Neural Control and Coordination 4.0
Neural Control and Coordination 4.0
• Functions of all organs or organ system of our body must be coordinated to maintain normal
physiology of our body.
• In human body the neural system and the endocrine system jointly coordinate and integrate
activities of all the organs so that they function in a synchronised fashion.
• Co-ordination is the process through which two or more organs interact & complement the
functions of one another. For example, when we do physical exercises, the energy demand is
increased for maintaining an increased muscular activity. The supply of oxygen is also increased.
The increased supply of oxygen necessitates an increase in the rate of respiration, heart beat,
increased blood flow via blood vessels.
• When physical exercise is stopped, the activities of lungs, heart and kidney gradually return to the
normal condition.
• The neural system provides an organised network of point-to-point connections for a quick
coordination.
The endocrine system provides chemical integration through hormones.
• Nervous system and endocrine system are called Integrative system of the body.
• Nervous system offers high speed services but nerve fibres do not innervate all cells of the body
and the cellular functions need to be continuously regulated, therefore a special kind of
coordination and integration at the level of cells is provided by hormones.
Neural System
• The neural system of all animals is composed of highly specialised cells called neurons which can
detect, receive and transmit different kinds of stimuli.
• The neural organisation is very simple in lower invertebrates. For example, in Hydra it is composed
of a network of neurons.
• The neural system is better organised in insects, where a brain is present along with a number of
ganglia and neural tissues.
• The vertebrates have a more developed neural system.
• Nervous Tissue: Nervous tissue originates from ectoderm and is specialized for receiving stimuli
(Excitability) and transmit messages (conductivity).
NEURAL TISSUE
skeletal
• The human neural system is divided into two parts - CNS and PNS
• The CNS includes the brain and the spinal cord and is the site of information processing and control.
• The PNS comprises of all the nerves of the body associated with the CNS (Cranial and spinal nerves).
the nerve fibres of the PNS are of two types: Afferent fibres and Efferent fibres
• The afferent nerve fibres transmit impulses from tissues/organs to the CNS and the efferent fibres
transmit regulatory impulses from the CNS to the concerned peripheral tissues/organs.
• The PNS is divided into two divisions:
(A) Somatic Neural System (SNS)
(B) Autonomic Neural System (ANS)
• The somatic neural system relays impulses from the CNS to skeletal muscles while the autonomic
neural system transmits impulses from the CNS to the involuntary organs and smooth muscles of
the body.
• The autonomic neural system has two antagonistic units to regulate activities of visceral organs:-
sympathetic and parasympathetic system.
• Visceral nervous system is the part of PNS that contains the whole complex of nerves, fibres,
ganglia and plexuses by which impulses travel from the central nervous system to the viscera and
from the viscera to the central nervous system.
• A nerve cell is made up of cell body & cell processes like dendron and axon:
• Endoplasmic reticulum & ribosome form granules like structure called as Nissl's granules.
(B) Dendron:
• It is a small and highly branched cell process. It's fine branches are called dendrites. Some
receptor's are found on the dendrites, so dendron receive the stimuli & carry signals towards
the cyton (centripetal conduction).
• Axon is the functional part of nerve cell, and term nerve fibre usually refer to Axon.
• Cytoplasm of axon called axoplasm contains neurofibrils and mitochondria but no Nissl’s
granules.
• The terminal end of axon is Telodendria and button shape structure are called as Synaptic
knob, which possess synaptic vesicles containing chemicals called neurotransmitters.
• The axons transmit nerve impulse away from the cell body to a synapse or to a neuro-
muscular junction.
• Myelin sheath is discontinuous around the Axon. These interruptions where Axon is uncovered
by myelin sheath are called nodes of Ranvier.
• In the peripheral nerves, myelinogenesis begins with the deposition of myelin sheath in
concentric layer around the axon by schwann cells. Schwann cell encloses all nerve fibres in
PNS.
• Neurilemma or schwann cells are not present in CNS, therefore myelinogenesis process occurs
with the help of oligodendrocytes.
