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Gog Comparitive Study of Commercial Antacids

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12 views

Gog Comparitive Study of Commercial Antacids

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mridul.sp2812
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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V.

PROCEDURE

1. Firstprepareapproximately1litreofapproximatelyN/10solutionof
HClbydiluting10mlofthegiven10MHClacid to1litre.

2. Nextprepare1litreofapprox.N/10NaOHsolutionbydissolving4.0gof
NaOHpowderto make1litreofsolution.

3.SimilarlyprepareN/10Na2CO3solutionbyweighing
exactly1.325gofanhydrousNa2CO3andthendissolvingitinwatertoprepareexactly
0.25Lor250mlofNa2CO3solution.
4. Now,standardizetheHClsolutionbytitratingitagainst thestandard
Na2CO3solutionusingmethylorangeasindicator.

5. SimilarlystandardizetheNaOHsolutionbytitratingitagainststandardizedHClso
lutionusingphenolopthaleinasindicator.Stopthetitration when
thepinkcolorofthesolutiondisappears.
6.Now,powderthefourantacidsamplesandweigh0.5gofeach.
7.Add25mlofthestandardisedHCltoeach
oftheweighedsamplestakeninconicalflas
ks.Makesurethattheacidisinslightexcess
sothatneutraliseallthebasiccharacterofthetabletpowder.
8. Addafewdropsofphenolpthaleinindicatorandwarmtheflaskoverabunsenburner
tillmostofthepowderdissolves.
9. Filtertheinsolublematerial.

10.Titratethissolutionagainst
thestandardisedNaOHsolution,tillapermanentpinkishtingeinsobtained.
11.Repeatthesameexperimentforallothersamplestoo.
VII.OBSERVATIONS

 Standardisation of HCl solution:

Volume of 0.1N Na2CO3 taken = 20 ml

Indicator used = Methyl Orange

SERIAL BURETTE READINGS VOLUME OF


No. INITIAL READING FINAL READING ACID USED
(ml)
1. 0 17 17
2. 18 35 17

Applying normality equation,

N1 V1 = N2 V2
(acid) (base)

N1 x 17 = 0.1 x 20
Normality of HCl, N1= 2/17 = 0.11 ≈ 0.1

 Standardization of NaOH Solution:

Volume of the given NaOH solution taken = 20.0 ml

Indicator used = Phenolphthalein


SERIAL BURETTE READINGS VOLUME OF
No. INITIAL READING FINAL READING ACID USED
(ml)
1. 0 16 16
2. 17 33 16

Volume of acid used = 16 ml

Applying normality equation,


N1 V’1 = N’2 V’2
(acid) (base)
0.11 x 16 = N’2 x 20

Normality of HCl, N’2 = (0.11*16)/20 = 0.09 ≈ 0.1

 Analysis of antacid tablets:

 Weight of the antacid tablet powder = 0.5 g


 Volume of HCl solution added = 30 ml
 Volume of sample solution taken = 20 ml
for titration

VOLUME OF (NaOH) USED


ANTACID
FOR NEUTRALIZING
UNUSED (HCL)

1.Eno Pineapple 29

2. Eno Lemon 24

3.Digene Lime 9

4.Omez 24

5. Pephyrous 40

6. Gelusil 22
VIII.RESULT
 1g of Eno Pineapple required 29 ml of Sodium Hydroxide (NaOH) to
titrate it completely.
 1 g of Eno Lemon required 24 ml of Sodium Hydroxide (NaOH) solution
to titrate it completely.
 1 g of Digene lime required 9 ml of Sodium Hydroxide (NaOH) to titrate
it.
 1 g of Omez required 24 ml of Sodium Hydroxide (NaOH) to titrate it
completely.
 1 g of Pephyrous required 40 ml of Sodium Hydroxide (NaOH) to titrate
it completely.
 1 g of Gelusil required 22 ml of Sodium Hydroxide (NaOH) to titrate it
completely.

Based on the hypothesis of the experiment, the antacid which requires the least
amount of Sodium Hydroxide (NaOH) is the best antacid. From the recorded
observation, Digene© requires the least (5 ml), and is therefore the best Antacid.

IX.SUMMARY AND CONCLUSION


Antacids play a very important role in relieving many patients suffering from
gastric hyperacidity, commonly referred to as gastritis. This project was
undertaken to analyze the best commercially available antacid according to the
amount of hydrochloric acid they could neutralize.
After exploring many books and websites to find out more about antacids, we
were clear of its role and its applications. We started our project by powdering
the various antacid samples and making sure that the apparatus were clean.
Later we standardized various solutions and prepared N/10 HCl solution and
N/10 NaOH solution. This was done by titrating various solutions and using the
respective indicators.
The powdered antacid samples weighing 1 gram each was each added to 30 ml
of the standardized solution of HCl in separate conical flasks. These solutions
were later titrated with the standardized NaOH and the readings were noted.
These readings were helpful in deciding the amount of HCl that each antacid
could neutralize.
Various antacids could neutralize a specific amount of the acid. pephyrous was
the poorest among all antacids. Eno pineapple had a slightly higher alkaline
nature while Eno lemon and Omez proved to neutralize to same amount .
Gelusil had a higher concentration of the base. Digene had the highest basic
character!
Thus, on the basis of the experiment conducted, it was adjudged that Digene
was the best commercially available antacid.

X.BIBLIOGRAPHY

Websites:
• http://www.reachoutmichigan.org/funexperiments/quick/csustan/antacid
• http://icn2.umeche.maine.edu/genchemlabs/Antacid/antacid2.htm
• http://www.chem.latech.edu/~deddy/chem104/104Antacid.htm
• http://www.images.google.com
• http://www.wikipedia.com
• http://www.pharmaceutical-drug-manufacturers.com

Books

 Comprehensive Practical Chemistry Class XII

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