05 Nervous System
05 Nervous System
NERVOUS
SYSTEM
Trisha Isabel F. Guioguio, RN, MAN
Sensory input
Sensory receptor
Integration
Motor output
Organization
Peripheral Nervous System
Nervous
System. Sensory
(afferent)
Motor
(efferent)
Sense Somatic
organs Autonomic
(voluntary)
(involuntary)
Skeletal
Cardiac and
muscles
smooth muscle,
glands
Parasympathetic Sympathetic
Organization
Peripheral Nervous System
Nervous
System. Sensory
(afferent)
Motor
(efferent)
Sense Somatic
organs Autonomic
(voluntary)
(involuntary)
Skeletal
Cardiac and
muscles
smooth muscle,
glands
Parasympathetic Sympathetic
Capillar
y
Neuro
n Neuro
M
n icrogli
Astrocyt al
e cell
(a) Astrocytes are the most (b) Microglial cells are phagocytes
abundant that
and versatile neuroglia. defend CNS cells.
Myelin
Fluid-filled sheath Process of
cavity Ependym
oligodendro
al
cyte
cells or
Brain Ner
ve
spinal
fibe
cord
rs
(c) Ependymal cells line tissue (d) Oligodendrocytes have
cerebrospinal processes that form
fluid–filled cavities. myelin sheaths around CNS
nerve fibers.
Nissl substance
Structure of a Axon
hillock
Axon
neuron. Nucleolus
One
Schwann
cell
Node of
Axon
Ranvier
terminal
Schwann cells,
forming the myelin
sheath on axon
(a)
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Figure 7.4b Structure of a typical motor neuron.
Neuron
cell body
Dendrite
(b)
Schwann cell
cytoplasm
Schwann cell
Axon plasma membrane
Schwann cell
nucleus
(a)
(b)
Neurilemma
Myelin
sheath
(c)
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Neurons classified by function
Central process (axon)
Sensory
neuron Spinal cord
Cell
(central nervous system)
body
Ganglion
Dendrites Peripheral
process (axon)
Afferent
transmission Interneuron
(association
neuron)
Receptors Peripheral
nervous
system
Efferent transmission
Motor neuron
To effectors
(muscles and glands)
Afferent
transmission Interneuron
(association
neuron)
Receptors Peripheral
nervous
system
Efferent transmission
Motor neuron
To effectors
(muscles and glands)
Cell body
Axon
Dendrites
(a) Multipolar neuron
Cell body
Dendrite Axon
(b) Bipolar neuron
Dendrites
Cell body
Short single
process
Axon
Peripheral Central
process process
(c) Unipolar neuron
Cerebral
hemisphere
Outline of
diencephalon
Midbrain
Cerebellum
Brain stem
(a) 13 weeks
Cerebral
hemisphere
Diencephalon
Cerebellum
Brain stem
Lateral sulcus
Frontal
Occipital lobe lobe
Occipital
Temporal lobe Temporal lobe
lobe
Cerebellum
Pons Superior
Sulcus
Cerebral
white
Fissure matter
(a deep sulcus)
(a)
Central sulcus
Primary motor area Primary somatic sensory
Premotor area area
Anterior Gustatory area (taste)
association area
• Working memory Speech/language
and judgment (outlined by dashes)
Motor Sensory
Motor map in Anterior
Sensory map in
Shoul
precentral gyrus postcentral gyrus
Head
Ha earm
Trunk
Neck
Trunk
Arm
ow
Hip
Leg
der
Knee
Elb t
Arm
Wri
Hip
Ha
rs
r
nd
Elb
Fi
Fo
e
nd
ow
s
ng
ng
e
Fi
Knee
rs
Th
b
um
um
Foot
b
Th
Nec
e
Ey
Bro k se
w o
N
Eye Toes ce
Fa
s
Face Genitals Lip
Lips Teeths
Gum
Jaw
Jaw
Tongue
Lateral sulcus
Occipital lobe
Temporal lobe
Cerebellum
Pons
Cerebral cortex Medulla
(gray matter) oblongata
Gyrus Spinal
cord
Sulcus
Cerebral
Fissure white
(a deep sulcus) matter
(a)
© 2018 Pearson Education, Ltd.