Diagram
• Neurons in which myelin sheath is present, are called myelinated nerve fibres. In some neurons
• Myelinated nerve fibres are found in spinal and cranial nerves. Unmyelinated nerve fibre
is enclosed by a Schwann cell that does not form a myelin sheath around the axon, and is
commonly found in autonomous and the somatic neural systems.
difference in ionic concentration across the membrane. Plasma membrane (Axolemma) contains
different types of ion channels. This axolemma is selectively permeable to different ions.
Over shoot
+20
0
-20
Repolarisation
-40 Depolarisation
Threshold
-60
{
level -70
-80 Hyperpolarisation
0 1 2 3 4 5 6 7
milli seconds
Saltatory Conduction
• Mechanism: When the AP develops in presynaptic membrane. It becomes permeable for Ca ++, Ca++
enter presynaptic membrane & neurotransmitter vesicles burst due to the stimulation by Ca ++ and
they release neurotransmitters in synaptic cleft.
• Neurotransmitter reaches the postsynaptic membrane via synaptic cleft & binds to specific
receptors (Proteins). This binding open up ion channels, allowing the entry of ions which can
generate a new potential on post synaptic membrane.
• Some neurotransmitters like acetylcholine (Ach), when binds to their receptors, open up Na + ion
channels and causes depolarisation of post synaptic membrane. The new potential generated is
called Excitatory post synaptic potential (EPSP) which generates Action Potential on post synaptic
neuron.
• If inhibitory neuro transmitter (GABA) binds with post synaptic membrane than Cl– gated channels
get open and hyperpolarization of neuron occurs. Now the potential is called inhibitory
postsynaptic potential (IPSP) & further nerve conduction get blocked.
Concept Builder
2. Rapid movement of Na+ ions from extracellular fluid to inside the nerve cell leads to:
(1) Polarisation (2) Depolarisation
(3) Repolarisation (4) All of these
Brain Meninges:
(1) Duramater:
• This is the first and the outermost membrane which is thick, strong and elastic layer.
• It remain attached with the inner surface of the cranium.
(2) Arachnoid:
• It is middle, thin and delicate layer and found only in mammals. (Mammalian character)
• At several places it forms villi like foldings to absorb CSF called arachnoid villi.
• Space between duramater & arachnoid is called subdural space which is filled with serous fluid.
(3) Piamater:
• Inner most, thin and transparent membrane, which is firmly attached to the brain.
• Space between arachnoid & piamater is called subarachnoid space, which is filled with CSF.
Cerebrospinal-Fluid (CSF):
• The fore brain consists of Cerebrum and Diencephalon (Mainly thalamus and hypothalamus).
(1) Cerebrum:
Cerebrum forms the major part of the brain which is most developed in human.
• Cerebrum consists of two cerebral hemispheres, on the dorsal surface a longitudinal groove is
present between two cerebral hemispheres called as median fissure. Both the cerebral
hemispheres remain connected with each other by curved thick white nerve fibre called corpus
callosum found in only higher mammals.
• Each cerebral hemisphere is divided into 4 lobes-Anterior, Middle, Posterior and Lateral.
• Anterior lobe is also called frontal lobe (largest lobe) while middle lobe is called as parietal
lobe. Posterior lobe is called as occipital lobe and lateral lobe is Temporal lobe.
• The outer part of cerebral hemisphere is called Cerebral cortex and thrown into prominent
folds. These folds are found as ridges and grooves on dorsal surface of cerebral hemisphere.
Ridge are known as Gyri while grooves are called sulci. Gyri and sulci increase the surface area
of cerebrum and provide additional space for more neurons.
• The cerebral cortex referred to as the grey matter due to its greyish appearance. The neuron
cell bodies are concentrated here giving the colour. This thick layer of grey matter is also known
as sign of evolutionary advancement.
• The cerebral cortex contains three types of functional areas:
(i) Sensory Area: Analysis of sensory impulses (Touch, Pain, Temperature etc.)
