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Model paper 1

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16 views

Model paper 1

Uploaded by

Supraja Rajasekaran
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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INSTITUTE OF PHARMACOLOGY, MADRAS MEDICAL COLLEGE

THEORY MODEL EXAMINATION – PAPER I


Date: 14/11/2024 Time: 3 hrs Total marks: 100 marks

I. Essay (1 x 15 = 15 marks)
1) A 50-year-old man presented with complaints of tightness and discomfort over the chest
episodically particularly after exertion and relieved within 5-10 minutes of rest. The resting
ECG was normal, but stress test showed ischemic changes.
a) Classify the drugs used to treat the above clinical condition (3)
b) Discuss in detail about nitrates (7)
c) Add a brief note on Ivabradine (5)

2) A businessman aged 40 years suffered loss in his business & became very depressed. He
stopped going out and withdrew socially.
a) Enumerate the antidepressants for therapy (3)
b) Write in detail about SSRIs (7)
c) Therapeutic uses and Adverse effects of Tricyclic antidepressants. (5)

II. Short notes (10 x 5 = 50 marks)


1) Redistribution of drugs and its clinical significance
2) Clinical uses of anticholinesterases
3) Prostaglandin drugs as antiglaucoma drugs
4) Write a brief note on febuxostat
5) Anticholinergic bronchodilators
6) Succinylcholine apnea
7) Treatment of status epilepticus
8) Explain in detail about labetalol
9) Low molecular weight heparins
10) Principles of bioethics

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III. MCQs (20 x 1 = 20 marks)

1. A 6-year-old child admitted with viral fever, developed Reye’s syndrome. Which NSAID could
have caused the above condition?
a. Acetaminophen b. Aspirin
c. Celecoxib d. Diclofenac

2. A 25-year-old man presented with sudden onset of running and itchy nose, sneezing, partial
nasal blockage. Similar episodes occurring on and off during the spring season. Select the
appropriate intranasal antihistamine for allergic rhinitis.
a. Desloratadine b. Levocetirizine
c. Fexofenadine d. Azelastine

3. What is the mechanism of action of Erenumab?


a. Calcitonin gene related peptide receptor blocker
b. 5HT1D/1B agonism
c. Weak calcium channel blockade
d. Prostaglandin synthesis inhibition

4. Which of the following antitussive has NMDA receptor antagonistic action?


a. Acetylcysteine b. Codeine
c. Dextromethorphan d. Bromhexine

5. A 40-year-old man presents with episodic breathlessness accompanied by wheezing which is


often following exertion. Following drugs are used to control bronchial asthma except
a. Fluticasone b. Salbutamol
c. Salmeterol d. Monteleukast

6. All are phases of clinical trials except


a. Human pharmacology b. Therapeutic confirmation
c. Reproduction & Teratogenicity studies d. Post marketing surveillance

7. Which drug undergoes Hoffman elimination?


a. Atracurium b. Rifampicin
c. Omeprazole d. Phenytoin

8. What is tachyphylaxis?
a. Drug resistance b. Drug dependence
c. Intolerance d. Acute tolerance

9. Pick out the shortest acting mydriatic


a. Tropicamide b. Homatropine
c. Cyclopentolate d. Darifenacin

10. Following are drugs used for the treatment of ADHD except
a. Atomoxetine b. Sibutramine
c. Amphetamine d. Methylphenidate
11. First dose effect is seen with
a. Doxazosin b. Tamsulosin
c. Prazosin d. Phentolamine

12. The reversal agent for terminating the action of Vecuronium is


a. Neostigmine b. Sugamadex
c. Edrophonium d. Dantrolene sodium

13. An upper limb fracture reduction under Bier’s block was planned for a 25-year-old man. Which
among the following cardiotoxic local anesthetic is contraindicated in this patient?
a. Bupivacaine b. Lidocaine
c. Tetracaine d. Prilocaine

14. Which general anesthetic can be used in hypovolemic patients?


a. Propofol b. Sevoflurane
c. Nitrous oxide d. Ketamine

15. A 70-year-old man with complaints of failing to fall asleep occasionally for the past few
months which was unrelated to anxiety or physical illness. Which of the following drug can be
prescribed for the above patient?
a. Phenobarbitone b. Flumazenil
c. Zolpidem d. Gabapentin

16. Neuroprotective antiparkinsonian drug is


a. Carbidopa b. Amantadine
c. Rasagiline d. Ropinirole

17. Nesiritide which is being used for refractory CHF is


a. Recombinant Brain Natriuretic Peptide
b. Neprilysin inhibitor
c. Inodilator
d. Aldosterone antagonist

18. Ultrashort acting β1 blocker used for emergency control of ventricular rate in atrial fibrillation/
atrial flutter is
a. Esmolol b. Sotalol
c. Propranolol d. Betaxolol

19. Which is the paradoxical use of Thiazide diuretic?


a. Hyperuricemia b. Hearing loss
c. Diabetes insipidus d. Hyperglycemia

20. All are GP IIb/IIIa inhibitors except


a. Abciximab b. Eptifibatide
c. Tirofiban d. Ticagrelor

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