Figure 7.14 Sensory and motor areas of the cerebral cortex.
Posterior
Motor Sensory
Motor map in Anterior
Sensory map in
Shoul
precentral gyrus postcentral gyrus
Head
Ha earm
Trunk
Neck
Trunk
Arm
ow
Hip
Leg
der
Knee
Elb t
Arm
Wri
Hip
Ha
rs
r
nd
Elb
Fi
Fo
e
nd
ow
s
ng
ng
e
Fi
Knee
rs
Th
b
um
um
Foot
b
Th
Nec
e
Ey
Bro k se
w o
N
Eye Toes ce
Fa
s
Face Genitals Lip
Lips Teeths
Gum
Jaw
Jaw
Tongue
Central sulcus
Primary motor area Primary somatic sensory
Premotor area area
Anterior Gustatory area (taste)
association area
• Working memory Speech/language
and judgment (outlined by dashes)
Lateral sulcus
Occipital lobe
Temporal lobe
Cerebellum
Pons
Cerebral cortex Medulla
(gray matter) oblongata
Gyrus Spinal
cord
Sulcus
Cerebral
Fissure white
(a deep sulcus) matter
(a)
© 2018 Pearson Education, Ltd.
Figure 7.15 Frontal section (facing posteriorly) of the brain showing commissural, association, and projection fibers running through the cerebrum and the lower CNS.
Fornix
Internal
Thalamus capsule
Third
ventricle
Pons Projection
fibers
Medulla oblongata
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Figure 7.12b Development and regions of the human brain.
Cerebral
hemisphere
Diencephalon
Cerebellum
Brain stem
Cerebral hemisphere
Corpus callosum
Third ventricle
Choroid plexus of third
ventricle
Occipital lobe of
cerebral hemisphere
Thalamus
Anterior (encloses third ventricle)
commissure Pineal gland
(part of epithalamus)
Hypothalamus Corpora
quadrigemina
Optic chiasma
Cerebral
Midbrain
aqueduct
Pituitary gland
Cerebral
peduncle
Mammillary body
Fourth ventricle
Pons
Choroid plexus
Medulla oblongata (part of epithalamus)
Spinal cord Cerebellum
(a)
Radiations
to cerebral
cortex
Auditory
Visual impulses impulses
Cerebral hemisphere
Corpus callosum
Third ventricle
Choroid plexus of third
ventricle
Occipital lobe of
cerebral hemisphere
Thalamus
Anterior (encloses third ventricle)
commissure Pineal gland
(part of epithalamus)
Hypothalamus Corpora
quadrigemina
Optic chiasma
Cerebral
Midbrain
aqueduct
Pituitary gland
Cerebral
peduncle
Mammillary body
Fourth ventricle
Pons
Choroid plexus
Medulla oblongata (part of epithalamus)
Spinal cord Cerebellum
(a)
Radiations
to cerebral
cortex
Auditory
Visual impulses impulses
Cerebral hemisphere
Corpus callosum
Third ventricle
Choroid plexus of third
ventricle
Occipital lobe of
cerebral hemisphere
Thalamus
Anterior (encloses third ventricle)
commissure Pineal gland
(part of epithalamus)
Hypothalamus Corpora
quadrigemina
Optic chiasma
Cerebral
Midbrain
aqueduct
Pituitary gland
Cerebral
peduncle
Mammillary body
Fourth ventricle
Pons
Choroid plexus
Medulla oblongata (part of epithalamus)
Spinal cord Cerebellum
(a)
Skin of scalp
Periosteum
Bone of skull
Periosteal Dura
Meningeal mater
Superior
sagittal sinus Arachnoid mater
Subdural Pia mater
space Arachnoid granulation
Subarachnoid Blood
space vessel
Falx cerebri
(in longitudinal
(a)
fissure only)
Skull
Scalp
Superior
sagittal sinus
Occipital lobe Dura mater
Tentorium
cerebelli Transverse
Cerebellum sinus
Temporal
Arachnoid mater bone
over medulla oblongata
(b)
Lateral ventricle
Anterior horn
Septum
pellucidum Interventricular
foramen
Inferior
horn
Third ventricle
Lateral Cerebral aqueduct
aperture
Fourth ventricle
Central canal
Lateral ventricle
Anterior horn
Posterior
Interventricular horn
foramen
4
Superior
sagittal sinus Arachnoid granulation
Cervical
Cervical spinal nerves
enlargement C8