(ii) Motor Area: Generation of motor impulses.
(iii) Association Area: These are large regions that are neither clearly sensory nor motor in function.
They are responsible for certain complex functions like:
• Intersensory Association: As you are aware that all sensory inputs like touch, sound, light,
smell are sent to brain. These different sensations require association and inter connection
with each other for their proper interpretation.
• Memory: Memory of past events is recorded by the association areas also with the different
lobes of the cerebrum. Memory is basically of two types: Short term memory and long term
memory.
• Communication: The ability of communication also controlled by the association areas of
cerebral cortex.
Function of Cerebrum: It is the most important part of brain because it controls and regulates
different part of brain. This is the centre of conscious senses, will power, voluntary movements,
knowledge, etc.
2. Diencephalon:
• It is small chamber like posterior part of fore brain which is surrounded by cerebrum. It consists
of 3 parts.
(i) Epithalamus (ii) Thalamus (iii) Hypothalamus
(i) Epithalamus: It form the roof of diencephalon (Along with corpus callosum). Pineal body is
attached with epithalamus & control biological clock.
• It is a small part of brain. The midbrain is located between Thalamus / Hypothalamus of the fore
brain and pons of the hind brain. A canal called Cerebral aqueduct/Aqueduct of Sylvius passes
through the midbrain.
• The dorsal position of the mid brain consists mainly of four round swellings (lobes) called corpora
quadrigemina.
Cerebral aqueduct/
Aqueduct of sylvius
Crura cerebri/
Anterior Cerebral peduncle
• The mid brain receives and integrates visual, tactile and auditory inputs.
• The hind brain comprises cerebellum, pons and medulla (also called the medulla oblongata).
1. Cerebellum:
• It is made up of 3 lobe (2 large lateral lobe and 1 small middle lobe-vermis). Both lateral lobes
become enlarged and spherical in shape. so lateral lobe of cerebellum are also called as cerebellar
hemisphere. Cerebellum has very convoluted surface in order to provide the additional space for
many more neurons.
2. Pons:
• It is a small spherical projection, which is situated between the midbrain and medulla oblongata.
• It consists of longitudinal and transverse tracts of myelinated nerve fibres.
Function:- It regulates the breathing reaction through pneumotaxic centre.
3. Medulla Oblongata:
• Posterior part of hind brain and is tubular and cylindrical in shape. Medulla of brain is connected
to spinal cord.
• Mid brain, pons and medulla are situated in one axis and it is called as Brain stem.
Functions: It is the most important part of brain which controls the involuntary activities of internal
organs of the body e.g. cardiovascular reflex, respiration, metabolism, gastric secretion etc. As well
as this act as conduction path for all impulses between spinal cord and remaining portions of brain.
• It is also concerned with simple reflex action like sneezing, salivation, coughing, swallowing,
vomiting, yawning etc.
1. Mark the area of cerebral cortex responsible for complex functions like intersensory association
memory and communication:
(1) Sensory area (2) Motor area (3) Association area (4) Both (1) & (2)
Reflex Arc:
The nervous path used for a reflex action is called reflex arch. It includes a receptor, atleast one
afferent neuron, one efferent neuron and an effector organ.
• The afferent neuron receives signal from a sensory organ and transmits the impulse via a dorsal
nerve root into the CNS (Grey matter), where sensory impulses are converted into motor impulses.
• The efferent neuron then carries these motor impulses from CNS to the effector (muscles).
• These muscles get contracted and thus response (reflex action) get completed.
(iii) On the Basis of Synapse:
(B) Polysynaptic:
• In this type of reflex arc, there are one or more small neurons found in between the
sensory and motor neurons. These small neurons are called connector neuron or inter
neurons e.g. withdrawal reflex of foot.
• In such synapse, nerve impulse will have to travel through more than one synapse.
