Principles of inheritance 6.

Who among the following used the

frequency of recombination between gene
1. Mandel published his work in 1865 but it
pairs on the same chromosome as a
remained unrecognised till 1900. Which of
measure of distance between genes and
the following reason was not responsible
mapped their position
for it
(1) Davenport (2) Sturtevant
(1) Communication was not easy
(3) Morgan (4) Nillson
(2) His concept of genes (factors) as stable
7. If yellow body, white eyed drosophila is
and discrete unit was not accepted by his
crossed with wild brown body red eyes
contemporaries as an explanation for
drosophila. Then what would be frequency
apparently continuous variations
of recombinants in F1 generation
(3) Use of mathematics to explain
(1) 100 % (2) 1.3 %
biological phenomenon
(3) 98.7 % (4) 0 %
(4) Use of emasculation technique
8. The map distance between genes A and B
2. Parallelism between charomosome and
is 3 units, between B and C is 10 units and
behaviour of gene was established by
between C and A is 7 units. The order of
(1) de Varies, Correns and Tschermark
the genes in a linkage map constructed on
(2) Sutton and Boveri
the above data would perhaps be
(3) Bateson and Punnet
(a) A, B, C (b) A, C, B
(4) Landsteiner and de Castello
(c) B, C, A (d) B, A, C
3. Who among the following united the
9. Crossing over in diploid organism is
knowledge of chromosomal segregation
responsible for
with Mendelian principles and called it
(a) Dominance of genes
chromosomal theory of inheritance
(b) Linkage between genes
(1) Bateson (2) Boveri
(c) Segregation of alleles
(3) Sutton (4) Correns
(d) Recombination of linked allele
4. 46. Experimental verification of
10. The percentage of crossing over will be
chromosomal theory of inheitance was
more if
proposed by
(a) Linked genes are located far apart from
(1) Tschermark (2) de Vries
each other
(3) Sutton (4) Morgan
(b) Linked genes are located close to each
5. Drosophila melanogaster is best material
for study of inheritance. Which of the other
following reason is not appropriate for (c) Genes are not linked
selection of Drosophila (d) Genes are located in a different cell
(1) They can grow on simple synthetic 11. Physical association of two genes is
medium known as
(2) They complete their life cycle in about (a) Heterozygosis (b) Linkage
two weeks
(c) Recombination (d) Homozygosis
(3) Single mating could produce small
number of progeny
(4) Clear differentiation of the sexes
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12. Find out the incorrect statement. Molecular basis of inheritance
(a) Morgan carried out several dihybrid 15. Which of the following is correct with
crosses in drosophila to study the genes respect to E.coli.?
that were sex linked. (1) E.coli divides once in 40 minutes.
(b) Sturtevant used the frequency of (2) E.coli is parasite in human digestive
recombination between gene pairs on the track.
same chromosome as a measure of the (3) The genetic material of E.coli has
distance between genes and mapped their 4.6x106 bp.
position on chromosome. (4) The genetic material of E.coli has
(c) Henking gave the term X-body. 4.6x109 bp
(d) Boveri united the knowledge of 16. Assertion: In the molecular structure of
chromosomal segregation with Mendelian RNA, uracil is present instead of thymine.
principles and called it the chromosomal Reason: 5-methyl uracil is another
theory of inheritance. chemical name for thymine.
13. Which cross shows very tight linkage? (1) Both assertion and reason are correct,
and reason explains assertion.
(2) Both assertion and reason are correct,
but reason does not explain assertion.
(3) Assertion is true but reason is false.
(4) Assertion is false but reason is true.
17. Which of the following is a true statement?
(1) Bacteriophage Lambda has 48502
bases in its DNA structure.
(2) Thymine is common for both DNA and
RNA, cytosine is present only in DNA.
(3) Haploid content of human DNA is
3.3x106 bp.
(4) Two nucleotides are linked through
31 x51 phosphodiester linkage to form a
dinucleotide.
18. DNA is negatively charged because of the
present of …..
(a) Cross A (b) Cross B (1) Deoxyribose (2) Phosphate group
(c) Both (a) and (b) (d) None of these (3) Thymine (4) Guanine
14. Why drosophila melanogaster is suitable 19. Match the following:
for the study of genetical variation? A) DNA, an acedic I) F.Crick
(a) Could be grown on simple synthetic substance in nucleus
medium in laboratory. B) “X”-ray diffraction II) J.Watson and F.Crick
data providers
(b) Complete life cycle is 2 weeks and
C) Proposal of Double III) Mourice Wilkins and
single mating produces a large number of Helix model for DNA R.Franklin
progeny flies. D) Central dogma in IV) F.Meisher
(c) Clear sexual dimorphism is present and molecular biology
many types of heredity variation can be (1) A-I; B-IV; C-III; D-II
seen with low power microscope. (2) A-IV; B-III; C-II; D-I
(d) All of these (3) A-II; B-IV; C-I; D-III
(4) A-IV; B-II; C-III; D-I

