46. If the sequence of bases in the coding stand 11 2 36 2
of a double stranded DNA is 5’ GTTCGAGTC- 12 1 37 1
3’, the sequence of bases in its transcript will 13 2 38 3
be: 14 4 39 4
1) 5’-GACUCGAAC-3’
15 1 40 3
2) 5’-CAAGCUCAG-3’
16 1 41 1
3) 5’-GUUCGAGUC-3’
17 1 42 3
4) 5’-CUGAGCUUG-3’
18 4 43 1
47. The tRNA anticodon 3-UAC-5 will pair with 19 2 44 1
the mRNA codon: 20 3 45 1
1) 5’-AUU-3’ 21 2 46 3
2) 5’-UAC-3’ 22 3 47 3
3) 5’-AUG-3’ 23 3 48 1
4) 3’-GUA-5’ 24 1 49 4
25 2 50 4