Concept Builder
1. Which of the following statement is not correct regarding epinephrine and nor-epinephrine?
(1) Both act like as neurotransmitter (2) Secreted by adrenal medulla
(3) They are antagonistic neurotransmitter (4) Both are catecholamines
2. Which of the following is not involved in all types of reflex actions?
(1) Receptor (2) Effector (3) Interneuron (4) Sensory neuron
Extra Points
42. The one way or unidirectional transmission 49. Excitement, Pleasure, Rage, Fear &
of nerve impulsive in our body is Motivation are function of :
maintained by : (1) Amygdala (2) Thalamus
(1) Synapse (3) Hypothalamus (4) Hippocampus
(2) Myelin sheath
50. Which one of the following menix is
(3) Membrane polarity
present only in mammalian brain ?
(4) Interneurons
(1) Duramater (2) Arachnoid
43. Na+/K+ pump in a cell is an example of: (3) Piamater (4) None of them
(1) Osmotic movement 51. Limbic system or limbic lobe is formed by :
(2) Diffusion a. Hippocampus
(3) Passive transport
b. Amygdala
(4) Active transport
c. Hypothalamus
(C) Structure and Function of Brain d. Outer parts of cerebral hemispheres
44. Corpus callosum connects : e. Inner parts of cerebral hemispheres
(1) Two cerebral hemisphere (1) a, b and c
(2) Two optic lobes (2) a, b and d
(3) Two olfactory lobes (3) a, b and e
(4) Optic chiasma (4) a, b, c and e
56. Which is correct about pons varolii? 65. Drinking of alcohol affects mostly :
(1) Situated between midbrain & Medulla (1) Cerebrum
Oblongata (2) Cerebellum
(2) Pons contains pneumotaxic centre (3) Medulla oblongata
(3) Inner grey, outer white matter (4) Thalamus
(4) All of the above
66. Most of the involuntary action are
57. The decoding and interpretation of visual controlled by :
information is carried out by which part of (1) Medulla oblongata
the brain ? (2) Cerebrum
(1) Frontal lobe (2) Parietal lobe (3) Cerebellum
(3) Temporal lobe (4) Occipital lobe (4) Thalamus
58. Tree like projections of white matter called 67. When the medulla oblongata (M.O.) is
Arbor vitae is a part of : damaged, then what happen ?
(1) Cerebrum (2) Cerebellum (1) Immediately die
(3) Midbrain (4) Forebrain (2) Die after few hrs
59. Cerebral hemispheres of mammals consist of (3) Live at 1 hrs & after it may die
(1) Outer grey matter and central white matter (4) No effect
(2) Outer white matter and central grey matter 68. Cerebral hemisphere is the centre of all
(3) Gray matter and white matter inter the following except one :
mingled (1) Taste (2) Smell
(4) Gray matter only (3) Balance (4) Thinking
73. The inner parts of cerebral hemispheres 80. Which of the following is not true to reflex
and a group of associated deep structures actions?
like amygdala, hippocampus, etc; form a (1) Spontaneous
complex structure called : (2) Controlled by spinal cord only
(1) Reticular system (3) Automatic
(2) Corpora quadrigemina (4) Involuntary
(3) Limbic lobe/limbic system
(4) Arbor vitae 81. Which one of the following statements is
correct?
74. The cerebrum wraps around a structure (1) Neither hormones control neural activity
called thalamus, which is : nor the neuron control endocrine activity
(1) A major coordinating centre for (2) Endocrine glands regulate neural
sensory signal only
activity, but not vice versa
(2) A major centre for motor signalling
(3) Neurons regulate endocrine activity, but
(3) A major coordinating centre for
not vice versa
sensory and motor signalling
(4) Endocrine glands regulate neural activity,
(4) Not a nervous part of a brain
and nervous system regulates endocrine
75. Association areas in cerebral cortex are: glands.
(1) Sensory areas
(2) Motor areas 82. Which one of the following does not act as
(3) Responsible for intersensory associations, a neurotransmitter?
memory and communication (1) Norepinephrine (2) Cortisone
(4) None of the above is correct (3) Acetylcholine (4) Epinephrine
2. Mark the incorrect statement regarding (2) 1-b-i, 2-c-iii, 3-d-iv, 4-a-ii
Knee jerk reflex?
