Microbiology Question Bank
Microbiology Question Bank
1. Name the various methods of horizontal gene transfer. Describe the role of
conjugation in Antimicrobial Resistance. (2022)
IMMUNOLOGY
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2. An old lady from Mumbai suburban area presented with fever, chills, and rigor
for a duration of 5 days. Patient had an episode of convulsion also. Anaemia
and splenomegaly were present. On peripheral blood smear examination
multiple ring forms and crescent shaped gametocytes inside RBCs was
observed.
A] What is the etiological agent in the above clinical condition?
B] Describe briefly the life cycle of etiological agent.
C] Write the pathogenesis, clinical manifestations and complications
produced.
D] Write the laboratory diagnosis of it. (2021)
3. A 54 year old male presented with fever, chills, rigor for a duration of 4 days.
The patient developed convulsions prior to admission. He was started on
ceftriaxone by a private medical practitioner, but it did not improve. On
physical examination muscle tone and tendon reflexes were reduced.
Anaemia and splenomegaly were present. The blood sample was collected
for CBC and peripheral blood smear examination, which revealed Anaemia
and erythrocytes with 3 or 4 ring forms..
A] What is the most probable clinical diagnosis?
B] Draw the different forms of this aetiological agent.
C] Describe the life cycle of this pathogen.
D] Discuss the pathogenicity and life threatening complications of this
pathogen. (2022)
GASTROINTESTINAL INFECTIONS
2. A 6 year old boy developed severe watery diarrhoea and vomiting. The stool
sample received in the microbiology laboratory had rice water appearance.
A] Enumerate the aetiological agents causing diarrhoea.
B] what is the probable etiological diagnosis in this case?
C] Describe the pathogenesis of this condition.
D] Add a note on its laboratory diagnosis (2021 x3)
<repeated w/ a 4 year old boy>
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RESPIRATORY TRACT INFECTIONS
A 18 years old male was admitted to hospital with complaints of low grade
fever, loss of weight and appetite with cough & expectoration for the last 4
weeks. The sputum sent to the microbiology lab revealed long and slender
beaded AFBs.
A] What is your provisional diagnosis?
B] Describe Pathogenesis of this condition and Laboratory diagnosis in detail
C] Add a note on drug resistance of this etiological agent. (2021 x2)
<there is another question in one of the next papers with the only difference
being its a 24 year old male rather than an 18 year old male so I'm not writing
that>
1. Toxoplasma gondii (2006, 2009, 2010, 2013, 2017, 2018) + life cycle (2008)
2. Immunoprophylaxis of poliomyelitis (2006, 2008, 2009)
3. Cryptococcus neoformans (2011, 2013)
4. Advantages and Disadvantages of Oral Polio Vaccine and Killed Polio
Vaccine. (2013)
5. Immunoprophylaxis for rabies. (2013, 2018)
6. Tetanospasmin (2018)
7. Cystericerus (2006)
A 4 year old boy was brought to the emergency room by parents with
complaints of high grade fever, neck rigidity and altered sensorium for the last
3 days. Physical examination showed when neck is passively flexed, his legs
also get flexed (positive Brudzinski’s sign). The direct examination of the CSF
sample received in the microbiology laboratory showed Gram positive,
Lanceolate shaped diplococci.
A] What is a probable etiological agent in this case?
B] Describe the method to confirm the diagnosis in the laboratory.
C] Add a note on available vaccines to prevent the infection. (2021 x2)
1. Trichomonas vaginalis (2006, 2008 x2, 2010, 2011, 2012, 2013, 2018)
2. Serological tests for Syphilis (2007, 2010)
3. VDRL Test (2012, 2018)
+ Principles, Applications, Advantages, Limitations of VDRL (2014)
4. Significant Bacteriuria (2014, 2016)
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MISCELLANEOUS