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Vasopressors guideline in IGOT ICU
All patients with hypotension
After 20ml/ kg fluid NS or RL bolus administration over 1 to 2 hours Measure lactate >2mmol And MAP less than 55 mmHg Check for Cardiac status, IVC and B-lines in Lung Start Moradrenaline preferable through central line, in emergency Can give through peripheral line Single strength – 8ml + 5% dextrose or NS 42 ml total = 50ml through infusion pump This is 80 microgram/ ml Contains 4mg Noradrenaline base Double strength – 16ml + 5% dextrose or NS 34 ml total = 50ml through Infusion pump This is 160 microgram/ ml Contains 8mg Noradrenaline / kg/min If the dose reaches 0.2 ug/ kg/min refractory shock High mortality If the dose reaches 0.2 ug/kg – severe shock Add Vasopressin – Dose 0.001 to 0.003 units/kg Not responding give –Hudrocortisone 100mg stat Vasopressin Infusion for sepsis 0.01 – Usually started at 3 ml/hour,………………………….max 4 to 5 ml/hour 20units/ml, add 2.5ml to 47.5 ml NS 1ml = 1unit Start at 1 ml can titrate 4 to 5ml/ hr
Dobutamine – SINGLE strength -250 mg in 50 ml (5 mg in 1 ml)
Dosage 60kg 70kg 80kg 100kg
Ug/kg/min 3l/hr Ml/hr Ml/hr Ml/hr 5 microgram/kg/min 3.6 4.2 4.8 6 10microgram/kg/ 7.2 8.4 9.6 12 min 15microgram/kg/ 10.8 12.6 14.4 18 min 20microgram/kg/ 14.4 16.8 19.2 24 min g/1 mEq/1 Dextrose Intravenous fluids MOsm/1a Na - C1 K Ca Mg Lactate (g/1) 5% Dextrose in water (D5W) 278 50 5% Dextrose in 0.45% NaCl 405 77 77 50 5% Dextrose in 0.9% NaCl 561 154 154 50 5% Dextrose in Ringer’s solution 525 130 109 4 3 50 Ringer’s solution 309 147 156 4 4 -45 Lactated Ringer’s solution 275 130 109 4 3 28 5% Dextrose in Lactated 525 130 109 4 3 28 50 Ringer’s solution Plasmaytch 298 140 98 5 3 0.45 % NaCl 154 77 77 0.9% NaCl 308 154 154 3.0% Saline 1026 513 513 5.0% Saline 1710 855 855 7.5% Saline 2566 1283 1283 20% Mannitol 1098 a osmolarity = calculated value (osm/1 – mg ÷ molecular weigh X 10 X valene) b Acctate 27 mEq/1 and gluconate 23 mEq/1.