BACKGROUND

It has around 133 genera and in excess of 3,800 species. Psidium guajava
and it's everything parts have an old history of therapeutic worth [1].The
evergreen bush-like tree Psidium guajava reaches a height of 6 to 25
feet. depicts various plant parts, including its leaves, flowers, organic
products, and seeds likewise, bark. The plant Psidium guajava (common
name-guava) is notable tree which is bounteously developed for organic
product. It has place to phylum Magnoliophyta, class Magnoliopsida
furthermore, Myrtaceae family. [2] s a wide spreading association of
branches. The majority of its bent branches exhibit inverse leaves with
three to sixteen centimeter-long petioles. The The variety of leaves is
wide and clear green, and they have Additionally, prominent veins.
White flowers are produced. blooms with in-curved petals having a nice
fragrant. Blooms have four to six petals and yellow shaded anthers
Moreover, the insects fertilize themselves. Organic guava product goes
from little to medium estimated with 3 to 6 cm length.[3]

Fig. 1 Various parts of guava (a) Leaves (b) Fruit (c)

Seeds in the fruit (d) Bark
Chemical composition of guava

Guava are the rich wellspring of minerals, like calcium, potassium, sulfur,
sodium, iron, boron, magnesium, manganese, and nutrients vitamin C , A
and B. Rejuvenating balm is available in leaves which contain α-pinene,
limonene, β-pinene, isopropyl liquor, menthol, terpenyl acetic acid
derivation, caryophyllene, longicyclene and β-bisabolen .[4] ursolic acid
is also tracked down in the guava leaves which have anti-inflammatory .
[5,6] The chemical structures of ursolic acid have been shown in fig2

Fig.2 structure of ursolic acid

Medicinal importance of guava

Psidium guajava a tropical plant which is utilized as food and medication.

Numerous nations have a long history of using guava for medicinal
purposes . The delicate leaves of the plant have been utilized as a tonic
to treat stomach related conditions like looseness of the bowels and the
runs in the native clinical Brazil and Mexico. In brazil and mexico the
delicate leaves of guava used in dysentery and diarrhoea . it is used as
treatment of gastroenteritis, hypertension, diabetes, caries and relief
from discomfort and for development in locomotors coordination. Its
leaf's extract is being utilized as a medication in cough and oral ulcers
and in some swollen gums wound. [7,8] In ayurveda it is considered as
tridosha nashaka.[9] Psidium guajava can act as antioxidant,
antimicrobial, antispasmodic, anti-diabetic, anticancer, anti
inflammatory and hepatoprotective impacts.[10,11]

ANTI-DIARRHOEA
the product of Psidium guajava have an exceptionally huge anti-diarrhea
action and are protected to use as shown by the high LD50 value. This
supports the conventional utilization of the ethanolic organic product
concentrate of Psidium guajava as natural solution for treatment of the
diarrhoea.[12]Guava leaf extract contains dynamic mixtures that are
likely anti-diarrhoea, including steroid, triterpenoid, phenolics, alkaloids,
flavonoids, saponins and tannins.[13] It is recommended utilize an
option in contrast to giving guava leaves as a treatment or counteraction
of intense diarrhea .[14]

ANTI-OXIDANT

antioxidant is an inhibitor for the oxidation of biomolecule , it is very

important for the defence of a living system against oxidative
stress .guava leaf extracts may provide health-promoting effects. it is a
potential source of natural antioxidants. it is contain gallic acid, Ellagic
Acid and Ascorbic acid which work as antioxidant . [15,16]

References
1. Sampath Kumar NS, Sarbon NM, Rana SS, Chintagunta AD, Prathibha
S, Ingilala SK, Jeevan Kumar SP, Sai Anvesh B, Dirisala VR. Extraction of
bioactive compounds from Psidium guajava leaves and its utilization in
preparation of jellies. AMB Express. 2021 Dec;11:1-9.
2. Kaneria M, Chanda S. Phytochemical and pharmacognostic evaluation
of leaves of Psidium guajava L.(Myrtaceae). Pharmacognosy Journal.
2011 Jul 1;3(23):41-5
3. Naseer S, Hussain S, Naeem N, Pervaiz M, Rahman M. The
phytochemistry and medicinal value of Psidium guajava (guava). Clinical
phytoscience. 2018 Dec;4(1):1-8.
4. Kumar M, Tomar M, Amarowicz R, Saurabh V, Nair MS, Maheshwari
C, Sasi M, Prajapati U, Hasan M, Singh S, Changan S. Guava (Psidium
guajava L.) leaves: Nutritional composition, phytochemical profile, and
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5. Diwakar R, Shaikh I, Dawda H, Mukundan U. Phytochemical
evaluation and quantitative estimation of corosolic and ursolic acid from
Psidium guajava. World J. Pharmaceut. Res. 2016 Jan 5;5:1318-27.
6. Yin R, Li T, Tian JX, Xi P, Liu RH. Ursolic acid, a potential anticancer
compound for breast cancer therapy. Critical reviews in food science and
nutrition. 2018 Mar 4;58(4):568-74.
7. Kim MH, Kim JN, Han SN, Kim HK. Ursolic acid isolated from guava
leaves inhibits inflammatory mediators and reactive oxygen species in
LPS-stimulated macrophages. Immunopharmacology and
immunotoxicology. 2015 May 4;37(3):228-35.
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phytochemistry and medicinal value of Psidium guajava (guava). Clinical
phytoscience. 2018 Dec;4(1):1-8.
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doi: 10.2174/1386207326666230426093315. PMID: 37170987.
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Antidiarrheal activity of ethanolic fruit extract of Psidium guajava
(Guava) in castor oil induced diarrhea in albino rats. National Journal of
Physiology, Pharmacy and Pharmacology. 1970 Jan 1;3(2):191-.
13. Chechani B, Roat P, Hada S, Yadav DK, Kumari N. Psidium guajava:
An insight into ethnomedicinal uses, phytochemistry, and pharmacology.
Combinatorial Chemistry & High Throughput Screening. 2024 Jan
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Diarrhea In Toddlers. Journal for Quality in Public Health. 2023 May
22;6(2):374-9.
15. He Q, Venant N. Antioxidant power of phytochemicals from
Psidium guajava leaf. Journal of Zhejiang University-Science A. 2004
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16. Masuda T, Inaba Y, Maekawa T, Takeda Y, Yamaguchi H,
Nakamoto K, Kuninaga H, Nishizato S, Nonaka A. Simple detection
method of powerful antiradical compounds in the raw extract of plants
and its application for the identification of antiradical plant constituents.
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