MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION

(Autonomous)
(ISO/IEC - 27001 - 2005 Certified)

MODEL ANSWER
SUMMER– 17 EXAMINATION
Subject Title: PHARMACEUTICS-I 0805
Subject Code:
__________________________________________________________________________________________________

Important Instructions to examiners:

1) The answers should be examined by key words and not as word-to-word as given in the model answer
scheme.
2) The model answer and the answer written by candidate may vary but the examiner may try to assess the
understanding level of the candidate.
3) The language errors such as grammatical, spelling errors should not be given more Importance (Not
applicable for subject English and Communication Skills.
4) While assessing figures, examiner may give credit for principal components indicated in the figure. The
figures drawn by candidate and model answer may vary. The examiner may give credit for any equivalent
figure drawn.
5) Credits may be given step wise for numerical problems. In some cases, the assumed constant values may
vary and there may be some difference in the candidate’s answers and model answer.
6) In case of some questions credit may be given by judgement on part of examiner of relevant answer based
on candidate’s understanding.
7) For programming language papers, credit may be given to any other program based on equivalent concept.

Page No.1/31
 MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION
(Autonomous)
(ISO/IEC - 27001 - 2005 Certified)

MODEL ANSWER
SUMMER– 17 EXAMINATION
Subject Title: PHARMACEUTICS-I 0805
Subject Code:
__________________________________________________________________________________________________

Q. Su Answer Marking
No. b Scheme
Q.
N.
Q.1 Attempt any SIX Of the following 12Marks
(a) Define Pharmacopoeia. Give example. (2M)
Pharmacopoeia: Pharmakon means “a drug” and poein means “to make”. (1M)
Pharmacopoeia is defined as a compressive book which is issued under the authority of
government and contains a list of drugs and formulae used for medicinal preparation with
description and the tests for those substances and the standards to which they must confirm.
Example: (0.5 X
I.P., B.P., USP, European Pharmacopoeia, etc. 2= 1M)

(b) Define container and closure. (2M)

Container is a device that holds the drug and it may or may not be in direct contact with the (1+ 1)
pharmaceutical preparations.
Closure is the device by means of which container can be opened and closed.

(c) What are qualities of good container? The container should be: (2M)
i. Neutral 0.5x4=2
ii. No interaction.
iii. Stability against environmental factor.
iv. Withstand wear and tear during handling.
v. Easy to remove dose.
vi. Withstand changes in pressure and temperature.
vii. Labeled easily
viii. Non-toxic.
ix. Closure easily removable/replaceable.
(d) What is difference between filtration and clarification 2M

Page No.2/31
 MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION
(Autonomous)
(ISO/IEC - 27001 - 2005 Certified)

MODEL ANSWER
SUMMER– 17 EXAMINATION
Subject Title: PHARMACEUTICS-I 0805
Subject Code:
__________________________________________________________________________________________________
(0.5 X 4
Filtration Clarification
= 2M)
Filtration may be defined or When solids are in small amount (less
separation of a solid from fluid by than1%) , the process is usually spoken as
means of by means of porous clarification
medium that retain the solid but
allows fluid to pass.

Filter paper is used Talcum is used.

Different filter media are used No filter media is used
Intention of filtration may be the Intention of Clarification may be the
collection of filter cake. collection of filtrate.

(e) Give application of freeze drying. 2M

(i) The process is mainly used for drying of biological products such as antibiotics, (1x2
blood products, vaccines ,enzymes preparation, microbiological cultures etc. =2M)
(ii) The heat sensitive material can be dried.
(f) What are advantages of water as menstruum for extraction? 2M
• It is cheap & easily available. 0.5x4=2
• Non –toxic
• Non inflammable.
• It has wide solvent action.
(g) What are advantages of evaporating still? 2M
• It is simple to construct. 0.5x4=2
• Easy to clean and maintain.
• The vapors are condensed in it. It increases the speed of evaporation and the costly
solvent can be recovered. E.g. ethyl alcohol.
• As vapors are condensed there is no chance of discomfort to the operator.
• A vacuum pump can be fitted to the condenser for operation under reduced pressure.
(h) Calculate the quality of dextrose required to prepare one quart of 5% solution. 2M

Page No.3/31
 MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION
(Autonomous)
(ISO/IEC - 27001 - 2005 Certified)

MODEL ANSWER
SUMMER– 17 EXAMINATION
Subject Title: PHARMACEUTICS-I 0805
Subject Code:
__________________________________________________________________________________________________
4.375 gr. in 1 fl ounce = 1% w/v solution
4.375x5(21.874gr. )in 1 fl ounce = 5% w/v solution
21.874 gr. in 1 fl ounce = 5% w/v solution
? gr. in 40 fl ounce = 5% w/v solution [As 1 quart=40 fl ounce]
21.874x40/1=875 gr in 40 fl ounce = 5% w/v solution
Solution: Dextrose required is 875 gr in40 fl.ounce (1 quart)is required
Or
4.375 gr. in 1 fl ounce = 1% w/v solution
Therefore, 4.375 X 40 X 5 = 875 grain [As 1 quart=40 fl ounce]

(i) Draw a labelled diagram of double cone blender 2M

Q.2 (a) Attempt any FOUR Of the following 12M

Page No.4/31