(3) 1-a-i, 2-d-iv, 3-c-iii, 4-b-ii
(1) Occurs quickly and without involvement
of your conscious effort. (4) 1-c-i, 2-d-iv, 3-a-ii, 4-b-iii
9. In man the osmotic centres are situated in : 14. Which of the following statements is
incorrect about cortex of cerebrum?
(1) Cerebrum
(1) It consists of grey matter
(2) Hypothalamus
(2) It consists of white matter
(3) Pituitary gland (3) It shows prominent folds
(4) Medulla oblongata (4) It contains motor areas, sensory areas
and association areas.
10. Osmolarity and satiety centres are located
15. Hypothalamus does not control:
in?
(1) Thermoregulation
(1) Hypothalamus (2) Urge for eating and drinking
(2) Cerebrum (3) Produces hormones that regulate the
synthesis and secretion of pituitary
(3) Medulla oblongata
hormone
(4) Pons veroli (4) Creative thinking and consciousness
19. Assertion (A): Withdrawal reflex is 23. Assertion (A): Neuron is the longest cell
controlled by spinal cord. of human body.
Reason (R): Initially cerebrum is involved Reason (R): It contain dendrites and
and require alertness for perform this axon.
reflex. (1) Both (A) & (R) are true and the (R) is
(1) Both (A) & (R) are true and the (R) is
the correct explanation of the (A)
the correct explanation of the (A)
(2) Both (A) & (R) are true but the (R) is
(2) Both (A) & (R) are true but the (R) is
not the correct explanation of the (A)
not the correct explanation of the (A)
(3) (A) is true but (R) is false (3) (A) is true but (R) is false
(4) Both (A) and (R) are false (4) Both (A) and (R) are false
20. Assertion (A): Amygdala body is a part of 24. Assertion (A): Nerve impulse conduction
limbic system. is one way conduction.
Reason (R): It controls the mood Reason (R): Neurotransmitters are only
especially anger and rage. present at axon terminals.
(1) Both (A) & (R) are true and the (R) is (1) Both (A) & (R) are true and the (R) is
the correct explanation of the (A) the correct explanation of the (A)
(2) Both (A) & (R) are true but the (R) is (2) Both (A) & (R) are true but the (R) is
not the correct explanation of the (A) not the correct explanation of the (A)
(3) (A) is true but (R) is false (3) (A) is true but (R) is false
(4) Both (A) and (R) are false
(4) Both (A) and (R) are false
34. In the diagram of the lateral view of the 36. Which of following is correct match
human brain, parts are indicated by
(1) Axon – transmits nerve impulse
alphabets. Choose the answer in which
these alphabets have been correctly towards cell body
matched with the part which they (2) Dendrites – project out of cell body
indicate. and contains Nissl’s granules
(3) Unipolar neuron – Cell body with 2
axon
(4) Bipolar neuron – Cell body with 1
axon and 2 or more dendrites
(A) Nervous System and Nervous Tissue In the above given flow chart, choose the
option which show’s correct
39.
identification for A, B, C & D in given
below table:
40.
B
D
Exercise - II
Que. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Ans. 2 4 4 2 4 1 3 4 2 1 1 2 1 2 4 2 1 2 3 2
Que. 21 22 23 24 25 26 27 28 29
Ans. 3 2 2 2 1 1 1 1 1
Exercise – III
Que. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Ans. 1 1 2 1 1 1 1 1 2 2 1 1 3 4 4 2 3 2 3 1
Que. 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40
Ans. 1 1 2 1 1 4 4 3 4 4 1 3 4 4 1 2 1 3 3 1
Que. 41 42 43 44 45 46 47 48 49
Ans. 1 2 2 3 3 1 4 2 2