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Hemant

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Hemant

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Vasopressors guideline in IGOT ICU

All patients with hypotension


After 20ml/ kg fluid NS or RL bolus administration over 1 to 2 hours
Measure lactate >2mmol
And MAP less than 55 mmHg
Check for Cardiac status, IVC and B-lines in Lung
Start Moradrenaline preferable through central line, in emergency
Can give through peripheral line
Single strength – 8ml + 5% dextrose or NS 42 ml total = 50ml through infusion pump
This is 80 microgram/ ml
Contains 4mg Noradrenaline base
Double strength – 16ml + 5% dextrose or NS 34 ml total = 50ml through
Infusion pump
This is 160 microgram/ ml
Contains 8mg Noradrenaline / kg/min
If the dose reaches 0.2 ug/ kg/min refractory shock
High mortality
If the dose reaches 0.2 ug/kg – severe shock
Add Vasopressin – Dose 0.001 to 0.003 units/kg
Not responding give –Hudrocortisone 100mg stat
Vasopressin
Infusion for sepsis 0.01 –
Usually started at 3 ml/hour,………………………….max 4 to 5 ml/hour
20units/ml, add 2.5ml to 47.5 ml NS
1ml = 1unit
Start at 1 ml can titrate 4 to 5ml/ hr

Dobutamine – SINGLE strength -250 mg in 50 ml (5 mg in 1 ml)

Dosage 60kg 70kg 80kg 100kg


Ug/kg/min 3l/hr Ml/hr Ml/hr Ml/hr
5 microgram/kg/min 3.6 4.2 4.8 6
10microgram/kg/ 7.2 8.4 9.6 12
min
15microgram/kg/ 10.8 12.6 14.4 18
min
20microgram/kg/ 14.4 16.8 19.2 24
min
g/1
mEq/1 Dextrose
Intravenous fluids MOsm/1a Na - C1 K Ca Mg Lactate (g/1)
5% Dextrose in water (D5W) 278 50
5% Dextrose in 0.45% NaCl 405 77 77 50
5% Dextrose in 0.9% NaCl 561 154 154 50
5% Dextrose in Ringer’s solution 525 130 109 4 3 50
Ringer’s solution 309 147 156 4 4 -45
Lactated Ringer’s solution 275 130 109 4 3 28
5% Dextrose in Lactated 525 130 109 4 3 28 50
Ringer’s solution
Plasmaytch 298 140 98 5 3
0.45 % NaCl 154 77 77
0.9% NaCl 308 154 154
3.0% Saline 1026 513 513
5.0% Saline 1710 855 855
7.5% Saline 2566 1283 1283
20% Mannitol 1098
a osmolarity = calculated value (osm/1 – mg ÷ molecular weigh X 10 X valene)
b Acctate 27 mEq/1 and gluconate 23 mEq/1.

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