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540 views22 pagesNDDS MCQ
Novel drug delivery system
Uploaded by
stillstill970Copyright
© © All Rights Reserved
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/ 22
RUNGTA INSTITUTE OF PHARMACEUTICAL EDUCATION & RESEARCH
Kohka-Kurud Road, Bhilai (C.G.)
Second Sessional Theory Examination (Nov-Dec22)
B. Pharm 7** Semester
Subject: Novel Drug Delivery System
Duration: 04 hr.
Que 1: Multiple Choice question [1x10 = 10 M]
1-Regarding the skin
Getic epidermis is the thickest layer
The stratum corneum is the greatest barrie}
to transdermal transport
The dermis has a rich capillary blood
supply
|. Skin hydration is a cause of inter
individual variation in drug absorption
2. Problems with opioid TDDS include
a. Poor patient compliance
b. Allergy
c. Constipation
SP Respintiory depression
3. What is the size of nanoparticles?
a. 10-100 nm
1-100 nm
}0-1000 nm
4, The absorption of the ophthalmic drug does
not depend on which of the following
a. Physiochemical properties of the
permeating molecule
b. Drainage of tears
c. Output of tears
MBB. Size of the eyeball
5. is carrier for haemoglobin
1. Neosome
b. Nanoparticle
mE Aquasomes
d. Phytosomes
6. Physicochemical factor effecting TDDS
a. Sunlight
S™9_ Partition coefficient
©. Air pollution
d. Cold season
7. Preservative used in the Nasal spray is
Paraben
b. PEG
Subject code: 341754(41)
Date: 15.12.22
Max. Marks: 30
Glycerine
d. Acetone
8. What type of process does the liposomes
undergoes
See Oxidation
b. Acetylation
c. Reduction
d. Isomerization
). Which of the following is a natural polymer
used in nanoparticles?
a. Polycaprolactone
Polylactic acid
mm Alginate
d. polystyrene
10, Sodium taurocholate used as penetration |
euhancer is
a. A surfactant
b. Fatty acid with surfactant property
# isile salt with surfactant property
4, Bile salt with no surfactant property
Que 2: Long Answer Question [10x1=10M]
ANY 01
1. Describe transdermal drug delivery system
(TDDS) with examples and explain in
detail about the basic component of
‘TDDS.
2. What is targeted drug delivery system?
Explain formulation and application of
liposome and nanoparticles.
Ques 3: Short Answer Question (Any2)
[5x2=10]
1 Elaborate the advantages and disadvantages of
intrauterine drug delivery system (IUDs)
2. Write a note on application of Gastroretentive
drug delivery system.
3. Give different methods or approaches to
overcome ocular barriers, 341754(41)
p. Pharmacy (Seventh Semester) Examination,
April-May 2023
(New Scheme)
(Pharmacy Branch)
NOVEL DRUG DELIVERY SYSTEM
Theory-(BP704T)
Time Allowed : Three hours
Maximum Marks : 75
Note : Anwser all questions from Section~‘A”
Attempt any two questions from Section~'B”
and seven questions from Section-'C
Section-*A’
(Multiple Choice Questions) 20x1=20
Note : Aitempt all the questions. Each question
carries 1 mark,
175441) PTO hoose the correct answer
ize of controlled release
dosag,
we
sit compliance fom,
(b) Reduction in frequency Of dosing
proved efficacy in treatment
meni) Al] of the above
‘The release kinetic on controlled drug delivery;
usually follows the order : "4
(2) First order
© Ze00 order
(©) pH dependent
(4) None of the above a
@) Following is the example of natural polymer
(@) Protein
(0) Keratin
(c) Cellulose 4
~ All of the above
cy)
Structural pa
Parameter that co:
'at Contriby
hydrophobicity ee
34175441)
(vil)
134
(a) Chain stiffness
(b) High degree of crystallinity
(c) Presence of highly hydrophobic group
All of the above
‘Wurster apparatus is used in following method
of microen capsulation?
(a) Coacervation phase separation
Air suspension
(©) Multiorifice centrifugal process
(d) Polymerization
Implants are typically administered with following
routes except :
) Subcutaneously
(b) Sublingually
(c) Intramuscularly
(@) Intravenously
Mucoadhesion due to the filling of the irregularities
on a rough surface by a mucoadhe:
liquid is :
(a) Adsorption theory
341754(41) PTO. I4]
—") Weiting theory
(c) Mechanical theory
(a) Fracture theory
(iti), Which charge is carried by
the mucus ety, (xi)
at physiological pH?
(@) Positive
SS) Negative
(c) Both
(d) None of the above
5 - » oa)
(&) Which of the following is NOT an advantages of
the TDDS?
(2) Noninvasive
(b) Avoids GI tract
mmc) Larzer doses can be administered ©
cD)
indices.
(%) ‘The primary barriers to transdermal drug delis
“ A
(a) Dermis
Se) Epidermis (stratum comeum)
SHI7S4(41)
is]
(c) Hypodermis,
(d) All of the above
Which of the following is not a type of Floating
Drug Delivery System?
