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Unit 5 1

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34 views

Unit 5 1

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harini.sam7
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INTRODUCTION TO COMPUTATIONAL BIOLOGY

UNIT-5
IMMUNOBIOLOGY

CHOOSE THE BEST ANSWER


1. Which of the following systems protects our body against disease-causing microbes?
(a) Immune system
(b) Digestive system
(c) Excretory system
(d) Respiratory system
2. Which of the following immunity is present from our birth?
(a) Innate Immunity
(b) Active immunity
(c) Passive immunity
(d) Acquired immunity
3. Neutrophils, basophil, lymphocytes, eosinophil and monocytes are examples of
________.
(a) Physical barrier
(b) Cellular barriers
(c) Cytokine barriers
(d) Physiological barriers
4. B-cells and T-cells are two types of cells involved in _______________.
(a) Innate Immunity
(b) Active immunity
(c) Passive immunity
(d) Acquired immunity
5. The common disorders caused by a poor immune system include ________
(a) Epidemic Diseases
(b) Deficiency diseases
(c) Autoimmune diseases
(d) None of the above
6. Which of the following statements is true about Passive Immunity?
(a) This immunity causes reactions
(b) This immunity develops immediately
(c) This immunity lasts only for a few weeks or months
(d) All of the above.
7. Which of the following cells is involved in humoral immunity?
(a) T-cells
(b) B-cells
(c) Mast cells
(d) Both T and B cells
8. Which of the following immunity is obtained during a lifetime?
(a) Innate immunity
(b) Active immunity
(c) Passive immunity
(d) Both (b) and (c)
9. Cells Involved In Innate Immunity are_________.
(a) Phagocytes
(b) Macrophages
(c) Natural Killer Cells
(d) All of the above
10. Which of the following immunity is called the first line of defence?
(a) Innate Immunity
(b) Active immunity
(c) Passive immunity
(d) Acquired immunity
11) Which of the following cells is involved in cell-mediated immunity?
(a) Leukaemia
(b) T cells
(c) Mast cells
(d) Thrombocytes
12) Which of the following protects our body against disease-causing pathogens?
(a) Respiratory system
(b) Immune system
(c) Digestive system
(d) Respiratory system
13) Hepatitis is an example of _______.
(a) Subunit Vaccine
(b) Killer Vaccine
(c) Toxoids Vaccine
(d) Recombinant Vaccine
14) Which of the following statements is true about the IgM of humans?
(a) IgM can cross the placenta
(b) IgM can protect the mucosal surface
(c) IgM is produced by high-affinity plasma cells
(d) IgM is primarily restricted in the circulation
15) Interferons are
(a) Cytokine barriers
(b) Physical barriers
(c) Cellular barriers
(d) Physiological barriers
16) Which of the following cells of the immune system do not perform phagocytosis?
(a) Macrophage
(b) Neutrophil
(c) Eosinophil
(d) Basophil
17) Monocytes differentiate into which kind of phagocytic cells?
(a) Neutrophil
(b) B cell
(c) Macrophage
(d) T cell

18) Natural killers cells are found in all of the following except:

a) Blood
b) Thymus
c) Spleen
d) Lymph nodes
e) Red bone marrow
19.Wandering macrophages are phagocytes that develop from:
a) Neutrophils
b) Fixed macrophages
c) Basophils
d) Monocytes
e) Eosinophils

20. Which is not one of the four characteristic symptoms of inflammation?


a) Redness
b) Swelling
c) Pain
d) Heat
e) Cyanosis
21.Which of the following is involved in cell mediated immunity?
a) B cell
b)T cell
c)both T & B
d) mast cells
22. Which of the following does NOT belong to granulocyte?
a)basophil
b)neutrophil
c)eosinophil
d) monocytes
23. Immunoinformatics is also known as ----------------------.
a)computational immunology
b) ophthalmology
c)oncology
d) both b & c
24. Majority of antigen are ---------------.
a)proteins
b)lipids
c)carbohydrates
d)nucleic acids
25. Small chemical groups on the antigen that react with the antibody is ----------------.
a)epitope
b)isotope
c)allotope
d)paratope
26. -------------------- is the father of Immunology.
a) Edward Jenner
b) Louis Pasteur
c) Charles Darwin
d)Leeuwenhoek
27. ------------- is the region on an antibody which recognizes the epitope.
a) paratope
b) binding site
c) antigen-determinant site
d)epitope
28. Humoral immune response is mediated by antibodies produced by --------------------.
a) T-cells
b) B lymphocytes
c) NK cells
d) dendritic cells
29. Immunization is an example for ------------------.
a) natural active immunity
b) artificial active immunity
c)natural passive immunity
d) artificial passive immunity
30.The study of immunome reactions is ---------------.
a) immunology
b) vaccinology
c) immunomics
d)proteomics
31. ---------------- is an example for agranulocytes.
a) basophils
b) monocytes
c) neutrophils
d) eosinophils
8 Marks
1. Explain about innate immunity
2. Enumerate on inflammatory response
3. Write a short note on vaccine
4. Describe about leucocytes and its function
5. What is immune engineering? Explain in detail
6. Explain cell mediated and humoral immune response
7. Differentiate active and passive immunity
8. Write a short note on adaptive immunity
9.Differentiate innate and adaptive immunity
10. Write a short note on immunoinformatics
11. Write a short note on the cells of the immune system
12. What is an epitope? Write a short note on the types of epitope present in our immune system

15 Marks
1. Data storage, analysis and interpretation contributes a major part of research and
development. Discuss on the prospects of engineering and design in these in silico processes
towards the better understanding of defense mechanism of the body.
2. Describe how virus variants can be effectively targeted using modern prediction and vaccine
designing strategies.
3. What kind of immunity is attained when weakened antigens are introduced into the body?
Explain
4. How is computational approach useful in predicting the active sites of the antigen that causes
diseases? What approach can be used to predict the antigen and antibody interaction in silico?

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