Dura and
arachnoid Thoracic
mater spinal nerves
Lumbar
enlargement T12
End of spinal cord
Lumbar
Cauda spinal nerves
equina L5
End of S1 Sacral
meningeal
spinal nerves
coverings
S5
Spinal nerve
Ventral (anterior)
Dorsal root of
horn of gray matter
spinal nerve
Arachnoid mater
Dura mater
Interneuron
carrying response Brain stem
to motor neuron
Cell body of sensory
neuron in sensory
ganglion
Interneuron carrying
Nerve
sensory information to
Skin
cerebral cortex
Sensory
receptors
Cervical spinal cord
Muscle
White matter
Motor output Gray matter
Interneuron
Motor neuron
cell body
© 2018 Pearson Education, Ltd.
© 2018 Pearson Education, Ltd.
How Your
Neurons
Communicate
The Nerve Impulse
[Na+ ]
1 Resting membrane is polarized. In the resting state, the external face of the membrane is
[K+] slightly positive; its internal face is slightly negative. The chief extracellular ion is sodium (Na +),where
as the chief intracellular ion is potassium (K+). The membrane is relatively impermeable to both ions.
Na+
2 Stimulus initiates local depolarization. A stimulus changes the permeability of a local
Na+ “patch” of the membrane, and sodium ions diffuse rapidly into the cell. This changes the polarity of
the membrane (the inside becomes more positive; the outside becomes more negative) at that site.
Na+
3 Depolarization and generation of an action potential. If the stimulus is strong enough,
depolarization causes membrane polarity to be completely reversed, and an action
Na+
potential is initiated.
The Nerve Impulse
4 Propagation of the action potential. Depolarization of the first membrane patch causes permeability
changes in the adjacent membrane, and the events described in step 2 are repeated. Thus, the action
potential propagates rapidly along the entire length of the membrane.
K+
5 Repolarization. Potassium ions diffuse out of the cell as the membrane permeability changes
K+ again, restoring thenegative charge on the inside of the membrane and the positive charge on the
outside surface. Repolarization occurs in the same direction as depolarization.
Cell
Na+ – K+
exterior pump
6 Initial ionic conditions restored. The ionic conditions
Na+ Diffusion
K+ Diffusion
Plasma of the resting state are restored later by the activity of the
membrane sodium-potassium pump. Three sodium ions are ejected for
every two potassium ions carried back into the cell.
Cell
interior
How neurons communicate at chemical synapses
Axon of
transmittin
g
Receivin
neuron
g
neuron 2 Transmitting
Vesicle neuron 4
1 3
fuses Neurotrans-
Dendrit Action Neurotrans-
with mitter binds
e potential mitter is
plasma to receptor
arrives.
Vesicle released into
membran on receiving
Axon sSynapti synaptic
e. neuron’s
terminal cleft.
c membrane.
Synapti
cleft
c Ion Neurotransmitt
cleft channel er
s molecules
Receiving
neuron
How neurons communicate at chemical synapses
Neurotransmitter is
Neurotransmitter broken down and
released.
Receptor Na+
Na+
Receiving neuron
BioFlix:
How Synapses Work
1 Receptor
Interneuron
Interneuron
5 Effector organ
5 Effector organ
3 Interneuron
5 Effector organ
(c) Three-neuron reflex arc
Figure 7.11c Simple reflex arcs. Slide 2
1 Sensory receptor
3 Interneuron
3 Interneuron
3 Interneuron
5 Effector organ
(c) Three-neuron reflex arc
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Structures of the
Peripheral
Nervous System:
12 Cranial Nerves
Figure 7.22 Structure of a nerve.
