Cell Cycle
Cell Cycle
Cell Cycle
• Cell growth, DNA replication and cell division constitute a cell cycle
• Events happening in a cell cycle is genetically controlled
• Duration of cell cycle varies in different organisms and different types of cells. The average duration of the human cell cycle is 24 hrs, whereas a yeast cell
completes one cell cycle in 90 minutes
• The cell cycle is divided into Interphase and M phase
• Interphase: Cell growth and replication of DNA. It constitutes 95% of the duration of a cell cycle
• M Phase: Mitosis (cell division)
A. Interphase
Interphase is the time lapse between two successive M phases of cell division. The cell prepares
for division, grows and DNA replication takes place. Interphase is further divided into three
phases: G1, S, G2
• G1 Phase or Gap 1: It is the gap between previous mitosis and DNA replication of the
next cell cycle
• S Phase or Synthesis: In this phase DNA replication takes place. The DNA content of the
cell doubles and centriole duplicates. It is important to note that the chromosome number
remains the same
• G2 Phase or Gap 2: The cell continues to grow and prepare for mitosis. Protein synthesis
takes place. In an adult human being, there are many cells, which do not divide, e.g. heart
cells divide occasionally only to replace injured and dead cells. These cells enter an
inactive phase called G0 or the quiescent stage of the cell cycle
B. M Phase: This is the phase where actual cell division occurs. The number of chromosomes in
the parent and daughter cells remains the same so it is also known as equational division.
Karyokinesis, i.e. nuclear division is followed by cytokinesis, i.e. division of the cytoplasm to
give rise to two daughter cells