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20 mm 120 mm

Package leaflet: Information for the user xxxxxxxxx • cyclosporin (for skin conditions, rheumatoid • loss of appetite (anorexia)
arthritis and in organ transplantation) • hyperactivity or agitation
Ciprofloxacin 500 mg Film-Coated Tablets • anti-arrhythmics: medicines that can alter your • headache, dizziness, sleeping problems or taste

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heart rhythm (e.g. quinidine, hydroquinidine, disorders
Ciprofloxacin hydrochloride disopyramide, amiodarone, sotalol, • vomiting, abdominal pain, digestive problems
dofetilide, ibutilide), tricyclic such as stomach upset (indigestion/heartburn),
Read all of this leaflet carefully before taking this medicine because it contains important antidepressants, some antimicrobials (that or wind
information for you: belong to the group of macrolides), some • increased amount of certain substances in the
• Keep this leaflet as you may need to read it again. antipsychotics. blood (transaminase and/or bilirubin)
• If you have any further questions, ask your doctor or pharmacist. Ciprofloxacin may increase the levels of the following • rash, itching or hives
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their medicines in your blood: • joint pain in adults
signs of illness are the same as yours. • pentoxifylline (for circulatory disorders) • poor kidney function
• pains in your muscles and bones, feeling unwell

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• If you get any of the side effects talk to your doctor or pharmacist. This includes any possible side effects not • caffeine
• duloxetine (for depression, diabetic nerve (asthenia), or fever
listed in this leaflet. See section 4.
damage or incontinence) • increase in blood alkaline phosphatase (a
What is in this leaflet: Tell your doctor immediately if any of the following • lidocaine (for heart conditions or anaesthetic certain substance in the blood)
1. What Ciprofloxacin 500mg Tablets are and occurs while taking Ciprofloxacin 500mg Tablets. use) Rare side effects (may affect up to 1 in 1,000
what they are used for Your doctor will decide whether treatment with • sildenafil (e.g. for erectile dysfunction). people):
2. What you need to know before you take Ciprofloxacin 500mg Tablets needs to be stopped. Some medicines reduce the effect of Ciprofloxacin. • inflammation of the bowel (colitis) linked to
Ciprofloxacin 500mg Tablets Tell your doctor if you take or wish to take:. antibiotic use (can be fatal in very rare cases)
• Severe, sudden allergic reaction (an
3. How to take Ciprofloxacin 500mg Tablets • antacids (see Section 2: Warnings and precautions)
anaphylactic reaction/shock, angio-oedema).
4. Possible side effects • omeprazole • changes to the blood count (leukopenia,

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Even after the first dose, there is a small chance
5. How to store your Ciprofloxacin 500mg • mineral supplements leukocytosis, neutropenia, anaemia), increased
that you may experience a severe allergic
Tablets • sucralfate or decreased amounts of a blood clotting factor
reaction with the following symptoms: tightness
6. Contents of the pack and other information • a polymeric phosphate binder (e.g. sevelamer (thrombocytes)
in the chest, feeling dizzy, sick or faint or
or lanthanum carbonate) • allergic reaction, swelling (oedema), or rapid
1. What Ciprofloxacin 500mg Tablets are experiencing dizziness when standing up. If this
• medicine or supplements containing calcium,
and what they are used for happens stop taking Ciprofloxacin and swelling of the skin and mucous membranes
contact your doctor immediately. magnesium, aluminium or iron. (angio-oedema)
Ciprofloxacin 500mg Tablets are an antibiotic If these preparations are essential, take Ciprofloxacin • increased blood sugar levels (hyperglycaemia)
• If your eyesight becomes impaired or if your
belonging to the fluoroquinolone family. Ciprofloxacin about two hours before or no sooner than four hours • decreased blood sugar levels (hypoglycaemia)
eyes seem to be otherwise affected, consult an
Tablets are used for the treatment of severe bacterial after taking them. (see Section 2: Warnings and precautions)
eye specialist immediately.

