Indian Institue of Technology 1
Indian Institue of Technology 1
CourseNo:MD1001
Course Type:
Description:To introduce the concepts of mechanics in a mathematical setting and expand to apply for
physiological systems
TextBooks:1. Yohan Payan and J. Ohayon, Biomechanics of living Organs, Academic Press, 2017 2. Jay
Humphrey and Sherry L.O’Rourke, An introduction to biomechanics, Springer, 2004
ReferenceBooks:1. Y.C. Fung, Biomechanics: Mechanical Properties of living tissues, Springer, 1981
Prereqisites:
CourseNo:MD1002
Course Type:
Description:To enumerate the six levels of structural organization of the human body
TextBooks:1. Lauralee Sherwood, Human Physiology – from Cells to Systems , Cenage Learning, 2016 2.
Saladin K.S., Anatomy and Physiology, McGraw Hill, 2018
ReferenceBooks:1. Rod Philips el al., Physical Biology of the Cell, Garland Science, 2013
Prereqisites:
Indian Institue of Technology 2
CourseNo:MD1003
Course Type:
CourseContent:Highlights of linear Algebra – Matrix multiplication and solving linear equations, vector
spaces and subspaces, determinants, eigenvalues and eigenvectors Numerical differentiation ODE –
Classification and examples, solution of linear time -invariant ODEs, convolution integral and Laplace
Transform Methods Numerical Solution of ODEs Partial differentiation and examples of PDEs The course will
have a practical session (e.g. numerical methods, solvers) of three hours a week
TextBooks:1. G. Strang, Introduction to linear algebra, (6th edition), Wellesley – Cambridge Press, 2016 2.
L.V. Fausett, Applied Numerical Analysis using MATLAB, Pearson, 2009 3. E. Kreyzig, Advanced Engineering
Mathematics,
ReferenceBooks:1. Jospeh Distefano III, Dynamic Systems Biology Modelling and Simulation, Academic
Press, 2013 2. C. Cobelli, E. Carson, Introduction to modeling in physiology and medicine, 2nd Edition,
Academic Press, 2019
Prereqisites:
CourseNo:MD2001
Course Type:
Description:To develop software skills for the students that are relevant to the discipline
TextBooks:1. B. Dathan and S. Ramnath, Object – Oriented Analysis, Design and Implementation, Second
Edition, Springer, 2015 2. H. Ferrone, Learning C# by developing games with UNITY
ReferenceBooks:
Prereqisites:
Indian Institue of Technology 3
CourseNo:MD2002
CourseName:Introduction to Anatomy
Course Type:
Description:To teach various modern methods of visualization techniques for medicine To introduce various
imaging modalities in medical imaging To introduce normal adult and paediatric anatomy as visualised in
medical images To bring out the normal imaging appearance of the structures and their relationships on
planar radiographic, ultrasound, CT, MRI images To teach location, recognition and description of anatomical
surface landmarks and relate this to the normal anatomical relationship of the structures of each region
Virtual reality, Augmented Reality and Mixed Reality in medical visualisation
CourseContent:Introduction of overall anatomical structure of the body Acquisition of medical image data –
x-ray imaging, CT, MRI and Ultrasound Sectional Anatomy of cranium, facial bones and brain using CT, MRI
(T1 and T2 weighted) and CTA and MRA of the cerebral arteries, CT venogram, cranial nerve system. Spine –
Vertebrae, ligaments, muscles, spinal cord and nerve roots using CT, MRi and 2D X-ray Imaging of the neck •
Imaging of the thorax with detailed imaging of the heart and vasculature using CT, MRI, CTA and MRA •
Introduction to echocardiography Imaging of the abdomen – liver, spleen, gallbladder and biliary system,
pancreas, intestine and urinary system Imaging of the pelvis, upper and lower extremity
TextBooks:1. Denise L. Lazo, Fundamentals of Sectional Anatomy, An Imaging Approach, Cengage Learning,
2015 2. Lorrie L. Kelley and Connie M. Peterse, Sectional Anatomy for Imaging Professional, Elsevier, 2018
ReferenceBooks:3. Jean Francios, J. Jorge, D.S. Lopes, Digital Anatomy, Springer, 2021 4. Spratt, J.D.,
