MOOD STABILIZERS
DRUG NAME lithium (Lithobid)
CLASS Mood stabilizer; antimanic agent
Inhibition of norepinephrine and dopamine release in the brain
MECHANISM OF ACTION Increase of serotonin production in the brain
Alteration of Na+/ K+ ion transport (brain, muscle cells)
INDICATIONS Bipolar disorder
ROUTE(S) OF PO
ADMINISTRATION
Nausea, vomiting, diarrhea
Muscle weakness, hyperreflexia, ataxia
Slurred speech
SIDE EFFECTS
Seizures
Nephrogenic diabetes insipidus (polyuria, polydipsia)
Serotonin syndrome
Boxed warning: toxicity
Pregnancy, breastfeeding
Children < 12 years
CONTRAINDICATIONS AND Cardiac / renal / hepatic impairment
CAUTIONS Schizophrenia, brain trauma, brain organ syndrome
NSAIDs, ACE inhibitors, diuretics
Dehydration, hyponatremia
Thyroid disease
Assessment and monitoring
Mental status
Medication history
Baseline labs: BUN, creatinine, electrolytes, TSH, liver function,
thyroid function, negative pregnancy test
NURSING CONSIDERATIONS Client education
Take as prescribed; do not crush or chew
Do not stop even if feeling better
Take with meals or milk
Regular monitoring of lithium levels required
Keep fluid and sodium balance consistent
Report signs or symptoms of toxicity
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