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infections. They only work with specific strains of • Pain and swelling in the joints and tendinitis Ciprofloxacin 500mg Tablets with food and drink • confusion, disorientation, anxiety reactions,
bacteria. and inflammation or rupture of tendons may Large amounts of dairy products particularly milk or strange dreams, or hallucinations
Adults occur rarely. Your risk is increased if you are yoghurt may slow down ciprofloxacin uptake, • pins and needles, unusual sensitivity to stimuli of
• respiratory tract, urinary tract, genital tract elderly (above 60 years of age), have received therefore ciprofloxacin should be taken 1 to 2 hours the senses, decreased skin sensitivity, tremors,
infections in men and women, stomach and an organ transplant, have kidney problems or if before or at least 4 hours after these products. seizures (see Section 2: Warnings and
intra-abdominal infections, skin and soft tissue, you are being treated with corticosteroids. precautions), or giddiness
Inflammation and ruptures of tendons may occur Surgical procedures • eyesight problems including double vision
bone and joint infections. Tell your doctor that you are taking
• long lasting or recurring ear or sinus infections within the first 48 hours of treatment and even (diplopia)
up to several months after stopping of ciprofloxacin because pain relief and sedative • ringing in the ear (tinnitus), temporary hearing
• anthrax inhalation exposure medicines administered prior to surgery can
Ciprofloxacin 500mg Tablets therapy. At the first loss (particularly high frequencies), impaired

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Ciprofloxacin may be used in the management of also be affected by ciprofloxacin.
patients with low white blood cell counts sign of pain or inflammation of a tendon (for hearing
(neutropenia) who have a fever that is suspected to example in your ankle, wrist, elbow, shoulder or If one of the above-mentioned situations is • increased heart rate (tachycardia)
be due to a bacterial infection. knee), stop taking Ciprofloxacin 500mg Tablets, applicable to you, your doctor may decide to • widening of blood vessel (vasodilation), low
contact your doctor and rest the painful area. prescribe another medicine or to adjust the blood pressure, or fainting
If you have a severe infection or one that is caused Avoid any unnecessary exercise as this might dose of Ciprofloxacin 500mg Tablets or the • shortness of breath (dyspnoea) including
by more than one type of bacterium, you may be increase the risk of a tendon rupture. other medicine. asthmatic symptoms, swelling of the voice box
given additional antibiotic treatment in addition to • If you suffer from epilepsy or other (larynx) with difficulties in breathing (larynx
Ciprofloxacin Tablets. neurological conditions such as cerebral It is advisable never to use several medicines oedema)
ischemia or stroke, you may experience side at the same time without consulting your doctor • liver disorders, or hepatitis
Children and adolescents
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effects associated with the central nervous first. • sensitivity to light (see Section 2: Warnings and
Ciprofloxacin Tablets are used in children and
system. If this happens, stop taking Pregnancy precautions)
adolescents, under specialist medical supervision to
Ciprofloxacin and contact your doctor If you are pregnant or breast feeding, think you • sudden (acute) kidney failure, blood or crystals
treat the following bacterial infections:
immediately. may be pregnant or are planning to have a in the urine with discomfort when passing urine
• lung and bronchial infections in children and
• You may experience psychiatric reactions the baby, ask your doctor or pharmacist for advice (crystalluria) (see Section 2: Warnings and
adolescents suffering from cystic fibrosis
first time you take Ciprofloxacin. If you suffer before taking this medicine. precautions), urinary tract inflammation
• complicated urinary tract infections, including
from depression or psychosis, your symptoms • fluid retention or excessive sweating
infections that have reached the kidneys It is preferable to avoid the use of Ciprofloxacin
may become worse under treatment with • increased levels of the enzyme amylase
(pyelonephritis) during pregnancy.
• anthrax inhalation exposure Ciprofloxacin. In rare cases, depression or Very rare side effects (may affect up to 1 in 10,000
psychosis can progress to thoughts of suicide,
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Ciprofloxacin Tablets may also be used to treat other Breast-feeding people):

