ASsIGNMENT 0:

Q# Sae he aUSLAng quaatASO bad an Dejuitsn

and laaAicatsn
Alky hidss ? G the clasaicalien
eyA helidoÀ uuith Autabl examale
MEhohalogen diwatues CCallid
alkylhauides
CH3-CH2- Bu ethyl bYOmid
Clasaihicluen halida
Puma Aleyt
ce Hlogen Atlachcol
ynCy ccuban cÉem
the C sbon aTemhich n atkchd
to
CH3- CHz B
CH3- CHz- cH2-cL
ethylSmide
nAsny chisle
econduy ALy haica Hcuogen i atached)
secondiut.tahecd
whichw
CUHbo

cH3- CH-Ct3
ctom
tD tu
s th ccbon atom
g00e CChorn.
Bu
2-bonoopn
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 Teuctiauy AKy hallc' Hcuogso s attached
Cbon ctenm
tha moecaeboh

CHa -C- CH3

2-chlcxo-2-methylpcpane
acehss ithn Aitokole xnnles

CHz -cHZ-OH: cthy cucohol

cLCasiicoien enchyduoxy Alcehsl
Raumçuy
the
alahas-OH sup

Atoched to Ons M lcbon

" CHz-CH - OH Ethyl alcohal
CH3-(H-CH2-OH nprAL alcohal

Hhe Secondauy cakon ctom Seondy coubon

citsm s thccuon ctom which w ttachud to
CH¡-(H-CH3
OH
2- propanat
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 (2

Teuticuy cleohalsi- -OHd auupis atached to tthe

th canbon ctom whch isAlachd tothe

OH

2-mathl2opnol
etheus
with Siitabe eoXaMmples

uwhich cgen at
gercy peLnicl aa= R-0-R
Fthe
whnbotth the aleyl ud cur he smL, Hhuy
Me
CAe Rnousn c simn eth

ethesed
CH--CH CH-0-CH2-CHs
cimethleth cthythyl ethe
implr
ethiy etht.

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G-Ahat ce nhne 2 Exnln uith examnly
MEmati hycuoxyl compendaj
nucleu
OH cuoups atcchecd to aremattc
i-e te

nhenol

Dow's puocesi: Chleobenzne

aq Socuin hydioxce at cubSt 62% ke
B ¢ ConAettd to
Socuinn nhenoxicL, uhich ann aicication

ti 2NaoH 629k

300 atm ew
Chloiobehzonl Socdim
phenoxide
ONQ QH

phno

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 2
ngte (ontinsus etheuificcLSn Auoceas.
th enaumn

conc: HzSOuntumoleclcut ehyduusn Takes ae

n ethH Thii mohod
paucien s Anae ethe
H2sou R-o-R

COnuet methanol ntte cumethy! eths

CHa-0H HO-CHs Hasoy CH3-0-(H Ho
s13k
mthcnol
dipathy
eth

Rapae diethyleths tom cthaAol

H2sou Cis-OC, H
H
UISK

ehunol
diethy
ethe

Fuon Diazomethans
Diazonetha eac ith alcohols, thi presene
4 HBEa catalys tu 4orm thsw
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 when diazomathnl acted wth ethunol
catalysl. gie
mehoxy ethne
C2Hs-OH + CH2N2 HBE Cets-0 CHa N

ethanol
etihylmthyl
ethey

Solu the allouung quesisn baard on

Mechcnnim
Qlhat is McUkaWAniko|s Rul ? Explcun the
mchan[i sMOHkOuhi kok's H
Wlhen annamtucal alkne ueacta with
can whaymmiuical eagent he ugatw pat.
haslat numbeH

4 H-Br
CH ÙH
The ariisn
In
elecTuonhilicadditsn acisa
ueacE
Lh Uat Sbep pi bond atiacks enhyduocAn
qositi charxge) and
Secanda CCubonun ien
sn moL +CAble
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 undaram)
EDUCATIONAL
USE FOR
CH3
AquoU
CH3
Aacisn SN' enmu an
mc buttay
y hydmyai ALKCLin
emcmple Autkble
withBxnlain Nehnam Ractan Q2hti)
SN4
oopun 2-
CH CH3
CH.
B
Isn uopanl
Secndauy
CH2 cHS
CH CH3
H CH
CH
Aocluct maya
MoSpan
A 2- to eil
dtp,OmiclAO In
atacks
an BH campauec thi
ceebonuem
tyoumwdin
na hnce
amount
as
 Kincucs expcadiSh Ti Àd sbseUd that
the
Gn thi concentuCLicn o) t bulyl buomicL
anc hence t is calud undmoeue

Rte KCCCH2)a -BJ

whe K: Rat contunt

bOmicesinuad inMat dlunnngtp

uceec in tuo Aad
he t i i Aup is ALnhile thedecond
dtumining dtup (eDs)

auCd slouy undeugoe hettucuticfaen

a t- buty ccubonium
The t- buty cukoim_uan has nlanas Spz
hubuidizcd coubon: th (Cuibon ctem
CH3 qAOu cH n n dthi Sameplne
CH3
Bu --By + Br

CH
(H CH
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TS
 |FeLmalicn s Poducta NucLcphill ucapiclly.
att aces thi cauboniun uen Mom both
uith inuaien and uientuen a contiqexctian
un equal amount ie uaemie mxtue is

CH3
Eyont
.Backsicu sicu
NHO-CHr OH

-CH3 H3
Atack CHyHa
Attettk

(Hs

CH3
CHQH
CH3
CH3
501. Rtention
la- Racani CCHa)e(-Br
TCnaitien stut-l CTS) ar Step NO-1
Ct- butyl cabanim sn
Kanitien gtae- I (TS) kay &tep No2
acawalin
AH: Heat uacton

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 B
-

wwhat SN2Rontiusn Mechanwm :Exnlaun

wh itcle eKample
Conslde alkaliil hydacas ay mthy bxcnicl
CHa-0H+KBr
Cahaue iation
capenda unsn the conceniuausA the
clegnhil cs ulk c thd a the cuR
halide & thiusu,it s a ise Cancd oideu

Late kOH1CCH3-BiJ
whKi Rau constant
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 A chnmical JUOctisn ncy nuse Aage Dumbey

" This Atup is cCued cus Rat Detemining tep.

Nechanism
ace sicde AtCLcK Nucuophiu atlacks the cbon
tom uom he back (ie annste to By)Sice
becaua en- dinsl uutsisn batuen puialy
nagatuucly chauged broiAi. and OH sns
H H
HO By HO- --Br 4 By
B H
H H
FSumtuen Tuanaitusn SiuU (Ome
A the OH anucches Cubon uom th back
Side eae band iEned betuLD cutbon
& oH At the Som timthe bond batwen CCuubon

boncded ui th coubon Thà (omplaçk has higheat

eng
Jactd
ngt be

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 Eunalu dhe TS. comnli buCCLRS counfi
quies methanol as the end uccuLCt
|Steverchemiduy: When the Melecle Jacta by
SN? atsh mechcunim, the uecluct
keued thinueaion
uuth inueaion ay caDkiguvtiso

ahn the change n enuqy is nsttd agaunit

AactUsn, thí c u rabtcuinc

Substeutia RoachiSn2)
on
Trahition NU Br
Stcte ((ant be
H isolctec'
cenauggna)
Triqanal bipseamia
gecrct
Recaclant))

A
Puccti
itlsuhuelual

acometu

ructtcn lccxcluict1 ( eencTicn Droguca)

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