Salkowski, l.R., Loukas, m. Turmezi, T., Weir, J. Abrahms, P.H., Imaging Atlas of Human Anatomy, Elsevier,
2021
Prereqisites:
CourseNo:MD2003
Course Type:
CourseContent:Fluid as a continuum, state of stress and fluid motion in physiology –Conservation laws –
Navier – Stokes equation, Bernoulli equation, first and second law of thermodynamics, introduction to heat
transfer in physiology Anatomy of blood vessels, arterial wall mechanics, blood cells and plasma, blood
rheology, blood flow in arteries and veins, wave propagation in arterial system, flow separation, turbulent
flows in physiological systems, pulsatile flow - Wormersley flow Physiology of microcirculation – arterioles and
local control, capillaries and mass exchange, heat transfer in microcirculation, lymphatic system – lymph
physiology and lymphatic flow Measurement of pressure and flow in physiological system Pressure
measurement - indirect measurement, direct – intravascular and cathetertransducer measuring system Flow
measurement – indicator dilution method – Fick technique, dye dilution, thermodilution, electromagnetic flow
meters, doppler flow meter Vascular Pathologies
TextBooks:1. David A. Rubenstein et al., Biofluid Mechanics, 3rd Edition, Academic Press, 2022 2. L. White,
Biofluid Mechanics in Cardiovascular System, McGraw Hill, 2006
Prereqisites:
Indian Institue of Technology 4
CourseNo:MD2004
Course Type:
Description:1 To introduce to the electrical circuits, and analysis of the circuits, and software tools for the
same 2. To understand the sources of bioelectric and magnetic signals and their biomedical applications
CourseContent:Basic concepts – electric current, voltage etc. Ohms law, Kirchhoff laws, Delta – Wye
conversion Analysis methods – Nodal analysis, mesh analysis, source transformation, Thevenin – Norton
equivalent circuit Operational Amplifier based circuits Volume source and volume conductor – homogeneous
volume conductor – inhomogeneous volume conductor – modelling of volume source and volume conductor
Introduction to source field models and their applications to physiology Lead vector – definition – examples –
and applications to ECG Magnetic fields and Bio magnetic measurements Introduction to electromyogram –
electrical activity of muscle – surface EMG and its spectral analysis – modelling intramuscular EMG
Laboratory will have electrical and electronics experiments reiterating the theoretical understanding.
TextBooks:1. Boylestad, R, Introductory Network Analysis, 12th Edition, Pearson, 2013 2. Keskin, A.U.,
Electrical Circuits in biomedical Engineering, Springer, 2017 3. Plonsey R., Barr R.C., Bioelectricity A.
Quantitative Approach. New York, NY: Springer; 2007. 4. L. Sornmo and P. Laguna, Biomedical Signal
processing in cardiac and neurological applications, Elsevier, 2005 5.J. Malmivuo, and R. Plonsey,
Bioelectromagnetism, OUP, 1995
ReferenceBooks:
Prereqisites:
Indian Institue of Technology 5
CourseNo:MD1004
CourseName:Medical Biochemistry
Course Type:
Description:1. To understand the biochemistry of human body fluids 2. To learn the disorders of carbohydrate,
protein and lipid metabolism 3. To appreciate enzymology and disease associated with it 4. To acquire knowledge
on organ specific biochemical tests 5. To understand the significance of nutritional biochemistry in human health
TextBooks:Title – Medical Biochemistry. Authors: John W. Baynes and Marek H. Dominiczak. 7th Edition, 2020.
ISBN: Hardcover: 978-0-7020-7317-1; eBook ISBN: 978-0-7020-7318-8 Title: Biochemistry for Medical
Professionals. Author: Michael W. King. 2nd Edition, 2017; Publisher: Jones & Bartlett Publishers. ISBN:
Hardcover: 978-1284104993, eBook ISBN: 978-1284104993 Title: Clinical Biochemistry: An Illustrated Colour
Text. Authors: Allan Gaw, Michael J. Murphy, and Rajeev Srivastava. 7th Edition, 2020; Publisher: Churchill
Livingstone. ISBN: Hardcover: 978-0702073663, eBook ISBN: 978-0702077456
ReferenceBooks:Title: Harper's Illustrated Biochemistry. Authors: Robert K. Murray, Dale A. Granner, Peter A.