specific severe infections in children and adolescents suicide attempts, or completed suicide. If this Ciprofloxacin is passed into human breast milk. • reduction in red blood cells due to extensive
when your doctor considered this necessary. happens, stop taking Ciprofloxacin and contact You must not breast-feed your child during destruction of these cells (haemolytic anaemia),
your doctor immediately. treatment with ciprofloxacin, due to the risk of a dangerous drop in a type of white blood cells
2. What you need to know before you take • You may rarely experience symptoms of nerve malformation of joint cartilage and other (agranulocytosis), a drop in the number of red
Ciprofloxacin 500mg Tablets damage (neuropathy) such as pain, burning, harmful effects in the breast-fed infant. and white blood cells and platelets
tingling, numbness and/or weakness especially (pancytopenia), which may be fatal; and bone
Do NOT take Ciprofloxacin 500mg Tablets if you in the feet and legs or hands and arms. If this Driving and using machines
or your child: marrow depression, which may also be fatal
happens stop taking Ciprofloxacin and inform Ciprofloxacin can reduce your attention. If you
• have a known allergic reaction to (see Section 2: Warnings and precautions)
your doctor immediately in order to prevent the suffer from dizziness, do not drive or operate
• migraine, disturbed coordination, unsteady walk
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ciprofloxacin, to other quinolone drugs or to development of potentially irreversible condition. machines, which require your full
any of the other ingredients of this medicine (gait disturbance), disorder of sense of smell
• Quinolone antibiotics may cause an increase of concentration.
listed in Section 6. (olfactory disorders), pressure on the brain
your blood sugar levels above normal levels 3. How to take Ciprofloxacin 500mg Tablets (intracranial pressure and psuedotumor cerebri)
• are taking tizanidine (see section 2: Taking (hyperglycaemia), or lowering of your blood
other medicines) • visual colour distortions
sugar levels below normal levels, potentially You should follow your doctor's instructions and • inflammation of the wall of the blood vessels
Warnings and precautions leading to loss of consciousness (hypoglycaemic check the pharmacist's label for how many tablets to (vasculitis)
coma) in severe cases (see section 4). This is take, and when. The usual doses for different types • pancreatitis
Before taking this medicine important for people who have diabetes. If you of infections treated with Ciprofloxacin 500mg
You should not take fluoroquinolone/quinolone • death of liver cells (liver necrosis) very rarely
suffer from diabetes, your blood sugar should be Tablets are given below as a guide: leading to life-threatening liver failure
antibacterial medicines, including Ciprofloxacin carefully monitored. Respiratory tract infections 1 tablet twice a day for
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500mg Tablets, if you have experienced any serious • small pin-point bleeding under the skin
• Diarrhoea may develop while you are taking 7 to 14 days. (petechiae); various skin eruptions or rashes
adverse reaction in the past when taking a quinolone antibiotics including Ciprofloxacin, or even Pyelonephritis 1 tablet twice a day for 7 to 14 days.
or fluoroquinolone. In this situation, you should inform • worsening of the symptoms of myasthenia
several weeks after you have stopped taking Prostatitis 1 tablet twice a day for up to 28 days
your doctor as soon as possible. gravis (see Section2: Warnings and precautions)
them. If it becomes severe or persistent or you Severe gastroenteritis 1 tablet twice a day for 3 to
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notice that your stool contains blood or mucus, 7 days. Frequency not known (cannot be estimated from
Talk to your doctor before taking Ciprofloxacin stop taking Ciprofloxacin immediately, as this Skin and soft tissue infections 1 tablet twice a day the available data)
500mg Tablets can be life-threatening. Do not take medicines for 5 to 10 days. • abnormal fast heart rhythm, life-threatening
• if you have ever had kidney problems because that stop or slow down bowel movements and Bone and joint infections 1 tablet twice a day for irregular heart rhythm, alteration of the heart
your treatment may need to be adjusted contact your doctor. 4 to 6 weeks or longer. rhythm (called ‘prolongation of QT interval’, seen
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• if you suffer from epilepsy or other • Tell the doctor or laboratory staff that you are Severe systemic infections 1 tablet twice a day. on ECG, electrical activity of the heart)
neurological conditions taking Ciprofloxacin if you have to provide a Acute, uncomplicated gonorrhea a single dose of • pustular rash
• if you have a history of tendon problems during blood or urine sample. 1 tablet. • influence on blood clotting (in patients treated
previous treatment with antibiotics such as • If you suffer from kidney problems, tell the with Vitamin K antagonists).
The actual dose may be adjusted to take into account
Ciprofloxacin Tablets doctor because your dose may need to be • feeling highly excited (mania) or feeling great
your age, severity of infection and how well your
• if you are diabetic because you may experience adjusted. optimism and overactivity (hypomania)
kidneys are working. If you have a severe infection
a risk of hypoglycaemia with ciprofloxacin • Ciprofloxacin may cause liver damage: If you • syndrome associated with impaired water
and serious kidney problems your doctor may take
• if you have myasthenia gravis (a type of muscle notice any symptoms such as loss of appetite, excretion and low levels of sodium (SIADH).
regular blood samples to check your recovery and
weakness) jaundice (yellowing of the skin), dark urine, • loss of consciousness due to severe decrease in
ensure you are receiving the correct dose. Ideally
• if you have heart problems: Caution should be itching or tenderness of the stomach, stop taking blood sugar levels (hypoglycaemic coma).
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these tablets should be swallowed whole with a glass