Axon
Myelin sheath
Endoneurium
Perineurium
Epineurium
Fascicle
Blood
vessels
III Oculomotor
IV Trochlear
VI Abducens
I Olfactory II Optic
V Trigeminal V Trigeminal
VII Facial
Vestibular
branch
Cochlear
branch
VIII Vestibulocochlear
X Vagus
IX Glossopharyngeal
XII Hypoglossal XI Accessory
Structures of the
Peripheral
Nervous System:
Spinal Nerves
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Ltd.
Spinal Nerves
Spinal nerves
• 31 pairs
• Formed by the combination of the ventral
and dorsal roots of the spinal cord
• Named for the region of the spinal cord
from which they arise
Figure 7.24a Spinal nerves.
C1
2
3 Ventral rami form
Cervical 4
nerves 5 cervical plexus
6 (C1 – C5)
7 Ventral rami form
8*
T1 brachial plexus
2 (C5 – C8; T1)
3
4
Thoracic 5
nerves 6
7
8 No plexus
9 formed
10 (intercostal
Lumbar 1 nerves)
nerves 1
12 (T2 – T12)
Sacral L1
nerves 2
3 Ventral rami form
4 lumbar plexus
(L1 – L4)
5
Spinal
cord
Ventral
Ventral ramus
root
Spinal nerve
(b)
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Table 7.3 Spinal Nerve Plexuses (1 of 3)
Axillary nerve
Humerus
Radial
nerve
Musculo-
cutaneous
nerve
Ulna
Radius
Ulnar nerve
Median
nerve
Femoral nerve
Lateral femoral
cutaneous nerve
Obturator nerve
Femur
Anterior femoral
cutaneous nerve
Saphenous nerve
Superior gluteal
nerve
Inferior gluteal
nerve
Sciatic nerve
Posterior femoral
cutaneous nerve
Common fibular
nerve
Tibial nerve
Sural (cut) nerve
Deep fibular
nerve
Superficial fibular
nerve
Plantar branches
Autonomic
Nervous
System
(Parasympathetic vs
Sympathetic)
Figure 7.26 Comparison of the somatic and autonomic nervous systems.
Central
nervous system Peripheral nervous system Effector organs
Acetylcholine
Sympathetic Ganglion
division Acetylcholine Epinephrine and
Autonomic norepinephrine
nervous Blood Glands
system vessel
Adrenal medulla
Acetylcholine
Parasympathetic Cardiac
division muscle
Ganglion
KEY
: Preganglionic Postganglionic Myelination Preganglionic Postganglionic
axons axons axons axons
(sympathetic) (sympathetic) (parasympathetic) (parasympathetic)
Parasympathetic Sympathetic
Eye Eye
Brain stem
Salivary Skin
glands Cranial
Sympathetic Salivary
ganglia glands
Heart Cervical
Lungs Lungs
T1 Heart
Stomach
Thoracic
Stomach Pancreas
Liver
Pancreas and gall-
L1
bladder
Liver and Adrenal
Lumbar
gall- gland
bladder
Bladder Bladder
Sacral
Genitals nerves Genitals
(S2–S4)
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Figure 7.28 Sympathetic pathways.
Collateral ganglion
(such as the celiac)
Autonomic Functioning
Sympathetic—“fight or flight” division
Response to unusual stimulus when emotionally or physically
stressed or threatened
Takes over to increase activities
Remember as the “E” division
Exercise
Excitement
Emergency
Embarrassment
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Ltd.
Autonomic Functioning
Parasympathetic—“housekeeping” activites
“Rest-and-digest” system
Conserves energy
Maintains daily necessary body functions
Remember as the “D” division
Digestion
Defecation
Diuresis
Table 7.4 Effects of the Sympathetic and Parasympathetic Divisions of the Autonomic Nervous System (1 of 2)