(a) Effervescent Systems
(b) Non Effervescent Systems
(0) Raft Forming Systems
Metered Dosing Systems
Normal pH of the nasal secretions in adult is
(a) 75-85
55-65
(©) 7-8
(d) 5-6
A lipid bilayer structure that encloses an internal
aqueous volume
~ Liposome
(0) Solid lipid nanoparticle
(a) Nanoparticle
Pro
SH1784(41) a SS —-"_ ©
ian) Use of monoclonal antibodies for drug dati
ery
to tumors is:
Active targeting
(b) Passive targeting
(c) Triggered drug targeting
(d) Vector targeting
(xv) Ideal characteristics of targeted drug delivery
system is
(a) Nontoxic
(>) Biocompatible and Physicochemically stable
(c) Predictable and controllable rate of drug
release
) All of the above
(xvi) The body’s natural immune system is used in
: 3417544)
wr0
ee (2)
1, Choose the correct answer :
131
i is used in which
Ihe body's natural immune system 15
{
(i) Discosomes are ;
iv) i :
: types of targeting +
NW Active
i shy Passive
(c) Physical
(@) Giant Liposomes
Giant Niosomes
(©) Giant Ethosomes
@ Giant transfersomes
(@ Dual :
Wurster apparatus is used in which method 0}
Pilo-20 s marketed preparation of : eS 7 oe
ts “0 (@ Coacervation phase separation
(®) SODI oom ai
a my Air suspension
Se) Ocusert
(@) Multiorifice centrifugal process
.
' : : erine device is =
i a :
Gil) Hydrophilic polymers used in controlled ocular (i) The non-medicated Intraut
system is:
(@) Para gard
() Polyacrylic acids (by-Lippes loop
(oy Progestasert
(©) Sodium carboxy methly cellulose
(©) Carbomer
mm All of the above
ss 341754(41)
es
@ Mirena ae
nulations the elimi
(i) For Controlled release formulations
PTO
34n754{41) halflife should bey
(@) Less than 2
2 hours
©) More than § hours
>) etwees
1 2t0 6 hous: =
(@) None
(il) The biological factor j influen
act of controlled release p
() Partition Coefficient
Uencing the
Product is :
/
ion
©) Molecular size
©) Sohibitity
lon-activated DDS is whic
h type of activated
System :
©) Chemical
©) Biochemical
©) Allofthe above
10)
&
Following is continuous
Pm release system ;
icoadhesve system,
sara, —_// ‘
“Sign ang,
ene
ist
stem
(by Colon targeted syst
Wo release system
2) Dissolution controlled
©)
tem
(4) Intestinal release syst
which
under
direct effect of pH comes
‘The dir .
C targeting approac}
(a) Active targeting 2
Passive targeting
ing
(©) Inverse treatin
(@) Physical targeting - z
ii fier to
di) What is the primary barr fransdermal
ii)
delivery +
1) Demis
@) ! rie
(© Hypodermis _ pes
ibove:
(@) All the al #
i spray
“The preservative used in nasal
iti)
(a) PEG
(b) Glycerine
#10
341754(41) araben
(d) Acetone
xiv) The absorption of the ophthalmic di
depend on which of the folloy
So Size of the eyeball
(®) Physicochemical properties of the
ving :
molecule i “ating
(@) Ourput of tears
©) Release kinetis from dissolution contro
is governed by :
(2) Fick’s law of Diffusion
Pies Whitney Equation /
(©) Zeto order
(4) First order
Gi) Different types of mecty
‘anism of release of Sustain
release systems are :
(2) Dissolution Controlled SR systems
~—
341754¢41)
(esi THE és
led a
aes (viii) Out
wm )
fusion controlled SR systems
is controlled SR systems
(by D
() Osmos!
epg AIl the above
vice containing pilocarpine and alginic acid
* ini
ina drug reservoir is used for :
in
(a) Diabetes Therapy (
i (b) Dental ‘Therapy
Sen ocilar Therapy
(@ Tuberculosis Therapy
of following which is Not a techique of micro
encapsulation : /
(@) Air suspension and coating
(©) Coating,
er Miking
s
‘ion and coaccervation
(@) Phase separati
Noe
ic acid resins are :
(ix) Sulphonic acid resins .
(@) Weak cation exchange resins
‘meas Strong cation exchange re eS
3417544)
~ | 18)
c) We ii
« Weak Anion exchange regi,
/ ‘Sins
) Strong Anion exchange resi |
7 : Section-* 7
(Short Answer Type Questions)
OS) Targeting di
| . Tugs to specific o L 45-32
) Spatial placemnt ‘Called
() Temporal delivery
Sah
he:
Note : Attempt any seven questions. Each question
carries 5 marks.
Cation of implants with examples.
(@) None of the above
jc components of transdermal drug delivery
Section-B
Iiition based controlled drug delivery
(Long Answ,
*r Type Questions) 5
*10=94)
Note :
+ Atte
pt any
qestions,
Each
question
two
Carries 10 marks,
Discuss formulation consideration of buccal drug delivery
systems.
mpl
10. Discuss advantages, disadvantages and appli
of Intra Uterine devices with suitable
ications of
> (any two):
(a) Liposomes
(b) anopartieles— /2 sosouses
341754041)
41754041) Page 18 of 44
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341754(41)
B. Pharmacy (Seventh Semester) Examination,
Nov.-Dec. 2021
(PCI Scheme)
(Pharmacy Branch)
NOVEL DRUG DELIVERY SYSTEM-THEORY
(BP704T)
Time Allowed : Three hours
Maximum Marks : 75
Note »Anwser all questions from Section-‘A’.
Attempt any two questions from Section~'B
and seven questions from Section-
Section-‘A?
(Multiple Choice Questions) 20x1=20
Note : Attempt all questions from MCQs. All
questions carry 1 mark,
341754(41) PTO
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1. Choose the correct answer
@ Drugs having
suitable candidate for controled release drug
transport mechanisms