taken when using this kind of medicine, if you Ciprofloxacin and contact your doctor See section 2.
of water. These tablets can be taken at any time, with
were born with or have a family history of immediately. or without food. Taking the tablets on an empty Very rare cases of long lasting (up to months or
prolonged QT interval (seen on ECG, electrical • Ciprofloxacin may cause a reduction in the stomach will speed up the uptake, whilst dairy years) or permanent adverse drug reactions, such as
recording of the heart), have salt imbalance in number of white blood cells and your resistance products such as milk or yoghurt may slow down the tendon inflammation, tendon rupture, joint pain, pain
the blood (especially low levels of potassium or to infection may be decreased. If you uptake of ciprofloxacin in the stomach. in the limbs, difficulty in walking, abnormal sensations
magnesium in the blood), have a very slow heart experience an infection with symptoms such as
If you take more Ciprofloxacin 500mg Tablets sucha s pins and needles, tingling, tickling, burning,
rhythm (called ‘bradycardia’), have a weak heart fever and serious deterioration of your general
than you should numbness or pain (neuropathy), depression, fatigue,
(heart failure), have a history of heart attack condition, or fever with local infection symptoms
If you take more than you should, or in the event of sleep disorders, memory impairment, as well as
(myocardial infarction), you are female or elderly such as sore throat/pharynx/mouth or urinary
an overdose, seek medical advice immediately and, if impariment of hearing, vision, and taste and smell
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or you are taking other medicines that result in problems you should see your doctor
possible, take any remaining tablets or this leaflet have been associated with administration of
abnormal ECG changes (see section Other immediately. A blood test will be taken to check
with you to show the doctor. quinolone and fluorquinolone antibiotics, in some
medicines and Ciprofloxacin 500mg Tablets) possible reduction of white blood cells
cases irrespective of pre-existing risk factors.
• if you have been diagnosed with an enlargement (agranulocytosis). It is important to inform your If you forget to take Ciprofloxacin 500mg Tablets
or "bulge" of a large blood vessel (aortic doctor about your medicine. If you forget to take your medicine take the missed Cases of an enlargement and weakening of the
aneurysm or large vessel peripheral aneurysm) • Your skin becomes more sensitive to sunlight dose as soon as possible and then continue as aortic wall or a tear in the aortic wall (aneurysms
• if you have experienced a previous episode of or ultraviolet (UV) light when taking normal. However, if it is almost time for your next and dissections), which may rupture and may be
aortic dissection (a tear in the aorta wall) Ciprofloxacin. Avoid exposure to strong dose, do not take the missed dose and continue as fatal, and of leaking heart valves have been
• if you have been diagnosed with leaking heart sunlight, sunlamps or other sources of UV usual. Do not take a double dose to make up for the reported in patients receiving fluoroquinolones. See
valves (heart valve regurgitation) radiation. If exposure to sunlight is inevitable you forgotten one. also section 2.
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• if you have a family history of aortic aneurysm or should use sun cream to protect yourself. If you
Reporting of side effects
aortic dissection or congenital heart valve experience a fever, rash, itching or small red
spots on the skin, you should consult your
If you stop taking Ciprofloxacin 500mg Tablets
You should continue to take these tablets for as If you get any side effects, talk to your doctor or Artwork
disease, or other risk factors or predisposing
long as directed by your doctor. It is important that pharmacist. This includes any possible side effects
conditions (e.g. connective tissue disorders such doctor immediately since the treatment may be
not listed in this leaflet. You can also report side
Brand: Dr Reddy’s
as Marfan syndrome or Ehlers-Danlos discontinued. you complete the course of treatment, even if you
• Crystalluria, (presence of crystals in the urine begin to feel better after a few days. If you stop taking effects directly via the Yellow Card Scheme at: Product Name: Ciprofloxacin
syndrome, Turner syndrome, Sjögren’s
with discomfort when passing urine) may occur. this medicine too soon, your symptoms may return. www.mhra.gov.uk/yellowcard search for MHRA
syndrome (an inflammatory autoimmune
Consult your doctor as your urine needs to be Yellow Card in the Google Play or Apple App Store. Strength: 500 mg
disease), or vascular disorders such as If you have any further questions on the use of this
tested. Furthermore, you should drink a By reporting side effects you can help provide more
Takayasu arteritis, giant cell arteritis, Behcet’s medicine, ask your doctor or pharmacist.
sufficient amount of liquid (about 1.5-2 litres per information on the safety of this medicine. Form: Tablets
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disease, high blood pressure, or known

