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BME741 Review Paper Topic

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Yousef Ahmad2
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22 views2 pages

BME741 Review Paper Topic

Uploaded by

Yousef Ahmad2
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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BME741-BIOMATERIALS AND MATERIALS TISSUE INTERACTIONS

Title

Materials & Relevant Tissue Interactions for Peripheral Nerve


Conduits

Abstract

Peripheral injuries can lead loss of function and therefore to physical


disability and chronic pain which may affect the health and lifestyle of the
affected. Peripheral nerves however unlike it's central counterpart, can be
regenerated

Various techniques have been developed to regenerate and repair nerve


damage such as the gold standard The autologous nerve graft and special
surgical interventions. However, they do have those own complications
which limit the compete regeneration of the nerve. one promising
technique is the nerve conduit which combines biomaterials with growth
factors that stimulates the nerve regeneration

Peripheral Nerve conduits are biomedical devices responsible for


facilitating joining peripheral nerves and facilitate peripheral nerve
regeneration.
The conduits uses a variety of classes of materials such as biopolymers
and synthetic polymers as scaffolds and several surface modifications are
utilized in order to achieve an effective regeneration of the peripheral
nerve such as surface patterning. Many properties, be it structural or
functional affect the performance of these conduits and must be selected
carefully for optimal function

In this review, materials that make up the peripheral conduits will be


discussed as well as their tissue reactions, both desirable and undesirable
ones. Properties and failure modes will be expanded upon, and fabrication
techniques will be summarized. And it's ability to deposit growth and
neurotrophic factors that stimulates the regeneration and enhances it .The
aim of the review is act as gateway for those interested in neural tissue
engineering and peripheral nerve regeneration as well as providing a
recent reference and summary for new advances in this field

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