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20. Which one of the following is a false 26. The experiments which provides
statement? unequivocal proof that DNA is the genetic
(1) The backbone of DNA strands material – conducted by
constituted by Sugar-Phosphate. (1) Avery, McLeod and Mc Carty.
(2) Uniform distance between the two (2) Hershy and Chase.
strands of DNA helix is present, because (3) Wilkins and Franklin.
purine comes opposite to a pyrimidine. (4) Watson and Crick.
(3) The two strands are coiled in a 27. Hershy – Chage experiments shows
righthanded fashion and the pitch of the following steps, chronologically
helix is 0.34A0 (1) Blending, Infection, Centrifugation.
(4) The plane of one base pair stacks over (2) Centrifugation, Infection, Blending.
the other in double helix (3) Infection, Centrifugation, Blending.
21. Identify the correct match. (4) Infection, Blending, Centrifugation.
(1) Histones – rich in Lysine and Leucine. 28. Statement 1: A molecule that can act as a
(2) A Nucleosome – has 200 bases of DNA genetic material should be able to express
helix. itself in the form of Mendelian characters.
(3) R-strain of bacteria – produce smooth Statement 2: RNA being unstable mutate
colonies. at a faster rate.
(4) Euchromatin – transcriptionally active (1) Both statement-1 and statement-2 are
22. Which one of the following experiments correct.
concluded that “DNA is the hereditary (2) Statement-1 is correct, statement 2 is
material” but not convinced by all incorrect.
biologists. (3) Statement 1 is incorrect, statement 2 is
(1) Frederick Griffith correct.
(2) M.Meselson and F.Stahl (4) Both statement-1 and statement-2 are
(3) A.Hershey and M.Chase false.
(4) O.Avery, C.McLeod and Mc carty. 29. The polarity of a template strand of DNA
23. Whose experiment did not define the which produce discontinuously
biochemical nature of the genetic material. synthesised DNA fragments is
(1) F.Crick (2) F.Griffith (1) 51→ 31 (2) 31→51
(3) A.Hershey et.al. (4) F.Meischer
(3) 31→ 31 (4) 51→51
24. The packaging of chromatin at higher level
30. Which one of the following is a true
requires
statement?
(1) Histone proteins (1) Monocistronic structural genes of
(2) Non-histone chromosomal proteins eukaryotes have uninterrupted coding
(3) Non-histone nucleoplasic proteins sequence.
(4) Proteins of nucleolus. (2) The transcription and translations can
25. Which statement is true in the context of be coupled in Bacteria.
(3) Unexpressed coding sequences on
histones?
mRNA are called exons.
(1) They are positively charged acedic (4) Introns appear in matured or processed
proteins. RNA.
(2) They are positively charged amphoteric 31. In Eukarytic cells, RNA polymerase III is
proteins. transcribing _____.
(3) They are positively charged basic (1) 28S.Rrna, 18S-rRNA and 5.85-rRNA
proteins. (2) hn RNA
(4) They are negatively charged acedic (3) 5.srRNA; 5.8 srRNA; tRNA
proteins. (4) tRNA; 5 srRNA and ‘snRNA’
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32. Which statement of the following is true, 39. If the length of human cell DNA is 2.2m,
with respect to splicing of hn RNA? then the number of base pairs in in human
(1) Removal of exons and joining of cell?
introns is called splicing – in mRNA. (1) 4.6 x 109 bp (2) 46 x 106 bp
(2) Removal of only exons is called (3) 6.6 x 109 bp (4) 4.6 x 106 bp
splicing. 40. During DNA replication, the
(3) Removal of introns and joining of discontinuously synthesized fragments are
exons in a defined order. joined by…
(4) Removal of introns only. (1) DNA helicase
33. Tayler et, al – experimentally proved the (2) DNA-gyrases
semi conservation DNA replication in the (3) DNA polymerase I
chromosomes during mitosis in ‘fababean’ (4) DNA ligase
by using. 41. The initial structure formed at the
(1) Radioactive guanosine beginning of coiling of DNA around
(2) Radioactive cytidine histones is called.
(3) Radioactive thymidine (1) Nucleon (2) Nucleoid
(4) Radioactive adenosine (3) Nucleosome (4) Solenoid
34. In DNA recombination procedures, vector 42. is always 1, for all
is required because it provides
(1) ds DNA molecules of all eukaryotes
(1) “Origin of replication”
(2) ds DNA molecules of some organisms
(2) “Promoter region”
and all viruses
(3) “Terminator region”
(3) ds DNA molecules of all prokaryotes
(4) “Operator region”
and eukaryotes and also viruses (with ds
35. Polyploidy in certain organism may result
DNA)
due to
(4) ssDNA of ϕ - x – 174 – B. phage
(1) A failure is DNA replication after cell
43. In bacterial during the process of
division.
transcription is bacteria, the opening of the
(2) A failure in cell division after DNA
helix of DNA is by the activity of
replication.
(1) DNA dependent RNA polymerase
(3) A mistake in DNA replication.
(2) RNA dependent RNA polymerase
(4) A failure in the interphase after DNA
(3) Helicase
replication.
(4) Topoisomerase
36. RNA is unstable because it is
44. In monohybrid cross proportion of 3 : 1
(1) a catalyst with non-reactive nature
explains:
(2) a catalyst hence reactive
(1) Dominance
(3) a non-catalyst which is reactive
(2) Segregation
(4) having single strand and with uracil
(3) Both (1) and (2)
37. 2,4 – dioxy pyrimidine is also called
(4) Unit factor
(1) Thymine (2) Cytosine
45. Study of family history about inheritance
(3) Guanine (4) Uracil
of a particular trait in several generations
38. Hershey and chase in their experiments
of a family called
used… (to prove that DNA is the genetic
(1) Phylogeny
material)
(2) Ontogeny
(1) 32S ;35P (2) 35S ; 32P
(3) Pedigree analysis
(3) 30S ;32P (4) 35S; 35P
(4) Cladistics

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