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3-Propylidenephthalide 076

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14 views3 pages

3-Propylidenephthalide 076

Uploaded by

Arfianda Bachtiar
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Amendment 51 IFRA STANDARD

3-Propylidenephthalide

CAS-No.: 17369-59-4
The scope of this Standard includes, but is not limited to the CAS number(s) indicated
above; any other CAS number(s) used to identify this fragrance ingredient should be
considered in scope as well.

Synonyms: 3-Propylidenephthalide
1(3H)-Isobenzofuranone, 3-propylidene-
3-Propylidene-2-benzofuran-1(3H)-one
Propylidene phthalide

History: Publication date: 2023 (Amendment 51) Previous 1977


Publications: 1994
2008
2020

Implementation For new creation*: March 30, 2024


dates: For existing creation*: October 30, 2025
*These dates apply to the supply of fragrance mixtures (formulas) only, not to the
finished consumer products in the marketplace.

RECOMMENDATION: RESTRICTION

MAXIMUM ACCEPTABLE CONCENTRATIONS IN THE FINISHED PRODUCT (%):

Category 1 0.072 % Category 7A 0.82 %

Category 2 0.022 % Category 7B 0.82 %

Category 3 0.43 % Category 8 0.042 %

Category 4 0.40 % Category 9 0.79 %

Category 5A 0.10 % Category 10A 2.8 %

Category 5B 0.10 % Category 10B 2.8 %

Category 5C 0.10 % Category 11A 1.6 %

Category 5D 0.10 % Category 11B 1.6 %

Category 6 0.24 % Category 12 No restriction

FLAVOR REQUIREMENTS: Due to the possible ingestion of small amounts of

2023 (Amendment 51) 1/3


Amendment 51 IFRA STANDARD

3-Propylidenephthalide

fragrance ingredients from their use in products in


Categories 1 and 6, materials must not only comply
with IFRA Standards but must also be recognized
as safe as a flavoring ingredient as defined by the
IOFI Code of Practice (www.iofi.org). For more
details see chapter 1 of the Guidance for the use of
IFRA Standards.

CONTRIBUTIONS FROM OTHER SOURCES: SEE ANNEX ON CONTRIBUTIONS FROM


OTHER SOURCES

INTRINSIC PROPERTY DRIVING RISK DERMAL SENSITIZATION


MANAGEMENT:

RIFM SUMMARIES:

Maximum acceptable concentrations are based on a comprehensive safety assessment, considering


various endpoints. Depending on the outcome of the safety assessment, it might be one or more
endpoint(s) that will drive the derivation of the concentration levels. If more than one endpoint is of
relevance, the maximum acceptable concentrations for each product category are derived from comparing
maximum permitted level per endpoint consideration (e.g. dermal sensitization and/or systemic toxicity).
Such maximum acceptable concentrations correspond to the lowest level obtained per category.

Additional information is available in the RIFM safety assessment for 3-Propylidenephthalide, which can
be downloaded from the RIFM Fragrance Material Safety Assessment Center:
http://fragrancematerialsafetyresource.elsevier.com/.

EXPERT PANEL FOR FRAGRANCE SAFETY RATIONALE / CONCLUSION:

The Expert Panel for Fragrance Safety reviewed all the available data for 3-Propylidenephthalide and
recommends the concentrations for the 12 different product categories, which are the maximum acceptable
concentrations of 3-Propylidenephthalide in the various product categories.

REFERENCES:

The IFRA Standard on 3-Propylidenephthalide is based on at least one of the following publications:

• The RIFM Safety Assessment on 3-Propylidenephthalide if available at the RIFM Fragrance Material
Safety Assessment Center: http://fragrancematerialsafetyresource.elsevier.com

• Api A.M., Belsito D., Bruze M., Cadby P., Calow P., Dagli M. L., Dekant W., Dent M., Ellis G., Fryer A. D.,
Fukayama M., Griem P., Hickey C., Kromidas L., Lalko J., Liebler D.C., Miyachi Y., Politano V.T., Renskers
K., Ritacco G., Salvito D., Schultz T.W., Sipes I. G., Smith B., Vitale D., Wilcox D.K. (2015). Criteria for the
Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients.
Food Chem Toxicol. 2015 Aug;82 Suppl:S1-S19
(http://fragrancematerialsafetyresource.elsevier.com/sites/default/files/Criteria_Document_Final.pdf).

• Salvito D.T., Senna R. J., Federle T.W. (2002). A framework for prioritizing fragrance materials for
aquatic risk assessment. Environ Toxicol Chem. 2002;21:1301-1308
(https://www.ncbi.nlm.nih.gov/pubmed/12069318).

2023 (Amendment 51) 2/3


Amendment 51 IFRA STANDARD

3-Propylidenephthalide

Additional information on the application of IFRA Standards is available in the Guidance for the use of IFRA
Standards, publicly available at www.ifrafragrance.org.

2023 (Amendment 51) 3/3

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