Mayes, and Victor W. Rodwell. 31st Edition, 2020; Publisher: McGraw-Hill Education; ISBN: Hardcover:
978-1260543270; eBook ISBN: 978-1260543362 Title: Principles of Biochemistry; Authors: Albert L. Lehninger,
David L. Nelson, and Michael M. Cox. 7th Edition, 2020; Publisher: W. H. Freeman. Hardcover: 978-1464187974;
eBook ISBN: 978-1464187981
Prereqisites:
Indian Institue of Technology 6
CourseNo:MD1005
Course Type:
Description:1. To teach a framework for physiological system modelling 2. To expose the students to solve
mathematical models using scientific software 3. To introduce fundamental concepts of dynamical systems
TextBooks:1. Jospeh Distefano III, Dynamic Systems Biology Modelling and Simulation, Academic Press,
2013 2. C. Cobelli, E. Carson, Introduction to modeling in physiology and medicine, 2nd Edition, Academic
Press, 2019 3. Physiological control systems: Analysis, simulation, estimation, second edition, Wiely, 2018
ReferenceBooks:1. Jerry J. Batzel et al. , Mathematical Modeling and validation in Physiology, Springer 2012
Prereqisites:
Indian Institue of Technology 7
CourseNo:MD2005
Course Type:
Description:1. To introduce basic principles of medical microbiology, clinical –immunology and –pathology. 2. To
appreciate the principles and application of microscopy in microbiology and pathology. 3. To teach basic biology of
bacteria, virus, fungi and other parasitic pathogens related with human diseases. 4. To understand the role of the immune
system in the development of immune-mediated diseases, including allergies, autoimmune diseases, and immunodeficiency
disorders. 5. To provide an understanding about the pathogenesis of human diseases caused by various pathogens.
CourseContent:Microbiology and pathology i) History of microbiology, General Pathology – history and principles of
pathology, Microscopic pathology Bacterial and Viral Pathology – i) General structure of bacteria and virus ii) Mechanism of
bacterial and viral pathogenesis – an overview iii) Bacterial pathogens and the diseases – Staphylococcus, Streptococcus,
Neisseria, Enterobacteriaceae (Escherichia, Klebsiella, Enterobacter, Proteus, Salmonella and Shigella). Campylobacter,
Helicobacter. Vibro cholera, Clostridia (spore-forming anaerobic bacteria), Pseudomonas, Mycobacteria. Brucella,
Hemophilus species, Treponema, Leptospira, Legionella, Chlamydia and mycoplasmas iv) Basic Pathogenesis of specific
virus families’ relevance to human diseases – Coronaviridae, Adenoviridae, Hepadnaviridae, Herpesviridae, Reoviridae,
Retorviridae, Orthomyxoviridae, Paramyxoviridae, Papillomaviridae, Picornaviridae & Togaviridae Fungal Pathology – i)
classification, structure, and function of fungi, fungal pathogenesis, and the host response to fungal infections, including
aspergillosis, candidiasis, and cryptococcosis. Parasitic Pathology - i) classification, parasitic pathogenesis, and the host
response to parasitic infections. Major medically important protozoa and associate diseases – Leishmania, Plasmodium
malaria, Toxoplasma gondii, Trichomonas vaginalis, Trypanosomes, Entamobea histolytica. ii) Emerging Infectious
Diseases: recent advances in the understanding of newly emerging infectious diseases, including SARS, MERS, and
COVID-19. Immunology/Immuno-pathology i) Introduction to Immunology, structure and function of Immune system ii)
Innate Immunity: Toll-like receptors, complement system, phagocytosis. iii) Acquired Immunity: T and B cell immunity,
humoral and cell-mediated immunity, antibody structure and function. Passive Immunity and immune evasion strategies. B.
S. in Medical Sciences and Engineering Curriculum, IIT Madras Page 16 iv) Antigens and Antigen Presentation: antigen
processing and presentation, Major Histocompatibility Complex (MHC) molecules, T cell receptor (TCR) structure and
function. General structure of antibodies, antigen- antibody reactions. v) Immune Tolerance: central and peripheral
tolerance, self-tolerance mechanisms, regulatory T cells. vi) Immunological Disorders: autoimmune diseases, immune-
deficiencies and allergies – including mechanisms of allergy, type 1 hypersensitivity reactions, atopic diseases and food
allergies. vii) Vaccines: Types of vaccines, vaccine development and production, vaccine efficacy and safety. viii)
Immunotherapy – cancer and infectious diseases. Immunotherapy in combination with chemotherapy, radiation therapy or
targeted therapy. ix) Transplantation Immunology: mechanisms of transplant rejection, tolerance induction, and
