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SKIN
• Skin : largest sensory organ
• 16% of body weight • Mucocutaneous junction: areas where skin is continuous with the mucous membrane. Eg: lips, anus, eyelids, nostrils • Functions: 1. Protection 2. Barrier 3. Temperature regulation 4. Sensory 5. Excretory Structure: 1. Epidermis: surface layer of epithelium 2. Dermis: middle connective tissue 3. Hypodermis: deepest loose connective tissue layer Epidermis- Contacts external environment Lined by stratified squamous epithelium Avascular Consists of epithelial cells: 1. Stratum basale 2. stratum spongiosum 3. Stratum granulosum 4. Stratum lucidum 5. Stratum corneum Non-epithelial cells: 1. Melanocytes: present in stratum basale. Form melanin responsible for imparting color. In eyes they are present in choroid layer. 2. Langerhans cells: Produce immunological response in skin. 3. Merkel cells: Mechanoreceptors (sensitive to touch). Innervated by sensory nerves. • Dermis: Highly vascular Consists of connective tissue containing collagen fibers, elastic fibers, blood vessels, lymph vessels and nerves. It is connected underneath to deep fascia. The collagen and elastic fibers provide strength and toughness. • Layers of dermis: 1. Papillary layer- loose connective tissue rich in vascular supply, provide nutrition to epidermis. 2. Reticular layer- dense connective tissue bands running parallel. Form “clevage lines of langer” (surgically important- incisions are made along these lines, to ensure early healing) Dermatomes: Area of skin supplied by a single spinal segment. Importance- helps in localization of injury by testing of the loss of sensation in a conscious patient. • Hypodermis: Deepest layer consisting of large amount of adipose tissue and blood supply. • Fascia: Fibrous tissue laid as sheets/bands. Location: below skin surface, covering and separating muscles, organs and other tissues. Structure: dense connective tissue, consists of collagen fibers. Function: Sliding and gliding surface for muscles to reduce friction Suspends organs in their anatomical location Transmits movement from muscles to bones to which they are attached (oriented along the direction of pull) Types: • Superficial: Loose connective tissue layer. Connects skin to underlying deep fascia. Also called as subcutaneous tissue. Functions: 1. Acts as a packaging material between delicate structures. 2. Heat insulation: consists of fat 3. Allows movement of skin over underlying structures. • Deep fascia: Dense, tough, fibrous and inelastic layer deep to superficial fascia Devoid of fat Covers muscles, nerves, bone, cartilage Avascular Richly innervated with sensory receptors In certain areas deep fascia gets modified to form extensions or thickenings. Intermuscular septum- Septa between muscle groups performing different functions. Nerve coverings- Epineurium, perineurium, endoneurium Tendon sheaths Flexor fibrous sheaths- Deep fascia on finger flexors prevent bow stringing of flexors tendons by holding them close to joints. Aponeurosis- In region of palm and sole deep fascia is thickened to form aponeurosis (palmar and plantar aponeurosis, to protect the underlying structures) Interosseus membrane- In forearm and leg, deep fascia get modified to form interosseus membrane which keeps bones at optimum distance, increase surface area for muscle attachment and assist in transmitting weight from one bone to other Retinacula- Present near joints. Deep fascia is thickened to form retinacula, that holds tendons in place. Seen where tendons cross joints. Covering for glands/capsule- Deep fascia gets split in certain regions to enclose glands and form their covering. Sheath- Covering around arteries. Eg: carotid sheath • Subserous fascia: Lies between inner layer of deep fascia and serous membrane lining body cavities. Allows flexibility and movement of internal organs. Eg: abdominal fascia Body cavities:
A body cavity is a fluid filled space.
Function: protects the internal organs. Divided as dorsal and ventral based on their location. Dorsal cavities: cranial cavity and vertebral cavity Ventral cavities: thoracic and abdominopelvic cavity. • Serous Membranes: Comprises of a parietal and visceral layer The parietal layer and visceral layer surfaces facing the body cavity are secretory in nature. Act as a source of lubrication for internal organs Sometimes they exist in continuity, making a double fold of serous membrane suspending body structures from body wall. Eg: mesentery