atherosclerosis, rheumatoid arthritis (a disease day). 4. Possible side effects 5. How to store Ciprofloxacin
of the joints) or endocarditis (and infection of the • Tuberculosis test (Mycobacterium).
Like all medicines, this medicine can cause 500mg Tablets Component: Leaflet
heart)) Ciprofloxacin may cause a false test result.
• If you feel sudden, severe pain in your side-effects although not everybody gets them. Keep this medicine out of the sight and reach of
• if you or a member of your family is known to • muscle pain and/or weakness, inflammation of
have a deficiency in glucose-6-phosphate abdomen, chest or back, which can be children. Do not store above 25°C and keep in the Pack Size:
symptoms of aortic aneurysm and dissection, the joints and joint pain, increased muscle tone original container. Do not use this medicine after the
dehydrogenase (G6PD) (disease of the red
blood cells based on a hereditary enzyme go immediately to an emergency room. Your risk and cramping, inflammation of the tendons or expiry date which is stated on the label after ‘Exp Country: UK
may be increased if you are being treated with tendon rupture, particularly affecting the large (MM/YY)’. The expiry date refers to the last day of
deficiency)because taking ciprofloxacin may Date Created:
lead to a destruction of red blood cells causing systemic corticosteroids. tendon at the back of the ankle (Achilles tendon)
that month. Do not throw away any medicines via 22/01/2019
(see Section 2: Warnings and precautions)
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anaemia. Signs of anaemia are a feeling of • If you start experiencing a rapid onset of wastewater or household waste. Ask your pharmacist
shortness of breath, especially when you lie • unusual feelings of pain, burning tingling,
how to throw away medicines you no longer use.
Date Modified: 18 NOV 2020
weakness and in more severe cases, numbness or muscle weakness in the
breathlessness and pale skin. down flat in your bed, or you notice swelling of These measures will help protect the environment. Version: 2.1
extremities (neuropathy) (see Section 2:
your ankles, feet or abdomen, or a new onset
If you feel sudden, severe pain in your abdomen, Warnings and precautions) 6. Contents of the pack and other
chest or back, go immediately to an emergency
of heart palpitations (sensation of rapid or
irregular heartbeat), you should inform a doctor
• severe allergic reactions (anaphylactic reaction information Technical Information
room. or anaphylactic shock, which can be fatal –
immediately. What Ciprofloxacin 500mg Tablets contain: Die Cut Guides
serum sickness) (see Section 2: Warnings and
For the treatment of some genital tract infections, Other medicines and Ciprofloxacin 500mg precautions) Each tablet contains ciprofloxacin hydrochloride
your doctor can prescribe another antibiotic in Tablets. • mental disturbances (psychotic reactions equivalent to 500mg ciprofloxacin. The other
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addition to ciprofloxacin. If there is no improvement in Tell your doctor or pharmacist if you are taking, have potentially leading to thoughts of suicide, suicide ingredients are maize starch, microcrystalline
symptoms after 3 days of treatment, please consult recently taken or might take any other medicines. attempts, or completed suicide) (see Section 2 cellulose, sodium starch glycolate, anhydrous
your doctor Ciprofloxacin can increase the level of the following Warnings and precautions) colloidal silica, magnesium stearate, hypromellose,
substances in the blood: • depression (potentially leading to thoughts of macrogol 400 and titanium dioxide (E171). Min Font Size:
While taking Ciprofloxacin 500mg Tablets
• Agomelatine suicide, suicide attempts, or completed suicide)
8.5pt
What Ciprofloxacin 500mg Tablets looks like and Printer: India
Prolonged, disabling and potentially irreversible • Zolpidem • flu-like symptoms, followed by a painful red or
contents of the pack:
serious side effects Do not take Ciprofloxacin together with tizanidine, purplish rash that spreads, blisters on your skin, Dimensions: 555x140mm
Ciprofloxacin 500mg Tablets are white, oval shaped
Fluoroquinolone/quinolone antibacterial medicines. because this may cause side effects such as low mouth, nose or genitals, or red, painful, watery
film-coated tablets debossed ‘C500’ on one side with
Including Ciprofloxacin 500mg Tablets, have been blood pressure and sleepiness (see section 2: "Do eyes, signs of the potentially fatal
a breakline on the other. They are packaged in blister
Project: CC1000046522
Stevens-Johnson syndrome or toxic epidermal
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associated with very rare but serious side effects, not take Ciprofloxacin"). packs of 10, 12, 20 or 100 tablets or also in
some of them being long lasting (continuing months necrolysis
high-density polyethylene containers of 50, 100 or Colours
or years), disabling or potentially irreversible. This If Ciprofloxacin 500mg Tablets and one of the • yellow and/or itchy skin, a sign of jaundice
500 tablets. Not all pack sizes may be marketed.
includes tendon, muscle and joint pain of the following medicines are given at the same time, (cholestatic icterus). Process Black