immunosuppression. Introduction to - i) Hematology: red blood cells, white blood cells, platelets, anemias, leukemias,
coagulation disorders. ii) Clinical Cytology: Pap smears, fine-needle aspiration, bronchial and urinary cytology, flow
cytometry. iii) Transfusion Medicine: blood typing, cross-matching, compatibility testing, transfusion reactions, and
transfusion transmitted infections. iv) Introduction to histology, Immunohistochemistry, bacterial, viral, fungal and cancer
cell culture, tissue culture, biopsy, autopsy, flow cytometry. Practical (pathology/microbiology labs in hospital) 3 credits i)
Sample collection from humans, transport of specimens, isolation of bacteria, virus and fungi from clinical specimens. ii)
Microscopy: light and electron microscopes to examine tissues and cells, and to identify the structures and features of cells
and tissues; including endocrine tissue morphology, normal and abnormal morphology of liver, heart and kidney. iii)
Histology: preparation of tissue specimens for microscopic examination, including embedding, sectioning, and staining
techniques; including tumor tissues. iv) Immunohistochemistry: Antibodies and molecular b
TextBooks:1. Title: Prescott's Microbiology. Authors: Joanne Willey, Linda Sherwood, Chris Woolverton. 10th edition,
2019. Publisher: McGraw-Hill Education. ISBN: 9781260299180 2. Title: Text book of Microbiology. Authors: R
Ananthanarayan, CK Jayaram Paniker and Reba Kanungo. 11th edition, 2020. Universities Press (India) Pvt. Ltd.. 3. Title:
Essential Clinical Immunology. Authors: Helen Chapel, Mansel Haeney, Sir Graham Steven, and Trevor Lawley. 6th edition
2015, publisher - John Wiley & Sons. ISBN: 9781118442708. 4. Title: Immunology. Editors: David Male, Victoria Male, and
Ray Stokes Peebles. 2020, Publisher: Elsevier. ISBN: 9780702078446 5. Title: Rapid Review Microbiology and Immunology.
Authors: Ken S. Rosenthal & Michael J Tan y. 3rd Edition, 2010. Publisher Mosby; ISBN Number – 9780323069380 6. Title:
Robbins & Cotran Pathologic Basis of Disease (Robbins Pathology). Authors - Vinay Kumar, Abul K. Abbas, Jon C. Aster.
10th edition, 2020; Publisher: Elsevier. ISBN: 978-0323531139.
ReferenceBooks:Title: Medical Microbiology. Authors - Patrick R. Murray, Ken S. Rosenthal, and Michael A. Pfaller. 9th
edition, 2020, Publisher – Elsevier. ISBN - 9780323673228. 2. Title: Medical Microbiology. Authors - David Greenwood,
Richard CD., Slack, John Forrest Peutherer. 16th edition,1992. ELBS with Churchill Livingstone. 3. Title: Clinical
Immunology: Principles and Practice. Authors - Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Henry M.
Lederman, Michael F. Fanger, and Annette L. Baumeister. 3rd edition, 2018. Publisher – Elsevier. ISBN: 9780323552071.
4. Title: Kuby Immunology. Authors: Judy Owen, Jenni Punt, and Sharon Stranford. 8th edition, 2018; Publisher: W. H.
Freeman and Company. ISBN: 978-1319114701. 5. Title: Underwood's Pathology: A Clinical Approach. Author: Simon
Cross. Edition: 6th, 2017; Publisher: Churchill Livingstone. ISBN: 9780702051348 6. Title: Rapid Review Pathology. Author:
Edward F. Goljan. 4th edition, 2019. Publisher: Elsevier. ISBN: 9780323528707
Prereqisites:
Indian Institue of Technology 8
CourseNo:MD5005
Course Type:
Description:1. To introduce cardiac and respiratory mechanics 2. To familiarise the students with the
diseases of the heart and lungs 3. To impart knowledge of devices and therapies
CourseContent:Anatomy and physiology of the heart – Cardiovascular system, electrical activity of the heart,
ECG and its interpretation Cardiac muscle mechanics, function & cycle, Neurohumoral control of the heart.
Wave travel and reflection, heart as a pump, Ventriculo-Arterial coupling, arterial and pulmonary
hemodynamics. Mathematical Modelling of the circulatory system Respiratory physiology and mechanics of
respiration, alveolar – capillary exchange, oxygen and carbon dioxide transport, control of respiration.
Mathematical models in respiratory mechanics Diseases of the heart and lungs. Diagnostic measurement tools
Familiarising with Devices and therapies – pharmacotherapy, cardiac ablation and arrhythmias, cardiac
pacemakers, surgical interventions, LVADS and ECMO The student will spend half a day per week in the
hospital
TextBooks:1. Nocolas Westerhof et al., Snapshots of hemodynamics, Springer, 2019 2. Richard E. Klabunde,
Cardiovascular Physiology Concepts, Lippincot, Willims & Wilkins, 2005
ReferenceBooks:1. Paul A. Iaizzo, Handbook of Cardiac Anatomy, Physiology and Devices, Springer, 2009
Prereqisites: