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U-Science_Intro

Uploaded by

mo
Copyright
© © All Rights Reserved
Available Formats
Download as PDF, TXT or read online on Scribd
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U: The Mind Company 2021

Axis Noninvasive Brain


Stimulation
Organization Structure
Key Leaders

Dr. JEFF SPITZNER PHD Dr. SAM KHOZIN MD Dr. DAVID Dr. MOHAMMAD NAMI
MSQM MOHAMMED ABOUELSOUD MISHELEVICH MD/PhD MD/PHD
CHAIRMAN
CIO CEO BOARD CMO

Ph.D. The Ohio MD Ross Applied Physics + MD/Ph.D. Johns MD/Ph.D. Shiraz
State University University School Computational Hopkins University of
of Medicine Neuroscience, University Medicine
Postdoc The Ohio State
Massachusetts MSQM Duke University Former Consulting EWHC Harvard
Institute of University - The Professor of Medical School
Technology (MIT) Fuqua School of Founder at U Neurosurgery at
Business Stanford
University School
of Medicine
Our Solution Side Effects

Noninvasive Brain Stimulation


is used for 20 minutes every day to stimulate the
frontal cortex and induce inter-hemispheric coherence
across the hemispheres. The device is built on decades
of research around transcranial stimulation. The
Stimulation parameters are optimized and personalized
for each disease and person respectively.
Noninvasive + Portable
Clinical Data at End of Presentation
N=30 fMRI Trial for Alzheimer's Disease
Pharmacology
Complete Data Summary
Milestones 2021
600,000+ Minutes of Device use with only 1 Adverse Event
Submission of 1 Non-Provisional Patent
Q1

Clinical Significant Evidence showing reversal of Dementia + Multiple


Q2
Sclerosis

N=30 fMRI + QEEG Clinical Trial for Alzheimer's Disease Initiated Q3

Mayo Clinics + Marshall University STTR Grants Sumbissions Q3

N=5 QEEG Clinical Trial for Parkinson's Disease Initiated Q4


Male, Age 72, Secondary
Multiple Progressive Multiple
Sclerosis 3/1/21
Sclerosis
"they used to be clenched together knee pressed against knee......now my legs are spread apart"
4/2/21
"my legs remain relaxed.........but we noticed slight movement when I try to wiggle my
toes......sometimes my fingers unclench but not consistently "
4/2/21
"From my perspective, the device continues to improve XXX ability to open his hand, and it’s also
contributing to his legs involuntarily moving out of their position on the footrests of his wheelchair."
4/6/21
"Left Leg Stretching and toes wiggling at night, stopped in the morning."

4/17/21
"whenever XXX moved my body to...for instance...adjust me in my seat or change my shirt...my upper
body and arms would intensely spasm for a moment...no pain just a couple seconds of spasming"
Parkinson's Disease

Downstream Action
Potential Propagation
to STN through Pulsed
Current along
Corticospinal tract
Parkinson's Male, Age 60, Parkinson's
Disease Disease with Night Sweats
April 21. Used device for 20 minutes. Took the device off. He ‘reports that he feels
more balanced and stable. Toes are still numb. A little bit of tremor in my left hand.

April 22. After the device, toes are still numb but not hurting, feeling
grounded/swinging/steady. Usually there is unsteadiness when standing. More steady t
unsteady now.

April 26. His stopping and turning when walking is a lot more improved.
Male, Age 68, Parkinson's
Parkinson's
Disease with Right Extremities
Disease Tremor (Treatment Resistant to
Red Light Therapy)
5/1/21
Action and resting tremor, very rigid and slow both right arm and right leg,

7/17/21 (13 weeks of device)


Tremor is minimal after Rock Steady Boxing (didn't happen before device).
Attitude is better. When relaxed throughout the day, tremor just stops.

New Phenomenas: When walking slowly, he has better control of gait. Tremor stop throughout
the day due to deep relaxation.
Alzheimer's Disease

Global Reduced Neural Mass


Forceps Minors is most critical region to stimulate
using 2 Frontal Electroedes
Female, Age 57, Moderate to
Alzheimer's
Severe Alzheimer's Disease,
Disease Using Device 2 times a day

9/29/20 Baseline
She cannot remember her name, fear when using restroom, mild state of psychosis

12/20/20 (12 weeks of Device Use)


She has slightly improved memory, recalled her name and country of origin, she counted up to 10, she
has no fear/problems with urination but has problems with bowel movements

5/28/20 (8+ Months of Device Use)


The progression of the disease has declined dramatically. The patient exhibited improved recognition
compared to baseline. We also observed reduced cognitive decline. Her eating, sleeping and bathroom
use is good. Her appetite is great. Her mood significantly improved. She doesn’t get angry like before at
all.
Female, Age 70, Moderate
Alzheimer's
Alzheimer's Disease, Using
Disease Device 2 times a day

6/4/21 Baseline
She can’t find her way home… She is very anxious She cannot stay for 1 hour at house without getting
anxious Memory loss started at 2015… she started to repeat questions and short term memory loss
was evident during phone conversations...She struggles dressing and she struggles in the shower…. She
gets confused in the bathroom and in the bedroom dressing. She forgets her husband to her dad
sometimes

9/15/20 (Week 15 of Device Use)


She learned how to put her cardigan; she is dressing a little more independently recently. She is staying
up more. She seems inclined to stay out of the house more. She turns around and answering back to
husband. Recalling conversations with husband
80+ Consented Volunteers
Individuals Suffering from Major Depressive Disorder, Bipolar
Mental Illness Disorder, or General Anxiety Disorder
Case Stuides
Anectodes after 4 weeks: "I can't get enough"
"I am not depressed" "It's getting better everyday" "I am getting off
of my medications after 20 years"

0-95% Improvement in Mood


An average of 76.6% increase in mood from initial
volunteers as measured by PHQ-9 Results after 4
weeks with a cohort of 8 volunteers

No Adverse Effects Reported


600,000+ minutes recorded use of the device with No
Short or Long Term Adverse Effects except for skin
tingling
Traumatic Brain Injury 6-Week Use
Went from reciting test questions
out loud (Week 1) to Reciting test
questions in Mind (Week 3)

"I can actually feel my brain working


differently trying to retain auditory
input and internal input"

"The device has made me so


enlightened"
Traumatic Brain Injury 6-Week Use
Went from reciting test questions
out loud (Week 1) to Reciting test
questions in Mind (Week 3)

"I can actually feel my brain working


differently trying to retain auditory
input and internal input"

"The device has made me so


enlightened"
MD/PhD Burnout
Case Study
6-Week Use

"I am definitely feeling


the effects. Very
impressive!!" (Day 1)
Veteran Case Study
6-Week Use

Anxiety
+
Depression
Anxiety/Depression Case Study
5-Week Use

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