upper and lower limbs, difficulty in walking, special care must be taken: • hypersensitivity reaction called DRESS (Drug Marketing Authorisation Holder and
abnormal sensations such as pins and needles, Reaction with Eosinophilia and Systemic Manufacturer:
Tell your doctor if you are taking:
tingling, tickling, numbness or burning Symptoms). UK: Dr. Reddy’s Laboratories (UK) Ltd
• Vitamin K antagonists (e.g. warfarin) or other
(paraesthesia), sensory disorders including oral-anti-coagulants (to thin the blood) 6 Riverview Road, Beverley, HU17 0LD UK
Other side effects may include:
impairment of vision, taste and smell, and • probenecid (for gout) Ciprofloxacin 500mg Tablets PL08553/0174
hearing, depression, memory impairment, severe • methotrexate (for certain types of cancer, Common side effects (may affect up to 1 in 10
Date of preparation 11/2020
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fatigue, and severe sleep disorders. psoriasis, rheumatoid arthritis) people):

• theophylline (for breathing problems) • nausea, diarrhoea
If you experience any of these side effects after • joint pains in children © Dr Reddy’s Laboratories (UK) Ltd
• tizanidine (for muscle spasticity in multiple
taking Ciprofloxacin 500mg Tablets, contact your
sclerosis) Uncommon side effects (may affect up to 1 in 100
doctor immediately prior to continuing treatment. You
• olanzapine and clozapine (antipsychotics) people):
and your doctor will decide on continuing the
• ropinirole (for Parkinson’s disease) • fungal superinfections
treatment considering also an antibiotic from another Dr. Reddy’s Laboratories (UK) Ltd
• phenytoin (for epilepsy) • a high concentration of eosinophils, a type of
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class. 6 Riverview Road, Beverley, HU17 0LD, UK

• metoclopramide (for nausea and vomiting) white blood cell.